| Dynamic Changes in Serum IGF-I and Growth During Infancy: Associations to Body Fat, Target Height, and PAPPA2 Genotype. | Dynamic Changes in Serum IGF-I and Growth During Infancy: Associations to Body Fat, Target Height, and PAPPA2 Genotype.
Upners EN, Ljubicic ML, Busch AS, Fischer MB, Almstrup K, Petersen JH, Jensen RB, Hagen CP, Juul A. | 02/19/2022 |
| Short stature with low insulin-like growth factor 1 availability due to pregnancy-associated plasma protein A2 deficiency in a Saudi family. | Short stature with low insulin-like growth factor 1 availability due to pregnancy-associated plasma protein A2 deficiency in a Saudi family.
Babiker A, Al Noaim K, Al Swaid A, Alfadhel M, Deeb A, Martín-Rivada Á, Barrios V, Pérez-Jurado LA, Alfares A, Al Alwan I, Argente J. | 02/19/2022 |
| Genetic Study of IL6, GDF5 and PAPPA2 in Association with Developmental Dysplasia of the Hip. | Genetic Study of IL6, GDF5 and PAPPA2 in Association with Developmental Dysplasia of the Hip.
Harsanyi S, Zamborsky R, Krajciova L, Kokavec M, Danisovic L., Free PMC Article | 02/5/2022 |
| Serum Inhibin-A and PAPP-A2 in the prediction of pre-eclampsia during the first and second trimesters in high-risk women. | Serum Inhibin-A and PAPP-A2 in the prediction of pre-eclampsia during the first and second trimesters in high-risk women.
Keikkala E, Forstén J, Ritvos O, Stenman UH, Kajantie E, Hämäläinen E, Räikkönen K, Villa PM, Laivuori H. | 12/11/2021 |
| Associations of plasma PAPP-A2 and genetic variations with salt sensitivity, blood pressure changes and hypertension incidence in Chinese adults. | Associations of plasma PAPP-A2 and genetic variations with salt sensitivity, blood pressure changes and hypertension incidence in Chinese adults.
Wang Y, Jia H, Gao WH, Zou T, Yao S, Du MF, Zhang XY, Chu C, Liao YY, Chen C, Wang D, Ma Q, Hu JW, Wang KK, Yan Y, Sun Y, Hu GL, Niu ZJ, Zhou HW, Zhang X, Wang X, Li CH, Chen FY, Gao K, Zhang J, Guan YJ, Chang J, Yang TL, Mu JJ. | 10/30/2021 |
| Disorders caused by genetic defects associated with GH-dependent genes: PAPPA2 defects. | Disorders caused by genetic defects associated with GH-dependent genes: PAPPA2 defects.
Fujimoto M, Andrew M, Dauber A., Free PMC Article | 06/26/2021 |
| Netazepide Inhibits Expression of Pappalysin 2 in Type 1 Gastric Neuroendocrine Tumors. | Netazepide Inhibits Expression of Pappalysin 2 in Type 1 Gastric Neuroendocrine Tumors.
Lloyd KA, Parsons BN, Burkitt MD, Moore AR, Papoutsopoulou S, Boyce M, Duckworth CA, Exarchou K, Howes N, Rainbow L, Fang Y, Oxvig C, Dodd S, Varro A, Hall N, Pritchard DM., Free PMC Article | 05/15/2021 |
| PAPP-A2 and Inhibin A as Novel Predictors for Pregnancy Complications in Women With Suspected or Confirmed Preeclampsia. | PAPP-A2 and Inhibin A as Novel Predictors for Pregnancy Complications in Women With Suspected or Confirmed Preeclampsia.
Neuman RI, Alblas van der Meer MM, Nieboer D, Saleh L, Verdonk K, Kalra B, Kumar A, Alpadi K, van den Meiracker AH, Visser W, Danser AHJ., Free PMC Article | 03/20/2021 |
| Uteroplacental Ischemia Is Associated with Increased PAPP-A2. | Uteroplacental Ischemia Is Associated with Increased PAPP-A2.
Lamale-Smith LM, Gumina DL, Kramer AW, Browne VA, Toledo-Jaldin L, Julian CG, Winn VD, Moore LG., Free PMC Article | 12/12/2020 |
| The potential role of pregnancy-associated plasma protein-A2 in angiogenesis and development of preeclampsia. | The potential role of pregnancy-associated plasma protein-A2 in angiogenesis and development of preeclampsia.
Chen X, Chen K, Feng Y, Ren C, Li W, Xiao J, Fan L, Beejadhursing R, Xi L, Chen S. | 09/12/2020 |
| PAPP-A2 consistently decreased throughout childhood. PAPP-A2 levels positively correlated with the percent free IGF-I and negatively with intact IGFBP-3. correlative findings suggest that PAPP-A2 is an important regulator of the percent free IGF-I which can be a marker of perturbations in the GH/IGF-I axis. | Anthropometric and biochemical correlates of PAPP-A2, free IGF-I, and IGFBP-3 in childhood.
Fujimoto M, Khoury JC, Khoury PR, Kalra B, Kumar A, Sluss P, Oxvig C, Hwa V, Dauber A., Free PMC Article | 02/29/2020 |
| Total IGFBP 5, PAPPA, PAPPA2 and Stanniocalcin-2. | Circulating levels of the components of the GH/IGF-1/IGFBPs axis total and intact IGF-binding proteins (IGFBP) 3 and IGFBP 4 and total IGFBP 5, as well as PAPPA, PAPPA2 and Stanniocalcin-2 levels are not altered in response to energy deprivation and/or metreleptin administration in humans.
Pilitsi E, Peradze N, Perakakis N, Mantzoros CS. | 02/15/2020 |
| PAPP-A2 mutation is associated with idiopathic short stature. | Letter to the Editor: History and clinical implications of PAPP-A2 in human growth: When reflecting on idiopathic short stature leads to a specific and new diagnosis: Understanding the concept of "low IGF-I availability".
Argente J, Pérez-Jurado LA. | 11/17/2018 |
| The findings suggest a possible pathophysiological link between the development of Fetal growth restriction and the expression of PAPPA, PAPPA2 and PLAC-1. | Placental expression of PAPPA, PAPPA-2 and PLAC-1 in pregnacies is associated with FGR.
Sifakis S, Androutsopoulos VP, Pontikaki A, Velegrakis A, Papaioannou GI, Koukoura O, Spandidos DA, Papantoniou N., Free PMC Article | 09/15/2018 |
| Pregnancy associated plasma protein-A (PAPP-A) appears to be a potentially useful biomarker for short-term risk stratification of patients presenting with chest pain of ischemic origin (Review). | Pregnancy associated plasma protein-A as a prognostic biomarker of all-cause mortality and cardiovascular events in patients presenting with chest pain: a systematic review.
Papanastasiou CA, Kokkinidis DG, Oikonomou EK, Mantziaris VG, Foley TR, Karamitsos TD, Waldo SW, Armstrong EJ. | 08/25/2018 |
| PAPP-A2 is increased in Hemodialysis patients and interacts with PAPP-A on patients prognosis. | Pregnancy-Associated Plasma Protein A2 in Hemodialysis Patients: Significance for Prognosis.
Kalousová M, Dusilová-Sulková S, Kuběna AA, Zakiyanov O, Levová K, Bocková M, Gedeonová E, Song XC, Ermini ML, Špringer T, Homola J, Tesař V, Zima T. | 06/30/2018 |
| This review evaluates the current data concerning PAPP-A2 function, and particularly the effect of PAPP-A2 mutation on growth. | PAPP-A2 a new key regulator of growth.
Banaszak-Ziemska M, Niedziela M. | 02/3/2018 |
| These patients provide important insights into the regulation of longitudinal growth in humans, documenting the critical role of PAPP-A2 in releasing IGF-I from its binding proteins. | Mutations in pregnancy-associated plasma protein A2 cause short stature due to low IGF-I availability.
Dauber A, Muñoz-Calvo MT, Barrios V, Domené HM, Kloverpris S, Serra-Juhé C, Desikan V, Pozo J, Muzumdar R, Martos-Moreno GÁ, Hawkins F, Jasper HG, Conover CA, Frystyk J, Yakar S, Hwa V, Chowen JA, Oxvig C, Rosenfeld RG, Pérez-Jurado LA, Argente J., Free PMC Article | 09/16/2017 |
| Short-term treatment with progressive doses of rhIGF1 (recombinant human insulin-like growth factor-1) improved growth in two siblings with deficiency of PAPP-A2 (pregnancy-associated plasma protein-A2) [due to a homozygous loss-of-function frameshift mutation in exon 3 of the PAPP-A2 gene (p.D643fs25*)] that resulted in postnatal growth failure due to resulting decrease in IGF1 bioavailability. [CASE REPORT] | Treatment With Recombinant Human Insulin-Like Growth Factor-1 Improves Growth in Patients With PAPP-A2 Deficiency.
Muñoz-Calvo MT, Barrios V, Pozo J, Chowen JA, Martos-Moreno GÁ, Hawkins F, Dauber A, Domené HM, Yakar S, Rosenfeld RG, Pérez-Jurado LA, Oxvig C, Frystyk J, Argente J., Free PMC Article | 06/3/2017 |
| in situ hybridization (ISH) and immunohistochemistry (IHC) were employed to examine the spatial and temporal expression of PAPPA2 in the human fetomaternal interface. | Expression of PAPPA2 in human fetomaternal interface and involvement in trophoblast invasion and migration.
Wang HY, Zhang Z, Yu S. | 03/25/2017 |
| PAPP-A2 is differentially expressed in different trophoblast populations and shows strong down regulation in the mid second trimester in chorionic villous samples. | Differential expression of human placental PAPP-A2 over gestation and in preeclampsia.
Kramer AW, Lamale-Smith LM, Winn VD., Free PMC Article | 10/22/2016 |
| overexpression in Down syndrome from placental mRNA to maternal serum protein | Pregnancy associated plasma protein-A2: a novel biomarker for Down syndrome.
Munnangi S, Gross SJ, Madankumar R, Salcedo G, Reznik SE., Free PMC Article | 07/4/2015 |
| The association between this PAPPA2 single nucleotide polymorphism and developmental dysplasia of the hip was evaluated. | A replication study for the association of rs726252 in PAPPA2 with developmental dysplasia of the hip in Chinese Han population.
Shi D, Sun W, Xu X, Hao Z, Dai J, Xu Z, Chen D, Teng H, Jiang Q., Free PMC Article | 05/16/2015 |
| The upregulation of PAPP-A2 observed in preeclampsia at term occurs early in pregnancy, before the symptoms develop. | First-trimester levels of pregnancy-associated plasma protein A2 (PAPP-A2) in the maternal circulation are elevated in pregnancies that subsequently develop preeclampsia.
Crosley EJ, Durland U, Seethram K, MacRae S, Gruslin A, Christians JK., Free PMC Article | 04/18/2015 |
| PAPPA2 may be upregulated in severe pre-eclampsia and, functionally, this may be mediated via increased placental hypoxia known to occur with this pregnancy disorder. | PAPPA2 is increased in severe early onset pre-eclampsia and upregulated with hypoxia.
Macintire K, Tuohey L, Ye L, Palmer K, Gantier M, Tong S, Kaitu'u-Lino TJ. | 09/6/2014 |