| Once trans-SNARE complexes that form large, stable pores by Ca2+-synaptotagmin 1, they can only be closed by the action of the N-ethylmaleimide sensitive factor(NSF). Time-resolved measurements reveal that NSF-mediated pore closure occurs via a complex 'stuttering' mechanism. | Resolving kinetic intermediates during the regulated assembly and disassembly of fusion pores.
Das D, Bao H, Courtney KC, Wu L, Chapman ER., Free PMC Article | 04/11/2020 |
| Results indicate that glucocorticoid hormones increase AMPA receptor mediated synaptic transmission and synaptic insertion of AMPA receptors via a mechanism that requires NSF/GluA2 interaction. This may contribute to the memory enhancing effects of glucocorticoid hormones. | Interactions between N-Ethylmaleimide-sensitive factor and GluA2 contribute to effects of glucocorticoid hormones on AMPA receptor function in the rodent hippocampus.
Xiong H, Cassé F, Zhou M, Xiong ZQ, Joels M, Martin S, Krugers HJ. | 01/13/2018 |
| We have found increased expression of NSF gene in basolateral amygdala and perirhinal cortex in groups of rats undergoing taste habituation. | Increased N-Ethylmaleimide-Sensitive Factor Expression in Amygdala and Perirhinal Cortex during Habituation of Taste Neophobia.
Gómez-Chacón B, Gámiz F, Foster TC, Gallo M., Free PMC Article | 11/5/2016 |
| Results indicate that the persistence of long-term memory depends on the maintenance of a steady-state level of synaptic GluA2/AMPARs, which requires the interaction of NSF with GluA2 | The maintenance of long-term memory in the hippocampus depends on the interaction between N-ethylmaleimide-sensitive factor and GluA2.
Migues PV, Hardt O, Finnie P, Wang YW, Nader K. | 05/16/2015 |
| TCST increases the expression of NSF in the hippocampus of adult rats with focal cerebral ischemia, which may contribute to the protection of the injured brain. | Identification of differentially expressed proteins and validation of the changes of N-ethylmaleimide-sensitive factor in rats with focal cerebral ischemia after transection of the cervical sympathetic trunk.
Qu Y, Ma KN, Li XZ. | 05/9/2015 |
| NSF-GluR2 interactions increase in the nucleus accumbens after cocaine withdrawal. | Interactions between N-ethylmaleimide-sensitive factor and GluR2 in the nucleus accumbens contribute to the expression of locomotor sensitization to cocaine.
Lu HF, Wu PF, Yang YJ, Xiao W, Fan J, Liu J, Li YL, Luo Y, Hu ZL, Jin Y, Wang F, Chen JG., Free PMC Article | 05/3/2014 |
| a model of NSF-mediated disassembly in which the reaction is initiated by a 1:1 interaction between alpha-SNAP and the ternary SNARE complex, followed by NSF binding. | Disassembly of all SNARE complexes by N-ethylmaleimide-sensitive factor (NSF) is initiated by a conserved 1:1 interaction between α-soluble NSF attachment protein (SNAP) and SNARE complex.
Vivona S, Cipriano DJ, O'Leary S, Li YH, Fenn TD, Brunger AT., Free PMC Article | 11/16/2013 |
| The interaction of N-ethylmaleimide-sensitive factor (NSF) with glutamate receptor 2 (GluR2) is necessary for fear memory consolidation. | Interaction between N-ethylmaleimide-sensitive factor and GluR2 is essential for fear memory formation in lateral amygdala.
Joels G, Lamprecht R., Free PMC Article | 01/1/2011 |
| Concomitant with the decrease in NSF, GluR2 and GluR3 were decreased and GluR1 was conversely increased in the postsynaptic density fraction 24 h after complete Freund adjuvant injection | N-ethylmaleimide-sensitive fusion protein (NSF) is involved in central sensitization in the spinal cord through GluR2 subunit composition switch after inflammation.
Katano T, Furue H, Okuda-Ashitaka E, Tagaya M, Watanabe M, Yoshimura M, Ito S. | 01/21/2010 |
| Synaptic stabilization of AMPA receptors by NSF involves disruption of GluR2-PICK1 interactions. | NSF ATPase and alpha-/beta-SNAPs disassemble the AMPA receptor-PICK1 complex.
Hanley JG, Khatri L, Hanson PI, Ziff EB. | 01/21/2010 |
| These data demonstrate that spontaneous recurrent seizure impairs spatial learning memory and suggest that the down-regulation of NSF expression pattern in the hippocampus and the loss of DA neurons in ventral tegmental area. | Abnormal expression of epilepsy-related gene ERG1/NSF in the spontaneous recurrent seizure rats with spatial learning memory deficits induced by kainic acid.
Yin S, Guan Z, Tang Y, Zhao J, Hong J, Zhang W. | 01/21/2010 |
| Pctaire1 phosphorylates N-ethylmaleimide-sensitive fusion protein | Pctaire1 phosphorylates N-ethylmaleimide-sensitive fusion protein: implications in the regulation of its hexamerization and exocytosis.
Liu Y, Cheng K, Gong K, Fu AK, Ip NY. | 01/21/2010 |
| The functional interaction between three bona fide regulators of neurotransmitter release, such as GABAB receptor (GBR), NEM sensitive fusion (NSF) and Protein Kinase C, could shed new light on the modulation of presynaptic GBR action. | Coordinated action of NSF and PKC regulates GABAB receptor signaling efficacy.
Pontier SM, Lahaie N, Ginham R, St-Gelais F, Bonin H, Bell DJ, Flynn H, Trudeau LE, McIlhinney J, White JH, Bouvier M., Free PMC Article | 01/21/2010 |
| A yeast two-hybrid screen using NSF as bait identified Rab11-FIP3 and the Pak-binding nucleotide exchange factor betaPIX as putative binding partners | Novel putative targets of N-ethylmaleimide sensitive fusion protein (NSF) and alpha/beta soluble NSF attachment proteins (SNAPs) include the Pak-binding nucleotide exchange factor betaPIX.
Martin HG, Henley JM, Meyer G., Free PMC Article | 01/21/2010 |
| GluR2-NSF-betaSNAP-PICK1 complex is regulated directly by Ca(2+), allowing for the transduction of Ca(2+) signals into concerted alterations in protein-protein interactions to bring about changes in AMPAR trafficking during synaptic plasticity. | NSF binds calcium to regulate its interaction with AMPA receptor subunit GluR2.
Hanley JG., Free PMC Article | 01/21/2010 |
| NSF interaction is necessary for rapid incorporation of alpha-amino-3-hydroxy-5-methylisoxazolepropionate (AMPA) receptor subunits into synapses and is sufficient to confer this property on the AMPA receptor GluR3 subunit. | NSF interaction is important for direct insertion of GluR2 at synaptic sites.
Beretta F, Sala C, Saglietti L, Hirling H, Sheng M, Passafaro M. | 01/21/2010 |
| Thus, our data demonstrate that the multiple fusion steps in GLUT4 trafficking have differential quantitative requirements for NSF activity. | Demonstration of differential quantitative requirements for NSF among multiple vesicle fusion pathways of GLUT4 using a dominant-negative ATPase-deficient NSF.
Chen X, Matsumoto H, Hinck CS, Al-Hasani H, St-Denis JF, Whiteheart SW, Cushman SW. | 01/21/2010 |