| Structural basis for the immune recognition and selectivity of the immune receptor PVRIG for ligand Nectin-2. | Structural basis for the immune recognition and selectivity of the immune receptor PVRIG for ligand Nectin-2.
Hu S, Han P, Wang M, Cao X, Liu H, Zhang S, Zhang S, Liu J, Han Y, Xiao J, Chen Q, Miao K, Qi J, Tan S, Gao GF, Wang H. | 08/1/2024 |
| Exercise-induced beta2-adrenergic Receptor Activation Enhances the Antileukemic Activity of Expanded gammadelta T-Cells via DNAM-1 Upregulation and PVR/Nectin-2 Recognition. | Exercise-induced β2-adrenergic Receptor Activation Enhances the Antileukemic Activity of Expanded γδ T-Cells via DNAM-1 Upregulation and PVR/Nectin-2 Recognition.
Baker FL, Smith KA, Mylabathula PL, Zúñiga TM, Diak DM, Batatinha H, Niemiro GM, Seckeler MD, Pedlar CR, O'Connor DP, Colombo J, Katsanis E, Simpson RJ., Free PMC Article | 07/15/2024 |
| PVRL2 Suppresses Antitumor Immunity through PVRIG- and TIGIT-independent Pathways. | PVRL2 Suppresses Antitumor Immunity through PVRIG- and TIGIT-independent Pathways.
Yang J, Wang L, Byrnes JR, Kirkemo LL, Driks H, Belair CD, Aguilar OA, Lanier LL, Wells JA, Fong L, Blelloch R., Free PMC Article | 05/28/2024 |
| CD112 Supports Lymphatic Migration of Human Dermal Dendritic Cells. | CD112 Supports Lymphatic Migration of Human Dermal Dendritic Cells.
Haghayegh Jahromi N, Gkountidi AO, Collado-Diaz V, Blatter K, Bauer A, Zambounis L, Medina-Sanchez JD, Russo E, Runge P, Restivo G, Gousopoulos E, Lindenblatt N, Levesque MP, Halin C., Free PMC Article | 03/15/2024 |
| The SNP rs6859 in NECTIN2 gene is associated with underlying heterogeneous trajectories of cognitive changes in older adults. | The SNP rs6859 in NECTIN2 gene is associated with underlying heterogeneous trajectories of cognitive changes in older adults.
Rajendrakumar AL, Arbeev KG, Bagley O, Yashin AI, Ukraintseva S, Alzheimer’s Disease Neuroimaging Initiative., Free PMC Article | 02/29/2024 |
| Single-cell RNA sequencing highlights the role of PVR/PVRL2 in the immunosuppressive tumour microenvironment in hepatocellular carcinoma. | Single-cell RNA sequencing highlights the role of PVR/PVRL2 in the immunosuppressive tumour microenvironment in hepatocellular carcinoma.
Li A, Ji B, Yang Y, Ye B, Zhu Q, Hu X, Liu Y, Zhou P, Liu J, Gao R, Zhou Q, Kang B, Jiang Y., Free PMC Article | 07/5/2023 |
| Relative Expression of BATF and CD112 in PBMC of Patients with Chronic Lymphocytic Leukemia. | Relative Expression of BATF and CD112 in PBMC of Patients with Chronic Lymphocytic Leukemia.
Najafi A, Sabaghi M, Asgarian-Omran H, Valadan R, Shekarriz R, Zaboli E, Janbabai G, Tehrani M., Free PMC Article | 07/5/2023 |
| Nectin2 influences cell apoptosis by regulating ANXA2 expression in neuroblastoma. | Nectin2 influences cell apoptosis by regulating ANXA2 expression in neuroblastoma.
Zhang S, Jiang C, Su Y, Gui J, Yue Z, Jian B, He S, Ma X., Free PMC Article | 05/23/2023 |
| Metabolic Overlap between Alzheimer's Disease and Metabolic Syndrome Identifies the PVRL2 Gene as a New Modulator of Diabetic Dyslipidemia. | Metabolic Overlap between Alzheimer's Disease and Metabolic Syndrome Identifies the PVRL2 Gene as a New Modulator of Diabetic Dyslipidemia.
Guardiola M, Muntané G, Martínez I, Martorell L, Girona J, Ibarretxe D, Plana N, Bullido MJ, Vilella E, Ribalta J., Free PMC Article | 05/3/2023 |
| Association and interaction of TOMM40 and PVRL2 with plasma amyloid-beta and Alzheimer's disease among Chinese older adults: a population-based study. | Association and interaction of TOMM40 and PVRL2 with plasma amyloid-β and Alzheimer's disease among Chinese older adults: a population-based study.
Liang X, Liu C, Liu K, Cong L, Wang Y, Liu R, Fa W, Tian N, Cheng Y, Wang N, Hou T, Du Y, Qiu C. | 04/30/2022 |
| Nectin-2 in general and in the brain. | Nectin-2 in general and in the brain.
Mizutani K, Miyata M, Shiotani H, Kameyama T, Takai Y. | 03/19/2022 |
| Nectin-2 Acts as a Viral Entry Mediated Molecule That Binds to Human Herpesvirus 6B Glycoprotein B. | Nectin-2 Acts as a Viral Entry Mediated Molecule That Binds to Human Herpesvirus 6B Glycoprotein B.
Ogawa H, Fujikura D, Namba H, Yamashita N, Honda T, Yamada M., Free PMC Article | 02/19/2022 |
| DNAM-1/CD226 is functionally expressed on acute myeloid leukemia (AML) cells and is associated with favorable prognosis. | DNAM-1/CD226 is functionally expressed on acute myeloid leukemia (AML) cells and is associated with favorable prognosis.
Chashchina A, Märklin M, Hinterleitner C, Salih HR, Heitmann JS, Klimovich B., Free PMC Article | 12/11/2021 |
| DNA methylation QTL analysis identifies new regulators of human longevity. | DNA methylation QTL analysis identifies new regulators of human longevity.
Szymczak S, Dose J, Torres GG, Heinsen FA, Venkatesh G, Datlinger P, Nygaard M, Mengel-From J, Flachsbart F, Klapper W, Christensen K, Lieb W, Schreiber S, Häsler R, Bock C, Franke A, Nebel A., Free PMC Article | 08/7/2021 |
| ubiquitination of Nectin2 promotes its degradation and is responsible for protein intracellular retention and inhibition of the ubiquitin pathway results in increased Nectin2 surface expression and enhances tumor cell susceptibility to NK cell cytotoxicity | The Ubiquitin-proteasome pathway regulates Nectin2/CD112 expression and impairs NK cell recognition and killing.
Molfetta R, Milito ND, Zitti B, Lecce M, Fionda C, Cippitelli M, Santoni A, Paolini R. | 05/30/2020 |
| we demonstrate that PVRIG and PVRL2 are expressed in human cancers and the PVRIG-PVRL2 and TIGIT-PVR pathways are nonredundant inhibitory signaling pathways. | PVRIG and PVRL2 Are Induced in Cancer and Inhibit CD8(+) T-cell Function.
Whelan S, Ophir E, Kotturi MF, Levy O, Ganguly S, Leung L, Vaknin I, Kumar S, Dassa L, Hansen K, Bernados D, Murter B, Soni A, Taube JM, Fader AN, Wang TL, Shih IM, White M, Pardoll DM, Liang SC., Free PMC Article | 04/11/2020 |
| Structural analysis of currently available homodimeric structures of both nectin-2 and N-cadherin followed by molecular docking as well as complementary mutagenesis studies revealed the binding interface of this novel interaction. | Molecular and structural bases of interaction between extracellular domains of nectin-2 and N-cadherin.
Duraivelan K, Basak AJ, Ghosh A, Samanta D. | 08/31/2019 |
| Nectin cell adhesion molecule 2 (Nectin-2) expression in ovarian cancer may support tumor cell adhesion, leading to growth and lymph node metastasis. | Nectin-2 in ovarian cancer: How is it expressed and what might be its functional role?
Bekes I, Löb S, Holzheu I, Janni W, Baumann L, Wöckel A, Wulff C., Free PMC Article | 06/29/2019 |
| Nectin-2 mutation in men with severe teratospermia | Detection of candidate nectin gene mutations in infertile men with severe teratospermia.
Bronson R, Mikhailik A, Schwedes J, Gnatenko D, Hatchwell E., Free PMC Article | 06/9/2018 |
| In the infection with 3 MLD50 (50 % mouse lethal dose), effective resistance was not observed in transgenic mice expressing nectin-2Ig. | Comparison of the antiviral potential among soluble forms of herpes simplex virus type-2 glycoprotein D receptors, herpes virus entry mediator A, nectin-1 and nectin-2, in transgenic mice.
Fujimoto Y, Tomioka Y, Ozaki K, Takeda K, Suyama H, Yamamoto S, Takakuwa H, Morimatsu M, Uede T, Ono E. | 09/23/2017 |
| Our data provide important structural and biochemical determinants responsible for the recognition of nectin-2 by TIGIT. | Structural, mutational and biophysical studies reveal a canonical mode of molecular recognition between immune receptor TIGIT and nectin-2.
Samanta D, Guo H, Rubinstein R, Ramagopal UA, Almo SC., Free PMC Article | 09/16/2017 |
| Chromosomal breakpoints involved the PVRR2 gene in 19q31 is associated with Diffuse Large B-Cell Lymphomas. | Novel IGH and MYC Translocation Partners in Diffuse Large B-Cell Lymphomas.
Otto C, Scholtysik R, Schmitz R, Kreuz M, Becher C, Hummel M, Rosenwald A, Trümper L, Klapper W, Siebert R, Küppers R, “Molecular Mechanisms in Malignant Lymphomas” Network Project. | 07/22/2017 |
| energetic basis for the TIGIT/nectin-2 interaction and revealed that an "aromatic key" of nectin-2 is critical for this interaction, whereas variations in the lock were tolerated. | Recognition of nectin-2 by the natural killer cell receptor T cell immunoglobulin and ITIM domain (TIGIT).
Deuss FA, Gully BS, Rossjohn J, Berry R., Free PMC Article | 07/15/2017 |
| PVRL2 is a plasma cholesterol-responsive gene acting at endothelial sites of vascular inflammation to regulate transendothelial migration of leukocytes. | Poliovirus Receptor-Related 2: A Cholesterol-Responsive Gene Affecting Atherosclerosis Development by Modulating Leukocyte Migration.
Rossignoli A, Shang MM, Gladh H, Moessinger C, Foroughi Asl H, Talukdar HA, Franzén O, Mueller S, Björkegren JL, Folestad E, Skogsberg J. | 06/24/2017 |
| Serum levels of nectin-2 may have diagnostic roles for colorectal cancer patients. | Serum nectin-2 levels are diagnostic and prognostic in patients with colorectal carcinoma.
Karabulut M, Gunaldi M, Alis H, Afsar CU, Karabulut S, Serilmez M, Akarsu C, Seyit H, Aykan NF. | 10/29/2016 |