| The glycocalyx core protein Glypican 1 protects vessel wall endothelial cells from stiffness-mediated dysfunction and disease. | The glycocalyx core protein Glypican 1 protects vessel wall endothelial cells from stiffness-mediated dysfunction and disease.
Mahmoud M, Mayer M, Cancel LM, Bartosch AM, Mathews R, Tarbell JM., Free PMC Article | 01/29/2022 |
| These data suggest that fluid shear stress induced the cell junctional clustering of lipid rafts with their anchored glypican-1 and associated HS. | Fluid shear stress induces the clustering of heparan sulfate via mobility of glypican-1 in lipid rafts.
Zeng Y, Waters M, Andrews A, Honarmandi P, Ebong EE, Rizzo V, Tarbell JM., Free PMC Article | 11/16/2013 |
| Glypican increased fibroblast growth factor-2 expression and neurite extension in cortical neuron cultures. | Intracerebral chondroitinase ABC and heparan sulfate proteoglycan glypican improve outcome from chronic stroke in rats.
Hill JJ, Jin K, Mao XO, Xie L, Greenberg DA., Free PMC Article | 09/1/2012 |
| Suggest that membrane proteoglycans glypican-1/syndecan-4 participate in the sequence of events triggered by diabetes and inflicted on cardiac and skeletal muscles. | Changes in cardiac heparan sulfate proteoglycan expression and streptozotocin-induced diastolic dysfunction in rats.
Strunz CM, Matsuda M, Salemi VM, Nogueira A, Mansur AP, Cestari IN, Marquezini MV., Free PMC Article | 09/10/2011 |
| conclusion, gpc-1 expression in odontoblast-like cells is associated with the early differentiation but not with the formation of reparative dentine. | Effect of glypican-1 gene on the pulp cells during the reparative dentine process.
Murakami Masuda Y, Wang X, Yokose S, Yamada Y, Kimura Y, Okano T, Matsumoto K. | 02/12/2011 |
| Data suggest that glypican-1 acts as a positive regulator of muscle differentiation by sequestering FGF-2 in lipid rafts and preventing its binding and dependent signaling. | A novel mechanism of sequestering fibroblast growth factor 2 by glypican in lipid rafts, allowing skeletal muscle differentiation.
Gutiérrez J, Brandan E., Free PMC Article | 04/12/2010 |
| Glypican-1 was coexpressed with slit2 mRNA in reactive astrocytes, suggesting that glypican-1 might also prevent regenerating axons from entering into brain lesions. | Slit and glypican-1 mRNAs are coexpressed in the reactive astrocytes of the injured adult brain.
Hagino S, Iseki K, Mori T, Zhang Y, Hikake T, Yokoya S, Takeuchi M, Hasimoto H, Kikuchi S, Wanaka A. | 01/21/2010 |
| altered HSPGs contribute to enhanced signaling of FGF-2 via FGFR1c in gliomas with glypican-1 playing a significant role in this mitogenic pathway | Glypican-1 is frequently overexpressed in human gliomas and enhances FGF-2 signaling in glioma cells.
Su G, Meyer K, Nandini CD, Qiao D, Salamat S, Friedl A., Free PMC Article | 01/21/2010 |
| Glypican-1 has an important role in peripheral nerve terminal differentiation. | Glypican-1 and alpha4(V) collagen are required for Schwann cell myelination.
Chernousov MA, Rothblum K, Stahl RC, Evans A, Prentiss L, Carey DJ., Free PMC Article | 01/21/2010 |
| glypican-1 is involved in the neuronal-like differentiation of PC12 cells and could play an important role on the regeneration responses of peripheral nerves | Role of glypican-1 in the trophic activity on PC12 cells induced by cultured sciatic nerve conditioned medium: identification of a glypican-1-neuregulin complex.
Malavé C, Villegas GM, Hernández M, Martínez JC, Castillo C, Suárez de Mata Z, Villegas R. | 01/21/2010 |
| FSH, through its second messengers (increase in intracellular cAMP and intracellular calcium), downregulated the glypican-1 mRNA expression in Sertoli cells from 20-day-old rats. | Regulation of glypican-1, syndecan-1 and syndecan-4 mRNAs expression by follicle-stimulating hormone, cAMP increase and calcium influx during rat Sertoli cell development.
Brucato S, Bocquet J, Villers C. | 01/21/2010 |
| glypican-1 heparan sulfate degradation in rat C6 glioma cells is regulated by ceruloplasmin | Involvement of glycosylphosphatidylinositol-linked ceruloplasmin in the copper/zinc-nitric oxide-dependent degradation of glypican-1 heparan sulfate in rat C6 glioma cells.
Mani K, Cheng F, Havsmark B, David S, Fransson LA. | 01/21/2010 |
| Glypican-1 mRNA is present in sensory neurons of the dorsal root ganglion of adult rats and is up-regulated after peripheral and central nerve injury. | Dynamic changes in glypican-1 expression in dorsal root ganglion neurons after peripheral and central axonal injury.
Bloechlinger S, Karchewski LA, Woolf CJ. | 01/21/2010 |