| RING1 missense variants reveal sensitivity of DNA damage repair to H2A monoubiquitination dosage during neurogenesis. | RING1 missense variants reveal sensitivity of DNA damage repair to H2A monoubiquitination dosage during neurogenesis.
Ryan CW, Regan SL, Mills EF, McGrath BT, Gong E, Lai YT, Sheingold JB, Patel K, Horowitz T, Moccia A, Tsan YC, Srivastava A, Bielas SL., Free PMC Article | 09/17/2024 |
| RING induces cell cycle arrest and apoptosis in human breast cancer cells by regulating the HSF1/MT2A axis. | RING induces cell cycle arrest and apoptosis in human breast cancer cells by regulating the HSF1/MT2A axis.
Liu D, Guo Y, Du Q, Zhu Y, Guo Y. | 06/10/2024 |
| RING1 Inhibition Has a Cell-Specific Antitumoral Role by Promoting Autophagy in Endometrial Cancer Cells. | RING1 Inhibition Has a Cell-Specific Antitumoral Role by Promoting Autophagy in Endometrial Cancer Cells.
Szustka A, Kozal K, KrzeĊlak A. | 01/17/2024 |
| Essential role of MESP1-RING1A complex in cardiac differentiation. | Essential role of MESP1-RING1A complex in cardiac differentiation.
Liang Q, Wang S, Zhou X, Li Y, Xing S, Sha Y, Yang F, Huang W, Liu N, Li Z, Chen Y, Xu Y, Zhu P, Lan F, Sun N. | 12/3/2022 |
| XIST served as an endogenous competitive RNA modulating miR-744, leading to the miR-744/RING1 signaling pathway inhibition and Wnt/beta-catenin signaling pathway activation in non-small cell lung cancer. | Down-regulation of lncRNA XIST inhibits cell proliferation via regulating miR-744/RING1 axis in non-small cell lung cancer.
Wang J, Cai H, Dai Z, Wang G. | 04/11/2020 |
| LncRNA C5orf66-AS1, as a competitive endogenous RNA, regulated the effect of RING1 on the proliferation, apoptosis and cell cycle of cervical cancer cells through adsorbing miR-637. | Long non-coding RNA C5orf66-AS1 promotes cell proliferation in cervical cancer by targeting miR-637/RING1 axis.
Rui X, Xu Y, Jiang X, Ye W, Huang Y, Jiang J., Free PMC Article | 11/30/2019 |
| High RING1 expression is associated with hepatocellular carcinoma. | The E3 Ligase RING1 Targets p53 for Degradation and Promotes Cancer Cell Proliferation and Survival.
Shen J, Li P, Shao X, Yang Y, Liu X, Feng M, Yu Q, Hu R, Wang Z. | 11/3/2018 |
| Mutation of RING1 is associated with neurodevelopmental abnormalities | De novo mutation in RING1 with epigenetic effects on neurodevelopment.
Pierce SB, Stewart MD, Gulsuner S, Walsh T, Dhall A, McClellan JM, Klevit RE, King MC., Free PMC Article | 07/28/2018 |
| study identified novel interactions between CD147 and RING1, recovered CD147 nuclear envelope distribution in melanoma cells, and suggested a new mechanism underlying how cytoplasmic CD147 promotes melanoma development | Nuclear envelope-distributed CD147 interacts with and inhibits the transcriptional function of RING1 and promotes melanoma cell motility.
Chen J, Peng C, Lei L, Zhang J, Zeng W, Chen X., Free PMC Article | 11/11/2017 |
| The release of epigenetic repression by nitrosylation of RING1A is critical for effective cell transdifferentiation. | Transdifferentiation Requires iNOS Activation: Role of RING1A S-Nitrosylation.
Meng S, Zhou G, Gu Q, Chanda PK, Ospino F, Cooke JP., Free PMC Article | 05/7/2017 |
| The polycomb complex proteins BMI1 and RING1A regulate the ubiquitination of chromatin associated proteins bound to promoters. | RING1A and BMI1 bookmark active genes via ubiquitination of chromatin-associated proteins.
Arora M, Packard CZ, Banerjee T, Parvin JD., Free PMC Article | 08/13/2016 |
| On the basis of these results, we proposed that the expression of Ring1 protein may be a novel indicator of hepatocellular carcinoma prognosis. | Upregulated expression of polycomb protein Ring1 contributes to poor prognosis and accelerated proliferation in human hepatocellular carcinoma.
Xiong Y, Hu B, Wei L, Jiang D, Zhu M. | 04/23/2016 |
| High RING1 expression is associated with non-small cell lung cancer. | Polycomb group oncogene RING1 is over-expressed in non-small cell lung cancer.
Zhou Y, Wan C, Liu Y, Lv L, Chen B, Ni R, Huang Y, Li Y, Zheng X, Yang D, Mao G, Xue Q. | 02/28/2015 |
| HSCARG interacts with RING1 and inhibits RING1 ubiquitination. | HSCARG, a novel regulator of H2A ubiquitination by downregulating PRC1 ubiquitin E3 ligase activity, is essential for cell proliferation.
Hu B, Li S, Zhang X, Zheng X., Free PMC Article | 07/19/2014 |
| Overexpression of the EZH2, RING1, and BMI1 genes is common in MDS and indicate poor prognosis. The products of these genes might participate in epigenetic regulation of Myelodysplastic syndromes. | Overexpression of the EZH2, RING1 and BMI1 genes is common in myelodysplastic syndromes: relation to adverse epigenetic alteration and poor prognostic scoring.
Xu F, Li X, Wu L, Zhang Q, Yang R, Yang Y, Zhang Z, He Q, Chang C. | 07/2/2011 |
| Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator) | MicroRNA-related genetic variations as predictors for risk of second primary tumor and/or recurrence in patients with early-stage head and neck cancer.
Zhang X, Yang H, Lee JJ, Kim E, Lippman SM, Khuri FR, Spitz MR, Lotan R, Hong WK, Wu X., Free PMC Article | 12/5/2010 |
| USP7 was identified as a deubiquitinating enzyme that regulates the ubiquitination state of RING1B. | Regulation of the Polycomb protein RING1B ubiquitination by USP7.
de Bie P, Zaaroor-Regev D, Ciechanover A. | 10/23/2010 |
| Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) | Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
Bailey SD, Xie C, Do R, Montpetit A, Diaz R, Mohan V, Keavney B, Yusuf S, Gerstein HC, Engert JC, Anand S, DREAM investigators., Free PMC Article | 09/15/2010 |
| Studies in mammalian cells have found a multiplicity of protein complexes containing Ring1A and Ring1B, suggesting an expanded regulatory role for Ring1A, Ring1B proteins in the epigenetic regulation of gene expression. | Role of polycomb proteins Ring1A and Ring1B in the epigenetic regulation of gene expression.
Vidal M. | 01/21/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | See all PubMed (4) articlesGene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
Talmud PJ, Drenos F, Shah S, Shah T, Palmen J, Verzilli C, Gaunt TR, Pallas J, Lovering R, Li K, Casas JP, Sofat R, Kumari M, Rodriguez S, Johnson T, Newhouse SJ, Dominiczak A, Samani NJ, Caulfield M, Sever P, Stanton A, Shields DC, Padmanabhan S, Melander O, Hastie C, Delles C, Ebrahim S, Marmot MG, Smith GD, Lawlor DA, Munroe PB, Day IN, Kivimaki M, Whittaker J, Humphries SE, Hingorani AD, ASCOT investigators, NORDIL investigators, BRIGHT Consortium. High-density SNP screening of the major histocompatibility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions.
Barcellos LF, May SL, Ramsay PP, Quach HL, Lane JA, Nititham J, Noble JA, Taylor KE, Quach DL, Chung SA, Kelly JA, Moser KL, Behrens TW, Seldin MF, Thomson G, Harley JB, Gaffney PM, Criswell LA. Single nucleotide polymorphisms of microRNA machinery genes modify the risk of renal cell carcinoma.
Horikawa Y, Wood CG, Yang H, Zhao H, Ye Y, Gu J, Lin J, Habuchi T, Wu X. Conditional analyses on the T1DGC MHC dataset: novel associations with type 1 diabetes around HLA-G and confirmation of HLA-B.
Eike MC, Becker T, Humphreys K, Olsson M, Lie BA. | 10/19/2008 |
| PcG protein RING1 is associated with adverse pathological features and clinical PSA recurrence in prostate cancer. | Polycomb-group oncogenes EZH2, BMI1, and RING1 are overexpressed in prostate cancer with adverse pathologic and clinical features.
van Leenders GJ, Dukers D, Hessels D, van den Kieboom SW, Hulsbergen CA, Witjes JA, Otte AP, Meijer CJ, Raaphorst FM. | 01/21/2010 |