| Abnormal expression of long non-coding RNA FGD5-AS1 affects the development of ovarian cancer through regulating miR-107/RBBP6 axis. | Abnormal expression of long non-coding RNA FGD5-AS1 affects the development of ovarian cancer through regulating miR-107/RBBP6 axis.
Zhang W, Shi J, Liu G. | 06/24/2023 |
| RBBP6 activates the pre-mRNA 3' end processing machinery in humans. | RBBP6 activates the pre-mRNA 3' end processing machinery in humans.
Boreikaite V, Elliott TS, Chin JW, Passmore LA., Free PMC Article | 05/21/2022 |
| The lncRNA SLCO4A1-AS1/miR-876-3p/RBBP6 axis regulates cell proliferation and apoptosis in acute lymphocytic leukemia via the JNK signaling pathway. | The lncRNA SLCO4A1-AS1/miR-876-3p/RBBP6 axis regulates cell proliferation and apoptosis in acute lymphocytic leukemia via the JNK signaling pathway.
Mao J, Gao W, Xue L, Wang J, Zhao L. | 12/4/2021 |
| Analysis of the expression and association of retinoblastoma binding protein 6 with the JNK signaling pathway in prostate cancers. | Analysis of the expression and association of retinoblastoma binding protein 6 with the JNK signaling pathway in prostate cancers.
Guan WY, Zhao S, Luo YN. | 08/14/2021 |
| RBBP6 aggravates the progression of ovarian cancer by targeting PIK3R6. | RBBP6 aggravates the progression of ovarian cancer by targeting PIK3R6.
Liu YJ, Cui LL, Liu ZS, Jia RY, Ding YX, Xu LZ. | 07/3/2021 |
| RBBP6, a RING finger-domain E3 ubiquitin ligase, induces epithelial-mesenchymal transition and promotes metastasis of colorectal cancer. | RBBP6, a RING finger-domain E3 ubiquitin ligase, induces epithelial-mesenchymal transition and promotes metastasis of colorectal cancer.
Xiao C, Wu G, Zhou Z, Zhang X, Wang Y, Song G, Ding E, Sun X, Zhong L, Li S, Weng J, Zhu Z, Chen J, Wang X., Free PMC Article | 08/22/2020 |
| In the present study, elevated expression of PACT was detected in cisplatin-resistant A2780/CP cells relative to cisplatin-sensitive A2780cells. | PACT cessation overcomes ovarian cancer cell chemoresistance to cisplatin by enhancing p53-mediated apoptotic pathway.
Yang X, Zhang Q, Yang X, Zhao M, Yang T, Yao A, Tian X. | 01/18/2020 |
| A crystal structure of the VP30-RBBP6 peptide complex revealed that RBBP6 mimics the viral nucleoprotein (NP) binding to the same interface of VP30. | Protein Interaction Mapping Identifies RBBP6 as a Negative Regulator of Ebola Virus Replication.
Batra J, Hultquist JF, Liu D, Shtanko O, Von Dollen J, Satkamp L, Jang GM, Luthra P, Schwarz TM, Small GI, Arnett E, Anantpadma M, Reyes A, Leung DW, Kaake R, Haas P, Schmidt CB, Schlesinger LS, LaCount DJ, Davey RA, Amarasinghe GK, Basler CF, Krogan NJ., Free PMC Article | 08/31/2019 |
| RBBP6 might potentiate cervical carcinoma cell viability. | RBBP6 promotes human cervical carcinoma malignancy via JNK signaling pathway.
Teng F, Ruan HJ, Xu J, Ni J, Qian B, Shen R, Gao LJ. | 09/15/2018 |
| Results from a study on gene expression variability markers in early-stage human embryos shows that RBBP6 is a putative expression variability marker for the 3-day, 8-cell embryo stage. | Variability of Gene Expression Identifies Transcriptional Regulators of Early Human Embryonic Development.
Hasegawa Y, Taylor D, Ovchinnikov DA, Wolvetang EJ, de Torrenté L, Mar JC., Free PMC Article | 07/23/2018 |
| RBBP6 overexpression could resist colorectal cancer cells against radiation. | RBBP6 increases radioresistance and serves as a therapeutic target for preoperative radiotherapy in colorectal cancer.
Xiao C, Wang Y, Zheng M, Chen J, Song G, Zhou Z, Zhou C, Sun X, Zhong L, Ding E, Zhang Y, Yang L, Wu G, Xu S, Zhang H, Wang X., Free PMC Article | 04/21/2018 |
| These results suggest that the RBBP6-3 isoform may be involved in promoting apoptosis in cancerous cells. | Expression analysis and association of RBBP6 with apoptosis in colon cancers.
Dlamini Z, Rupnarain C, Naicker S, Hull R, Mbita Z. | 11/5/2016 |
| RBBP6 is a candidate gene for myeloproliferative neoplasms (MPNs) susceptibility in a subset of pedigrees with familial MPN. | Germline RBBP6 mutations in familial myeloproliferative neoplasms.
Harutyunyan AS, Giambruno R, Krendl C, Stukalov A, Klampfl T, Berg T, Chen D, Milosevic Feenstra JD, Jäger R, Gisslinger B, Gisslinger H, Rumi E, Passamonti F, Pietra D, Müller AC, Parapatics K, Breitwieser FP, Herrmann R, Colinge J, Bennett KL, Superti-Furga G, Cazzola M, Hammond E, Kralovics R., Free PMC Article | 07/30/2016 |
| High expression levels of RBBP6 and high apoptosis levels were found in HIV-associated nephropathy (HIVAN) cases. This direct association between RBBP6 expression and apoptosis levels suggests that RBBP6 play a role in HIVAN pathogenesis. | The association of RBBP6 variant 3 expressions with apoptosis in human immunodeficiency virus-associated nephropathy (HIVAN).
Mbita Z, Naicker S, Goetsch S, Dlamini Z. | 10/10/2015 |
| gene silencing sensitises breast cancer cells to staurosporine and camptothecin-induced cell death | Silencing RBBP6 (Retinoblastoma Binding Protein 6) sensitises breast cancer cells MCF7 to staurosporine and camptothecin-induced cell death.
Moela P, Choene MM, Motadi LR. | 04/18/2015 |
| RBBP6 prevents DNA damage by destabilizing the transcriptional repressor ZBTB38. | The RBBP6/ZBTB38/MCM10 axis regulates DNA replication and common fragile site stability.
Miotto B, Chibi M, Xie P, Koundrioukoff S, Moolman-Smook H, Pugh D, Debatisse M, He F, Zhang L, Defossez PA. | 01/3/2015 |
| RBBP6 gene variants are associated with glioma and contribute to glioma susceptibility | Association of genetic variants in the retinoblastoma binding protein 6 gene with the risk of glioma: a case-control study in a Chinese Han population.
Hu D, Zhang S, Zhao Y, Wang S, Wang Q, Song X, Lu D, Mao Y, Chen H. | 01/3/2015 |
| implicate RBBP6 and iso3 as novel regulators of 3' processing, especially of RNAs with AU-rich 3' UTRs. | RBBP6 isoforms regulate the human polyadenylation machinery and modulate expression of mRNAs with AU-rich 3' UTRs.
Di Giammartino DC, Li W, Ogami K, Yashinskie JJ, Hoque M, Tian B, Manley JL., Free PMC Article | 12/20/2014 |
| these findings suggest that RBBP6 isoform 3 is a cell cycle regulator and may be deregulated in carcinogenesis | De-regulation of the RBBP6 isoform 3/DWNN in human cancers.
Mbita Z, Meyer M, Skepu A, Hosie M, Rees J, Dlamini Z. | 09/1/2012 |
| AGO2, PACT and TRBP are required for the efficient functioning of Dicer in cells | The role of Dicer protein partners in the processing of microRNA precursors.
Koscianska E, Starega-Roslan J, Krzyzosiak WJ., Free PMC Article | 07/21/2012 |
| Taken together with the structural similarities to U-box-containing proteins, our data suggest that RBBP6 plays a role in chaperone-mediated ubiquitination and possibly in protein quality control. | Solution structure of RING finger-like domain of retinoblastoma-binding protein-6 (RBBP6) suggests it functions as a U-box.
Kappo MA, Ab E, Hassem F, Atkinson RA, Faro A, Muleya V, Mulaudzi T, Poole JO, McKenzie JM, Chibi M, Moolman-Smook JC, Rees DJ, Pugh DJ., Free PMC Article | 04/28/2012 |
| RBBP6 may be involved in the degradation of p53, thereby enhancing cell proliferation and inhibiting apoptosis in lung cancer. | Expression and function of retinoblastoma binding protein 6 (RBBP6) in human lung cancer.
Motadi LR, Bhoola KD, Dlamini Z. | 12/31/2011 |
| The authors showed that RBBP6 and its isolated RING finger domain were able to ubiquitinate YB-1, resulting in its degradation in the proteosome. As a result, RBBP6 was able to suppress the levels of YB-1 in vivo and reduce its transactivational ability. | RBBP6 interacts with multifunctional protein YB-1 through its RING finger domain, leading to ubiquitination and proteosomal degradation of YB-1.
Chibi M, Meyer M, Skepu A, G Rees DJ, Moolman-Smook JC, Pugh DJ. | 01/21/2010 |
| RBBP6 has a role in mRNA processing and ubiquitin-like pathways | DWNN, a novel ubiquitin-like domain, implicates RBBP6 in mRNA processing and ubiquitin-like pathways.
Pugh DJ, Ab E, Faro A, Lutya PT, Hoffmann E, Rees DJ., Free PMC Article | 01/21/2010 |
| P2P-R expression may be translationally regulated by PUM2 and that P2P-R may modulate translation by influencing ribosomal protein gene expression | P2P-R expression is genetically coregulated with components of the translation machinery and with PUM2, a translational repressor that associates with the P2P-R mRNA.
Scott RE, White-Grindley E, Ruley HE, Chesler EJ, Williams RW. | 01/21/2010 |