| These findings demonstrate that ZBTB32 is a key transcription factor in CD8+ effector T cells that is required for the balanced regulation of effector versus memory responses to infection. | Transient expression of ZBTB32 in anti-viral CD8+ T cells limits the magnitude of the effector response and the generation of memory.
Shin HM, Kapoor VN, Kim G, Li P, Kim HR, Suresh M, Kaech SM, Wherry EJ, Selin LK, Leonard WJ, Welsh RM, Berg LJ., Free PMC Article | 10/7/2017 |
| ZBTB32 is a novel negative regulator of antibody recall responses. | ZBTB32 Restricts the Duration of Memory B Cell Recall Responses.
Jash A, Wang Y, Weisel FJ, Scharer CD, Boss JM, Shlomchik MJ, Bhattacharya D., Free PMC Article | 08/5/2017 |
| This study showed that DCIR2(+) DCs are capable of inducing antigen-specific tolerance in the face of ongoing autoimmunity; Zbtb32 is a suppressive transcription factor that controls T cell-mediated autoimmunity. | DCIR2+ cDC2 DCs and Zbtb32 Restore CD4+ T-Cell Tolerance and Inhibit Diabetes.
Price JD, Hotta-Iwamura C, Zhao Y, Beauchamp NM, Tarbell KV., Free PMC Article | 01/16/2016 |
| Zbtb32 acts as a cellular 'hub' through which proinflammatory signals instruct a 'proliferation-permissive' state in NK cells, thereby allowing their prolific expansion in response to viral infection. | The transcription factor Zbtb32 controls the proliferative burst of virus-specific natural killer cells responding to infection.
Beaulieu AM, Zawislak CL, Nakayama T, Sun JC., Free PMC Article | 08/9/2014 |
| that Tzfp function as a transcriptional regulator and that loss of the protein leads to alterations in AR signaling | Tzfp represses the androgen receptor in mouse testis.
Furu K, Klungland A., Free PMC Article | 11/30/2013 |
| The study reports a remarkable >1000-fold upregulation of individual piRNAs in pachytene spermatocytes isolated from Tzfp-deficient murine testes. | Alkbh1 and Tzfp repress a non-repeat piRNA cluster in pachytene spermatocytes.
Nordstrand LM, Furu K, Paulsen J, Rognes T, Klungland A., Free PMC Article | 02/2/2013 |
| It is concluded that ROG can inhibit the expression of Th1 and Th2 cytokines by down-regulating the expression of ICOS, which might be a potential molecular target for asthma treatment. | Repressor of GATA-3 can negatively regulate the expression of T cell cytokines through modulation on inducible costimulator.
Zang YS, Fang Z, Liu YA, Li B, Xiu QY. | 01/5/2013 |
| Rog plays an inhibitory role in allergic inflammation. | Repressor of GATA negatively regulates murine contact hypersensitivity through the inhibition of type-2 allergic responses.
Hirasaki Y, Iwamura C, Yamashita M, Ito T, Kitajima M, Shinoda K, Namiki T, Terasawa K, Nakayama T. | 08/13/2011 |
| structure of zinc-finger domains; kinetics of DNA binding; DNA sequence-specific binding & nonsequence-specific binding occur simultaneously | Structure and DNA binding characteristics of the three-Cys(2)His(2) domain of mouse testis zinc finger protein.
Chou CC, Lou YC, Tang TK, Chen C. | 10/23/2010 |
| results indicate that ROG regulates allergic airway inflammation and airway hyperresponsiveness in a negative manner | Repressor of GATA regulates TH2-driven allergic airway inflammation and airway hyperresponsiveness.
Hirahara K, Yamashita M, Iwamura C, Shinoda K, Hasegawa A, Yoshizawa H, Koseki H, Gejyo F, Nakayama T. | 01/21/2010 |
| ROG is a critical part of a transcription factor NF-ATc2-initiated negative feedback mechanism of T cell activation. | A repressor of GATA-mediated negative feedback mechanism of T cell activation.
Miaw SC, Kang BY, White IA, Ho IC. | 01/21/2010 |
| ROG may confer CD8 T cell-specific repression of histone hyperacetylation and activation of the IL-4 gene locus. | CD8 T cell-specific downregulation of histone hyperacetylation and gene activation of the IL-4 gene locus by ROG, repressor of GATA.
Omori M, Yamashita M, Inami M, Ukai-Tadenuma M, Kimura M, Nigo Y, Hosokawa H, Hasegawa A, Taniguchi M, Nakayama T. | 01/21/2010 |
| Data show that ROG-deficient T cells are hypersensitive to anti-CD3 stimulation and produce more interleukin-2 (IL-2) due to enhanced NF-kappaB activity. | ROG negatively regulates T-cell activation but is dispensable for Th-cell differentiation.
Kang BY, Miaw SC, Ho IC., Free PMC Article | 01/21/2010 |
| PLZP in mice has roles in T-lymphocyte proliferation, cytokine production, and hematopoietic stem cell homeostasis | Disruption of PLZP in mice leads to increased T-lymphocyte proliferation, cytokine production, and altered hematopoietic stem cell homeostasis.
Piazza F, Costoya JA, Merghoub T, Hobbs RM, Pandolfi PP., Free PMC Article | 01/21/2010 |