| Identification and Validation of a PEX5-Dependent Signature for Prognostic Prediction in Glioma. | Identification and Validation of a PEX5-Dependent Signature for Prognostic Prediction in Glioma.
Qin X, Wang B, Lu X, Song Y, Wang W., Free PMC Article | 04/2/2024 |
| Insights into the critical role of the PXR in preventing carcinogenesis and chemotherapeutic drug resistance. | Insights into the critical role of the PXR in preventing carcinogenesis and chemotherapeutic drug resistance.
Niu X, Wu T, Li G, Gu X, Tian Y, Cui H., Free PMC Article | 03/26/2022 |
| A missense allele of PEX5 is responsible for the defective import of PTS2 cargo proteins into peroxisomes. | A missense allele of PEX5 is responsible for the defective import of PTS2 cargo proteins into peroxisomes.
Ali M, Khan SY, Rodrigues TA, Francisco T, Jiao X, Qi H, Kabir F, Irum B, Rauf B, Khan AA, Mehmood A, Naeem MA, Assir MZ, Ali MH, Shahzad M, Abu-Amero KK, Akram SJ, Akram J, Riazuddin S, Riazuddin S, Robinson ML, Baes M, Azevedo JE, Hejtmancik JF, Riazuddin SA. | 05/15/2021 |
| Competitive Microtubule Binding of PEX14 Coordinates Peroxisomal Protein Import and Motility. | Competitive Microtubule Binding of PEX14 Coordinates Peroxisomal Protein Import and Motility.
Reuter M, Kooshapur H, Suda JG, Gaussmann S, Neuhaus A, Brühl L, Bharti P, Jung M, Schliebs W, Sattler M, Erdmann R. | 05/8/2021 |
| Mitotic phosphorylation of Pex14p regulates peroxisomal import machinery. | Mitotic phosphorylation of Pex14p regulates peroxisomal import machinery.
Yamashita K, Tamura S, Honsho M, Yada H, Yagita Y, Kosako H, Fujiki Y., Free PMC Article | 03/28/2021 |
| The interactions with the docking proteins were independent of the PEX5 ubiquitination status whereas the interactions with the receptor export machinery (REM) components were increased when PEX5 is ubiquitinated | Chemically monoubiquitinated PEX5 binds to the components of the peroxisomal docking and export machinery.
Hagmann V, Sommer S, Fabian P, Bierlmeier J, van Treel N, Mootz HD, Schwarzer D, Azevedo JE, Dodt G., Free PMC Article | 10/26/2019 |
| These data suggest that PEX5 may be a critical regulator of lysosomal gene expression and autophagy through the mTOR-TFEB-autophagy axis under nutrient deprivation. | PEX5 regulates autophagy via the mTORC1-TFEB axis during starvation.
Eun SY, Lee JN, Nam IK, Liu ZQ, So HS, Choe SK, Park R., Free PMC Article | 02/16/2019 |
| This study provides evidence suggesting that monoubiquitinated PEX5 interacts directly with both PEX1 and PEX6 through its ubiquitin moiety and that the PEX5 polypeptide chain is globally unfolded during the ATP-dependent extraction event. | Peroxisomal monoubiquitinated PEX5 interacts with the AAA ATPases PEX1 and PEX6 and is unfolded during its dislocation into the cytosol.
Pedrosa AG, Francisco T, Bicho D, Dias AF, Barros-Barbosa A, Hagmann V, Dodt G, Rodrigues TA, Azevedo JE., Free PMC Article | 02/9/2019 |
| Data suggest that P7BP2 is localized to peroxisomes by binding to PEX5 via PEX7 in manner dependent on apparent PTS2 (type 2 peroxisomal targeting signal peptide) in N-terminal region of P7BP2; the PTS2 is subsequently cleaved off in peroxisomes. (P7BP2 = PEX7-binding protein-2; PEX5 = peroxisomal biogenesis factor-5; PEX7 = peroxisomal biogenesis factor-7) | A newly isolated Pex7-binding, atypical PTS2 protein P7BP2 is a novel dynein-type AAA+ protein.
Niwa H, Miyauchi-Nanri Y, Okumoto K, Mukai S, Noi K, Ogura T, Fujiki Y. | 01/12/2019 |
| these findings lend credit to the idea that inefficient catalase import, when coupled with the role of PEX5 as a redox-regulated import receptor, constitutes a cellular defense mechanism to combat oxidative insults of extra-peroxisomal origin. | The peroxisomal import receptor PEX5 functions as a stress sensor, retaining catalase in the cytosol in times of oxidative stress.
Walton PA, Brees C, Lismont C, Apanasets O, Fransen M. | 12/9/2017 |
| TRIM37-mediated ubiquitylation stabilizes PEX5 and promotes peroxisomal matrix protein import, suggesting that mulibrey nanism is a new peroxisomal biogenesis disorder. | TRIM37, a novel E3 ligase for PEX5-mediated peroxisomal matrix protein import.
Wang W, Xia ZJ, Farré JC, Subramani S., Free PMC Article | 10/7/2017 |
| Data suggest that soluble/cytosolic PEX5 interacts with PEX14/PEX13 complex, a model for the docking/translocation module (DTM) of the peroxisomal matrix protein translocon; PEX14/PEX13 complex appears to function in peroxisomal membrane as large cavity into which cytosolic PEX5 can enter to release its cargo. (PEX = peroxisomal biogenesis factor) | The peroxisomal matrix protein translocon is a large cavity-forming protein assembly into which PEX5 protein enters to release its cargo.
Dias AF, Rodrigues TA, Pedrosa AG, Barros-Barbosa A, Francisco T, Azevedo JE., Free PMC Article | 09/30/2017 |
| data reveal subpopulations of peroxisomes showing only weak colocalization between PEX14 and PEX5 or PEX11 but at the same time a clear compartmentalized organization. This compartmentalization, which was less evident in cases of strong colocalization, indicates dynamic protein reorganization linked to changes occurring in the peroxisomes. | Super-resolution Microscopy Reveals Compartmentalization of Peroxisomal Membrane Proteins.
Galiani S, Waithe D, Reglinski K, Cruz-Zaragoza LD, Garcia E, Clausen MP, Schliebs W, Erdmann R, Eggeling C., Free PMC Article | 05/6/2017 |
| our data suggest that insertion of the trimeric PEX5-PEX7-PTS2 protein complex into the DTM is probably accompanied by conformational alterations in PEX5 to allow release of the PTS2 protein into the organelle matrix | Revisiting the intraperoxisomal pathway of mammalian PEX7.
Rodrigues TA, Grou CP, Azevedo JE., Free PMC Article | 08/6/2016 |
| Our data suggest that the functional polymorphism rs3814058C>T in 3'-UTR of PXR may be a functional biomarker to predict risk of colorectal cancer | Functional variants inPXRare associated with colorectal cancer susceptibility in Chinese populations.
Ni H, Su B, Pan L, Li X, Zhu X, Chen X. | 07/30/2016 |
| PEX5 encodes two isoforms, PEX5L & PEX5S, & a homozygous frame shift mutation c.722dupA (p.Val242Glyfs( *)33), located in the PEX5L-specific exon 9, results in loss of PEX5L only. Loss of PEX5L results in deficient import of PTS2-tagged proteins | A novel type of rhizomelic chondrodysplasia punctata, RCDP5, is caused by loss of the PEX5 long isoform.
Barøy T, Koster J, Strømme P, Ebberink MS, Misceo D, Ferdinandusse S, Holmgren A, Hughes T, Merckoll E, Westvik J, Woldseth B, Walter J, Wood N, Tvedt B, Stadskleiv K, Wanders RJ, Waterham HR, Frengen E. | 07/16/2016 |
| bulky side chain within the recognition motif, which blocks contraction of the PEX5 binding cavity | Ligand-induced compaction of the PEX5 receptor-binding cavity impacts protein import efficiency into peroxisomes.
Fodor K, Wolf J, Reglinski K, Passon DM, Lou Y, Schliebs W, Erdmann R, Wilmanns M. | 01/30/2016 |
| Data show that ataxia-telangiectasia mutated (ATM) phosphorylates peroxisomal biogenesis factor 5 (PEX5) at serine 141 in response to reactive oxygen species. | ATM functions at the peroxisome to induce pexophagy in response to ROS.
Zhang J, Tripathi DN, Jing J, Alexander A, Kim J, Powell RT, Dere R, Tait-Mulder J, Lee JH, Paull TT, Pandita RK, Charaka VK, Pandita TK, Kastan MB, Walker CL., Free PMC Article | 01/30/2016 |
| the molecular recognition of PTS1 cargo proteins by Pex5p | Molecular recognition of PTS-1 cargo proteins by Pex5p: implications for protein mistargeting in primary hyperoxaluria.
Mesa-Torres N, Tomic N, Albert A, Salido E, Pey AL., Free PMC Article | 09/26/2015 |
| ubiquitination of peroxisome-targeting signal type 1 (PTS1) receptor Pex5p regulating PTS1 protein import | Distinct modes of ubiquitination of peroxisome-targeting signal type 1 (PTS1) receptor Pex5p regulate PTS1 protein import.
Okumoto K, Noda H, Fujiki Y., Free PMC Article | 12/20/2014 |
| PEX5 has a role in regulating peroxisome numbers by signaling to mediate pexophagy | PEX5 and ubiquitin dynamics on mammalian peroxisome membranes.
Brown AI, Kim PK, Rutenberg AD., Free PMC Article | 11/22/2014 |
| Cys11 in PEX5 serves as a functional redox switch regulating the peroxisomal/cytosolic localization of peroxisomal proteins. | PEX5, the shuttling import receptor for peroxisomal matrix proteins, is a redox-sensitive protein.
Apanasets O, Grou CP, Van Veldhoven PP, Brees C, Wang B, Nordgren M, Dodt G, Azevedo JE, Fransen M. | 07/19/2014 |
| The novel Pex14-binding site may represent the initial tethering site of Pex5 from which the cargo-loaded receptor is further processed in a sequential manner. | A novel Pex14 protein-interacting site of human Pex5 is critical for matrix protein import into peroxisomes.
Neuhaus A, Kooshapur H, Wolf J, Meyer NH, Madl T, Saidowsky J, Hambruch E, Lazam A, Jung M, Sattler M, Schliebs W, Erdmann R., Free PMC Article | 03/22/2014 |
| Translocation of proteins across the organelle membrane occurs downstream of a reversible docking step and upstream of the first cytosolic ATP-dependent step, i.e. before ubiquitination of PEX5. | A cargo-centered perspective on the PEX5 receptor-mediated peroxisomal protein import pathway.
Francisco T, Rodrigues TA, Freitas MO, Grou CP, Carvalho AF, Sá-Miranda C, Pinto MP, Azevedo JE., Free PMC Article | 12/7/2013 |
| The molecular mechanism of recognition by the peroxisomal receptor Pex5p, in complex with alanine-glyoxylate aminotransferase revealed by X-ray crystallography. | Molecular requirements for peroxisomal targeting of alanine-glyoxylate aminotransferase as an essential determinant in primary hyperoxaluria type 1.
Fodor K, Wolf J, Erdmann R, Schliebs W, Wilmanns M., Free PMC Article | 08/11/2012 |