| The purpose of this study was to clarify the assembly of taurine transporter (TauT/Slc6a6) and PSD-95/Disc-large/Zo-1 (PDZ) domain of Slc9a3r1 as a regulatory mechanism of Slc6a6-mediated GABA transport activity | Assembly of Taurine Transporter (Slc6a6) with Na(+)-H(+) Exchanger Regulatory Factor 1 (Slc9a3r1) Improves GABA Transport Activity by Increasing the Maximum Transport Velocity.
Tachikawa M, Yokoyama R, Akanuma SI, Hosoya KI. | 09/1/2018 |
| The results suggest that NHERF1 and NHERF2 down-regulated SR-B1 at least in part via the ubiquitin/proteasome pathway. | NHERF1 and NHERF2 regulation of SR-B1 stability via ubiquitination and proteasome degradation.
Lu X, He L, Zhou Q, Wang M, Shen WJ, Azhar S, Pan F, Guo Z, Hu Z. | 09/23/2017 |
| These results suggest that decreased renal NHERF-1 expression contributes to the impaired dopamine-mediated inhibition of NKA in PTCs from animal models of hypertension. | Loss of NHERF-1 expression prevents dopamine-mediated Na-K-ATPase regulation in renal proximal tubule cells from rat models of hypertension: aged F344 rats and spontaneously hypertensive rats.
Barati MT, Ketchem CJ, Merchant ML, Kusiak WB, Jose PA, Weinman EJ, LeBlanc AJ, Lederer ED, Khundmiri SJ., Free PMC Article | 08/19/2017 |
| data establish NHERF1 and NHERF2 as SR-BI protein binding partners that play a negative role in the regulation of SR-BI expression, selective CE transport, and steroidogenesis. | Regulation of expression and function of scavenger receptor class B, type I (SR-BI) by Na+/H+ exchanger regulatory factors (NHERFs).
Hu Z, Hu J, Zhang Z, Shen WJ, Yun CC, Berlot CH, Kraemer FB, Azhar S., Free PMC Article | 06/15/2013 |
| that NHERF1 associates with NaPi-2b in enterocytes and regulates NaPi-2b adaptation. | NHE3 regulatory factor 1 (NHERF1) modulates intestinal sodium-dependent phosphate transporter (NaPi-2b) expression in apical microvilli.
Giral H, Cranston D, Lanzano L, Caldas Y, Sutherland E, Rachelson J, Dobrinskikh E, Weinman EJ, Doctor RB, Gratton E, Levi M., Free PMC Article | 01/5/2013 |
| EBP50 is involved in the regulation of vascular smooth muscle cell migration and cytokinesis | EBP50 is involved in the regulation of vascular smooth muscle cell migration and cytokinesis.
Baeyens N, de Meester C, Yerna X, Morel N. | 12/10/2011 |
| Dynamic Na+-H+ exchanger regulatory factor-1 association and dissociation regulate parathyroid hormone receptor trafficking at membrane microdomains | Dynamic Na+-H+ exchanger regulatory factor-1 association and dissociation regulate parathyroid hormone receptor trafficking at membrane microdomains.
Ardura JA, Wang B, Watkins SC, Vilardaga JP, Friedman PA., Free PMC Article | 12/10/2011 |
| The cochlear localization of NHERF scaffolds suggests that they play important roles in the developmental regulation of ion transport, homeostasis, and auditory neurotransmission. | Postnatal developmental expression of the PDZ scaffolds Na+ -H+ exchanger regulatory factors 1 and 2 in the rat cochlea.
Kanjhan R, Hryciw DH, Yun CC, Bellingham MC, Poronnik P., Free PMC Article | 10/5/2011 |
| EBP50 redistribute apically in rat uterine epithelial cells at the time of implantation and in response to cell contact.( | Ezrin and EBP50 redistribute apically in rat uterine epithelial cells at the time of implantation and in response to cell contact.
Lecce L, Lindsay LA, Murphy CR. | 06/25/2011 |
| NHERF1 bound to an internal PDZ binding motif in megalin and that a loss of a single threonine residue abolished the interaction between megalin and NHERF1. | Na+-H+ exchanger regulatory factor 1 (NHERF1) PDZ scaffold binds an internal binding site in the scavenger receptor megalin.
Slattery C, Jenkin KA, Lee A, Simcocks AC, McAinch AJ, Poronnik P, Hryciw DH. | 05/28/2011 |
| In uterus, NHERF1 was expressed in the apical region of the luminal epithelium and glands in all stages of the estral cycle, and in both colon and uterus, the expression was independent of the proliferation status | Estrogens regulate the expression of NHERF1 in normal colon during the reproductive cycle of Wistar rats.
Cuello-Carrión FD, Troncoso M, Guiñazu E, Valdez SR, Fanelli MA, Ciocca DR, Kreimann EL. | 03/26/2011 |
| This study demonstrates the dynamic expression of EBP50 in vessels following injury and the effects of EBP50 on PTH1R function in vascular smooth muscle cells. | EBP50 inhibits the anti-mitogenic action of the parathyroid hormone type 1 receptor in vascular smooth muscle cells.
Song GJ, Barrick S, Leslie KL, Sicari B, Fiaschi-Taesch NM, Bisello A., Free PMC Article | 02/26/2011 |
| the activation of ROCK leads to the binding of moesin to EBP50, which interacts with several components of the cytoskeleton, resulting in a decrease in the contractile response. | Identification and functional implication of a Rho kinase-dependent moesin-EBP50 interaction in noradrenaline-stimulated artery.
Baeyens N, Horman S, Vertommen D, Rider M, Morel N. | 01/8/2011 |
| NHERF-1 binds to Mrp2, and plays a critical role in the canalicular expression of Mrp2 and its function as a determinant of glutathione-dependent, bile acid-independent bile flow | NHERF-1 binds to Mrp2 and regulates hepatic Mrp2 expression and function.
Li M, Wang W, Soroka CJ, Mennone A, Harry K, Weinman EJ, Boyer JL., Free PMC Article | 07/26/2010 |
| Data propose that the local regulation of the L1-ERM-actin pathway, at the level of the plasma membrane, underlies pGal-3-induced axon branching, and that galectin phosphorylation in situ could act as a molecular switch for the axon response to Gal-3. | Phosphorylation of adhesion- and growth-regulatory human galectin-3 leads to the induction of axonal branching by local membrane L1 and ERM redistribution.
Díez-Revuelta N, Velasco S, André S, Kaltner H, Kübler D, Gabius HJ, Abad-Rodríguez J. | 05/31/2010 |
| NHERF1 inhibited beta-arrestin2 binding to wtPTH1R but had no effect on beta-arrestin2 association with pdPTH1R. Such an effect may protect against PTH resistance or PTH1R down-regulation in cells harboring NHERF1. | NHERF1 regulates parathyroid hormone receptor desensitization: interference with beta-arrestin binding.
Wang B, Yang Y, Abou-Samra AB, Friedman PA., Free PMC Article | 01/21/2010 |
| CFTR is an important regulator of AQP9 and the interaction between AQP9, NHERF1, and CFTR may facilitate the activation of AQP9 by cAMP. | Role of NHERF1, cystic fibrosis transmembrane conductance regulator, and cAMP in the regulation of aquaporin 9.
Pietrement C, Da Silva N, Silberstein C, James M, Marsolais M, Van Hoek A, Brown D, Pastor-Soler N, Ameen N, Laprade R, Ramesh V, Breton S. | 01/21/2010 |
| Results indicated that PKC-induced phosphorylation of EBP50 occurred on the Ser337/Ser338 residue within the carboxyl-tail domain of the protein and truncation of Ser337/Ser338 also diminished PKC-induced oligomerization of EBP50. | Protein kinase C regulates the phosphorylation and oligomerization of ERM binding phosphoprotein 50.
Fouassier L, Nichols MT, Gidey E, McWilliams RR, Robin H, Finnigan C, Howell KE, Housset C, Doctor RB. | 01/21/2010 |