| Sumo-regulatory SENP2 controls the homeostatic squamous mitosis-differentiation checkpoint. | Sumo-regulatory SENP2 controls the homeostatic squamous mitosis-differentiation checkpoint.
Galán-Vidal J, García-Gaipo L, Molinuevo R, Dias S, Tsoi A, Gómez-Román J, Elder JT, Hochegger H, Gandarillas A., Free PMC Article | 08/19/2024 |
| Extracellular vesicle-mediated regulation of imatinib resistance in chronic myeloid leukemia via the miR-629-5p/SENP2/PI3K/AKT/mTOR axis. | Extracellular vesicle-mediated regulation of imatinib resistance in chronic myeloid leukemia via the miR-629-5p/SENP2/PI3K/AKT/mTOR axis.
Jiang Y, Xiao S, Huang S, Zhao X, Ding S, Huang Q, Xiao W, Li Z, Zhu H. | 08/1/2024 |
| Mitochondrial SENP2 regulates the assembly of SDH complex under metabolic stress. | Mitochondrial SENP2 regulates the assembly of SDH complex under metabolic stress.
Liu Y, Liu K, Thorne RF, Shi R, Zhang Q, Wu M, Liu L. | 10/5/2023 |
| SENP2 regulates mitochondrial function and insulin secretion in pancreatic beta cells. | SENP2 regulates mitochondrial function and insulin secretion in pancreatic β cells.
Nan J, Lee JS, Moon JH, Lee SA, Park YJ, Lee DS, Chung SS, Park KS., Free PMC Article | 04/30/2022 |
| Hepatic Small Ubiquitin-Related Modifier (SUMO)-Specific Protease 2 Controls Systemic Metabolism Through SUMOylation-Dependent Regulation of Liver-Adipose Tissue Crosstalk. | Hepatic Small Ubiquitin-Related Modifier (SUMO)-Specific Protease 2 Controls Systemic Metabolism Through SUMOylation-Dependent Regulation of Liver-Adipose Tissue Crosstalk.
Liu Y, Dou X, Zhou WY, Ding M, Liu L, Du RQ, Guo L, Qian SW, Tang Y, Yang QQ, Pan DN, Li XY, Lu Y, Cheng JK, Tang QQ. | 01/15/2022 |
| Silencing of SENP2 in Multiple Myeloma Induces Bortezomib Resistance by Activating NF-kappaB Through the Modulation of IkappaBalpha Sumoylation. | Silencing of SENP2 in Multiple Myeloma Induces Bortezomib Resistance by Activating NF-κB Through the Modulation of IκBα Sumoylation.
Xie H, Gu Y, Wang W, Wang X, Ye X, Xin C, Lu M, Reddy BA, Shu P., Free PMC Article | 11/21/2020 |
| Overexpression of SENP2 was correlated with a better overall survival of the Gastric Cancer patients with a marginally significance, indicating that SENP2 expression could be used as a novel biomarker to predict patient prognosis. | Comprehensive Analysis of the Canonical and Non-canonical Wnt Signaling Pathways in Gastric Cancer.
Wang L, Wang H, Duan X, Dai P, Li J. | 05/9/2020 |
| SENP2 regulates its substrate for desumoylation, and also the role of SENP2 in TGF-beta induced cancer cell migration. | The role of sentrin-specific protease 2 substrate recognition in TGF-β-induced tumorigenesis.
Chang CC, Huang YS, Lin YM, Lin CJ, Jeng JC, Liu SM, Ho TL, Chang RT, Changou CA, Ho CC, Shih HM., Free PMC Article | 10/12/2019 |
| he nuclear factor (NF)kappaB signaling pathway was also regulated by the overexpression of SENP2. On the whole, the findings of this study indicate tha SENP2 can act as a tumor suppressor in CLL cells, and may thus prove to be a novel target for CLL treatment in clinical practice. | SENP2 exerts an anti‑tumor effect on chronic lymphocytic leukemia cells through the inhibition of the Notch and NF‑κB signaling pathways.
Chen XL, Wang SF, Liang XT, Liang HX, Wang TT, Wu SQ, Qiu ZJ, Zhan R, Xu ZS., Free PMC Article | 04/6/2019 |
| SENP2 is amplified as part of the chromosome 3q amplification in many cancers and Increased SENP2 expression prolongs MDC1 focus retention and increases NHEJ and radioresistance | The deSUMOylase SENP2 coordinates homologous recombination and nonhomologous end joining by independent mechanisms.
Garvin AJ, Walker AK, Densham RM, Chauhan AS, Stone HR, Mackay HL, Jamshad M, Starowicz K, Daza-Martin M, Ronson GE, Lanz AJ, Beesley JF, Morris JR., Free PMC Article | 03/30/2019 |
| SENP2 binds to intracellular membranes where it interacts with membrane-associated proteins and has the potential to regulate their sumoylation and membrane-associated functions. | The SUMO-specific isopeptidase SENP2 is targeted to intracellular membranes via a predicted N-terminal amphipathic α-helix.
Odeh HM, Coyaud E, Raught B, Matunis MJ., Free PMC Article | 03/9/2019 |
| research achievements of SENP2 are reviewed in order to understand its related functions and the underlying molecular mechanisms and provide a clue for future research on SENP2 | SUMO1/sentrin/SMT3 specific peptidase 2 modulates target molecules and its corresponding functions.
Liu SL, Gao FH. | 12/1/2018 |
| Quantitative high-throughput screening identifies cytoprotective molecules that enhance SUMO conjugation via the inhibition of SUMO-specific protease (SENP)2. | Quantitative high-throughput screening identifies cytoprotective molecules that enhance SUMO conjugation via the inhibition of SUMO-specific protease (SENP)2.
Bernstock JD, Ye D, Smith JA, Lee YJ, Gessler FA, Yasgar A, Kouznetsova J, Jadhav A, Wang Z, Pluchino S, Zheng W, Simeonov A, Hallenbeck JM, Yang W., Free PMC Article | 11/10/2018 |
| Data show that Sentrin/SUMO specific protease (SENP2) interacts with N-myc downstream regulated gene 2 (NDRG2) and mediates the de-SUMOylation process of NDRG2. | SUMO-specific protease 2-mediated deSUMOylation is required for NDRG2 stabilization in gastric cancer cells.
Hu XY, Liu Z, Zhang KL, Feng J, Liu XF, Wang LY, Wang ZW. | 08/18/2018 |
| Data demonstrate that downregulation of SENP2 is correlated with poor prognosis in bladder cancer; SENP2 inhibits TGF-beta signaling and TGF-beta-induced EMT of bladder cancer cell; and that its overexpression contributes to suppress bladder cancer cell invasion and metastasis through deSUMOylation of TGF-betaRI. | SENP2 suppresses epithelial-mesenchymal transition of bladder cancer cells through deSUMOylation of TGF-βRI.
Tan M, Zhang D, Zhang E, Xu D, Liu Z, Qiu J, Fan Y, Shen B. | 10/7/2017 |
| The variability of the SENP1 and SENP2 genes may play a role in breast cancer occurrence. | Genetic Polymorphism of SUMO-Specific Cysteine Proteases - SENP1 and SENP2 in Breast Cancer.
Mirecka A, Morawiec Z, Wozniak K., Free PMC Article | 03/11/2017 |
| SENP2 inhibits MMP13 expression in BC cells through de-SUMOylation of TBL1/TBLR1, which inhibits nuclear translocation of beta-catenin. | SENP2 regulates MMP13 expression in a bladder cancer cell line through SUMOylation of TBL1/TBLR1.
Tan M, Gong H, Wang J, Tao L, Xu D, Bao E, Liu Z, Qiu J., Free PMC Article | 08/6/2016 |
| miR-181b targets SENP2 and positively regulated NF-kappaB activity. NF-kappaB activation by DNA damage in GBM cells confers resistance to radiation-induced death. | DNA damage-induced NF-κB activation in human glioblastoma cells promotes miR-181b expression and cell proliferation.
Xu RX, Liu RY, Wu CM, Zhao YS, Li Y, Yao YQ, Xu YH. | 11/28/2015 |
| data identify SENP2 as an important regulator of fatty acid metabolism in skeletal muscle | SUMO-Specific Protease 2 (SENP2) Is an Important Regulator of Fatty Acid Metabolism in Skeletal Muscle.
Koo YD, Choi JW, Kim M, Chae S, Ahn BY, Kim M, Oh BC, Hwang D, Seol JH, Kim YB, Park YJ, Chung SS, Park KS., Free PMC Article | 09/26/2015 |
| SENP2 regulates the transcriptional function of MEF2A via direct de-SUMOylation. | The E3 ligase APC/C-Cdh1 regulates MEF2A-dependent transcription by targeting SUMO-specific protease 2 for ubiquitination and degradation.
Lu H, Liu B, Zhang FJ, Zhang J, Dong R, Chen L, Qu DM, Lu Y, Yu BW., Free PMC Article | 09/5/2015 |
| p90RSK-mediated SENP2-T368 phosphorylation is a master switch in disturbed-flow-induced signaling. | Disturbed flow-activated p90RSK kinase accelerates atherosclerosis by inhibiting SENP2 function.
Heo KS, Le NT, Cushman HJ, Giancursio CJ, Chang E, Woo CH, Sullivan MA, Taunton J, Yeh ET, Fujiwara K, Abe J., Free PMC Article | 05/16/2015 |
| we show that WWOX required for stabilization of beta-catenin regulated by SENP2 in hepatocellular carcinoma cells | SENP2 regulated the stability of β-catenin through WWOX in hepatocellular carcinoma cell.
Jiang QF, Tian YW, Shen Q, Xue HZ, Li K. | 01/10/2015 |
| ESR1 repression by SENP2 is independent of its SUMO protease activity. | Transcriptional repression of estrogen receptor α signaling by SENP2 in breast cancer cells.
Nait Achour T, Sentis S, Teyssier C, Philippat A, Lucas A, Corbo L, Cavaillès V, Jalaguier S., Free PMC Article | 01/10/2015 |
| Many nucleoporins are mislocalized and, in some cases, reduced in level when SENP1 and SENP2 are codepleted. | The SUMO proteases SENP1 and SENP2 play a critical role in nucleoporin homeostasis and nuclear pore complex function.
Chow KH, Elgort S, Dasso M, Powers MA, Ullman KS., Free PMC Article | 08/16/2014 |
| Chromosome segregation depends on precise spatial and temporal control of sumoylation in mitosis; SENP1 and SENP2 are important mediators of this control. | SENP1 and SENP2 affect spatial and temporal control of sumoylation in mitosis.
Cubeñas-Potts C, Goeres JD, Matunis MJ., Free PMC Article | 06/14/2014 |