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    RELA RELA proto-oncogene, NF-kB subunit [ Homo sapiens (human) ]

    Gene ID: 5970, updated on 29-Oct-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    Mitochondrial RelA empowers mtDNA G-quadruplex formation for hypoxia adaptation in cancer cells.

    Mitochondrial RelA empowers mtDNA G-quadruplex formation for hypoxia adaptation in cancer cells.
    Tang GX, Li ML, Zhou C, Huang ZS, Chen SB, Chen XC, Tan JH.

    10/28/2024
    Unconventional p65/p52 NF-kappaB module regulates key tumor microenvironment-related genes in breast tumor-associated macrophages (TAMs).

    Unconventional p65/p52 NF-κB module regulates key tumor microenvironment-related genes in breast tumor-associated macrophages (TAMs).
    De Paolis V, Troisi V, Bordin A, Pagano F, Caputo V, Parisi C.

    10/25/2024
    Role of Inflammation and the NF-kappaB Signaling Pathway in Hirschsprung's Disease.

    Role of Inflammation and the NF-κB Signaling Pathway in Hirschsprung's Disease.
    Elkrewi EZ, Al Abdulqader AA, Khasanov R, Maas-Omlor S, Boettcher M, Wessel LM, Schäfer KH, Tapia-Laliena MÁ., Free PMC Article

    10/7/2024
    Multilevel Regulation of NF-kappaB Signaling by NSD2 Suppresses Kras-Driven Pancreatic Tumorigenesis.

    Multilevel Regulation of NF-κB Signaling by NSD2 Suppresses Kras-Driven Pancreatic Tumorigenesis.
    Feng W, Niu N, Lu P, Chen Z, Rao H, Zhang W, Ma C, Liu C, Xu Y, Gao WQ, Xue J, Li L., Free PMC Article

    09/24/2024
    p65 signaling dynamics drive the developmental progression of hematopoietic stem and progenitor cells through cell cycle regulation.

    p65 signaling dynamics drive the developmental progression of hematopoietic stem and progenitor cells through cell cycle regulation.
    Campbell CA, Calderon R, Pavani G, Cheng X, Barakat R, Snella E, Liu F, Peng X, Essner JJ, Dorman KS, McGrail M, Gadue P, French DL, Espin-Palazon R., Free PMC Article

    09/16/2024
    Bifidobacterium bifidum Strain BB1 Inhibits Tumor Necrosis Factor-alpha-Induced Increase in Intestinal Epithelial Tight Junction Permeability via Toll-Like Receptor-2/Toll-Like Receptor-6 Receptor Complex-Dependent Stimulation of Peroxisome Proliferator-Activated Receptor gamma and Suppression of NF-kappaB p65.

    Bifidobacterium bifidum Strain BB1 Inhibits Tumor Necrosis Factor-α-Induced Increase in Intestinal Epithelial Tight Junction Permeability via Toll-Like Receptor-2/Toll-Like Receptor-6 Receptor Complex-Dependent Stimulation of Peroxisome Proliferator-Activated Receptor γ and Suppression of NF-κB p65.
    Abdulqadir R, Al-Sadi R, Haque M, Gupta Y, Rawat M, Ma TY.,

    08/30/2024
    MiR-1976/NCAPH/P65 axis inhibits the malignant phenotypes of lung adenocarcinoma.

    MiR-1976/NCAPH/P65 axis inhibits the malignant phenotypes of lung adenocarcinoma.
    Huang P, Zhao H, Sun R, Liu C, Wu L, Wang Y, Gan Z, Yang X, Du J., Free PMC Article

    08/13/2024
    WSB1/2 target chromatin-bound lysine-methylated RelA for proteasomal degradation and NF-kappaB termination.

    WSB1/2 target chromatin-bound lysine-methylated RelA for proteasomal degradation and NF-κB termination.
    Zhang J, Yu Y, Zou X, Du Y, Liang Q, Gong M, He Y, Luo J, Wu D, Jiang X, Sinclair M, Tajkhorshid E, Chen HZ, Hou Z, Zheng Y, Chen LF, Yang XD., Free PMC Article

    06/12/2024
    Renal ischaemia-reperfusion injury is promoted by transcription factor NF-kB p65, which inhibits TRPC6 expression by activating miR-150.

    Renal ischaemia-reperfusion injury is promoted by transcription factor NF-kB p65, which inhibits TRPC6 expression by activating miR-150.
    Li S, Ma Q, Ma Z, Shi Y, Yu X, Gu B, Sun S, Yu C, Pang L., Free PMC Article

    04/22/2024
    A1CF Binding to the p65 Interaction Site on NKRF Decreased IFN-beta Expression and p65 Phosphorylation (Ser536) in Renal Carcinoma Cells.

    A1CF Binding to the p65 Interaction Site on NKRF Decreased IFN-β Expression and p65 Phosphorylation (Ser536) in Renal Carcinoma Cells.
    Liu Y, Yang J, Weng D, Xie Y., Free PMC Article

    04/17/2024
    Tumor Necrosis Factor Alpha-Induced Protein-3 Inhibits the Activation of Hepatic Stellate Cells by Regulating the p65 Molecule in the NF-kappaB Signaling Pathway.

    Tumor Necrosis Factor Alpha-Induced Protein-3 Inhibits the Activation of Hepatic Stellate Cells by Regulating the p65 Molecule in the NF-κB Signaling Pathway.
    Zhang H, Shi Z, Guo Y, Wu D, Yu G, Xu J.

    04/11/2024
    Silent information regulator 2 deficiency exacerbates chronic cold exposure-induced colonic injury and p65 activation in mice.

    Silent information regulator 2 deficiency exacerbates chronic cold exposure-induced colonic injury and p65 activation in mice.
    Guo J, Zhang H, Hu H, Zhao T, Ji H, Ma L, Lu J, Yuan J, Xu B.

    03/29/2024
    Role of NF-kappaB p65/TNF-alpha in Cell Apoptosis in the Fetal Membranes of Pregnant Women with Preterm Premature Rupture of Membranes.

    Role of NF-κB p65/TNF-α in Cell Apoptosis in the Fetal Membranes of Pregnant Women with Preterm Premature Rupture of Membranes.
    Tang SH, Tang X, Liu L, Peng L, Zhang HM, Zhang H, Long T, Wu PL, Zhang XP.

    03/28/2024
    The NF-kappaB RelA transcription factor is not required for CD8+ T-cell function in acute viral infection and cancer.

    The NF-κB RelA transcription factor is not required for CD8+ T-cell function in acute viral infection and cancer.
    Voisin A, Plaschka M, Perrin-Niquet M, Twardowski J, Boutemine I, Eluard B, Lalle G, Stéphan P, Bouherrou K, Tonon L, Pommier R, Ferrari A, Klein U, Wencker M, Baud V, Cassier PA, Grinberg-Bleyer Y., Free PMC Article

    03/22/2024
    The Prolonged Activation of the p65 Subunit of the NF-Kappa-B Nuclear Factor Sustains the Persistent Effect of Advanced Glycation End Products on Inflammatory Sensitization in Macrophages.

    The Prolonged Activation of the p65 Subunit of the NF-Kappa-B Nuclear Factor Sustains the Persistent Effect of Advanced Glycation End Products on Inflammatory Sensitization in Macrophages.
    Assis SIS, Amendola LS, Okamoto MM, Ferreira GDS, Iborra RT, Santos DR, Santana MFM, Santana KG, Correa-Giannella ML, Barbeiro DF, Soriano FG, Machado UF, Passarelli M., Free PMC Article

    03/14/2024
    Transcription factor RELA promotes hepatocellular carcinoma progression by promoting the transcription of m6A modulator METTL3.

    Transcription factor RELA promotes hepatocellular carcinoma progression by promoting the transcription of m6A modulator METTL3.
    Wu J, Wang W, Zheng Y, Deng W, Liu J.

    03/13/2024
    Insulin-like growth factor 2 mRNA-binding protein 3 enhanced melanoma migration through regulation of AKT1 and RELA expression.

    Insulin-like growth factor 2 mRNA-binding protein 3 enhanced melanoma migration through regulation of AKT1 and RELA expression.
    Sheen YS, Syu YJ, Chang YC, Hsieh PH, Liao YH, Lin MH, Chen CY, Chu CY, Chu CY.

    03/1/2024
    LAMB3 Promotes Intestinal Inflammation Through SERPINA3 and Is Directly Transcriptionally Regulated by P65 in Inflammatory Bowel Disease.

    LAMB3 Promotes Intestinal Inflammation Through SERPINA3 and Is Directly Transcriptionally Regulated by P65 in Inflammatory Bowel Disease.
    Liu F, Xu W, Wang Y, Huang Z, Zhu Z, Ou W, Tang W, Fu J, Liu C, Gu Y, Liu Y, Du P.

    02/7/2024
    miR-27a-3p upregulation by p65 facilitates cervical tumorigenesis by increasing TAB3 expression and is involved in the positive feedback loop of NF-kappaB signaling.

    miR‑27a‑3p upregulation by p65 facilitates cervical tumorigenesis by increasing TAB3 expression and is involved in the positive feedback loop of NF‑κB signaling.
    Li M, Gao Z, Wang S, Zhao Y, Xie H., Free PMC Article

    02/2/2024
    CRIP1 fosters MDSC trafficking and resets tumour microenvironment via facilitating NF-kappaB/p65 nuclear translocation in pancreatic ductal adenocarcinoma.

    CRIP1 fosters MDSC trafficking and resets tumour microenvironment via facilitating NF-κB/p65 nuclear translocation in pancreatic ductal adenocarcinoma.
    Liu X, Tang R, Xu J, Tan Z, Liang C, Meng Q, Lei Y, Hua J, Zhang Y, Liu J, Zhang B, Wang W, Yu X, Shi S., Free PMC Article

    11/30/2023
    The kinesin-14 family motor protein KIFC2 promotes prostate cancer progression by regulating p65.

    The kinesin-14 family motor protein KIFC2 promotes prostate cancer progression by regulating p65.
    Liu X, Lin Y, Long W, Yi R, Zhang X, Xie C, Jin N, Qiu Z, Liu X., Free PMC Article

    11/29/2023
    DDX5 (p68) orchestrates beta-catenin, RelA and SP1 mediated MGMT gene expression in human colon cancer cells: Implication in TMZ chemoresistance.

    DDX5 (p68) orchestrates β-catenin, RelA and SP1 mediated MGMT gene expression in human colon cancer cells: Implication in TMZ chemoresistance.
    Shaw R, Karmakar S, Basu M, Ghosh MK.

    11/20/2023
    Interplay between SUMO1-related SUMOylation and phosphorylation of p65 promotes hepatocellular carcinoma progression.

    Interplay between SUMO1-related SUMOylation and phosphorylation of p65 promotes hepatocellular carcinoma progression.
    Jiang C, Zhang C, Dai M, Wang F, Xu S, Han D, Wang Y, Cao Y, Liang Y, Zhang Z, Yan L, Shen Y, He K, Shen Y, Liu J.

    11/20/2023
    Paracrine activin B-NF-kappaB signaling shapes an inflammatory tumor microenvironment in gastric cancer via fibroblast reprogramming.

    Paracrine activin B-NF-κB signaling shapes an inflammatory tumor microenvironment in gastric cancer via fibroblast reprogramming.
    Jin Y, Cai Q, Wang L, Ji J, Sun Y, Jiang J, Wang C, Wu J, Zhang B, Zhao L, Qi F, Yu B, Zhang J., Free PMC Article

    11/13/2023
    NLRC3 deficiency promotes hypoxia-induced pulmonary hypertension development via IKK/NF-kappaB p65/HIF-1alpha pathway.

    NLRC3 deficiency promotes hypoxia-induced pulmonary hypertension development via IKK/NF-κB p65/HIF-1α pathway.
    Maimaitiaili N, Zeng Y, Ju P, Zhakeer G, E G, Yao H, Shi Y, Zhai M, Zhuang J, Peng W, Zhuoga D, Yu Q.

    09/20/2023
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