| miR8755p regulates IR and inflammation via targeting TXNRD1 in gestational diabetes rats. | miR‑875‑5p regulates IR and inflammation via targeting TXNRD1 in gestational diabetes rats.
Fu S, Fu S, Ma X, Yang X, Ling J., Free PMC Article | 05/15/2021 |
| Compensatory Neuroprotective Response of Thioredoxin Reductase against Oxidative-Nitrosative Stress Induced by Experimental Autoimmune Encephalomyelitis in Rats: Modulation by Theta Burst Stimulation. | Compensatory Neuroprotective Response of Thioredoxin Reductase against Oxidative-Nitrosative Stress Induced by Experimental Autoimmune Encephalomyelitis in Rats: Modulation by Theta Burst Stimulation.
Stevanovic I, Ninkovic M, Mancic B, Milivojevic M, Stojanovic I, Ilic T, Vujovic M, Djukic M., Free PMC Article | 03/13/2021 |
| Data suggest TrxR1 and NADPH directly protect PTP1B from inactivation by oxidation; this protection is independent of TRX1 and PRX2; this protection is blocked by auranofin (an inhibitor of TrxR1 and requires an intact selenocysteine residue in TrxR1. (TrxR1 = thioredoxin reductase 1; PTP1B = protein tyrosine phosphatase, non-receptor type 1; TRX1 = thioredoxin-1; PRX2 = paired related homeobox 2 protein) | Thioredoxin reductase 1 and NADPH directly protect protein tyrosine phosphatase 1B from inactivation during H(2)O(2) exposure.
Dagnell M, Pace PE, Cheng Q, Frijhoff J, Östman A, Arnér ESJ, Hampton MB, Winterbourn CC., Free PMC Article | 09/30/2017 |
| Inhibition of thioredoxin reductase-1 by brevetoxin-2 is via the formation of a Michael adduct between selenocysteine and the alpha, beta-unsaturated aldehyde moiety of the toxin. | Brevetoxin-2, is a unique inhibitor of the C-terminal redox center of mammalian thioredoxin reductase-1.
Chen W, Tuladhar A, Rolle S, Lai Y, Rodriguez Del Rey F, Zavala CE, Liu Y, Rein KS., Free PMC Article | 08/5/2017 |
| rat liver selenoenzyme thioredoxin reductase (Txnrd1, TR1) efficiently reduces tetrathionate | Reduction of Tetrathionate by Mammalian Thioredoxin Reductase.
Narayan V, Kudva AK, Prabhu KS., Free PMC Article | 11/7/2015 |
| DSW drinking reduced ulcer area as well as apoptotic signaling in acetic acid-induced duodenal ulcers. DSW, which contains selenium, provides intestinal protection against duodenal ulcers through the upregulation of Bcl-2 and thioredoxin reductase | Deep-sea water containing selenium provides intestinal protection against duodenal ulcers through the upregulation of Bcl-2 and thioredoxin reductase 1.
Yang CC, Yao CA, Lin YR, Yang JC, Chien CT., Free PMC Article | 10/17/2015 |
| Trp114 of TrxR1 serves a function reminiscent of an irreversible sensor for excessive oxidation. | The conserved Trp114 residue of thioredoxin reductase 1 has a redox sensor-like function triggering oligomerization and crosslinking upon oxidative stress related to cell death.
Xu J, Eriksson SE, Cebula M, Sandalova T, Hedström E, Pader I, Cheng Q, Myers CR, Antholine WE, Nagy P, Hellman U, Selivanova G, Lindqvist Y, Arnér ES., Free PMC Article | 09/12/2015 |
| Active TrxR1 and TrxR2 are required for cerebellar granule cell survival. | Thioredoxin/thioredoxin reductase system involvement in cerebellar granule cell apoptosis.
Bobba A, Casalino E, Petragallo VA, Atlante A. | 05/30/2015 |
| Sec-containing TrxR1 is absolutely required for self-sufficient growth of MEFs under high-glucose conditions, owing to an essential importance of this enzyme for elimination of glucose-derived H2O2. | Sec-containing TrxR1 is essential for self-sufficiency of cells by control of glucose-derived H2O2.
Peng X, Mandal PK, Kaminskyy VO, Lindqvist A, Conrad M, Arnér ES., Free PMC Article | 10/25/2014 |
| The aim of the current study was to determine why TrxR activity was reduced and whether reduced TrxR activity contributed to enhanced aging myocardial ischemia/reperfusion injury. | Thioredoxin reductase was nitrated in the aging heart after myocardial ischemia/reperfusion.
Wang K, Zhang J, Wang X, Liu X, Zuo L, Bai K, Shang J, Ma L, Liu T, Wang L, Wang W, Ma X, Liu H., Free PMC Article | 07/12/2014 |
| Data indicate that mammalian thioredoxin reductase (H-TrxR) reduces hypothiocyanous acid (HOSCN). | Selective metabolism of hypothiocyanous acid by mammalian thioredoxin reductase promotes lung innate immunity and antioxidant defense.
Chandler JD, Nichols DP, Nick JA, Hondal RJ, Day BJ., Free PMC Article | 09/7/2013 |
| Hyperoxia can up-regulate Trx1/TrxR1 expression in alveolar type II epithelial cells. | Effects of hyperoxia on cytoplasmic thioredoxin system in alveolar type epithelial cells of premature rats.
Shan R, Chang L, Li W, Liu W, Rong Z, Chen Y, Zeng L. | 04/13/2013 |
| Data indicate that Cu-ZnSod expression decreased upon long reperfusion and trxr1 expression did not vary. | Selection of reference genes in different myocardial regions of an in vivo ischemia/reperfusion rat model for normalization of antioxidant gene expression.
Vesentini N, Barsanti C, Martino A, Kusmic C, Ripoli A, Rossi A, L'Abbate A., Free PMC Article | 03/2/2013 |
| Inhibition of thioredoxin reductase at either gene expression or activity levels prevented NIS recovery, thus illustrating a new role played by this selenoprotein in the regulation of cell homeostasis and consequently in I(-) autoregulation. | Regulation of thyroid oxidative state by thioredoxin reductase has a crucial role in thyroid responses to iodide excess.
Leoni SG, Kimura ET, Santisteban P, De la Vieja A., Free PMC Article | 05/19/2012 |
| This study suggests that the over expression of TrxR1 in liver neoplasia can only partly be explained by increased growth. | The effect of sodium selenite on liver growth and thioredoxin reductase expression in regenerative and neoplastic liver cell proliferation.
Erkhembayar S, Mollbrink A, Eriksson LC. | 03/17/2012 |
| Data indicate that mercury was complexed with TrxR, but enzyme-generated selenide removed mercury as mercury selenide, regenerating the active site selenocysteine and cysteine residues required for activity. | Effects of selenite and chelating agents on mammalian thioredoxin reductase inhibited by mercury: implications for treatment of mercury poisoning.
Carvalho CM, Lu J, Zhang X, Arnér ES, Holmgren A. | 03/12/2011 |
| The thioredoxin reductase represents an important part of the antioxidant defense system. | The effect of iron(III) on the activity of selenoenzymes and oxidative damage in the liver of rats. Interaction with natural antioxidants and deferiprone.
Hodková A, Cerná P, Kotyzová D, Eybl V. | 02/26/2011 |
| TR1 and Trx1 interaction play key role in redox homoeostasis. | Mammalian thioredoxin reductase 1: roles in redox homoeostasis and characterization of cellular targets.
Turanov AA, Kehr S, Marino SM, Yoo MH, Carlson BA, Hatfield DL, Gladyshev VN., Free PMC Article | 09/13/2010 |
| TRX1 and TRX2 overexpression protected retinal ganglion cells(RCGs) from death after optic nerve axotomy, in oxidative stress, and in an animal model of glaucoma. | Overexpression of thioredoxins 1 and 2 increases retinal ganglion cell survival after pharmacologically induced oxidative stress, optic nerve transection, and in experimental glaucoma.
Caprioli J, Munemasa Y, Kwong JM, Piri N., Free PMC Article | 05/31/2010 |
| a low-activity form of TrxR with a cysteine substituted for the penultimate selenocysteine in the C-terminal active site was identified in selenium-deficient liver | Penultimate selenocysteine residue replaced by cysteine in thioredoxin reductase from selenium-deficient rat liver.
Lu J, Zhong L, Lönn ME, Burk RF, Hill KE, Holmgren A., Free PMC Article | 01/21/2010 |
| Crystal structure and catalysis of the selenoprotein thioredoxin reductase 1. | Crystal structure and catalysis of the selenoprotein thioredoxin reductase 1.
Cheng Q, Sandalova T, Lindqvist Y, Arnér ES. | 01/21/2010 |
| thioredoxin reductase is a prooxidant killer of cells in a pathway involving SecTRAPs | Cell death by SecTRAPs: thioredoxin reductase as a prooxidant killer of cells.
Anestål K, Prast-Nielsen S, Cenas N, Arnér ES., Free PMC Article | 01/21/2010 |
| TGR and GPx4 can serve as a novel disulfide bond formation system and contain a catalytic selenocysteine consistent with the role of selenium in male reproduction | Mammalian selenoprotein thioredoxin-glutathione reductase. Roles in disulfide bond formation and sperm maturation.
Su D, Novoselov SV, Sun QA, Moustafa ME, Zhou Y, Oko R, Hatfield DL, Gladyshev VN. | 01/21/2010 |
| selenoenzyme thioredoxin reductase is an important selenium-dependent ubiquinone reductase and may protect the cell from oxidative damage | The mammalian cytosolic selenoenzyme thioredoxin reductase reduces ubiquinone. A novel mechanism for defense against oxidative stress.
Xia L, Nordman T, Olsson JM, Damdimopoulos A, Björkhem-Bergman L, Nalvarte I, Eriksson LC, Arnér ES, Spyrou G, Björnstedt M. | 01/21/2010 |
| Data show that there is a prioritisation of TrxR2 over TrxR1 during Se deficiency. | Differential regulation of expression of cytosolic and mitochondrial thioredoxin reductase in rat liver and kidney.
Crosley LK, Méplan C, Nicol F, Rundlöf AK, Arnér ES, Hesketh JE, Arthur JR. | 01/21/2010 |