| Simultaneous depletion of RB, RBL1 and RBL2 affects endoderm differentiation of human embryonic stem cells. | Simultaneous depletion of RB, RBL1 and RBL2 affects endoderm differentiation of human embryonic stem cells.
Nakanoh S, Kadiwala J, Pinte L, Morell CM, Lenaerts AS, Vallier L., Free PMC Article | 12/3/2022 |
| PP2A/B55alpha substrate recruitment as defined by the retinoblastoma-related protein p107. | PP2A/B55α substrate recruitment as defined by the retinoblastoma-related protein p107.
Fowle H, Zhao Z, Xu Q, Wasserman JS, Wang X, Adeyemi M, Feiser F, Kurimchak AN, Atar D, McEwan BC, Kettenbach AN, Page R, Peti W, Dunbrack RL, Graña X., Free PMC Article | 11/27/2021 |
| Study found that the methylation of global DNA decreased gradually after irradiation, and the methylation of the promoter of RBL1 gene may play an important role in the induction of radioresistance for three dimensional cultured carcinoma cells. | Methylation of promoter of RBL1 enhances the radioresistance of three dimensional cultured carcinoma cells.
Pan D, Chen Y, Du Y, Ren Z, Li X, Hu B., Free PMC Article | 02/24/2018 |
| These findings in human skeletal muscle suggest that attenuated transcriptional repression through p107 may be a novel mechanism by which exercise stimulates mitochondrial biogenesis following exercise. | Decreased transcriptional corepressor p107 is associated with exercise-induced mitochondrial biogenesis in human skeletal muscle.
Bhattacharya D, Ydfors M, Hughes MC, Norrbom J, Perry CG, Scimè A., Free PMC Article | 12/9/2017 |
| The authors found that phosphorylation of residues S650 and S975 in p107 weakens the E2F4 transactivation domain binding. | Structural Conservation and E2F Binding Specificity within the Retinoblastoma Pocket Protein Family.
Liban TJ, Thwaites MJ, Dick FA, Rubin SM., Free PMC Article | 06/24/2017 |
| UL97 phosphorylates and inactivates the retinoblastoma protein-related p107 and p130 proteins | Human cytomegalovirus-encoded viral cyclin-dependent kinase (v-CDK) UL97 phosphorylates and inactivates the retinoblastoma protein-related p107 and p130 proteins.
Iwahori S, Umaña AC, VanDeusen HR, Kalejta RF., Free PMC Article | 06/24/2017 |
| Sequence analysis of the RB1 gene detected a novel mutation in bilateral retinoblastoma. | A case of bilateral retinoblastoma with a novel mutation presenting at retinopathy of prematurity screening.
Al-Abdi SY. | 07/26/2014 |
| MAGE-A11 is a proto-oncogene whose increased expression in prostate cancer reverses retinoblastoma-related protein p107 from a transcriptional repressor to a transcriptional activator of the androgen receptor and E2F1. | Proto-oncogene activity of melanoma antigen-A11 (MAGE-A11) regulates retinoblastoma-related p107 and E2F1 proteins.
Su S, Minges JT, Grossman G, Blackwelder AJ, Mohler JL, Wilson EM., Free PMC Article | 11/16/2013 |
| Single nucleotide polymorphism in the ultraconserved elements of RBL1 gene is associated with recurrence in colorectal adenocarcinoma. | Identification of polymorphisms in ultraconserved elements associated with clinical outcomes in locally advanced colorectal adenocarcinoma.
Lin M, Eng C, Hawk ET, Huang M, Lin J, Gu J, Ellis LM, Wu X., Free PMC Article | 02/9/2013 |
| Concomitant germline large cytogenetic 13q deletion and somatic mutations in the RB1 gene in unilateral retinoblastoma. | A 20.5-Mb germline deletion of 13q13.1-->q14.3 and somatic mutations of the RB1 gene in an 8-year-old girl with unilateral retinoblastoma, developmental delay and mental retardation.
Chen CP, Kao LY, Su YN, Chen M, Chang SD, Wang W. | 03/10/2012 |
| identification of a PP2A trimeric holoenzyme containing B55alpha, which plays a major role in restricting the phosphorylation state of p107 and inducing its activation in human cells. | B55alpha PP2A holoenzymes modulate the phosphorylation status of the retinoblastoma-related protein p107 and its activation.
Jayadeva G, Kurimchak A, Garriga J, Sotillo E, Davis AJ, Haines DS, Mumby M, Graña X., Free PMC Article | 10/23/2010 |
| Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) | Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR., Free PMC Article | 06/30/2010 |
| Data show that RB is associated with promoters in a manner similar to p107/p130 and that association is modulated by phosphorylation during cell cycle progression. | Retinoblastoma/p107/p130 pocket proteins: protein dynamics and interactions with target gene promoters.
Stengel KR, Thangavel C, Solomon DA, Angus SP, Zheng Y, Knudsen ES., Free PMC Article | 01/21/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | See all PubMed (3) articlesA Large-scale genetic association study of esophageal adenocarcinoma risk.
Liu CY, Wu MC, Chen F, Ter-Minassian M, Asomaning K, Zhai R, Wang Z, Su L, Heist RS, Kulke MH, Lin X, Liu G, Christiani DC. Cell cycle genes and ovarian cancer susceptibility: a tagSNP analysis.
Cunningham JM, Vierkant RA, Sellers TA, Phelan C, Rider DN, Liebow M, Schildkraut J, Berchuck A, Couch FJ, Wang X, Fridley BL, Ovarian Cancer Association Consortium, Gentry-Maharaj A, Menon U, Hogdall E, Kjaer S, Whittemore A, DiCioccio R, Song H, Gayther SA, Ramus SJ, Pharaoh PD, Goode EL. High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men.
Yerges LM, Klei L, Cauley JA, Roeder K, Kammerer CM, Moffett SP, Ensrud KE, Nestlerode CS, Marshall LM, Hoffman AR, Lewis C, Lang TF, Barrett-Connor E, Ferrell RE, Orwoll ES, Zmuda JM, MrOS Research Group. | 06/24/2009 |
| These data suggest that the FTS/Hook/FHIP complex functions to promote vesicle trafficking and/or fusion via the homotypic vacuolar protein sorting complex. | An FTS/Hook/p107(FHIP) complex interacts with and promotes endosomal clustering by the homotypic vacuolar protein sorting complex.
Xu L, Sowa ME, Chen J, Li X, Gygi SP, Harper JW., Free PMC Article | 01/21/2010 |
| P107 is needed for initiation of accelerated cellular senescence in the absence of Rb and introduces the concept that p130 may be required to prevent the onset of terminal growth arrest in unstimulated prostate cancer cells lacking a functional Rb allele. | Distinct roles for p107 and p130 in Rb-independent cellular senescence.
Lehmann BD, Brooks AM, Paine MS, Chappell WH, McCubrey JA, Terrian DM., Free PMC Article | 01/21/2010 |
| Differentiating human adipose-derived human stem cells (hASC), do not undergo clonal expansion and p130 expression gradually diminishes across differentiation. However, p107 expression is transiently increased during hASC differentiation. | Expression of p107 and p130 during human adipose-derived stem cell adipogenesis.
Ross AS, Tsang R, Shewmake K, McGehee RE Jr., Free PMC Article | 01/21/2010 |
| The repressor complex that Mip/LIN-9 forms with p107 takes functional precedence over the transcriptional activation linked to the Mip/LIN-9 and B-Myb interaction. | Mammalian Mip/LIN-9 interacts with either the p107, p130/E2F4 repressor complex or B-Myb in a cell cycle-phase-dependent context distinct from the Drosophila dREAM complex.
Pilkinton M, Sandoval R, Colamonici OR. | 01/21/2010 |
| Data suggest that p107, in addition to its interaction with E2F, inhibits cell proliferation through the control of Skp2 expression and the resulting stabilization of p27. | p107 inhibits G1 to S phase progression by down-regulating expression of the F-box protein Skp2.
Rodier G, Makris C, Coulombe P, Scime A, Nakayama K, Nakayama KI, Meloche S., Free PMC Article | 01/21/2010 |
| the PP2A catalytic subunit (PP2A/C) specifically interacts with both p130 and p107 in quiescent cells as well as cells progressing throughout the cell cycle | A dynamic equilibrium between CDKs and PP2A modulates phosphorylation of pRB, p107 and p130.
Garriga J, Jayaraman AL, Limón A, Jayadeva G, Sotillo E, Truongcao M, Patsialou A, Wadzinski BE, Graña X. | 01/21/2010 |
| p107 plays a constitutive role in the progression of papillary carcinoma of the thyroid and that decreased p107 expression may contribute to the transformation from follicular adenoma to follicular carcinoma and anaplastic transformation. | Decreased expression of p107 is correlated with anaplastic transformation in papillary carcinoma of the thyroid.
Ito Y, Yoshida H, Tomoda C, Uruno T, Takamura Y, Miya A, Kobayashi K, Matsuzuka F, Kuma K, Miyauchi A. | 01/21/2010 |
| p107 is a trancriptional regulator of the cell cycle genes. | Pocket protein complexes are recruited to distinct targets in quiescent and proliferating cells.
Balciunaite E, Spektor A, Lents NH, Cam H, Te Riele H, Scime A, Rudnicki MA, Young R, Dynlacht BD., Free PMC Article | 01/21/2010 |
| regulation of expression of p130, p107 and E2F-4 in human cells | Distinct phosphorylation events regulate p130- and p107-mediated repression of E2F-4.
Farkas T, Hansen K, Holm K, Lukas J, Bartek J. | 01/21/2010 |
| developmental expression of RB, p130 and p107 in mouse and human retina | Distinct patterns of expression of the RB gene family in mouse and human retina.
Spencer C, Pajovic S, Devlin H, Dinh QD, Corson TW, Gallie BL. | 01/21/2010 |
| These studies have revealed a novel mechanism of Trichostatin A action through derecruitment of a repressor from the Luteinizing hormone receptor gene promoter in a PI3K/PKCzeta-induced Sp1 phosphorylation-dependent manner. | Phosphatidylinositol 3-kinase/protein kinase Czeta-induced phosphorylation of Sp1 and p107 repressor release have a critical role in histone deacetylase inhibitor-mediated derepression [corrected] of transcription of the luteinizing hormone receptor gene.
Zhang Y, Liao M, Dufau ML., Free PMC Article | 01/21/2010 |