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    RNASE3 ribonuclease A family member 3 [ Homo sapiens (human) ]

    Gene ID: 6037, updated on 24-Sep-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    Exploring the role of eosinophil cationic protein (ECP) in schizophrenia: Insights and implications.

    Exploring the role of eosinophil cationic protein (ECP) in schizophrenia: Insights and implications.
    Obeagu EI., Free PMC Article

    09/17/2024
    [The auxiliary diagnostic value of ECP and MPO expression in nasal secretions in different types of rhinitis].

    [The auxiliary diagnostic value of ECP and MPO expression in nasal secretions in different types of rhinitis].
    Zou Z, Deng Y, Zhang Q, Long Z, Zhu W, Gao P, Xu Y, Zhou Y, Tao Z, Chen J., Free PMC Article

    04/5/2024
    Variants of IL6, IL10, FCN2, RNASE3, IL12B and IL17B loci are associated with Schistosoma mansoni worm burden in the Albert Nile region of Uganda.

    Variants of IL6, IL10, FCN2, RNASE3, IL12B and IL17B loci are associated with Schistosoma mansoni worm burden in the Albert Nile region of Uganda.
    Nyangiri OA, Mulindwa J, Namulondo J, Kitibwa A, Nassuuna J, Elliott A, Kimuda MP, Boobo A, Nerima B, Adriko M, Dunton NJ, Madhan GK, Kristiansen M, Casacuberta-Partal M, Noyes H, Matovu E, TrypanoGEN+ Research group of the H3Africa consortium., Free PMC Article

    12/21/2023
    Eosinophilic cationic protein (ECP) in the clinical work-up of chronic cough.

    Eosinophilic cationic protein (ECP) in the clinical work-up of chronic cough.
    DE Amici M, Piloni D, Tirelli C, Mariani F, Accordino G, Sacchi L, Testa G, Licari A, Corsico AG.

    05/4/2023
    Blood eosinophil cationic protein and eosinophil-derived neurotoxin are associated with different asthma expression and evolution in adults.

    Blood eosinophil cationic protein and eosinophil-derived neurotoxin are associated with different asthma expression and evolution in adults.
    Granger V, Zerimech F, Arab J, Siroux V, de Nadai P, Tsicopoulos A, Matran R, Akiki Z, Nadif R.

    05/28/2022
    Serum eosinophil cationic protein: a prognostic factor for early postoperative recurrence of nasal polyps.

    Serum eosinophil cationic protein: a prognostic factor for early postoperative recurrence of nasal polyps.
    Lu PC, Lee TJ, Huang CC, Chang PH, Chen YW, Fu CH.

    09/25/2021
    Haplotype of RNASE 3 polymorphisms is associated with severe malaria in an Indian population.

    Haplotype of RNASE 3 polymorphisms is associated with severe malaria in an Indian population.
    Mukhi B, Gupta H, Wassmer SC, Anvikar AR, Ghosh SK., Free PMC Article

    05/29/2021
    Eosinophil cationic protein is a potential surrogate marker of allergic contact dermatitis: A single-center, retrospective study of 216 patients.

    Eosinophil cationic protein is a potential surrogate marker of allergic contact dermatitis: A single-center, retrospective study of 216 patients.
    Kim J, Kim S, Lee YI, Kim J, Lee JH, Park CO.

    04/24/2021
    Human RNase3 immune modulation by catalytic-dependent and independent modes in a macrophage-cell line infection model.

    Human RNase3 immune modulation by catalytic-dependent and independent modes in a macrophage-cell line infection model.
    Lu L, Wei R, Prats-Ejarque G, Goetz M, Wang G, Torrent M, Boix E., Free PMC Article

    04/13/2021
    ECP is expressed in neutrophils and may help with diagnosis of inflammation

    [Expression of eosinophilic cationic protein in neutrophils and its effect on objective evaluation of nasal inflammation].
    Yu WT, Wang Y, Zhou Y, Zhu Y, Chen S, Wang YJ, Kong WJ, Chen JJ.

    09/14/2019
    ECP seems to be a novel prognostic serum marker for the outcome of melanoma patients, which is independent of LDH and easy to perform in clinical practice. The striking negative prognostic value of high ECP level is unanticipated and can guide patient management.

    Eosinophil-cationic protein - a novel liquid prognostic biomarker in melanoma.
    Krückel A, Moreira A, Fröhlich W, Schuler G, Heinzerling L., Free PMC Article

    06/22/2019
    Studied association of genetic variants of ribonuclease A family member 3 (RNASE3) with susceptibility to severe malaria in Senegal.

    Genetic variants of RNASE3 (ECP) and susceptibility to severe malaria in Senegalese population.
    Diop G, Derbois C, Loucoubar C, Mbengue B, Ndao BN, Thiam F, Thiam A, Ndiaye R, Dieye Y, Olaso R, Deleuze JF, Dieye A., Free PMC Article

    01/19/2019
    measuring serum ECP levels is helpful for assessing the efficacy of inhaled corticosteroids therapy in bronchial asthma children.

    Serum Eosinophil Cationic Protein Is a Useful Marker for Assessing the Efficacy of Inhaled Corticosteroid Therapy in Children with Bronchial Asthma.
    Guo CL, Sun XM, Wang XW, Guo Q.

    05/19/2018
    Data suggest that radioactive I(131) therapy leads to down-regulation of secretion of ECP from Th2 cells (helper-inducer T-lymphocytes) in post-thyroidectomy patients treated for differentiated thyroid cancer; in this study, ECP levels in serum were analyzed before, 3 days after, and 7 days after radiotherapy with I(131).

    Eosinophil Cationic Protein in Patients with Differentiated Thyroid Cancer Treated with Radioactive Iodine 131.
    Zivancevic-Simonovic S, Mihaljevic O, Kostic I, Ilic N, Mihajlovic D, Vasiljevic D, Mijatovic-Teodorovic L, Miletic-Drakulic S, Colic M.

    01/27/2018
    our data add new insights into the pathophysiology of AD, suggesting that BDNF which correlates with disease severity and ECP levels contributes to the regulation of inflammation in an eosinophil-, but not Th2-dependent manner.

    Childhood atopic dermatitis-Brain-derived neurotrophic factor correlates with serum eosinophil cationic protein and disease severity.
    Fölster-Holst R, Papakonstantinou E, Rüdrich U, Buchner M, Pite H, Gehring M, Kapp A, Weidinger S, Raap U.

    11/25/2017
    High circulating levels of eosinophil cationic protein are associated with increased incidence of ischemic stroke.

    Eosinophil Cationic Protein, Carotid Plaque, and Incidence of Stroke.
    Sundström J, Söderholm M, Borné Y, Nilsson J, Persson M, Östling G, Melander O, Orho-Melander M, Engström G.

    10/14/2017
    Studies mapped the structural determinants required for the eosinophil cationic protein (ECP)-bacterial lipopolysaccharide (LPS) interaction by nuclear magnetic resonance.

    Structural basis for endotoxin neutralization by the eosinophil cationic protein.
    Pulido D, Garcia-Mayoral MF, Moussaoui M, Velázquez D, Torrent M, Bruix M, Boix E.

    07/1/2017
    Increased MRP8/14 levels suggest the instability of the atherosclerotic plaque. ECP reflects the severity of coronary arteries stenosis, predicting atherosclerosis burden. They may become the new biomarkers of CAD.

    The Correlation of Serum Myeloid-Related Protein-8/14 and Eosinophil Cationic Protein in Patients with Coronary Artery Disease.
    Xia GL, Wang YK, Huang ZQ., Free PMC Article

    12/17/2016
    Children in the acute-phase group showed higher ECP mRNA expression level than those in the stable-phase and healthy control groups, while the level in the stable-phase was markedly higher than that in the healthy control group.

    Eosinophil cationic protein mRNA expression in children with bronchial asthma.
    Yu HY, Li XY, Cai ZF, Li L, Shi XZ, Song HX, Liu XJ.

    10/1/2016
    drug eluting stent polymers increase eosinophil cationic protein levels following percutaneous coronary intervention independently of C-reactive protein

    Permanent polymer of drug eluting stents increases eosinophil cationic protein levels following percutaneous coronary intervention independently of C-reactive protein.
    Niccoli G, Calvieri C, Minelli S, Copponi G, Montone RA, Imaeva A, Roberto M, Cosentino N, Crea F.

    08/22/2015
    Around half of all variance in serum ECP is explained by genetic factors. Serum ECP is influenced by sex, BMI, and airway responsiveness. Serum ECP and airway responsiveness seem not to share genetic variance.

    Genetic factors explain half of all variance in serum eosinophil cationic protein.
    Elmose C, Sverrild A, van der Sluis S, Kyvik KO, Backer V, Thomsen SF.

    07/25/2015
    eosinophil cationic protein levels can be used to diagnosis atopic dermatitis but cannot distinguish between intrinsic and extrinsic disease.

    Utility of eosinophil cationic protein levels in the diagnosis of intrinsic atopic dermatitis.
    Park SY, Oh S, Kim EJ, Yoon SY, Park HS, Yoon HS, Cho S.

    01/3/2015
    mRNA levels of eosinophil granule proteins, rather than sputum eosinophil%, may reflect airway hyperresponsiveness and airflow limitation.

    Expression levels of eosinophil granule protein mRNAs in induced sputum reflect airway hyperresponsiveness and airflow limitation.
    Jung JW, Kang HR, Lee HS, Park HW, Cho SH, Min KU, Sohn SW.

    12/6/2014
    The antimicrobial protein, Rnase 3, contributes to the host immune response against mycobacteria.

    Two human host defense ribonucleases against mycobacteria, the eosinophil cationic protein (RNase 3) and RNase 7.
    Pulido D, Torrent M, Andreu D, Nogués MV, Boix E., Free PMC Article

    11/6/2014
    ECP was elevated in nasal discharge of patients with nasal polyps compared to controls and those with allergic rhinitis or rhinosinusitis.

    Eosinophils and mast cells: a comparison of nasal mucosa histology and cytology to markers in nasal discharge in patients with chronic sino-nasal diseases.
    Gröger M, Bernt A, Wolf M, Mack B, Pfrogner E, Becker S, Kramer MF.

    05/24/2014
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