| Identification of RFX5 as prognostic biomarker and associated with immune infiltration in stomach adenocarcinoma. | Identification of RFX5 as prognostic biomarker and associated with immune infiltration in stomach adenocarcinoma.
Guo L, Liu D., Free PMC Article | 09/10/2022 |
| RFX5 promotes the progression of hepatocellular carcinoma through transcriptional activation of KDM4A. | RFX5 promotes the progression of hepatocellular carcinoma through transcriptional activation of KDM4A.
Chen DB, Xie XW, Zhao YJ, Wang XY, Liao WJ, Chen P, Deng KJ, Fei R, Qin WY, Wang JH, Wu X, Shao QX, Wei L, Chen HS., Free PMC Article | 03/13/2021 |
| RFX5 regulates gene expression of the Pcdhalpha cluster. | RFX5 regulates gene expression of the Pcdhα cluster.
Wang N, Jia ZL, Wu Q. | 11/28/2020 |
| RFX5 acts as a direct positive transcriptional regulator of TPP1 in hepatocellular carcinoma. | The transcription factor RFX5 is a transcriptional activator of the TPP1 gene in hepatocellular carcinoma.
Zhao Y, Xie X, Liao W, Zhang H, Cao H, Fei R, Wang X, Wei L, Shao Q, Chen H. | 03/25/2017 |
| Data show arginine methyltransferase PRMT6 methylates the AT-hook motif of regulatory factor RFX5 and downregulates HLA-DQ expression. | Differential regulation of MHCII genes by PRMT6, via an AT-hook motif of RFX5.
Stavride P, Arampatzi P, Papamatheakis J. | 12/21/2013 |
| these data have identified as novel pathway whereby SIRT1 maintains COL1A2 synthesis in SMCs by modulating RFX5 activity. | SIRT1 deacetylates RFX5 and antagonizes repression of collagen type I (COL1A2) transcription in smooth muscle cells.
Xia J, Wu X, Yang Y, Zhao Y, Fang M, Xie W, Wang H, Xu Y. | 03/30/2013 |
| RFXAP(C) consists of two alpha-helices that form a V-shaped structure that packs within the RFX5(N)(2) staple. | Solution structure of the heterotrimeric complex between the interaction domains of RFX5 and RFXAP from the RFX gene regulatory complex.
Laird KM, Briggs LL, Boss JM, Summers MF, Garvie CW., Free PMC Article | 10/23/2010 |
| TSA treatment enhances the association of CIITA with the transcription factor RFX5, which ameliorates the down-regulation of CIITA recruitment to target promoters by HDAC2. | HDAC2 deacetylates class II transactivator and suppresses its activity in macrophages and smooth muscle cells.
Kong X, Fang M, Li P, Fang F, Xu Y. | 01/21/2010 |
| RFXAP and RFXB have roles in relieving autoinhibition of RFX5 | Assembly of the RFX complex on the MHCII promoter: role of RFXAP and RFXB in relieving autoinhibition of RFX5.
Garvie CW, Boss JM. | 01/21/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | Association between the SERPING1 gene and age-related macular degeneration: a two-stage case-control study.
Ennis S, Jomary C, Mullins R, Cree A, Chen X, Macleod A, Jones S, Collins A, Stone E, Lotery A., Free PMC Article | 11/2/2008 |
| PPARgamma is within the RFX5.CIITA complex as judged by co-immunoprecipitation and DNA affinity precipitation studies | Peroxisome proliferator-activated receptor gamma interacts with CIITA x RFX5 complex to repress type I collagen gene expression.
Xu Y, Farmer SR, Smith BD. | 01/21/2010 |
| RFX5 binds to the collagen transcription start site and represses collagen gene expression | Interferon gamma repression of collagen (COL1A2) transcription is mediated by the RFX5 complex.
Xu Y, Wang L, Buttice G, Sengupta PK, Smith BD. | 01/21/2010 |
| The mutation for the fifth Bbare lymphocyte syndrome complementation group was found in RFX5 and was mapped to one of the arginines in a DNA-binding surface of this protein. Its wild-type counterpart restored function. | Mutation in a winged-helix DNA-binding motif causes atypical bare lymphocyte syndrome.
Nekrep N, Jabrane-Ferrat N, Wolf HM, Eibl MM, Geyer M, Peterlin BM. | 01/21/2010 |
| results demonstrate that RFX1 and RFX5 differentially interact with class I HDACs underlying the different pathways when repressing collagen synthesis | Regulatory factor for X-box family proteins differentially interact with histone deacetylases to repress collagen alpha2(I) gene (COL1A2) expression.
Xu Y, Sengupta PK, Seto E, Smith BD., Free PMC Article | 01/21/2010 |
| The identification of nuclear import and export sites on RFX molecules provides potential targets to modulate MHC class II expression. | A hierarchy of nuclear localization signals governs the import of the regulatory factor X complex subunits and MHC class II expression.
Nagarajan UM, Long AB, Harreman MT, Corbett AH, Boss JM. | 01/21/2010 |
| interaction at COL1A2 start site and transcription repression | The RFX family interacts at the collagen (COL1A2) start site and represses transcription.
Sengupta PK, Fargo J, Smith BD. | 01/21/2010 |