| The atypical chemokine receptor 2 reduces T cell expansion and tertiary lymphoid tissue but does not limit autoimmune organ injury in lupus-prone B6lpr mice. | The atypical chemokine receptor 2 reduces T cell expansion and tertiary lymphoid tissue but does not limit autoimmune organ injury in lupus-prone B6lpr mice.
Xia W, Eltrich N, Vielhauer V., Free PMC Article | 06/5/2024 |
| The atypical chemokine receptor-2 fine-tunes the immune response in herpes stromal keratitis. | The atypical chemokine receptor-2 fine-tunes the immune response in herpes stromal keratitis.
Yu T, Schuette F, Christofi M, Forrester JV, Graham GJ, Kuffova L., Free PMC Article | 12/24/2022 |
| ACKR2 limits skin fibrosis and hair loss through IFN-beta. | ACKR2 limits skin fibrosis and hair loss through IFN-β.
Butenko S, Ben Jashar N, Sheffer T, Sabo E, Schif-Zuck S, Ariel A. | 10/30/2021 |
| Analysis of lung stromal expression of the atypical chemokine receptor ACKR2 reveals unanticipated expression in murine blood endothelial cells. | Analysis of lung stromal expression of the atypical chemokine receptor ACKR2 reveals unanticipated expression in murine blood endothelial cells.
Hansell CAH, Love S, Pingen M, Wilson GJ, MacLeod M, Graham GJ., Free PMC Article | 10/31/2020 |
| ACKR2 dampens CCL5 levels and the consequent recruitment of CCR5(+) T helper 1 (Th1). | ACKR2 contributes to pulmonary dysfunction by shaping CCL5:CCR5-dependent recruitment of lymphocytes during influenza A infection in mice.
Tavares LP, Garcia CC, Gonçalves APF, Kraemer LR, Melo EM, Oliveira FMS, Freitas CS, Lopes GAO, Reis DC, Cassali GD, Machado AM, Mantovani A, Locati M, Teixeira MM, Russo RC. | 07/18/2020 |
| ACKR2 expression regulates inflammation in tumour-microenvironment. | Role of atypical chemokine receptor ACKR2 in experimental oral squamous cell carcinogenesis.
da Silva JM, Dos Santos TPM, Saraiva AM, Fernandes de Oliveira AL, Garlet GP, Batista AC, de Mesquita RA, Russo RC, da Silva TA. | 07/11/2020 |
| Atypical chemokine receptor 2 (ACKR2) is a expressed in most hypothalamic cells that is modulated by dietary intervention and acts to reduce diet-induced inflammation, leading to improved glucose tolerance due to improved insulin action. | Hypothalamic expression of the atypical chemokine receptor ACKR2 is involved in the systemic regulation of glucose tolerance.
Fioravante M, Bombassaro B, Ramalho AF, de Moura RF, Haddad-Tovolli R, Solon C, Dragano NR, Vettorazzi JF, Gaspar RS, Ropelle ER, Carneiro EM, Morari J, Velloso LA. | 02/8/2020 |
| CKR2 is important in limiting persistent inflammation, tubular loss, and renal fibrosis after ischemic acute kidney injury and, thus, can prevent progression to chronic renal disease. | The Atypical Chemokine Receptor 2 Limits Progressive Fibrosis after Acute Ischemic Kidney Injury.
Lux M, Blaut A, Eltrich N, Bideak A, Müller MB, Hoppe JM, Gröne HJ, Locati M, Vielhauer V. | 10/26/2019 |
| data indicate that ACKR2 may have a protective role during sepsis, and the absence of ACKR2 leads to exacerbated chemokine accumulation, neutrophil infiltration, and damage to vital organs. | The Atypical Chemokine Receptor ACKR2 is Protective Against Sepsis.
Castanheira FVES, Borges V, Sônego F, Kanashiro A, Donate PB, Melo PH, Pallas K, Russo RC, Amaral FA, Teixeira MM, Ramalho FS, Cunha TM, Liew FY, Alves-Filho JC, Graham GJ, Cunha FQ. | 08/17/2019 |
| this study shows that Ackr2 constrains NK cell migratory activity and promotes metastasis | The Atypical Chemokine Receptor Ackr2 Constrains NK Cell Migratory Activity and Promotes Metastasis.
Hansell CAH, Fraser AR, Hayes AJ, Pingen M, Burt CL, Lee KM, Medina-Ruiz L, Brownlie D, Macleod MKL, Burgoyne P, Wilson GJ, Nibbs RJB, Graham GJ., Free PMC Article | 07/27/2019 |
| ACKR2 controls the CC chemokine expression that drives the influx of CCR2(+) and CCR5(+) IFNgamma-producing gammadeltaT cells, tuning the Th17 response that mediated pulmonary fibrosis triggered by bleomycin instillation. | The atypical chemokine receptor ACKR2 drives pulmonary fibrosis by tuning influx of CCR2(+) and CCR5(+) IFNγ-producing γδT cells in mice.
Russo RC, Savino B, Mirolo M, Buracchi C, Germano G, Anselmo A, Zammataro L, Pasqualini F, Mantovani A, Locati M, Teixeira MM. | 07/6/2019 |
| ACKR2 is important in limiting renal inflammation and fibrotic remodeling in progressive nephrotoxic glomerulonephritis. | The atypical chemokine receptor 2 limits renal inflammation and fibrosis in murine progressive immune complex glomerulonephritis.
Bideak A, Blaut A, Hoppe JM, Müller MB, Federico G, Eltrich N, Gröne HJ, Locati M, Vielhauer V. | 01/5/2019 |
| ACKR2 (Ccbp2) is a key regulator of myeloid differentiation and function and its targeting unleashes the anti-metastatic activity of neutrophils. | ACKR2 in hematopoietic precursors as a checkpoint of neutrophil release and anti-metastatic activity.
Massara M, Bonavita O, Savino B, Caronni N, Mollica Poeta V, Sironi M, Setten E, Recordati C, Crisafulli L, Ficara F, Mantovani A, Locati M, Bonecchi R., Free PMC Article | 03/24/2018 |
| ACKR2 is induced after traumatic brain injuries and has a significant impact on mortality and lesion development acutely following closed head injury. | The scavenging chemokine receptor ACKR2 has a significant impact on acute mortality rate and early lesion development after traumatic brain injury.
Woodcock TM, Frugier T, Nguyen TT, Semple BD, Bye N, Massara M, Savino B, Besio R, Sobacchi C, Locati M, Morganti-Kossmann MC., Free PMC Article | 12/16/2017 |
| study found that the inflammatory chemokine CCL5 is mostly retained (75%) during the resolution of zymosan A peritonitis in mice; CCL5 exerts a novel proresolving role on macrophages when acting in concert with apoptotic PMN-expressed D6. | CCL5 Promotes Resolution-Phase Macrophage Reprogramming in Concert with the Atypical Chemokine Receptor D6 and Apoptotic Polymorphonuclear Cells.
Aswad M, Assi S, Schif-Zuck S, Ariel A. | 10/21/2017 |
| ACKR2 is an important regulator of branching morphogenesis in diverse biological context; this provide the first evidence of a role for chemokines and their receptors in postnatal development processes. | Atypical chemokine receptor ACKR2 controls branching morphogenesis in the developing mammary gland.
Wilson GJ, Hewit KD, Pallas KJ, Cairney CJ, Lee KM, Hansell CA, Stein T, Graham GJ., Free PMC Article | 09/30/2017 |
| Ackr2 expression levels limits development of cutaneous inflammatory responses in psoriasis. | Spread of Psoriasiform Inflammation to Remote Tissues Is Restricted by the Atypical Chemokine Receptor ACKR2.
Shams K, Wilson GJ, Singh M, van den Bogaard EH, Le Brocq ML, Holmes S, Schalkwijk J, Burden AD, McKimmie CS, Graham GJ., Free PMC Article | 07/22/2017 |
| ACKR2 deletion reduced renal inflammation in diabetes and the ultimate response was a high degree of protection from diabetic nephropathy. | Renal Protection by Genetic Deletion of the Atypical Chemokine Receptor ACKR2 in Diabetic OVE Mice.
Zheng S, Coventry S, Cai L, Powell DW, Jala VR, Haribabu B, Epstein PN., Free PMC Article | 10/29/2016 |
| Ackr2 deficiency does not suppress autoreactive T-cell priming and autoimmune pathology, but can enhance T-cell polarization toward Th17 cells. | The atypical chemokine receptor ACKR2 suppresses Th17 responses to protein autoantigens.
Hansell CA, MacLellan LM, Oldham RS, Doonan J, Chapple KJ, Anderson EJ, Linington C, McInnes IB, Nibbs RJ, Goodyear CS., Free PMC Article | 12/19/2015 |
| ACKR2 can regulate fetal growth, placental structure, and neonatal mortality in mice. | Atypical chemokine receptor ACKR2 mediates chemokine scavenging by primary human trophoblasts and can regulate fetal growth, placental structure, and neonatal mortality in mice.
Teoh PJ, Menzies FM, Hansell CA, Clarke M, Waddell C, Burton GJ, Nelson SM, Nibbs RJ. | 02/28/2015 |
| Further examination revealed that proximity of pro-lymphangiogenic macrophages to developing lymphatic vessel surfaces is increased in ACKR2-deficient mice and reduced in CCR2-deficient mice. | The chemokine receptors ACKR2 and CCR2 reciprocally regulate lymphatic vessel density.
Lee KM, Danuser R, Stein JV, Graham D, Nibbs RJ, Graham GJ., Free PMC Article | 01/3/2015 |
| some cells, including plasmacytoid dendritic cells, can express both CCR2 and ACKR2; that Ly6C(high) monocytes have particularly strong CCL2-scavenging potential in vitro and in vivo; and that CCR2 is a much more effective CCL2 scavenger than ACKR2. | Characterization of conventional and atypical receptors for the chemokine CCL2 on mouse leukocytes.
Ford LB, Cerovic V, Milling SW, Graham GJ, Hansell CA, Nibbs RJ., Free PMC Article | 08/23/2014 |
| Expression of the D6 receptor mediates dendritic cell function and promotes corneal allograft rejection. | Expression of the chemokine decoy receptor D6 mediates dendritic cell function and promotes corneal allograft rejection.
Hajrasouliha AR, Sadrai Z, Lee HK, Chauhan SK, Dana R., Free PMC Article | 07/26/2014 |
| Our data therefore indicate that D6 is able to play a cell-autonomous role as a migratory rheostat restricting migration of D6-expressing cells such as neutrophils | Cell-autonomous regulation of neutrophil migration by the D6 chemokine decoy receptor.
Rot A, McKimmie C, Burt CL, Pallas KJ, Jamieson T, Pruenster M, Horuk R, Nibbs RJB, Graham GJ., Free PMC Article | 08/31/2013 |
| These data demonstrate a novel role for D6 as a regulator of the transition from uninvolved to lesional skin in psoriasis. | Elevated expression of the chemokine-scavenging receptor D6 is associated with impaired lesion development in psoriasis.
Singh MD, King V, Baldwin H, Burden D, Thorrat A, Holmes S, McInnes IB, Nicoll R, Shams K, Pallas K, Jamieson T, Lee KM, Carballido JM, Rot A, Graham GJ., Free PMC Article | 02/9/2013 |