| The Mediator subunit MED12 promotes formation of HSF1 condensates on heat shock response element arrays in heat-shocked cells. | The Mediator subunit MED12 promotes formation of HSF1 condensates on heat shock response element arrays in heat-shocked cells.
Okada M, Fujimoto M, Srivastava P, Pandey A, Takii R, Nakai A. | 07/13/2023 |
| MED12 Regulates Human Adipose-Derived Stem Cell Adipogenesis and Mediator Kinase Subunit Expression in Murine Adipose Depots. | MED12 Regulates Human Adipose-Derived Stem Cell Adipogenesis and Mediator Kinase Subunit Expression in Murine Adipose Depots.
Venigalla S, Straub J, Idigo O, Rinderle C, Stephens JM, Newman JJ., Free PMC Article | 05/14/2022 |
| MED12 and BRD4 cooperate to sustain cancer growth upon loss of mediator kinase. | MED12 and BRD4 cooperate to sustain cancer growth upon loss of mediator kinase.
Sooraj D, Sun C, Doan A, Garama DJ, Dannappel MV, Zhu D, Chua HK, Mahara S, Wan Hassan WA, Tay YK, Guanizo A, Croagh D, Prodanovic Z, Gough DJ, Wan C, Firestein R. | 02/19/2022 |
| Glial-Specific Deletion of Med12 Results in Rapid Hearing Loss via Degradation of the Stria Vascularis. | Glial-Specific Deletion of Med12 Results in Rapid Hearing Loss via Degradation of the Stria Vascularis.
Huang TW, Iyer AA, Manalo JM, Woo J, Bosquez Huerta NA, McGovern MM, Schrewe H, Pereira FA, Groves AK, Ohlemiller KK, Deneen B., Free PMC Article | 12/4/2021 |
| Med12 is critically important in reproductive tract development, and Med12 loss of function does not cause tumorigenesis in reproductive tissues. | Med12 regulates ovarian steroidogenesis, uterine development and maternal effects in the mammalian egg.
Wang X, Mittal P, Castro CA, Rajkovic G, Rajkovic A., Free PMC Article | 02/2/2019 |
| Study provide evidence that Med12 regulates neural stem cell gene expression programs linked to adhesion and cell cycle progression but suppresses its adhesion by repressing the expression of cell adhesion molecules. | Mediator subunit Med12 contributes to the maintenance of neural stem cell identity.
Kim NH, Livi CB, Yew PR, Boyer TG., Free PMC Article | 09/9/2017 |
| alterations in MED12-dependent enhancer regulation may control both physiological and malignant hematopoiesis. | MED12 Regulates HSC-Specific Enhancers Independently of Mediator Kinase Activity to Control Hematopoiesis.
Aranda-Orgilles B, Saldaña-Meyer R, Wang E, Trompouki E, Fassl A, Lau S, Mullenders J, Rocha PP, Raviram R, Guillamot M, Sánchez-Díaz M, Wang K, Kayembe C, Zhang N, Amoasii L, Choudhuri A, Skok JA, Schober M, Reinberg D, Sicinski P, Schrewe H, Tsirigos A, Zon LI, Aifantis I., Free PMC Article | 07/22/2017 |
| The data reveal how the interplay between PRC1, ncRNA and Mediator complexes controls pluripotency and cellular differentiation. | Dual role of Med12 in PRC1-dependent gene repression and ncRNA-mediated transcriptional activation.
Papadopoulou T, Kaymak A, Sayols S, Richly H., Free PMC Article | 05/20/2017 |
| Med1 and Med12, two subunits of the mediator complex implicated in transcription initiation and long-range enhancer/promoter loop formation, are dynamically recruited to the IgH locus enhancers. | Mediator facilitates transcriptional activation and dynamic long-range contacts at the IgH locus during class switch recombination.
Thomas-Claudepierre AS, Robert I, Rocha PP, Raviram R, Schiavo E, Heyer V, Bonneau R, Luo VM, Reddy JK, Borggrefe T, Skok JA, Reina-San-Martin B., Free PMC Article | 07/30/2016 |
| leiomyomatous, Med12 c.131G>A variant-expressing uteri developed chromosomal rearrangements. | Med12 gain-of-function mutation causes leiomyomas and genomic instability.
Mittal P, Shin YH, Yatsenko SA, Castro CA, Surti U, Rajkovic A., Free PMC Article | 10/24/2015 |
| this work points to Med12 being an essential coregulator of transcription factors controlling neural tube closure. | Mosaic expression of Med12 in female mice leads to exencephaly, spina bifida, and craniorachischisis.
Rocha PP, Bleiss W, Schrewe H. | 01/1/2011 |
| show that in Med12 hypomorphic embryos, the Wnt/planar cell polarity pathway is disrupted and that canonical Wnt/beta-catenin signaling is impaired. | Med12 is essential for early mouse development and for canonical Wnt and Wnt/PCP signaling.
Rocha PP, Scholze M, Bleiss W, Schrewe H. | 08/23/2010 |
| Nanog and Med12 function in concert to regulate Nanog target genes and identify a novel role for Med12 in embryonic stem cell regulation. | Role for Med12 in regulation of Nanog and Nanog target genes.
Tutter AV, Kowalski MP, Baltus GA, Iourgenko V, Labow M, Li E, Kadam S. | 01/21/2010 |