| Human gastric cancer progression and stabilization of ATG2B through RNF5 binding facilitated by autophagy-associated CircDHX8. | Human gastric cancer progression and stabilization of ATG2B through RNF5 binding facilitated by autophagy-associated CircDHX8.
Wei G, Chen X, Ruan T, Ma X, Zhu X, Wen W, He D, Tao K, Wu C., Free PMC Article | 06/26/2024 |
| Downregulation of EphA2 stability by RNF5 limits its tumor-suppressive function in HER2-negative breast cancers. | Downregulation of EphA2 stability by RNF5 limits its tumor-suppressive function in HER2-negative breast cancers.
Li X, Wang F, Huang L, Yang M, Kuang E., Free PMC Article | 11/2/2023 |
| The E3 ligase RNF5 restricts SARS-CoV-2 replication by targeting its envelope protein for degradation. | The E3 ligase RNF5 restricts SARS-CoV-2 replication by targeting its envelope protein for degradation.
Li Z, Hao P, Zhao Z, Gao W, Huan C, Li L, Chen X, Wang H, Jin N, Luo ZQ, Li C, Zhang W., Free PMC Article | 02/13/2023 |
| Suppression of KSHV lytic replication and primary effusion lymphoma by selective RNF5 inhibition. | Suppression of KSHV lytic replication and primary effusion lymphoma by selective RNF5 inhibition.
Li X, Wang F, Zhang X, Sun Q, Kuang E., Free PMC Article | 02/11/2023 |
| The E3 Ubiquitin Ligase Ring Finger Protein 5 Ameliorates NASH Through Ubiquitin-Mediated Degradation of 3-Hydroxy-3-Methylglutaryl CoA Reductase Degradation Protein 1. | The E3 Ubiquitin Ligase Ring Finger Protein 5 Ameliorates NASH Through Ubiquitin-Mediated Degradation of 3-Hydroxy-3-Methylglutaryl CoA Reductase Degradation Protein 1.
Yang Q, Chen X, Zhang Y, Hu S, Hu F, Huang Y, Ma T, Hu H, Tian H, Tian S, Ji YX, She ZG, Zhang P, Zhang XJ, Hu Y, Yang H, Yuan Y, Li H. | 01/15/2022 |
| The ubiquitin ligase RNF5 determines acute myeloid leukemia growth and susceptibility to histone deacetylase inhibitors. | The ubiquitin ligase RNF5 determines acute myeloid leukemia growth and susceptibility to histone deacetylase inhibitors.
Khateb A, Deshpande A, Feng Y, Finlay D, Lee JS, Lazar I, Fabre B, Li Y, Fujita Y, Zhang T, Yin J, Pass I, Livneh I, Jeremias I, Burian C, Mason JR, Almog R, Horesh N, Ofran Y, Brown K, Vuori K, Jackson M, Ruppin E, Deshpande AJ, Ronai ZA., Free PMC Article | 10/23/2021 |
| RING-finger protein 5 promotes hepatocellular carcinoma progression and predicts poor prognosis. | RING-finger protein 5 promotes hepatocellular carcinoma progression and predicts poor prognosis.
Zhang Y, Li J, Chen H, Zhang C, You S, Zhao Y, Lin X, Yu Y, Fang F, Fang T, Wang X. | 08/7/2021 |
| Acetylation Stabilizes Phosphoglycerate Dehydrogenase by Disrupting the Interaction of E3 Ligase RNF5 to Promote Breast Tumorigenesis. | Acetylation Stabilizes Phosphoglycerate Dehydrogenase by Disrupting the Interaction of E3 Ligase RNF5 to Promote Breast Tumorigenesis.
Wang C, Wan X, Yu T, Huang Z, Shen C, Qi Q, Xiang S, Chen X, Arbely E, Ling ZQ, Liu CY, Yu W. | 05/29/2021 |
| Ring finger protein 5 activates sterol regulatory element-binding protein 2 (SREBP2) to promote cholesterol biosynthesis via inducing polyubiquitination of SREBP chaperone SCAP. | Ring finger protein 5 activates sterol regulatory element-binding protein 2 (SREBP2) to promote cholesterol biosynthesis via inducing polyubiquitination of SREBP chaperone SCAP.
Kuan YC, Takahashi Y, Maruyama T, Shimizu M, Yamauchi Y, Sato R., Free PMC Article | 12/12/2020 |
| Authors demonstrate that the V proteins of NDV and several other paramyxoviruses target MAVS for ubiquitin-mediated degradation through E3 ubiquitin ligase RING-finger protein 5 (RNF5). MAVS degradation leads to the inhibition of the downstream IFN-beta pathway and therefore benefits virus proliferation. | Newcastle Disease Virus V Protein Degrades Mitochondrial Antiviral Signaling Protein To Inhibit Host Type I Interferon Production via E3 Ubiquitin Ligase RNF5.
Sun Y, Zheng H, Yu S, Ding Y, Wu W, Mao X, Liao Y, Meng C, Ur Rehman Z, Tan L, Song C, Qiu X, Wu F, Ding C., Free PMC Article | 07/11/2020 |
| we found that RNF5 is differentially expressed in human bronchial epithelia from CF vs. control patients. Our results identify RNF5 as a target for therapeutic modalities to antagonize mutant CFTR proteins. | Genetic Inhibition Of The Ubiquitin Ligase Rnf5 Attenuates Phenotypes Associated To F508del Cystic Fibrosis Mutation.
Tomati V, Sondo E, Armirotti A, Caci E, Pesce E, Marini M, Gianotti A, Jeon YJ, Cilli M, Pistorio A, Mastracci L, Ravazzolo R, Scholte B, Ronai Z, Galietta LJ, Pedemonte N., Free PMC Article | 08/13/2016 |
| RNF5 is involved in the regulation of the L-glutamine carrier proteins SLC1A5 and SLC38A2. | Regulation of glutamine carrier proteins by RNF5 determines breast cancer response to ER stress-inducing chemotherapies.
Jeon YJ, Khelifa S, Ratnikov B, Scott DA, Feng Y, Parisi F, Ruller C, Lau E, Kim H, Brill LM, Jiang T, Rimm DL, Cardiff RD, Mills GB, Smith JW, Osterman AL, Kluger Y, Ronai ZA., Free PMC Article | 05/23/2015 |
| Our data suggest that RNF5 regulates the turnover of specific G protein-coupled receptors by ubiquitinating JAMP and preventing proteasome recruitment. | Novel, gel-free proteomics approach identifies RNF5 and JAMP as modulators of GPCR stability.
Roy SJ, Glazkova I, Fréchette L, Iorio-Morin C, Binda C, Pétrin D, Trieu P, Robitaille M, Angers S, Hébert TE, Parent JL., Free PMC Article | 04/5/2014 |
| In addition to confirming one of the top findings in the meta-analysis, TRIM26, RNF5 and HLA-DRB3 have been identified as potential candidate genes for schizophrenia. | Expression QTL analysis of top loci from GWAS meta-analysis highlights additional schizophrenia candidate genes.
de Jong S, van Eijk KR, Zeegers DW, Strengman E, Janson E, Veldink JH, van den Berg LH, Cahn W, Kahn RS, Boks MP, Ophoff RA, PGC Schizophrenia (GWAS) Consortium., Free PMC Article | 12/29/2012 |
| Rma1, an E3 ubiquitin ligase localized in the ER membrane, is involved in Pendrin degradation | Roles of 17-AAG-induced molecular chaperones and Rma1 E3 ubiquitin ligase in folding and degradation of Pendrin.
Lee K, Hong TJ, Hahn JS. | 10/13/2012 |
| JB12 cooperates with cytosolic Hsc70 and the ubiquitin ligase RMA1 to target CFTR and CFTRDeltaF508 for degradation. | The endoplasmic reticulum-associated Hsp40 DNAJB12 and Hsc70 cooperate to facilitate RMA1 E3-dependent degradation of nascent CFTRDeltaF508.
Grove DE, Fan CY, Ren HY, Cyr DM., Free PMC Article | 07/9/2011 |
| Observational study of gene-disease association. (HuGE Navigator) | High-density SNP screening of the major histocompatibility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions.
Barcellos LF, May SL, Ramsay PP, Quach HL, Lane JA, Nititham J, Noble JA, Taylor KE, Quach DL, Chung SA, Kelly JA, Moser KL, Behrens TW, Seldin MF, Thomson G, Harley JB, Gaffney PM, Criswell LA., Free PMC Article | 01/20/2010 |
| RNF5 associates with JAMP in the ER membrane. This association results in Ubc13-dependent RNF5-mediated noncanonical ubiquitination of JAMP. | Regulation of endoplasmic reticulum-associated degradation by RNF5-dependent ubiquitination of JNK-associated membrane protein (JAMP).
Tcherpakov M, Delaunay A, Toth J, Kadoya T, Petroski MD, Ronai ZA., Free PMC Article | 01/21/2010 |
| E3 ubiquitin ligase RNF5 interacted with MITA in a viral-infection-dependent manner | The ubiquitin ligase RNF5 regulates antiviral responses by mediating degradation of the adaptor protein MITA.
Zhong B, Zhang L, Lei C, Li Y, Mao AP, Yang Y, Wang YY, Zhang XL, Shu HB. | 01/21/2010 |
| Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator) | Association of MHC SNP genotype with susceptibility to type 1 diabetes: a modified survival approach.
McKinnon E, Morahan G, Nolan D, James I, Diabetes Genetics Consortium., Free PMC Article | 02/11/2009 |
| RNF5 is a novel regulator of breast cancer progression through its effect on actin cytoskeletal alterations. | Increased expression of the E3 ubiquitin ligase RNF5 is associated with decreased survival in breast cancer.
Bromberg KD, Kluger HM, Delaunay A, Abbas S, DiVito KA, Krajewski S, Ronai Z., Free PMC Article | 01/21/2010 |
| efficient bacterial escape into the cytosol of epithelial cells requires HsRMA1-mediated SopA ubiquitination and contributes to Salmonella-induced enteropathogenicity | Recognition and ubiquitination of Salmonella type III effector SopA by a ubiquitin E3 ligase, HsRMA1.
Zhang Y, Higashide W, Dai S, Sherman DM, Zhou D. | 01/21/2010 |
| the G(16)-mediated activation of IKK/NFkappaB by N(6)-cyclohexyladenosine requires a complex signaling network composed of multiple intermediates | G16-mediated activation of nuclear factor kappaB by the adenosine A1 receptor involves c-Src, protein kinase C, and ERK signaling.
Liu AM, Wong YH. | 01/21/2010 |
| RNF5 regulates cell motility by targeting paxillin ubiquitination and altered localization | RNF5, a RING finger protein that regulates cell motility by targeting paxillin ubiquitination and altered localization.
Didier C, Broday L, Bhoumik A, Israeli S, Takahashi S, Nakayama K, Thomas SM, Turner CE, Henderson S, Sabe H, Ronai Z., Free PMC Article | 01/21/2010 |