| HNF4alpha is required for Tkfc promoter activation by ChREBP. | HNF4α is required for Tkfc promoter activation by ChREBP.
Tsukamoto R, Watanabe K, Kodaka M, Iwase M, Sakiyama H, Inoue Y, Suzuki T, Yamamoto Y, Shimizu M, Sato R, Inoue J. | 08/7/2024 |
| Suppression of hepatic ChREBP-CYP2C50 axis-driven fatty acid oxidation sensitizes mice to diet-induced MASLD/MASH. | Suppression of hepatic ChREBP⍺-CYP2C50 axis-driven fatty acid oxidation sensitizes mice to diet-induced MASLD/MASH.
Zhang D, Zhao Y, Zhang G, Lank D, Cooke S, Wang S, Nuotio-Antar A, Tong X, Yin L., Free PMC Article | 07/11/2024 |
| ChREBP plays a pivotal role in the nutrient-mediated regulation of metabolic gene expression in brown adipose tissue. | ChREBP plays a pivotal role in the nutrient-mediated regulation of metabolic gene expression in brown adipose tissue.
Baek S, Seo DS, Kang J, Ahmad Y, Park S, Joo S, Kim K, Jang Y. | 07/8/2024 |
| Hepatic ChREBP orchestrates intrahepatic carbohydrate metabolism to limit hepatic glucose 6-phosphate and glycogen accumulation in a mouse model for acute Glycogen Storage Disease type Ib. | Hepatic ChREBP orchestrates intrahepatic carbohydrate metabolism to limit hepatic glucose 6-phosphate and glycogen accumulation in a mouse model for acute Glycogen Storage Disease type Ib.
Krishnamurthy KA, Rutten MGS, Hoogerland JA, van Dijk TH, Bos T, Koehorst M, de Vries MP, Kloosterhuis NJ, Havinga H, Schomakers BV, van Weeghel M, Wolters JC, Bakker BM, Oosterveer MH., Free PMC Article | 02/1/2024 |
| Knockdown of ChREBP ameliorates retinal microvascular endothelial cell injury and angiogenic responses in diabetic retinopathy. | Knockdown of ChREBP ameliorates retinal microvascular endothelial cell injury and angiogenic responses in diabetic retinopathy.
Sui Y, Du C, Wang M, Liu X, Chai Q, Liang S, Ma J, Duan J. | 01/27/2024 |
| The transcription factor ChREBP links mitochondrial lipidomes to mitochondrial morphology and progression of diabetic kidney disease. | The transcription factor ChREBP links mitochondrial lipidomes to mitochondrial morphology and progression of diabetic kidney disease.
Li L, Long J, Mise K, Poungavrin N, Lorenzi PL, Mahmud I, Tan L, Saha PK, Kanwar YS, Chang BH, Danesh FR., Free PMC Article | 10/4/2023 |
| Reactive oxygen species induce HNF-4alpha expression via the ASK1-CREB pathway, promoting ChREBP expression and lipogenesis in hepatocytes. | Reactive oxygen species induce HNF-4α expression via the ASK1-CREB pathway, promoting ChREBP expression and lipogenesis in hepatocytes.
Seo E, Nam H, Jun HS. | 01/28/2023 |
| HGFAC is a ChREBP-regulated hepatokine that enhances glucose and lipid homeostasis. | HGFAC is a ChREBP-regulated hepatokine that enhances glucose and lipid homeostasis.
Sargsyan A, Doridot L, Hannou SA, Tong W, Srinivasan H, Ivison R, Monn R, Kou HH, Haldeman JM, Arlotto M, White PJ, Grimsrud PA, Astapova I, Tsai LT, Herman MA., Free PMC Article | 01/14/2023 |
| Transcriptional regulation of Acsl1 by CHREBP and NF-kappa B in macrophages during hyperglycemia and inflammation. | Transcriptional regulation of Acsl1 by CHREBP and NF-kappa B in macrophages during hyperglycemia and inflammation.
Thevkar-Nagesh P, Habault J, Voisin M, Ruff SE, Ha S, Ruoff R, Chen X, Rawal S, Zahr T, Szabo G, Rogatsky I, Fisher EA, Garabedian MJ., Free PMC Article | 09/24/2022 |
| Inhibition of ChREBP ubiquitination via the ROS/Akt-dependent downregulation of Smurf2 contributes to lysophosphatidic acid-induced fibrosis in renal mesangial cells. | Inhibition of ChREBP ubiquitination via the ROS/Akt-dependent downregulation of Smurf2 contributes to lysophosphatidic acid-induced fibrosis in renal mesangial cells.
Kim D, Nam GY, Seo E, Jun HS., Free PMC Article | 05/14/2022 |
| ChREBPbeta is dispensable for the control of glucose homeostasis and energy balance. | ChREBPβ is dispensable for the control of glucose homeostasis and energy balance.
Recazens E, Tavernier G, Dufau J, Bergoglio C, Benhamed F, Cassant-Sourdy S, Marques MA, Caspar-Bauguil S, Brion A, Monbrun L, Dentin R, Ferrier C, Leroux M, Denechaud PD, Moro C, Concordet JP, Postic C, Mouisel E, Langin D., Free PMC Article | 04/2/2022 |
| Thyroid hormone signaling promotes hepatic lipogenesis through the transcription factor ChREBP. | Thyroid hormone signaling promotes hepatic lipogenesis through the transcription factor ChREBP.
Mendoza A, Tang C, Choi J, Acuña M, Logan M, Martin AG, Al-Sowaimel L, Desai BN, Tenen DE, Jacobs C, Lyubetskaya A, Fu Y, Liu H, Tsai L, Cohen DE, Forrest D, Wilson AA, Hollenberg AN., Free PMC Article | 01/29/2022 |
| The Roles of Carbohydrate Response Element Binding Protein in the Relationship between Carbohydrate Intake and Diseases. | The Roles of Carbohydrate Response Element Binding Protein in the Relationship between Carbohydrate Intake and Diseases.
Iizuka K., Free PMC Article | 01/15/2022 |
| ChREBP deficiency alleviates apoptosis by inhibiting TXNIP/oxidative stress in diabetic nephropathy. | ChREBP deficiency alleviates apoptosis by inhibiting TXNIP/oxidative stress in diabetic nephropathy.
Chen N, Song S, Yang Z, Wu M, Mu L, Zhou T, Shi Y. | 01/15/2022 |
| SIRT6 controls hepatic lipogenesis by suppressing LXR, ChREBP, and SREBP1. | SIRT6 controls hepatic lipogenesis by suppressing LXR, ChREBP, and SREBP1.
Zhu C, Huang M, Kim HG, Chowdhury K, Gao J, Liu S, Wan J, Wei L, Dong XC., Free PMC Article | 01/1/2022 |
| Hormonally Induced Hepatocellular Carcinoma in Diabetic Wild Type and Carbohydrate Responsive Element Binding Protein Knockout Mice. | Hormonally Induced Hepatocellular Carcinoma in Diabetic Wild Type and Carbohydrate Responsive Element Binding Protein Knockout Mice.
Nuernberger V, Mortoga S, Metzendorf C, Burkert C, Ehricke K, Knuth E, Zimmer J, Singer S, Nath N, Karim M, Yasser M, Calvisi DF, Dombrowski F, Ribback S., Free PMC Article | 12/4/2021 |
| The absence of hepatic glucose-6 phosphatase/ChREBP couple is incompatible with survival in mice. | The absence of hepatic glucose-6 phosphatase/ChREBP couple is incompatible with survival in mice.
Rajas F, Dentin R, Cannella Miliano A, Silva M, Raffin M, Levavasseur F, Gautier-Stein A, Postic C, Mithieux G., Free PMC Article | 09/4/2021 |
| A lack of ChREBP inhibits mitochondrial cristae formation in brown adipose tissue. | A lack of ChREBP inhibits mitochondrial cristae formation in brown adipose tissue.
Sakiyama H, Li L, Kuwahara-Otani S, Nakagawa T, Eguchi H, Yoshihara D, Shinohara M, Fujiwara N, Suzuki K. | 09/4/2021 |
| Effects of ChREBP deficiency on adrenal lipogenesis and steroidogenesis. | Effects of ChREBP deficiency on adrenal lipogenesis and steroidogenesis.
Takao K, Iizuka K, Liu Y, Sakurai T, Kubota S, Kubota-Okamoto S, Imaizumi T, Takahashi Y, Rakhat Y, Komori S, Hirose T, Nonomura K, Kato T, Mizuno M, Suwa T, Horikawa Y, Sone M, Yabe D. | 07/24/2021 |
| Hepatic Carbohydrate Response Element Binding Protein Activation Limits Nonalcoholic Fatty Liver Disease Development in a Mouse Model for Glycogen Storage Disease Type 1a. | Hepatic Carbohydrate Response Element Binding Protein Activation Limits Nonalcoholic Fatty Liver Disease Development in a Mouse Model for Glycogen Storage Disease Type 1a.
Lei Y, Hoogerland JA, Bloks VW, Bos T, Bleeker A, Wolters H, Wolters JC, Hijmans BS, van Dijk TH, Thomas R, van Weeghel M, Mithieux G, Houtkooper RH, de Bruin A, Rajas F, Kuipers F, Oosterveer MH., Free PMC Article | 05/8/2021 |
| Long non-coding RNA (lncRNA) H19 induces hepatic steatosis through activating MLXIPL and mTORC1 networks in hepatocytes. | Long non-coding RNA (lncRNA) H19 induces hepatic steatosis through activating MLXIPL and mTORC1 networks in hepatocytes.
Wang H, Cao Y, Shu L, Zhu Y, Peng Q, Ran L, Wu J, Luo Y, Zuo G, Luo J, Zhou L, Shi Q, Weng Y, Huang A, He TC, Fan J., Free PMC Article | 04/24/2021 |
| The glucose-sensing transcription factor ChREBP is targeted by proline hydroxylation. | The glucose-sensing transcription factor ChREBP is targeted by proline hydroxylation.
Heidenreich S, Weber P, Stephanowitz H, Petricek KM, Schütte T, Oster M, Salo AM, Knauer M, Goehring I, Yang N, Witte N, Schumann A, Sommerfeld M, Muenzner M, Myllyharju J, Krause E, Schupp M., Free PMC Article | 03/20/2021 |
| Role for carbohydrate response element-binding protein (ChREBP) in high glucose-mediated repression of long noncoding RNA Tug1. | Role for carbohydrate response element-binding protein (ChREBP) in high glucose-mediated repression of long noncoding RNA Tug1.
Long J, Galvan DL, Mise K, Kanwar YS, Li L, Poungavrin N, Overbeek PA, Chang BH, Danesh FR., Free PMC Article | 03/13/2021 |
| LXRalpha Regulates ChREBPalpha Transactivity in a Target Gene-Specific Manner through an Agonist-Modulated LBD-LID Interaction. | LXRα Regulates ChREBPα Transactivity in a Target Gene-Specific Manner through an Agonist-Modulated LBD-LID Interaction.
Fan Q, Nørgaard RC, Grytten I, Ness CM, Lucas C, Vekterud K, Soedling H, Matthews J, Lemma RB, Gabrielsen OS, Bindesbøll C, Ulven SM, Nebb HI, Grønning-Wang LM, Sæther T., Free PMC Article | 02/27/2021 |
| Hippo pathway cooperates with ChREBP to regulate hepatic glucose utilization. | Hippo pathway cooperates with ChREBP to regulate hepatic glucose utilization.
Shu ZP, Yi GW, Deng S, Huang K, Wang Y. | 02/27/2021 |