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    RORB RAR related orphan receptor B [ Homo sapiens (human) ]

    Gene ID: 6096, updated on 2-Nov-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    Comprehensive analysis of the prognosis and biological significance of RORbeta in head and neck squamous cell carcinoma.

    Comprehensive analysis of the prognosis and biological significance of ROR(β) in head and neck squamous cell carcinoma.
    Zheng J, Tang H, Yang Y, Yang K.

    01/15/2024
    RORB, an Alzheimer's disease susceptibility gene, is associated with viral encephalitis, an Alzheimer's disease risk factor.

    RORB, an Alzheimer's disease susceptibility gene, is associated with viral encephalitis, an Alzheimer's disease risk factor.
    Lehrer S, Rheinstein PH., Free PMC Article

    10/11/2023
    RORbeta suppresses the stemness of gastric cancer cells by downregulating the activity of the Wnt signaling pathway.

    RORβ suppresses the stemness of gastric cancer cells by downregulating the activity of the Wnt signaling pathway.
    Wen Z, Chen M, Guo W, Guo K, Du P, Fang Y, Gao M, Wang Q., Free PMC Article

    12/4/2021
    Inherited RORB pathogenic variants: Overlap of photosensitive genetic generalized and occipital lobe epilepsy.

    Inherited RORB pathogenic variants: Overlap of photosensitive genetic generalized and occipital lobe epilepsy.
    Sadleir LG, de Valles-Ibáñez G, King C, Coleman M, Mossman S, Paterson S, Nguyen J, Berkovic SF, Mullen S, Bahlo M, Hildebrand MS, Mefford HC, Scheffer IE., Free PMC Article

    10/24/2020
    Results show that NRIP2 regulates the activity of the Wnt pathway via RORbeta. RORbeta inhibits tumorigenesis and the self-renewal of cancer initiating cells (CCICs) and targets HBP1 in regulating Wnt pathway to inhibit tumorigenesis and the self-renewal of CCICs.

    Up-regulated NRIP2 in colorectal cancer initiating cells modulates the Wnt pathway by targeting RORβ.
    Wen Z, Pan T, Yang S, Liu J, Tao H, Zhao Y, Xu D, Shao W, Wu J, Liu X, Wang Y, Mao J, Zhu Y., Free PMC Article

    02/10/2018
    Nonsense variant in RORB was identified in four family members with epilepsy. Two de novo RORB deletions identified in patients with behavioral and cognitive impairment and epilepsy.

    Loss of function of the retinoid-related nuclear receptor (RORB) gene and epilepsy.
    Rudolf G, Lesca G, Mehrjouy MM, Labalme A, Salmi M, Bache I, Bruneau N, Pendziwiat M, Fluss J, de Bellescize J, Scholly J, Møller RS, Craiu D, Tommerup N, Valenti-Hirsch MP, Schluth-Bolard C, Sloan-Béna F, Helbig KL, Weckhuysen S, Edery P, Coulbaut S, Abbas M, Scheffer IE, Tang S, Myers CT, Stamberger H, Carvill GL, Shinde DN, Mefford HC, Neagu E, Huether R, Lu HM, Dica A, Cohen JS, Iliescu C, Pomeran C, Rubenstein J, Helbig I, Sanlaville D, Hirsch E, Szepetowski P., Free PMC Article

    07/15/2017
    associations between NR1D1, RORA and RORB genes and bipolar disorder.(

    Investigation of associations between NR1D1, RORA and RORB genes and bipolar disorder.
    Lai YC, Kao CF, Lu ML, Chen HC, Chen PY, Chen CH, Shen WW, Wu JY, Lu RB, Kuo PH., Free PMC Article

    02/13/2016
    Retinoic acid-related orphan receptor RORbeta, circadian rhythm abnormalities and tumorigenesis

    Retinoic acid-related orphan receptor RORβ, circadian rhythm abnormalities and tumorigenesis (Review).
    Feng S, Xu S, Wen Z, Zhu Y.

    01/30/2016
    these data demonstrate that Rorbeta regulates known osteogenic pathways, and may represent a novel therapeutic target for age-associated bone loss.

    Identification of Rorβ targets in cultured osteoblasts and in human bone.
    Roforth MM, Khosla S, Monroe DG., Free PMC Article

    02/15/2014
    Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)

    Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
    Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR., Free PMC Article

    06/30/2010
    Observational study and genome-wide association study of gene-disease association. (HuGE Navigator)

    Human variation in alcohol response is influenced by variation in neuronal signaling genes.
    Joslyn G, Ravindranathan A, Brush G, Schuckit M, White RL.

    04/7/2010
    Observational study of gene-disease association. (HuGE Navigator)See all PubMed (2) articles

    Evidence for genetic association of RORB with bipolar disorder.
    McGrath CL, Glatt SJ, Sklar P, Le-Niculescu H, Kuczenski R, Doyle AE, Biederman J, Mick E, Faraone SV, Niculescu AB, Tsuang MT.

    Association study of 21 circadian genes with bipolar I disorder, schizoaffective disorder, and schizophrenia.
    Mansour HA, Talkowski ME, Wood J, Chowdari KV, McClain L, Prasad K, Montrose D, Fagiolini A, Friedman ES, Allen MH, Bowden CL, Calabrese J, El-Mallakh RS, Escamilla M, Faraone SV, Fossey MD, Gyulai L, Loftis JM, Hauser P, Ketter TA, Marangell LB, Miklowitz DJ, Nierenberg AA, Patel J, Sachs GS, Sklar P, Smoller JW, Laird N, Keshavan M, Thase ME, Axelson D, Birmaher B, Lewis D, Monk T, Frank E, Kupfer DJ, Devlin B, Nimgaonkar VL.

    12/2/2009
    In the suprachiasmatic nucleus, ROR beta mRNA signals showed a peak at early daytime and a trough at early nighttime. ROR beta is a transcription factor possibly related to the circadian pacemaking system.

    Rhythmic expression of ROR beta mRNA in the mice suprachiasmatic nucleus.
    Sumi Y, Yagita K, Yamaguchi S, Ishida Y, Kuroda Y, Okamura H.

    01/21/2010
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