| ChemR23 activation attenuates cognitive impairment in chronic cerebral hypoperfusion by inhibiting NLRP3 inflammasome-induced neuronal pyroptosis. | ChemR23 activation attenuates cognitive impairment in chronic cerebral hypoperfusion by inhibiting NLRP3 inflammasome-induced neuronal pyroptosis.
Zhang Y, Zhang J, Zhao Y, Zhang Y, Liu L, Xu X, Wang X, Fu J., Free PMC Article | 11/28/2023 |
| Chemokine-like Receptor 1 in Brain of Spontaneously Hypertensive Rats Mediates Systemic Hypertension. | Chemokine-like Receptor 1 in Brain of Spontaneously Hypertensive Rats Mediates Systemic Hypertension.
Yamamoto A, Otani K, Okada M, Yamawaki H., Free PMC Article | 12/18/2021 |
| HOXA9-induced chemerin signals through CMKLR1/AMPK/TXNIP/NLRP3 pathway to induce pyroptosis of trophoblasts and aggravate preeclampsia. | HOXA9-induced chemerin signals through CMKLR1/AMPK/TXNIP/NLRP3 pathway to induce pyroptosis of trophoblasts and aggravate preeclampsia.
Quan XZ, Ye JH, Yang XZ, Xie Y. | 12/11/2021 |
| Acute intracerebroventricular injection of chemerin-9 increases systemic blood pressure through activating sympathetic nerves via CMKLR1 in brain. | Acute intracerebroventricular injection of chemerin-9 increases systemic blood pressure through activating sympathetic nerves via CMKLR1 in brain.
Yamamoto A, Matsumoto K, Hori K, Kameshima S, Yamaguchi N, Okada S, Okada M, Yamawaki H. | 05/22/2021 |
| Chemerin-9-induced contraction was enhanced through the upregulation of smooth muscle chemokine-like receptor 1 in isolated pulmonary artery of pulmonary arterial hypertensive rats. | Chemerin-9-induced contraction was enhanced through the upregulation of smooth muscle chemokine-like receptor 1 in isolated pulmonary artery of pulmonary arterial hypertensive rats.
Omori A, Goshima M, Kakuda C, Kodama T, Otani K, Okada M, Yamawaki H. | 02/2/2021 |
| immune cells infiltrating the target organ differentially express CMKLR1 in response to dietary modulations and has determined a deleterious role for CMKLR1 expressed on T cells specifically in the Dahl SS rat. | Parental Dietary Protein Source and the Role of CMKLR1 in Determining the Severity of Dahl Salt-Sensitive Hypertension.
Abais-Battad JM, Lund H, Fehrenbach DJ, Dasinger JH, Alsheikh AJ, Mattson DL., Free PMC Article | 11/23/2019 |
| This study found that chemerin and CMKLR1 protein levels were regulated in white adipose tissue by different conditions associated with metabolic changes such as nutritional status, sex steroids, pregnancy, and food composition. | Regulation of Chemerin and CMKLR1 Expression by Nutritional Status, Postnatal Development, and Gender.
Sanchez-Rebordelo E, Cunarro J, Perez-Sieira S, Seoane LM, Diéguez C, Nogueiras R, Tovar S., Free PMC Article | 01/12/2019 |
| CMKLR1 and GPR1 were widely expressed in vascular smooth muscle. | Chemerin Elicits Potent Constrictor Actions via Chemokine-Like Receptor 1 (CMKLR1), not G-Protein-Coupled Receptor 1 (GPR1), in Human and Rat Vasculature.
Kennedy AJ, Yang P, Read C, Kuc RE, Yang L, Taylor EJ, Taylor CW, Maguire JJ, Davenport AP., Free PMC Article | 12/23/2017 |
| Synovium from saline-treated (control) rats expressed CHemR23. There was a significant reduction in ChemR23 expression in the synovium at both the earlier and later time points in osteoarthritis pain model animals compared with saline-treated controls. | Targeting the D Series Resolvin Receptor System for the Treatment of Osteoarthritis Pain.
Huang J, Burston JJ, Li L, Ashraf S, Mapp PI, Bennett AJ, Ravipati S, Pousinis P, Barrett DA, Scammell BE, Chapman V., Free PMC Article | 08/19/2017 |
| These studies support the idea that chemerin modifies sympathetic nerve-mediated contraction through ChemR23 and that ChemR23 may be endogenously activated. | The adipokine chemerin amplifies electrical field-stimulated contraction in the isolated rat superior mesenteric artery.
Darios ES, Winner BM, Charvat T, Krasinksi A, Punna S, Watts SW., Free PMC Article | 07/1/2017 |
| These results show the expression of chemerin and CMKLR1 in rat cardiomyocytes and also show that chemerin induces insulin resistance in cardiomyocytes at least in part through the ERK1/2 pathway | Chemerin induces insulin resistance in rat cardiomyocytes in part through the ERK1/2 signaling pathway.
Zhang R, Liu S, Guo B, Chang L, Li Y. | 10/10/2015 |
| The chemerin/ChemR23 signaling axis participates in non-neuronal muscarinic receptor-mediated protection against endothelial dysfunction in cardiovascular system. | Stimulation of non-neuronal muscarinic receptors enhances chemerin/ChemR23 system in dysfunctional endothelial cells.
Zhao RJ, Pan ZY, Long CL, Cui WY, Zhang YF, Wang H. | 02/23/2013 |
| Changed expression of brain CMKLR1 is suggested to be involved in the mechanism of depression. | Chronic mild restraint stress rats decreased CMKLR1 expression in distinct brain region.
Guo X, Fu Y, Xu Y, Weng S, Liu D, Cui D, Yu S, Liu X, Jiang K, Dong Y. | 11/24/2012 |
| Data suggest the importance of immune response- and microglia activation-related genes in chronic neuropathic pain. Expression of the Calca (aka CGRP) gene in the dorsal horn of the spinal cord could be involved in persistence of its symptoms. | Comparison of gene expression profiles in neuropathic and inflammatory pain.
Rodriguez Parkitna J, Korostynski M, Kaminska-Chowaniec D, Obara I, Mika J, Przewlocka B, Przewlocki R. | 01/21/2010 |