| Radixin modulates the function of outer hair cell stereocilia. | Radixin modulates the function of outer hair cell stereocilia.
Prasad S, Vona B, Diñeiro M, Costales M, González-Aguado R, Fontalba A, Diego-Pérez C, Subasioglu A, Bademci G, Tekin M, Cabanillas R, Cadiñanos J, Fridberger A., Free PMC Article | 06/26/2021 |
| Radixin Relocalization and Nonmuscle alpha-Actinin Expression Are Features of Remodeling Cardiomyocytes in Adult Patients with Dilated Cardiomyopathy. | Radixin Relocalization and Nonmuscle α-Actinin Expression Are Features of Remodeling Cardiomyocytes in Adult Patients with Dilated Cardiomyopathy.
Cetinkaya A, Berge B, Sen-Hild B, Troidl K, Gajawada P, Kubin N, Valeske K, Schranz D, Akintürk H, Schönburg M, Kubin T, Choi YH, Richter M., Free PMC Article | 06/12/2021 |
| ERM-Dependent Assembly of T Cell Receptor Signaling and Co-stimulatory Molecules on Microvilli prior to Activation. | ERM-Dependent Assembly of T Cell Receptor Signaling and Co-stimulatory Molecules on Microvilli prior to Activation.
Ghosh S, Di Bartolo V, Tubul L, Shimoni E, Kartvelishvily E, Dadosh T, Feigelson SW, Alon R, Alcover A, Haran G. | 03/27/2021 |
| ERM Proteins at the Crossroad of Leukocyte Polarization, Migration and Intercellular Adhesion. | ERM Proteins at the Crossroad of Leukocyte Polarization, Migration and Intercellular Adhesion.
García-Ortiz A, Serrador JM., Free PMC Article | 12/5/2020 |
| Activation of PKC induces leukocyte adhesion by the dephosphorylation of ERM. | Activation of PKC induces leukocyte adhesion by the dephosphorylation of ERM.
Tachibana K, Ohnishi H, Ali Haghparast SM, Kihara T, Miyake J. | 09/19/2020 |
| Novel compound heterozygosity for c.129_130del, p.His43Glnfs*28 and c.76_79del, p.Lys26* in the RDX gene was identified in Chinese family with non-syndromic hearing loss. | Identification of novel variants in MYO15A, OTOF, and RDX with hearing loss by next-generation sequencing.
Bai X, Nian S, Feng L, Ruan Q, Luo X, Wu M, Yan Z., Free PMC Article | 07/4/2020 |
| This article reviews data pertaining to potential molecular interaction partners of ezrin and radixin in astrocytes, with a focus on PKC and GRK2, and in gliomas and other diseases, to stimulate further research on their potential roles in glia-synaptic physiology and pathology. [review] | Perspectives for Ezrin and Radixin in Astrocytes: Kinases, Functions and Pathology.
Derouiche A, Geiger KD., Free PMC Article | 01/11/2020 |
| Merlin regulates contact inhibition and is an integral part of cell-cell junctions, while ERM proteins, ezrin, radixin and moesin, assist in the formation and maintenance of specialized plasma membrane structures and membrane vesicle structures. [review] | Two Sides of the Coin: Ezrin/Radixin/Moesin and Merlin Control Membrane Structure and Contact Inhibition.
Michie KA, Bermeister A, Robertson NO, Goodchild SC, Curmi PMG., Free PMC Article | 08/24/2019 |
| CPI-17 drives Ras activity and tumorigenesis in melanomas in a two-fold way; inactivation of the tumor suppressor merlin and activation of the growth promoting ERM family. | CPI-17 drives oncogenic Ras signaling in human melanomas via Ezrin-Radixin-Moesin family proteins.
Riecken LB, Zoch A, Wiehl U, Reichert S, Scholl I, Cui Y, Ziemer M, Anderegg U, Hagel C, Morrison H., Free PMC Article | 02/24/2018 |
| The results reveal a supportive role of ERMs in cortical activities during cytokinesis, and also provide insight into the selective mechanism that preferentially associates cytokinesis-relevant proteins with the division site. | Dynamics and function of ERM proteins during cytokinesis in human cells.
Hiruma S, Kamasaki T, Otomo K, Nemoto T, Uehara R. | 11/4/2017 |
| Radixin knockdown suppresses the metastasis of SGC-7901 cells in vitro by up-regulation of E-cadherin. The NF-kappaB/snail pathway contributes to the regulation of E-cadherin in response to depletion of radixin. | Knockdown of Radixin Suppresses Gastric Cancer Metastasis In Vitro by Up-Regulation of E-Cadherin via NF-κB/Snail Pathway.
Zhu YW, Yan JK, Li JJ, Ou YM, Yang Q. | 02/18/2017 |
| Phospho-Ezrin/Radixin/Moesin (ERM) inhibit cell adhesion, and therefore, dephosphorylation of ERM proteins is essential for cell adhesion.Phospho-ERM induce formation and/or maintenance of spherical cell shape. | Inhibition of cell adhesion by phosphorylated Ezrin/Radixin/Moesin.
Tachibana K, Haghparast SM, Miyake J., Free PMC Article | 09/24/2016 |
| Intracellular sphingosine kinase 2-derived sphingosine-1-phosphate mediates epidermal growth factor-induced ezrin-radixin-moesin phosphorylation and cancer cell invasion. | Intracellular sphingosine kinase 2-derived sphingosine-1-phosphate mediates epidermal growth factor-induced ezrin-radixin-moesin phosphorylation and cancer cell invasion.
Adada MM, Canals D, Jeong N, Kelkar AD, Hernandez-Corbacho M, Pulkoski-Gross MJ, Donaldson JC, Hannun YA, Obeid LM., Free PMC Article | 02/13/2016 |
| High Radixin expression is associated with glioblastoma. | Radixin knockdown by RNA interference suppresses human glioblastoma cell growth in vitro and in vivo.
Qin JJ, Wang JM, Du J, Zeng C, Han W, Li ZD, Xie J, Li GL. | 08/29/2015 |
| Ezrin, radixin and moesin are unlikely targets for autoantibodies in demyelinating neuropathies. | Are ERM (ezrin/radixin/moesin) proteins targets for autoantibodies in demyelinating neuropathies?
Miyaji K, Shahrizaila N, Umapathi T, Chan YC, Hirata K, Yuki N. | 08/8/2015 |
| Data show that silencing ezrin-radixin-moesin (ERM) protein expression ablates deleted in colorectal carcinoma protein (DCC)-protein kinase A (PKA) interaction and specifically blocks netrin-induced PKA activity and phosphorylation. | Anchoring of protein kinase A by ERM (ezrin-radixin-moesin) proteins is required for proper netrin signaling through DCC (deleted in colorectal cancer).
Deming PB, Campbell SL, Stone JB, Rivard RL, Mercier AL, Howe AK., Free PMC Article | 05/16/2015 |
| These data suggest an association between RDX polymorphisms and the clinical features of RA patients, particularly the ESR | Association study of polymorphisms between the Radixin gene and rheumatoid arthritis in a Korean population.
Kim HK, Joo JS, Lee HY, Kwon JT, Sohn DR, Hong SJ, Kim HJ. | 12/20/2014 |
| Radixin was identified as a target gene of miR-196a/-196b. Elevated miR-196a/-196b expression in GC cells led to reduced radixin protein levels and vice versa. | MicroRNA-196a/-196b promote cell metastasis via negative regulation of radixin in human gastric cancer.
Tsai MM, Wang CS, Tsai CY, Chen CY, Chi HC, Tseng YH, Chung PJ, Lin YH, Chung IH, Chen CY, Lin KH. | 11/29/2014 |
| This study finding have implications concerning the importance of concomitant radixin upregulation in tumor progression and poor prognosis of patients with gliomas. | Concomitant microRNA-31 downregulation and radixin upregulation predicts advanced tumor progression and unfavorable prognosis in patients with gliomas.
Wang S, Jiao B, Geng S, Song J, Liang Z, Lu S. | 10/25/2014 |
| VIP regulates CFTR membrane expression and function in Calu-3 cells by increasing its interaction with NHERF1 and P-ERM in a VPAC1- and PKCepsilon-dependent manner. | VIP regulates CFTR membrane expression and function in Calu-3 cells by increasing its interaction with NHERF1 and P-ERM in a VPAC1- and PKCε-dependent manner.
Alshafie W, Chappe FG, Li M, Anini Y, Chappe VM. | 08/30/2014 |
| important role of ezrin-moesin-radixin proteins during HCV infection at the postentry level and highlight possible novel targets for HCV treatment. | Human ezrin-moesin-radixin proteins modulate hepatitis C virus infection.
Bukong TN, Kodys K, Szabo G., Free PMC Article | 03/15/2014 |
| ERM proteins play important differential roles in the thrombin-induced modulation of EC permeability, with moesin promoting barrier dysfunction and radixin opposing it. | Ezrin/radixin/moesin proteins differentially regulate endothelial hyperpermeability after thrombin.
Adyshev DM, Dudek SM, Moldobaeva N, Kim KM, Ma SF, Kasa A, Garcia JG, Verin AD., Free PMC Article | 11/2/2013 |
| Data suggest that P-glycoprotein associate with the F-actin cytoskeleton through ezrin/radixin/moesin (ERM) in CCR9/CCL25 induced multidrug resistance of acute T-lymphocytic leukemia (T-ALL) cells. | Activated ERM protein plays a critical role in drug resistance of MOLT4 cells induced by CCL25.
Zhang L, Xiao R, Xiong J, Leng J, Ehtisham A, Hu Y, Ding Q, Xu H, Liu S, Wang J, Tang DG, Zhang Q., Free PMC Article | 07/6/2013 |
| Control of adipogenesis by ezrin, radixin and moesin-dependent biomechanics remodeling. | Control of adipogenesis by ezrin, radixin and moesin-dependent biomechanics remodeling.
Titushkin I, Sun S, Paul A, Cho M. | 07/6/2013 |
| radixin plays an important role in promoting cell migration by regulating Rac1-mediated epithelial polarity and formation of adherens junctions through Vav GEFs. | Radixin regulates cell migration and cell-cell adhesion through Rac1.
Valderrama F, Thevapala S, Ridley AJ. | 03/30/2013 |