| Deletion of the Actin-Associated Tropomyosin Tpm3 Leads to Reduced Cell Complexity in Cultured Hippocampal Neurons-New Insights into the Role of the C-Terminal Region of Tpm3.1. | Deletion of the Actin-Associated Tropomyosin Tpm3 Leads to Reduced Cell Complexity in Cultured Hippocampal Neurons-New Insights into the Role of the C-Terminal Region of Tpm3.1.
Tomanić T, Martin C, Stefen H, Parić E, Gunning P, Fath T., Free PMC Article | 10/16/2021 |
| Tpm3.1 co-assembles onto these actin filaments, and this is followed later by recruitment of the myosin IIA motor. | Parallel assembly of actin and tropomyosin, but not myosin II, during de novo actin filament formation in live mice.
Masedunskas A, Appaduray MA, Lucas CA, Lastra Cagigas M, Heydecker M, Holliday M, Meiring JCM, Hook J, Kee A, White M, Thomas P, Zhang Y, Adelstein RS, Meckel T, Böcking T, Weigert R, Bryce NS, Gunning PW, Hardeman EC., Free PMC Article | 10/26/2019 |
| The role of TPM3.1 protein isoform in cell proliferation | Ras Transformation Overrides a Proliferation Defect Induced by Tpm3.1 Knockout.
Coombes JD, Schevzov G, Kan CY, Petti C, Maritz MF, Whittaker S, Mackenzie KL, Gunning PW. | 08/13/2016 |
| Tpm3 plays crucial roles in maintaining cortical actin integrity and asymmetric cell division during oocyte maturation, and that dynamic regulation of cortical actin by Tpm3 is critical to ensure proper polar body protrusion. | Non-muscle tropomyosin (Tpm3) is crucial for asymmetric cell division and maintenance of cortical integrity in mouse oocytes.
Jang WI, Jo YJ, Kim HC, Jia JL, Namgoong S, Kim NH., Free PMC Article | 08/15/2015 |
| TMBr-3 and TM5NM1 modestly affected actin assembly kinetics, in an opposite manner. | Purification of tropomyosin Br-3 and 5NM1 and characterization of their interactions with actin.
Kis-Bicskei N, Vig A, Nyitrai M, Bugyi B, Talián GC. | 10/25/2014 |
| Tropomyosin regulates cell migration during skin wound healing. | Tropomyosin regulates cell migration during skin wound healing.
Lees JG, Ching YW, Adams DH, Bach CT, Samuel MS, Kee AJ, Hardeman EC, Gunning P, Cowin AJ, O'Neill GM. | 07/13/2013 |
| Data conclude that exon 9d-containing isoforms are not essential for survival of neuronal cells and that isoform choice from the gamma-Tm gene is flexible in the brain | New aspects of tropomyosin-regulated neuritogenesis revealed by the deletion of Tm5NM1 and 2.
Fath T, Agnes Chan YK, Vrhovski B, Clarke H, Curthoys N, Hook J, Lemckert F, Schevzov G, Tam P, Watson CM, Khoo PL, Gunning P. | 08/23/2010 |
| Reduced expression of Tpm3, sarcomere genes and Lrtm1 in the diaphragm of mice with diaphragmatic defects. | Examination of FGFRL1 as a candidate gene for diaphragmatic defects at chromosome 4p16.3 shows that Fgfrl1 null mice have reduced expression of Tpm3, sarcomere genes and Lrtm1 in the diaphragm.
LopezJimenez N, Gerber S, Popovici V, Mirza S, Copren K, Ta L, Shaw GM, Trueb B, Slavotinek AM., Free PMC Article | 04/12/2010 |
| The expression of an inappropriate Tm in skeletal muscle results in increased susceptibility to contraction-induced damage | A cytoskeletal tropomyosin can compromise the structural integrity of skeletal muscle.
Kee AJ, Gunning PW, Hardeman EC. | 01/21/2010 |
| results indicate that a Tm5NM1-defined actin cytoskeleton is required for the normal excitation-contraction coupling in skeletal muscle | Cytoskeletal tropomyosin Tm5NM1 is required for normal excitation-contraction coupling in skeletal muscle.
Vlahovich N, Kee AJ, Van der Poel C, Kettle E, Hernandez-Deviez D, Lucas C, Lynch GS, Parton RG, Gunning PW, Hardeman EC., Free PMC Article | 01/21/2010 |
| role of different gamma isoforms in neuronal function by knockout methods | Modification of the tropomyosin isoform composition of actin filaments in the brain by deletion of an alternatively spliced exon.
Vrhovski B, Lemckert F, Gunning P. | 01/21/2010 |
| Tropomyosin 3 expression leads to hypercontractility and attenuates myofilament length-dependent Ca(2+) activation. | Tropomyosin 3 expression leads to hypercontractility and attenuates myofilament length-dependent Ca(2+) activation.
Pieples K, Arteaga G, Solaro RJ, Grupp I, Lorenz JN, Boivin GP, Jagatheesan G, Labitzke E, DeTombe PP, Konhilas JP, Irving TC, Wieczorek DF. | 01/21/2010 |
| low-molecular-weight products from the gammaTm gene are essential for both embryonic development and cell survival | Gamma tropomyosin gene products are required for embryonic development.
Hook J, Lemckert F, Qin H, Schevzov G, Gunning P., Free PMC Article | 01/21/2010 |
| tropomyosin isoforms regulate neuronal size and shape | Specific features of neuronal size and shape are regulated by tropomyosin isoforms.
Schevzov G, Bryce NS, Almonte-Baldonado R, Joya J, Lin JJ, Hardeman E, Weinberger R, Gunning P., Free PMC Article | 01/21/2010 |
| Tm-3 is up-regulated during osteoclastogenesis, indicating potential cell-specific functions. | Tropomyosin isoforms localize to distinct microfilament populations in osteoclasts.
McMichael BK, Kotadiya P, Singh T, Holliday LS, Lee BS. | 01/21/2010 |