| Downregulation of Elovl5 promotes breast cancer metastasis through a lipid-droplet accumulation-mediated induction of TGF-beta receptors. | Downregulation of Elovl5 promotes breast cancer metastasis through a lipid-droplet accumulation-mediated induction of TGF-β receptors.
Kieu TL, Pierre L, Derangère V, Perrey S, Truntzer C, Jalil A, Causse S, Groetz E, Dumont A, Guyard L, Arnould L, de Barros JP, Apetoh L, Rébé C, Limagne E, Jourdan T, Demizieux L, Masson D, Thomas C, Ghiringhelli F, Rialland M., Free PMC Article | 09/24/2022 |
| ELOVL5-mediated fatty acid elongation promotes cellular proliferation and invasion in renal cell carcinoma. | ELOVL5-mediated fatty acid elongation promotes cellular proliferation and invasion in renal cell carcinoma.
Nitta S, Kandori S, Tanaka K, Sakka S, Siga M, Nagumo Y, Negoro H, Kojima T, Mathis BJ, Shimazui T, Miyamoto T, Matsuzaka T, Shimano H, Nishiyama H., Free PMC Article | 08/13/2022 |
| ELOVL5 Is a Critical and Targetable Fatty Acid Elongase in Prostate Cancer. | ELOVL5 Is a Critical and Targetable Fatty Acid Elongase in Prostate Cancer.
Centenera MM, Scott JS, Machiels J, Nassar ZD, Miller DC, Zinonos I, Dehairs J, Burvenich IJG, Zadra G, Chetta PM, Bango C, Evergren E, Ryan NK, Gillis JL, Mah CY, Tieu T, Hanson AR, Carelli R, Bloch K, Panagopoulos V, Waelkens E, Derua R, Williams ED, Evdokiou A, Cifuentes-Rius A, Voelcker NH, Mills IG, Tilley WD, Scott AM, Loda M, Selth LA, Swinnen JV, Butler LM. | 08/14/2021 |
| The that maternal genetic variants in ELOVL2 and ELOVL5 were associated with PUFA levels in breast milk and that the combination of SNP haplotypes and higher DHA intake increased PUFA concentrations. | DHA intake interacts with ELOVL2 and ELOVL5 genetic variants to influence polyunsaturated fatty acids in human milk.
Wu霞吴义 Y, Wang 烟王 Y, Tian敏田慧 H, Lu逯通 T, Yu苗于 M, Xu慧徐文 W, Liu良刘国 G, Xie林谢 L., Free PMC Article | 08/15/2020 |
| The ELOVL5 gene was significantly differentially expressed in adipose tissues from unrelated type 2 diabetes (T2D) patients and in human pancreatic islets. The results demonstrate that blood-derived DNA methylation is associated with T2D risk as a proxy for cumulative epigenetic status in human adipose and pancreatic tissues. | Genome-wide methylation analysis identifies ELOVL5 as an epigenetic biomarker for the risk of type 2 diabetes mellitus.
Hwang JY, Lee HJ, Go MJ, Jang HB, Choi NH, Bae JB, Castillo-Fernandez JE, Bell JT, Spector TD, Lee HJ, Kim BJ., Free PMC Article | 11/30/2019 |
| Low ELOVL5 expression is associated with colorectal cancer. | Methylation associated transcriptional repression of ELOVL5 in novel colorectal cancer cell lines.
Boot A, Oosting J, van Eendenburg JDH, Kuppen PJK, Morreau H, van Wezel T., Free PMC Article | 10/21/2017 |
| common variations associated with polyunsaturated fatty acid levels in breast milk | Genetic Variants in the ELOVL5 but not ELOVL2 Gene Associated with Polyunsaturated Fatty Acids in Han Chinese Breast Milk.
Li X, Gan ZW, Ding Z, Wu YX, Chen XY, Tian HM, Liu GL, Yang YT, Xie L. | 07/1/2017 |
| SCA38 subtype is very rare in Mainland China; no disease-related gene mutations in ELOVL5. | SCA38 is rare in Mainland China.
Liu Z, Zeng S, Zeng J, Zhou Y, Zeng X, Jiang H, Shen L, Tang B, Wang J. | 09/17/2016 |
| performed a detailed promoter/enhancer analysis of ELOVL5 gene, and identified two new SREBP binding sites, one in the 10 kb upstream region and one in the exon 1 | Identification of human ELOVL5 enhancer regions controlled by SREBP.
Shikama A, Shinozaki H, Takeuchi Y, Matsuzaka T, Aita Y, Murayama T, Sawada Y, Piao X, Toya N, Oya Y, Takarada A, Masuda Y, Nishi M, Kubota M, Izumida Y, Nakagawa Y, Iwasaki H, Kobayashi K, Yatoh S, Suzuki H, Yagyu H, Kawakami Y, Yamada N, Shimano H, Yahagi N. | 04/16/2016 |
| In transfection experiments, subcellular localization of altered ELOVL5 showed a perinuclear distribution with a signal increase in the Golgi compartment, whereas the wild-type showed a widespread signal in the endoplasmic reticulum. | ELOVL5 mutations cause spinocerebellar ataxia 38.
Di Gregorio E, Borroni B, Giorgio E, Lacerenza D, Ferrero M, Lo Buono N, Ragusa N, Mancini C, Gaussen M, Calcia A, Mitro N, Hoxha E, Mura I, Coviello DA, Moon YA, Tesson C, Vaula G, Couarch P, Orsi L, Duregon E, Papotti MG, Deleuze JF, Imbert J, Costanzi C, Padovani A, Giunti P, Maillet-Vioud M, Durr A, Brice A, Tempia F, Funaro A, Boccone L, Caruso D, Stevanin G, Brusco A., Free PMC Article | 10/18/2014 |
| Changes in the mRNA-expression levels of FADS1 and 2 directly affect blood DGLA levels and D6D activity. This study suggests that lower mRNA-expressions of FADS2 and ELOVL5 are associated with higher risk of atopic eczema in young children. | Gene expression of desaturase (FADS1 and FADS2) and Elongase (ELOVL5) enzymes in peripheral blood: association with polyunsaturated fatty acid levels and atopic eczema in 4-year-old children.
Chisaguano AM, Montes R, Pérez-Berezo T, Castellote AI, Guerendiain M, Bustamante M, Morales E, García-Esteban R, Sunyer J, Franch A, López-Sabater MC., Free PMC Article | 05/31/2014 |
| a novel link between Elovl5-mediated synthesis of 18:1,n-7 and GNG through the control of the mTORC2-Akt-FoxO1 pathway | Elovl5 regulates the mTORC2-Akt-FOXO1 pathway by controlling hepatic cis-vaccenic acid synthesis in diet-induced obese mice.
Tripathy S, Jump DB., Free PMC Article | 06/1/2013 |
| minor allele copies at rs2294867 associated with an increase in total and LDL cholesterol...number of minor allele copies at rs761179 associated with increase in total cholesterol... However, associations not replicated in independent populations. | Genetic variation in fatty acid elongases is not associated with intermediate cardiovascular phenotypes or myocardial infarction.
Aslibekyan S, Jensen MK, Campos H, Linkletter CD, Loucks EB, Ordovas JM, Deka R, Rimm EB, Baylin A., Free PMC Article | 07/28/2012 |
| Typical POAG associated with ELOVL5 gene polymorphism may have a late rather than an early onset. | Association between SRBD1 and ELOVL5 gene polymorphisms and primary open-angle glaucoma.
Mabuchi F, Sakurada Y, Kashiwagi K, Yamagata Z, Iijima H, Tsukahara S. | 09/10/2011 |
| Not being breastfed resulted in a disadvantage in cognition (5 to 8 points) among children CC homozygote for rs2397142 (low ELOVL5 activity), but not among those carrying the G allele. | Genetic variants of the FADS gene cluster and ELOVL gene family, colostrums LC-PUFA levels, breastfeeding, and child cognition.
Morales E, Bustamante M, Gonzalez JR, Guxens M, Torrent M, Mendez M, Garcia-Esteban R, Julvez J, Forns J, Vrijheid M, Molto-Puigmarti C, Lopez-Sabater C, Estivill X, Sunyer J., Free PMC Article | 09/3/2011 |
| Our genome-wide association study identified SRBD1 and ELOVL5 as new susceptibility genes for (normal tension glaucoma) NTG. | Genome-wide association study of normal tension glaucoma: common variants in SRBD1 and ELOVL5 contribute to disease susceptibility.
Writing Committee for the Normal Tension Glaucoma Genetic Study Group of Japan Glaucoma Society, Meguro A, Inoko H, Ota M, Mizuki N, Bahram S, Writing Committee for the Normal Tension Glaucoma Genetic Study Group of Japan Glaucoma Society, Meguro A, Inoko H, Ota M, Mizuki N, Bahram S. | 07/26/2010 |
| Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) | Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR., Free PMC Article | 06/30/2010 |
| Observational study and genome-wide association study of gene-disease association. (HuGE Navigator) | Genome-wide association study of normal tension glaucoma: common variants in SRBD1 and ELOVL5 contribute to disease susceptibility.
Writing Committee for the Normal Tension Glaucoma Genetic Study Group of Japan Glaucoma Society, Meguro A, Inoko H, Ota M, Mizuki N, Bahram S, Writing Committee for the Normal Tension Glaucoma Genetic Study Group of Japan Glaucoma Society, Meguro A, Inoko H, Ota M, Mizuki N, Bahram S. | 06/30/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | Multiple genetic variants along candidate pathways influence plasma high-density lipoprotein cholesterol concentrations.
Lu Y, Dollé ME, Imholz S, van 't Slot R, Verschuren WM, Wijmenga C, Feskens EJ, Boer JM. | 09/24/2008 |