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    RBMY1A1 RNA binding motif protein Y-linked family 1 member A1 [ Homo sapiens (human) ]

    Gene ID: 5940, updated on 2-Nov-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    PIM1-Induced Cytoplasmic Expression of RBMY Mediates Hepatocellular Carcinoma Metastasis.

    PIM1-Induced Cytoplasmic Expression of RBMY Mediates Hepatocellular Carcinoma Metastasis.
    Chua HH, Chang MH, Chen YH, Tsuei DJ, Jeng YM, Lee PH, Ni YH., Free PMC Article

    12/31/2022
    Potential dual functional roles of the Y-linked RBMY in hepatocarcinogenesis.

    Potential dual functional roles of the Y-linked RBMY in hepatocarcinogenesis.
    Kido T, Tabatabai ZL, Chen X, Lau YC., Free PMC Article

    12/12/2020
    genetic association study in population in southwest China: Data suggest that copy number variation in RBMY1 is associated with sperm motility and asthenozoospermia; RBMY1 functional copy dosage is positively correlated with sperm motility; dosage insufficiency is independent genetic risk factor for asthenozoospermia; RBMY1 is an important candidate for male infertility in azoospermia factor (AZF) region of Y-chromosome.

    Copy number variation of functional RBMY1 is associated with sperm motility: an azoospermia factor-linked candidate for asthenozoospermia.
    Yan Y, Yang X, Liu Y, Shen Y, Tu W, Dong Q, Yang D, Ma Y, Yang Y.

    06/16/2018
    RBMY is a novel oncofetal protein that plays a key role in attenuating glycogen synthase kinase 3beta activity, leading to aberrant activation of Wnt/beta-catenin signaling, which facilitates malignant hepatic stemness.

    RBMY, a novel inhibitor of glycogen synthase kinase 3β, increases tumor stemness and predicts poor prognosis of hepatocellular carcinoma.
    Chua HH, Tsuei DJ, Lee PH, Jeng YM, Lu J, Wu JF, Su DS, Chen YH, Chien CS, Kao PC, Lee CN, Hu RH, Ni YH, Chang MH.

    02/6/2016
    results imply that different alternative splicing may happen in testis cells and probably difference of RBMY function during spermatogenesis is due to the differential expression of RBMY protein isoforms.

    Expression analysis of RNA-binding motif gene on Y chromosome (RBMY) protein isoforms in testis tissue and a testicular germ cell cancer-derived cell line (NT2).
    Alikhani M, Sharifi Tabar M, Mirshahvaladi S, Kheimeh A, Sadighi Gilani MA, Sabbaghian M., Free PMC Article

    04/19/2014
    One possible function of RBMY could be its involvement in sperm motility.

    Cellular ontogeny of RBMY during human spermatogenesis and its role in sperm motility.
    Abid S, Sagare-Patil V, Gokral J, Modi D.

    07/27/2013
    investigation of role of RBMY in spermatogenesis: isolation and identification of RBMY target mRNAs in testis; RBMY binds to only transcript variant 2 of Nek10; RBMY may take part in alternative splicing of Nek10

    Identifying mRNAs bound by human RBMY protein in the testis.
    Zeng M, Liang S, Zhao S, Liu Y, Sun H, Zhang S, Ma Y.

    08/6/2011
    regulates germline-specific splicing events; ectopic expression stimulated the inclusion of a testis-enriched exon

    Human RBMY regulates germline-specific splicing events by modulating the function of the serine/arginine-rich proteins 9G8 and Tra2-{beta}.
    Dreumont N, Bourgeois CF, Lejeune F, Liu Y, Ehrmann IE, Elliott DJ, Stévenin J.

    06/14/2010
    germ cell-specific RBMY and hnRNP G-T proteins were more efficient in stimulating TLE4-T incorporation than somatically expressed hnRNP G protein.

    The germ cell nuclear proteins hnRNP G-T and RBMY activate a testis-specific exon.
    Liu Y, Bourgeois CF, Pang S, Kudla M, Dreumont N, Kister L, Sun YH, Stevenin J, Elliott DJ., Free PMC Article

    02/8/2010
    Patients with complete Sertoli cell-only syndrome (SCOS) did not exhibit RBMY1 gene expression.

    Quantification of DDX3Y, RBMY1, DAZ and TSPY mRNAs in testes of patients with severe impairment of spermatogenesis.
    Lardone MC, Parodi DA, Valdevenito R, Ebensperger M, Piottante A, Madariaga M, Smith R, Pommer R, Zambrano N, Castro A.

    01/21/2010
    Using systematic evolution of ligands by exponential enrichment, we found that RNA stem-loops capped by a C(A)/(U)CAA pentaloop are high-affinity binding targets for hRBMY.

    The testis-specific human protein RBMY recognizes RNA through a novel mode of interaction.
    Skrisovska L, Bourgeois CF, Stefl R, Grellscheid SN, Kister L, Wenter P, Elliott DJ, Stevenin J, Allain FH., Free PMC Article

    01/21/2010
    Quantitative real-time PCR assays of this protein gave positive predictive values of 70 per cent for the recovery of sperm from testicular biopsy.

    Investigation of DAZ and RBMY1 gene expression in human testis by quantitative real-time PCR.
    Lavery R, Glennon M, Houghton J, Nolan A, Egan D, Maher M.

    01/21/2010
    RNA transport element RTE evolved as a high affinity RBM15 ligand to provide a splicing-independent link to NXF1, thereby ensuring efficient nuclear export and expression of retrotransposon transcripts

    RNA-binding motif protein 15 binds to the RNA transport element RTE and provides a direct link to the NXF1 export pathway.
    Lindtner S, Zolotukhin AS, Uranishi H, Bear J, Kulkarni V, Smulevitch S, Samiotaki M, Panayotou G, Felber BK, Pavlakis GN.

    01/21/2010
    RBMY is a new candidate oncogene specific for male liver cancer

    RBMY, a male germ cell-specific RNA-binding protein, activated in human liver cancers and transforms rodent fibroblasts.
    Tsuei DJ, Hsu HC, Lee PH, Jeng YM, Pu YS, Chen CN, Lee YC, Chou WC, Chang CJ, Ni YH, Chang MH.

    01/21/2010
    analyse the presence of DAZ, RBMY1, USP9Y, protamine-2, SRY and actin messenger RNA (mRNA) in testicular cells of men suffering from idiopathic azoospermia (RBMY1)

    A preliminary report on the implication of RT-PCR detection of DAZ, RBMY1, USP9Y and Protamine-2 mRNA in testicular biopsy samples from azoospermic men.
    Friel A, Houghton JA, Glennon M, Lavery R, Smith T, Nolan A, Maher M.

    01/21/2010
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