| Circulating extracellular vesicle-derived miR-1299 disrupts hepatic glucose homeostasis by targeting the STAT3/FAM3A axis in gestational diabetes mellitus. | Circulating extracellular vesicle-derived miR-1299 disrupts hepatic glucose homeostasis by targeting the STAT3/FAM3A axis in gestational diabetes mellitus.
Chen X, Tao X, Wang M, Cannon RD, Chen B, Yu X, Qi H, Saffery R, Baker PN, Zhou X, Han TL, Zhang H., Free PMC Article | 08/30/2024 |
| FAM3A plays a key role in protecting against tubular cell pyroptosis and acute kidney injury. | FAM3A plays a key role in protecting against tubular cell pyroptosis and acute kidney injury.
Li X, Yuan F, Xiong Y, Tang Y, Li Z, Ai J, Miao J, Ye W, Zhou S, Wu Q, Wang X, Xu D, Li J, Huang J, Chen Q, Shen W, Liu Y, Hou FF, Zhou L., Free PMC Article | 07/2/2024 |
| PANX1-mediated ATP release confers FAM3A's suppression effects on hepatic gluconeogenesis and lipogenesis. | PANX1-mediated ATP release confers FAM3A's suppression effects on hepatic gluconeogenesis and lipogenesis.
Hu CQ, Hou T, Xiang R, Li X, Li J, Wang TT, Liu WJ, Hou S, Wang D, Zhao QH, Yu XX, Xu M, Liu XK, Chi YJ, Yang JC., Free PMC Article | 07/2/2024 |
| FAM3A mediates the phenotypic switch of human aortic smooth muscle cells stimulated with oxidised low-density lipoprotein by influencing the PI3K-AKT pathway. | FAM3A mediates the phenotypic switch of human aortic smooth muscle cells stimulated with oxidised low-density lipoprotein by influencing the PI3K-AKT pathway.
Yang L, Du B, Zhang S, Wang M. | 10/20/2023 |
| In this case prenatal ultrasound images were suggestive of a serious but non-lethal skeletal dysplasia. Due to the uncertain prognosis the parents were offered Whole Exome Sequencing (WES), which identified a specific gene mutation in the FAMIIIa gene | Case report: targeted whole exome sequencing enables the first prenatal diagnosis of the lethal skeletal dysplasia Osteocraniostenosis.
Pemberton L, Barker R, Cockell A, Ramachandran V, Haworth A, Homfray T., Free PMC Article | 03/7/2020 |
| our data demonstrate that FAM3A positively regulates angiogenesis through activation of VEGFA transcription, suggesting that FAM3A may constitute a novel molecular therapeutic target for ischaemic vascular disease. | Endothelial FAM3A positively regulates post-ischaemic angiogenesis.
Xu W, Liang M, Zhang Y, Huang K, Wang C., Free PMC Article | 11/30/2019 |
| Fam3A may regulate high glucose-induced reactive oxygen species production in HUVECs via the p38 MAPK signaling pathway. | Role of Family with Sequence Similarity 3A in High Glucose-induced Oxidative Damage of Human Umbilical Vein Endothelial Cells.
Liao PZ, Liu D, Zheng YH. | 03/9/2019 |
| These results suggest that C/EBPbeta plays an important role in regulating FAM3A promoter activity and FAM3A inhibits adipocyte differentiation. | Transcriptional regulation analysis of FAM3A gene and its effect on adipocyte differentiation.
Kang T, Peng D, Bu G, Gu H, Zhang F, Zhang R, Zhou Y, Xiong Y, Lei M. | 01/28/2017 |
| In the present study, we report a putative human homologue of the antimicrobial Drosophila-derived drosomycin, designated drosomycin-like defensin (DLD), with specific antifungal activity. | Drosomycin-like defensin, a human homologue of Drosophila melanogaster drosomycin with antifungal activity.
Simon A, Kullberg BJ, Tripet B, Boerman OC, Zeeuwen P, van der Ven-Jongekrijg J, Verweij P, Schalkwijk J, Hodges R, van der Meer JW, Netea MG., Free PMC Article | 11/7/2014 |
| FAM3A plays crucial roles in the regulation of glucose and lipid metabolism in the liver, where it activates the PI3K-Akt signaling pathway by way of a Ca(2+) /CaM-dependent mechanism | FAM3A activates PI3K p110α/Akt signaling to ameliorate hepatic gluconeogenesis and lipogenesis.
Wang C, Chi Y, Li J, Miao Y, Li S, Su W, Jia S, Chen Z, Du S, Zhang X, Zhou Y, Wu W, Zhu M, Wang Z, Yang H, Xu G, Wang S, Yang J, Guan Y. | 06/21/2014 |
| Upregulation of FAM3A by PPARgamma activation is correlated with increased pAkt level in liver cells | FAM3A is a target gene of peroxisome proliferator-activated receptor gamma.
Zhou Y, Jia S, Wang C, Chen Z, Chi Y, Li J, Xu G, Guan Y, Yang J. | 08/31/2013 |
| Expressed prominently in the vascular endothelium, particularly capillaries, also in islets of Langerhans. | Cloning, expression, and initial characterization of a novel cytokine-like gene family.
Zhu Y, Xu G, Patel A, McLaughlin MM, Silverman C, Knecht K, Sweitzer S, Li X, McDonnell P, Mirabile R, Zimmerman D, Boyce R, Tierney LA, Hu E, Livi GP, Wolf B, Abdel-Meguid SS, Rose GD, Aurora R, Hensley P, Briggs M, Young PR. | 01/21/2010 |