| Association between RIT2 rs16976358 Polymorphism and Autism Spectrum Disorder in Asian Populations: A Meta-analysis. | Association between RIT2 rs16976358 Polymorphism and Autism Spectrum Disorder in Asian Populations: A Meta-analysis.
Wang J, Wei S, Zhang J, Wang H., Free PMC Article | 03/1/2023 |
| Association of RIT2 and RAB7L1 with Parkinson's disease: a case-control study in a Taiwanese cohort and a meta-analysis in Asian populations. | Association of RIT2 and RAB7L1 with Parkinson's disease: a case-control study in a Taiwanese cohort and a meta-analysis in Asian populations.
Liu TW, Wu YR, Chen YC, Fung HC, Chen CM. | 10/31/2020 |
| Dabrafenib targets B-Raf, and we confirmed a protein-protein interaction between B-Raf and Rit2, which is coded by RIT2, a Parkinson's disease (PD) risk gene in Asians and Caucasians. | In silico drug screening by using genome-wide association study data repurposed dabrafenib, an anti-melanoma drug, for Parkinson's disease.
Uenaka T, Satake W, Cha PC, Hayakawa H, Baba K, Jiang S, Kobayashi K, Kanagawa M, Okada Y, Mochizuki H, Toda T., Free PMC Article | 05/11/2019 |
| RIT2 gene was recently introduced as a susceptibility gene in neurological disorders, a group of major problems in human society affecting millions of people worldwide. Several variants, including single nucleotide polymorphisms and CNVs, have been identified and studied in different populations. | RIT2: responsible and susceptible gene for neurological and psychiatric disorders.
Daneshmandpour Y, Darvish H, Emamalizadeh B. | 07/14/2018 |
| Significant association of RIT2 Polymorphisms was observed between rs12456492 and two disorders, Parkinson's disease and essential tremor | RIT2 Polymorphisms: Is There a Differential Association?
Emamalizadeh B, Jamshidi J, Movafagh A, Ohadi M, Khaniani MS, Kazeminasab S, Biglarian A, Taghavi S, Motallebi M, Fazeli A, Ahmadifard A, Shahidi GA, Petramfar P, Shahmohammadibeni N, Dadkhah T, Khademi E, Tafakhori A, Khaligh A, Safaralizadeh T, Kowsari A, Mirabzadeh A, Zarneh AES, Khorrami M, Shokraeian P, Banavandi MJS, Lima BS, Andarva M, Alehabib E, Atakhorrami M, Darvish H. | 03/17/2018 |
| An RIT2 gene variant was found to be a risk factor for autism spectrum disorder in Iranian patients. | Ras-like without CAAX 2 (RIT2): a susceptibility gene for autism spectrum disorder.
Hamedani SY, Gharesouran J, Noroozi R, Sayad A, Omrani MD, Mir A, Afjeh SSA, Toghi M, Manoochehrabadi S, Ghafouri-Fard S, Taheri M. | 03/3/2018 |
| Findings indicate for the first time, selective advantage for a human-specific allele at an short tandem repeat locus in the human RIT2 core promoter. | The human RIT2 core promoter short tandem repeat predominant allele is species-specific in length: a selective advantage for human evolution?
Emamalizadeh B, Movafagh A, Darvish H, Kazeminasab S, Andarva M, Namdar-Aligoodarzi P, Ohadi M. | 10/7/2017 |
| RIT2 rs12456492 do not increase the risk of developing Parkinson's in Han Chinese. | Genetic association study between RIT2 and Parkinson's disease in a Han Chinese population.
Li JY, Zhang JH, Li NN, Wang L, Lu ZJ, Cheng L, Sun XY, Peng R. | 03/4/2017 |
| The current meta-analysis suggested that rs12456492 might be associated with increased PD risk in Asian populations, but studies using larger sample sizes and different ethnic populations will be needed to further confirm this association. | Genetic association of RIT2 rs12456492 polymorphism and Parkinson's disease susceptibility in Asian populations: a meta-analysis.
Lu Y, Liu W, Tan K, Peng J, Zhu Y, Wang X., Free PMC Article | 07/30/2016 |
| findings increase the likelihood of association between Parkinson's disease and RIT2 variant in Asian populations | RIT2, a susceptibility gene for Parkinson's disease in Iranian population.
Emamalizadeh B, Movafagh A, Akbari M, Kazeminasab S, Fazeli A, Motallebi M, Shahidi GA, Petramfar P, Mirfakhraie R, Darvish H. | 12/19/2015 |
| performed a case-control replication study in this population and investigated RIT2 rs12456492 variant in a large cohort of Chinese Han individuals | Assessment of RIT2 rs12456492 association with Parkinson's disease in Mainland China.
Liu ZH, Guo JF, Wang YQ, Li K, Sun QY, Xu Q, Yan XX, Xu CS, Tang BS. | 11/28/2015 |
| Its polymorphism is associated with Parkinson's disease in a Han Chinese population. | RIT2 polymorphism is associated with Parkinson's disease in a Han Chinese population.
Nie K, Feng SJ, Tang HM, Ma GX, Gan R, Zhao X, Zhao JH, Wang LM, Huang ZH, Huang J, Gao L, Zhang YW, Zhu RM, Duan ZP, Zhang YH, Wang LJ. | 11/28/2015 |
| The data of this study suggested that the RIT2 polymorphisms are associated with Parkinson disease etiology. | The RIT2 and STX1B polymorphisms are associated with Parkinson's disease.
Wang JY, Gong MY, Ye YL, Ye JM, Lin GL, Zhuang QQ, Zhang X, Zhu JH. | 11/21/2015 |
| the G allele, GG and GA genotype of rs12456492(A/G) polymorphism may increase the risk of Parkinson disease. [meta-analysis] | RIT2 rs12456492 polymorphism and the risk of Parkinson's disease: A meta-analysis.
Zhang X, Niu M, Li H, Xie A. | 10/31/2015 |
| failed to replicate the RIT2 rs12456492 variant as a genetic risk factor for Parkinson's disease in our population. | RIT2 variant is not associated with Parkinson's disease in a Taiwanese population.
Lin CH, Chen ML, Yu CY, Wu RM. | 01/18/2014 |
| These studies confirm the expression of RIT2 in retinal neuronal cells. | RIT2, a neuron-specific small guanosine triphosphatase, is expressed in retinal neuronal cells and its promoter is modulated by the POU4 transcription factors.
Zhang L, Wahlin K, Li Y, Masuda T, Yang Z, Zack DJ, Esumi N., Free PMC Article | 09/28/2013 |
| This meta-analysis identifies a novel Parkinson's disease locus, RIT2, that replicates several previously identified loci on chromosome 18. | Meta-analysis of Parkinson's disease: identification of a novel locus, RIT2.
Pankratz N, Beecham GW, DeStefano AL, Dawson TM, Doheny KF, Factor SA, Hamza TH, Hung AY, Hyman BT, Ivinson AJ, Krainc D, Latourelle JC, Clark LN, Marder K, Martin ER, Mayeux R, Ross OA, Scherzer CR, Simon DK, Tanner C, Vance JM, Wszolek ZK, Zabetian CP, Myers RH, Payami H, Scott WK, Foroud T, PD GWAS Consortium., Free PMC Article | 05/19/2012 |
| Rin interacts directly with dopamine transporter DAT in a protein kinase (PK)C-regulated manner and is required for PKC-mediated DAT internalization. | The plasma membrane-associated GTPase Rin interacts with the dopamine transporter and is required for protein kinase C-regulated dopamine transporter trafficking.
Navaroli DM, Stevens ZH, Uzelac Z, Gabriel L, King MJ, Lifshitz LM, Sitte HH, Melikian HE., Free PMC Article | 11/26/2011 |
| Observational study and genome-wide association study of gene-disease association. (HuGE Navigator) | Strong synaptic transmission impact by copy number variations in schizophrenia.
Glessner JT, Reilly MP, Kim CE, Takahashi N, Albano A, Hou C, Bradfield JP, Zhang H, Sleiman PM, Flory JH, Imielinski M, Frackelton EC, Chiavacci R, Thomas KA, Garris M, Otieno FG, Davidson M, Weiser M, Reichenberg A, Davis KL, Friedman JI, Cappola TP, Margulies KB, Rader DJ, Grant SF, Buxbaum JD, Gur RE, Hakonarson H., Free PMC Article | 06/30/2010 |
| Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) | Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR., Free PMC Article | 06/30/2010 |
| Modulates the activation of the Brn-3a regulated egr-1 promoter by the N-terminal domain of Brn-3a | Functional interaction between the small GTP-binding protein Rin and the N-terminal of Brn-3a transcription factor.
Calissano M, Latchman DS. | 01/21/2010 |
| Neuron-specific small GTPase Rin is involved in downstream signaling of plexin B3. | Plexin B3 promotes neurite outgrowth, interacts homophilically, and interacts with Rin.
Hartwig C, Veske A, Krejcova S, Rosenberger G, Finckh U., Free PMC Article | 01/21/2010 |
| observations establish Rin as a neuronal specific regulator of neurotrophin signaling, required to couple NGF stimulation to sustain activation of p38 MAP kinase and b-Raf signaling cascades required for neuronal development | Rin GTPase couples nerve growth factor signaling to p38 and b-Raf/ERK pathways to promote neuronal differentiation.
Shi GX, Han J, Andres DA. | 01/21/2010 |