| Inflammation in Hypervolemic Hemodialysis Patients: The Roles of RelB and Caspase-4. | Inflammation in Hypervolemic Hemodialysis Patients: The Roles of RelB and Caspase-4.
Ulrich C, Canim Z, Herberger E, Girndt M, Fiedler R., Free PMC Article | 01/11/2024 |
| NFkappaB pathway dysregulation due to reduced RelB expression leads to severe autoimmune disorders and declining immunity. | NFκB pathway dysregulation due to reduced RelB expression leads to severe autoimmune disorders and declining immunity.
Sharfe N, Dalal I, Naghdi Z, Lefaudeux D, Vong L, Dadi H, Navarro H, Tasher D, Ovadia A, Zangen T, Ater D, Ngan B, Hoffmann A, Roifman CM., Free PMC Article | 06/22/2023 |
| RelB represses miR-193a-5p expression to promote the phenotypic transformation of vascular smooth muscle cells in aortic aneurysm. | RelB represses miR-193a-5p expression to promote the phenotypic transformation of vascular smooth muscle cells in aortic aneurysm.
Liu Y, Tian X, Liu D, Zhang X, Yan C, Han Y. | 05/30/2023 |
| NF-kappaB Signaling Modulates miR-452-5p and miR-335-5p Expression to Functionally Decrease Epithelial Ovarian Cancer Progression in Tumor-Initiating Cells. | NF-κB Signaling Modulates miR-452-5p and miR-335-5p Expression to Functionally Decrease Epithelial Ovarian Cancer Progression in Tumor-Initiating Cells.
Kamdar RD, Harrington BS, Attar E, Korrapati S, Shetty J, Zhao Y, Tran B, Wong N, House CD, Annunziata CM., Free PMC Article | 05/19/2023 |
| RelB contributes to the survival, migration and lymphomagenesis of B cells with constitutively active CD40 signaling. | RelB contributes to the survival, migration and lymphomagenesis of B cells with constitutively active CD40 signaling.
Kuhn LB, Valentin S, Stojanovic K, Strobl DC, Babushku T, Wang Y, Rambold U, Scheffler L, Grath S, John-Robbert D, Blum H, Feuchtinger A, Blutke A, Weih F, Kitamura D, Rad R, Strobl LJ, Zimber-Strobl U., Free PMC Article | 10/1/2022 |
| RelB promotes the migration and invasion of prostate cancer DU145 cells via exosomal ICAM1 in vitro. | RelB promotes the migration and invasion of prostate cancer DU145 cells via exosomal ICAM1 in vitro.
Li W, Xu J, Cheng L, Zhao C, Zhang L, Shao Q, Guo F. | 04/9/2022 |
| The alternative RelB NF-kappaB subunit is a novel critical player in diffuse large B-cell lymphoma. | The alternative RelB NF-κB subunit is a novel critical player in diffuse large B-cell lymphoma.
Eluard B, Nuan-Aliman S, Faumont N, Collares D, Bordereaux D, Montagne A, Martins I, Cagnard N, Caly M, Taoui O, Lordello L, Lehmann-Che J, Tesson B, Martinez-Climent JA, Copie-Bergman C, Haioun C, Tilly H, Bonsang B, Vincent-Salomon A, Jais JP, Jardin F, Leroy K, Maiuri MC, Kroemer G, Molina TJ, Feuillard J, Baud V. | 03/12/2022 |
| Serum RelB is correlated with renal fibrosis and predicts chronic kidney disease progression. | Serum RelB is correlated with renal fibrosis and predicts chronic kidney disease progression.
Sun D, Xie N, Wang X, Wu W, Li XY, Chen X, Qian G, Li C, Zhang H, Jiang Y, Ye D, Liu D, Hu Y, Wang J, Chen W, Zhao Q, Zeng M, Zhang J, Wang L, Zhang X., Free PMC Article | 01/22/2022 |
| Crosstalk between Heart Failure and Cognitive Impairment via hsa-miR-933/RELB/CCL21 Pathway. | Crosstalk between Heart Failure and Cognitive Impairment via hsa-miR-933/RELB/CCL21 Pathway.
Feng W, Yang J, Song W, Xue Y., Free PMC Article | 01/15/2022 |
| RelB sustains endocrine resistant malignancy: an insight of noncanonical NF-kappaB pathway into breast Cancer progression. | RelB sustains endocrine resistant malignancy: an insight of noncanonical NF-κB pathway into breast Cancer progression.
Wang M, Zhang Y, Xu Z, Qian P, Sun W, Wang X, Jian Z, Xia T, Xu Y, Tang J., Free PMC Article | 08/14/2021 |
| Switch of NAD Salvage to de novo Biosynthesis Sustains SIRT1-RelB-Dependent Inflammatory Tolerance. | Switch of NAD Salvage to de novo Biosynthesis Sustains SIRT1-RelB-Dependent Inflammatory Tolerance.
Zhang J, Tao J, Ling Y, Li F, Zhu X, Xu L, Wang M, Zhang S, McCall CE, Liu TF., Free PMC Article | 10/31/2020 |
| Study demonstrated that tristetraprolin (TTP) binds to multiple intronic and exonic sites in the pre-mRNA/mRNA of the transcription factor RelB, correlating with the TTP-upregulated expression of RelB. These findings support a model in which TTP binding of RelB pre-mRNA/mRNA coordinates the RelB upregulation and activation of the innate immunity for antiviral response. | Tristetraprolin-RNA interaction map reveals a novel TTP-RelB regulatory network for innate immunity gene expression.
Tu Y, Wu X, Yu F, Dang J, Wei Y, Yu H, Liao W, Zhang Y, Wang J. | 07/18/2020 |
| Active RelB/p52 translocate into the nucleus to bind NF-kappaB response element of target gene promoter, and in turn, elicit recruitment of CBP and/or HDAC1 to regulate H3K9ac for epigenetic induction of parturition triggers | Integrated RNA-seq and ChIP-seq analysis reveals a feed-forward loop regulating H3K9ac and key labor drivers in human placenta.
Wang B, Wang P, Parobchak N, Treff N, Tao X, Wang J, Rosen T. | 03/14/2020 |
| Astrocytes display days-to-weeks long specific tolerance of cytokine genes, which is coordinated by NF-kappaB family member, RelB. However, in contrast to innate immune cells, astrocytic tolerance does not involve epigenetic silencing of the cytokine genes. Establishment of tolerance depends on persistent higher levels of RelB in tolerant astrocytes and its phosphorylation on serine 472. | RelB controls adaptive responses of astrocytes during sterile inflammation.
Gupta AS, Waters MR, Biswas DD, Brown LN, Surace MJ, Floros C, Siebenlist U, Kordula T., Free PMC Article | 02/15/2020 |
| Study reports that PAK4 is overexpressed in all human breast cancer subtypes and associated with poor outcome. PAK4 prevents senescence-like growth arrest in breast cancer cells in vitro, in vivo and ex vivo. PAK4-RELB-C/EBPbeta axis controls the senescence-like growth arrest and a PAK4 phosphorylation residue (RELB-Ser151) is critical for RELB-DNA interaction and transcriptional activity. | PAK4 suppresses RELB to prevent senescence-like growth arrest in breast cancer.
Costa TDF, Zhuang T, Lorent J, Turco E, Olofsson H, Masia-Balague M, Zhao M, Rabieifar P, Robertson N, Kuiper R, Sjölund J, Spiess M, Hernández-Varas P, Rabenhorst U, Roswall P, Ma R, Gong X, Hartman J, Pietras K, Adams PD, Defilippi P, Strömblad S., Free PMC Article | 12/14/2019 |
| The binding ability of NF-kappaB to p52/RelB was increased during the progression of cervical cancer. All cervical carcinoma biopsies showed increased expression of p50/RelA and p52/RelB, but the p52/RelB NF-kappaB protein complex showed elevated nuclear expression and binding ability, indicating a pathway other than the classical pathway. | Molecular mechanism and role of NF-κB in the early diagnosis of cervical cancer.
Hua F, Li CH, Gao YC, Li J, Meng F. | 11/23/2019 |
| In human liver diseases, RELB is upregulated in cholangiocytes. Activation of non-canonical NF-kB subunit RELB drives ductular reaction, oval cell activation and biliary driven fibrosis. | Nuclear Translocation of RELB Is Increased in Diseased Human Liver and Promotes Ductular Reaction and Biliary Fibrosis in Mice.
Elßner C, Goeppert B, Longerich T, Scherr AL, Stindt J, Nanduri LK, Rupp C, Kather JN, Schmitt N, Kautz N, Breuhahn K, Ismail L, Heide D, Hetzer J, García-Beccaria M, Hövelmeyer N, Waisman A, Urbanik T, Mueller S, Gdynia G, Banales JM, Roessler S, Schirmacher P, Jäger D, Schölch S, Keitel V, Heikenwalder M, Schulze-Bergkamen H, Köhler BC. | 04/6/2019 |
| Expression of RelB by cells of colorectal cancer patients is associated with poor survival | Alternative NF-κB signaling promotes colorectal tumorigenesis through transcriptionally upregulating Bcl-3.
Tao Y, Liu Z, Hou Y, Wang S, Liu S, Jiang Y, Tan D, Ge Q, Li C, Hu Y, Liu Z, Chen X, Wang Q, Wang M, Zhang X. | 03/2/2019 |
| Results show that GSK3beta modulates RelB degradation. | GSK3β modulates NF-κB activation and RelB degradation through site-specific phosphorylation of BCL10.
Abd-Ellah A, Voogdt C, Krappmann D, Möller P, Marienfeld RB., Free PMC Article | 12/22/2018 |
| The riboflavin transporter-3 (SLC52A3) 5'-flanking regions contain NF-kappaB p65/Rel-B-binding sites, which are crucial for mediating SLC52A3 transcriptional activity in esophageal squamous cell carcinoma (ESCC) cells. | SLC52A3 expression is activated by NF-κB p65/Rel-B and serves as a prognostic biomarker in esophageal cancer.
Long L, Pang XX, Lei F, Zhang JS, Wang W, Liao LD, Xu XE, He JZ, Wu JY, Wu ZY, Wang LD, Lin DC, Li EM, Xu LY., Free PMC Article | 11/3/2018 |
| Data show that TNF receptor-associated factor 3 (TRAF3) autophagy is driven by RAS and results in activation of transcription factor RelB (RELB). | Autophagy acts through TRAF3 and RELB to regulate gene expression via antagonism of SMAD proteins.
Newman AC, Kemp AJ, Drabsch Y, Behrends C, Wilkinson S., Free PMC Article | 09/29/2018 |
| TNF-alpha-induced expression of transport protein genes in HUVEC cells is associated with enhanced expression of RELB and NFKB2. | TNFα-Induced Expression of Transport Protein Genes in HUVEC Cells Is Associated with Enhanced Expression of Transcription Factor Genes RELB and NFKB2 of the Non-Canonical NF-κB Pathway.
Knyazev EN, Mal'tseva DV, Zacharyants AA, Zakharova GS, Zhidkova OV, Poloznikov AA. | 09/22/2018 |
| results suggest that changes in the relative concentrations of RelB, NIK:IKK1, and p100 during noncanonical signaling modulate this transitional complex and are critical for maintaining the fine balance between the processing and protection of p100. | The NF-κB subunit RelB controls p100 processing by competing with the kinases NIK and IKK1 for binding to p100.
Fusco AJ, Mazumder A, Wang VY, Tao Z, Ware C, Ghosh G. | 11/25/2017 |
| Low RELB expression is associated with Prostate Cancer. | RelB Expression Determines the Differential Effects of Ascorbic Acid in Normal and Cancer Cells.
Wei X, Xu Y, Xu FF, Chaiswing L, Schnell D, Noel T, Wang C, Chen J, St Clair DK, St Clair WH., Free PMC Article | 09/9/2017 |
| NF-kappaB RelB protein, but not RelA, displayed high expression in Endometrial cancer samples and cell lines. | RelB/NF-κB links cell cycle transition and apoptosis to endometrioid adenocarcinoma tumorigenesis.
Ge QL, Liu SH, Ai ZH, Tao MF, Ma L, Wen SY, Dai M, Liu F, Liu HS, Jiang RZ, Xue ZW, Jiang YH, Sun XH, Hu YM, Zhao YX, Chen X, Tao Y, Zhu XL, Ding WJ, Yang BQ, Liu DD, Zhang XR, Teng YC., Free PMC Article | 09/2/2017 |