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    RHCE Rh blood group CcEe antigens [ Homo sapiens (human) ]

    Gene ID: 6006, updated on 10-Oct-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    An intronic polymorphism associated with 2,3-bisphosphoglycerate levels in human red cells is linked to expression of RhCE blood groups.

    An intronic polymorphism associated with 2,3-bisphosphoglycerate levels in human red cells is linked to expression of RhCE blood groups.
    McGowan EC, Storry JR, Olsson ML., Free PMC Article

    08/26/2024
    Genetic polymorphisms and expression of Rhesus blood group RHCE are associated with 2,3-bisphosphoglycerate in humans at high altitude.

    Genetic polymorphisms and expression of Rhesus blood group RHCE are associated with 2,3-bisphosphoglycerate in humans at high altitude.
    D'Alessandro A, Earley EJ, Nemkov T, Stephenson D, Dzieciatkowska M, Hansen KC, Minetti G, Champigneulle B, Stauffer E, Pichon A, Furian M, Verges S, Kleinman S, Norris PJ, Busch MP, Page GP, Kaestner L., Free PMC Article

    03/29/2024
    Polymorphisms in the promoter regions of RHD and RHCE genes in the Chinese Han population.

    Polymorphisms in the promoter regions of RHD and RHCE genes in the Chinese Han population.
    Shao LN, Zheng ZW, Zhou SH, Zhang ST, Song WQ, Xia YX, Liang XH.

    11/16/2023
    RHCE variant alleles and risk of alloimmunization in Brazilians.

    RHCE variant alleles and risk of alloimmunization in Brazilians.
    Arnoni CP, Vendrame TAP, Silva FS, Cortez AJP, Latini FRM, Castilho L.

    02/16/2023
    Accurate long-read sequencing allows assembly of the duplicated RHD and RHCE genes harboring variants relevant to blood transfusion.

    Accurate long-read sequencing allows assembly of the duplicated RHD and RHCE genes harboring variants relevant to blood transfusion.
    Zhang Z, An HH, Vege S, Hu T, Zhang S, Mosbruger T, Jayaraman P, Monos D, Westhoff CM, Chou ST., Free PMC Article

    02/19/2022
    HLA-DRB1 molecules and the presentation of anchor peptides from RhD, RhCE, and KEL proteins.

    HLA-DRB1 molecules and the presentation of anchor peptides from RhD, RhCE, and KEL proteins.
    De Souza CP, Baleotti W, Moritz E, Sanches S, Lopes LB, Chiba AK, Donadi EA, Bordin JO.

    07/31/2021
    Variant genotypes associated with reduced expression of RhCE antigens among Brazilian blood donors.

    Variant genotypes associated with reduced expression of RhCE antigens among Brazilian blood donors.
    Dezan MR, Oliveira VB, Conrado MCAV, da Rocha MC, Luz F, Gallucci A, Pereira AC, Krieger JE, Rocha V, Mendrone-Junior A, Dinardo CL.

    07/24/2021
    RHCE*01 (c.499A>G, p.Met167Val) allele: Weak RhE expression which does not require the E-specific proline 226.

    RHCE*01 (c.499A>G, p.Met167Val) allele: Weak RhE expression which does not require the E-specific proline 226.
    Durieux-Roussel E, Laget L, Filosa L, Izard C, Bailly P, Chiaroni J.

    07/10/2021
    RHCE*02 (c.148G>A, p.Val50Ile) allele with silenced RHCE*Ce expression.

    RHCE*02 (c.148G>A, p.Val50Ile) allele with silenced RHCE*Ce expression.
    Anderson R, Vege S, Aeschlimann J, Westhoff C, Banerjee S, Yang J.

    06/26/2021
    RHD and RHCE molecular analysis in weak D blood donors and in patients with Rh antibodies against their own corresponding Rh antigen.

    RHD and RHCE molecular analysis in weak D blood donors and in patients with Rh antibodies against their own corresponding Rh antigen.
    Souza Silva TC, Cruz BR, Costa SS, Chiba AK, Barros MMO, Langhi DM, Bordin JO., Free PMC Article

    05/8/2021
    A Tutsi family harbouring two new RHCE variant alleles and a new haplotype in the Rh blood group system.

    A Tutsi family harbouring two new RHCE variant alleles and a new haplotype in the Rh blood group system.
    Deleers M, Thonier V, Claes V, Daelemans C, Peyrard T, El Kenz H.

    12/5/2020
    Identification and characterization of three novel RHCE*ce variant alleles affecting Rhc (RH4) reactivity.

    Identification and characterization of three novel RHCE*ce variant alleles affecting Rhc (RH4) reactivity.
    Filosa L, Izard C, Chiaroni J, Bailly P, Silvy M.

    06/6/2020
    novel silent RHCE allele in Chinese population.

    A novel silent RHCE allele in Chinese population.
    Zhao FY, Li Q, Zhang DM, Guo ZH, Wu YX, Wang F, Zhang JM, Qian M, Zhu ZY.

    05/2/2020
    These findings illustrate the diversity of RHD and RHCE alleles in the Moroccan population for the first time.

    Comprehensive phenotypic and molecular investigation of RhD and RhCE variants in Moroccan blood donors.
    El Housse H, El Wafi M, Ouabdelmoumene Z, Zarati F, Alid R, Nourichafi N, Bouisk K, Benajiba M, FĂ©rec C, Fichou Y, Habti N., Free PMC Article

    09/7/2019
    Four novel silenced RHCE.

    Four novel silenced RHCE.
    Aeschlimann J, Vege S, Paccapelo C, Westhoff CM.

    04/13/2019
    Among the weak D phenotypes in Tunisia, no novel RHD allele was found and almost 90% were caused by alleles of the weak D Type 4 cluster, of which 88% represented the weak D Type 4.0 allele. Based on established RH haplotypes for variant RHD and RHCE alleles and the lack of adverse clinical reports, we recommend D+ transfusions for patients with weak D Type 4.0 in Tunisia.

    Transfusion strategy for weak D Type 4.0 based on RHD alleles and RH haplotypes in Tunisia.
    Ouchari M, Srivastava K, Romdhane H, Jemni Yacoub S, Flegel WA., Free PMC Article

    09/8/2018
    study 94.9% of the partial D samples revealed altered RHCE variant alleles and 5.7% of the samples with altered RHD allele predicted partial c, partial e and the lack of the high prevalence hr(B) and hr(S) antigens.

    RHCE variants inherited with altered RHD alleles in Brazilian blood donors.
    Prisco Arnoni C, Guilhem Muniz J, de Paula Vendrame TA, de Medeiros Person R, Roche Moreira Latini F, Castilho L.

    02/3/2018
    sequence comparisons revealed high sequence similarity between Patr_RHbeta and Hosa_RHCE, while the chimpanzee Rh gene closest to Hosa_RHD was not Patr_RHalpha but rather Patr_RHgamma

    No Distinction of Orthology/Paralogy between Human and Chimpanzee Rh Blood Group Genes.
    Kitano T, Kim CG, Blancher A, Saitou N., Free PMC Article

    03/4/2017
    The purpose of this study was to determine the diversity and frequency of RHD-CE genotypes, predicting partial antigens in patients with sickle cell disease and in African Brazilian donors in order to find, through the use of RH genotyping, more closely matched donors for sickle cell disease patients who are alloimmunised to Rh antigens.

    Clinically relevant RHD-CE genotypes in patients with sickle cell disease and in African Brazilian donors.
    Gaspardi AC, Sippert EA, De Macedo MD, Pellegrino J Jr, Costa FF, Castilho L., Free PMC Article

    02/4/2017
    The RHCE gene intron 4 of Han Chinese, Tibetans, and Mongols differs from the RHD gene intron 4 in the presence of a 652-bp fragment.

    Intron 4 of the RH Gene in Han Chinese, Tibetan, and Mongol Populations.
    Liu C, Lv P, Zhang Y, Li X, Shang J, Zhao S, Li H, Zhou H.

    10/22/2016
    Six new RHCE alleles were identified, namely, RHCE*cE84A, RHCE*ce202G, RHCE*ce307T, RHCE*Ce377G, RHCE*ce697G,712G,733G,744C, and RHCE*Ce733G in individuals of diverse racial origin.

    Identification of six new RHCE variant alleles in individuals of diverse racial origin.
    Goldman M, Cemborain A, Cote J, El Hamss R, Flower RL, Garaizar A, Garcia-Sanchez F, Hyland CA, Kalvelage M, Londero D, Lopez GH, Revelli N, Rodriguez-Wilhelmi P, Villa A, Ochoa-Garay G.

    05/28/2016
    RHCE*cE94G encodes variable expression of c (RH4).

    RHCE*cE94G encodes variable expression of c (RH4).
    Yassai MB, Annen K, Bensing KM, Denomme GA.

    01/30/2016
    Rh antibodies in SCD patients with RH variants can be clinically significant and, therefore, matching patients based on RH variants should be considered.

    Variant RH alleles and Rh immunisation in patients with sickle cell disease.
    Sippert E, Fujita CR, Machado D, Guelsin G, Gaspardi AC, Pellegrino J Jr, Gilli S, Saad SS, Castilho L., Free PMC Article

    11/28/2015
    Through molecular genotyping we also identified polymorphisms in RhCE, Kell, Duffy, Colton, Lutheran and Scianna loci in donors and patients.

    Erythrocyte genotyping for transfusion-dependent patients at the Azienda Universitaria Policlinico of Naples.
    Belsito A, Costa D, Fiorito C, De Iorio G, Casamassimi A, Perrotta S, Napoli C.

    09/26/2015
    An uneven distribution of RH variant alleles between Dogon and Fulani, in Mali. A high incidence of predicted partial-C phenotype encoded by RHCE*Ce-D(4)-ce was found in Fulani.

    RH diversity in Mali: characterization of a new haplotype RHD*DIVa/RHCE*ceTI(D2).
    Ba A, Beley S, Chiaroni J, Bailly P, Silvy M.

    09/12/2015
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