| Prognostic Values Serum Cav-1 and NGB Levels in Early Neurological Deterioration After Intravenous Thrombolysis in Patients with Acute Ischemic Stroke. | Prognostic Values Serum Cav-1 and NGB Levels in Early Neurological Deterioration After Intravenous Thrombolysis in Patients with Acute Ischemic Stroke.
Zhang L, Wang C, Zhao M, Li X, Qu H, Xu J, Li D., Free PMC Article | 12/20/2023 |
| Neuroglobin inhibits pancreatic cancer proliferation and metastasis by targeting the GNAI1/EGFR/AKT/ERK signaling axis. | Neuroglobin inhibits pancreatic cancer proliferation and metastasis by targeting the GNAI1/EGFR/AKT/ERK signaling axis.
Wu F, He J, Deng Q, Chen J, Peng M, Xiao J, Zeng Y, Yi L, Li Z, Tian R, Jiang Z. | 06/12/2023 |
| Overexpression of Neuroglobin Promotes Energy Metabolism and Autophagy Induction in Human Neuroblastoma SH-SY5Y Cells. | Overexpression of Neuroglobin Promotes Energy Metabolism and Autophagy Induction in Human Neuroblastoma SH-SY5Y Cells.
Manganelli V, Salvatori I, Costanzo M, Capozzi A, Caissutti D, Caterino M, Valle C, Ferri A, Sorice M, Ruoppolo M, Garofalo T, Misasi R., Free PMC Article | 01/22/2022 |
| Neuroglobin: A New Possible Marker of Estrogen-Responsive Breast Cancer. | Neuroglobin: A New Possible Marker of Estrogen-Responsive Breast Cancer.
Solar Fernandez V, Fiocchetti M, Cipolletti M, Segatto M, Cercola P, Massari A, Ghinassi S, Cavaliere F, Marino M., Free PMC Article | 11/22/2021 |
| Conversion of Human Neuroglobin into a Multifunctional Peroxidase by Rational Design. | Conversion of Human Neuroglobin into a Multifunctional Peroxidase by Rational Design.
Chen SF, Liu XC, Xu JK, Li L, Lang JJ, Wen GB, Lin YW. | 06/26/2021 |
| Proteomic and Bioinformatic Investigation of Altered Pathways in Neuroglobin-Deficient Breast Cancer Cells. | Proteomic and Bioinformatic Investigation of Altered Pathways in Neuroglobin-Deficient Breast Cancer Cells.
Costanzo M, Fiocchetti M, Ascenzi P, Marino M, Caterino M, Ruoppolo M., Free PMC Article | 05/22/2021 |
| Neuroglobin and mitochondria: The impact on neurodegenerative diseases. | Neuroglobin and mitochondria: The impact on neurodegenerative diseases.
Fiocchetti M, Cracco P, Montalesi E, Solar Fernandez V, Stuart JA, Marino M. | 04/24/2021 |
| Early stage neuroglobin level as a predictor of delayed cerebral ischemia in patients with aneurysmal subarachnoid hemorrhage. | Early stage neuroglobin level as a predictor of delayed cerebral ischemia in patients with aneurysmal subarachnoid hemorrhage.
Ding C, Kang D, Chen P, Wang Z, Lin Y, Wang D, Lin Z, Gu J., Free PMC Article | 03/13/2021 |
| A neuroglobin-based high-affinity ligand trap reverses carbon monoxide-induced mitochondrial poisoning. | A neuroglobin-based high-affinity ligand trap reverses carbon monoxide-induced mitochondrial poisoning.
Rose JJ, Bocian KA, Xu Q, Wang L, DeMartino AW, Chen X, Corey CG, Guimarães DA, Azarov I, Huang XN, Tong Q, Guo L, Nouraie M, McTiernan CF, O'Donnell CP, Tejero J, Shiva S, Gladwin MT., Free PMC Article | 12/26/2020 |
| Neuroglobin As Key Mediator in the 17beta-Estradiol-Induced Antioxidant Cell Response to Oxidative Stress. | Neuroglobin As Key Mediator in the 17β-Estradiol-Induced Antioxidant Cell Response to Oxidative Stress.
Solar Fernandez V, Cipolletti M, Ascenzi P, Marino M, Fiocchetti M. | 10/10/2020 |
| Negative surface charges in neuroglobin modulate the interaction with cytochrome c. | Negative surface charges in neuroglobin modulate the interaction with cytochrome c.
Tejero J. | 09/12/2020 |
| This study contributes to the elucidation of involvement of neuroglobin in cellular mechanisms that provide neuroprotection and the upkeep of homeostasis. | Connecting the Dots in the Neuroglobin-Protein Interaction Network of an Unstressed and Ferroptotic Cell Death Neuroblastoma Model.
Van Acker ZP, Van Raemdonck GA, Logie E, Van Acker SI, Baggerman G, Vanden Berghe W, Ponsaerts P, Dewilde S., Free PMC Article | 05/16/2020 |
| Ngb may be a potential biomarker for reflecting brain tissue oxygen tension, brain metabolism, and functional outcome in severe aneurysmal subarachnoid hemorrhage patients and merits further study in the context of aneurysmal subarachnoid hemorrhage | Serum Ngb (Neuroglobin) Is Associated With Brain Metabolism and Functional Outcome of Aneurysmal Subarachnoid Hemorrhage.
Ding CY, Kang DZ, Wang ZL, Lin YX, Jiang CZ, Yu LH, Wang DL, Lin ZY, Gu JJ. | 02/22/2020 |
| Both H64V and A90P neuroglobin variants, which affect the haem coordination, seemed to be important to haem and protein secondary structure stabilities whereas F106L mutation did not affect those properties. | Impact of A90P, F106L and H64V mutations on neuroglobin stability and ligand binding kinetics.
André E, Derrien V, Sebban P, Assrir N, Lescop E, Bernad S. | 11/30/2019 |
| Using computational modeling and surface plasmon resonance experiments to obtain and characterize the complex formation. study identified important residues involved in the complex formation between oxidized human Ngb and Cyt c, including K72 in Cyt c, which is otherwise known to interact with the apoptotic protease-activation factor-1. | Investigating molecular interactions between oxidized neuroglobin and cytochrome c.
Tiwari PB, Chapagain PP, Üren A., Free PMC Article | 11/30/2019 |
| Ngb promotes axon regeneration via oxygen-Ngb-p38-GAP43 signaling during ischemia/reperfusion. | Neuroglobin boosts axon regeneration during ischemic reperfusion via p38 binding and activation depending on oxygen signal.
Xiong XX, Pan F, Chen RQ, Hu DX, Qiu XY, Li CY, Xie XQ, Tian B, Chen XQ., Free PMC Article | 08/3/2019 |
| Neuroglobin was positively correlated with neuron-specific enolase and duration of hypoglycemia (r=0.922 and 0.929 respectively | [Clinical value of serum neuroglobin in evaluating hypoglycemic brain injury in neonates].
Jiang FY, Liu HP, Chen LT, Song ZR, Xu S, Guo YX, Zhou L, Wang YK, Shu GH., Free PMC Article | 07/13/2019 |
| Neuroglobin could be used as biomarker for glaucoma diagnosis. | Plasmatic neuroglobin during the primitive open-angle glaucoma.
Ovono Abessolo F, Nnang JF, Aki TM, Matsanga Amoussa MDE, Ngou-Milama E. | 06/29/2019 |
| these results underline the 17beta-estradiol triggered pathways in E2-responsive breast cancer cells that involve NGB as a compensatory protein devoted to cancer cell survival. | Dissecting the 17β-estradiol pathways necessary for neuroglobin anti-apoptotic activity in breast cancer.
Fiocchetti M, Cipolletti M, Ascenzi P, Marino M. | 05/18/2019 |
| Neuroglobin correlates with cryptochrome-1 in obstructive sleep apnea with primary aldosteronism | Neuroglobin correlates with cryptochrome-1 in obstructive sleep apnea with primary aldosteronism.
Tedjasukmana R, Purba JS, Wanandi SI, Suyatna FD., Free PMC Article | 03/2/2019 |
| Neuroglobin functions as an important modulator of the Wnt/beta-Catenin and NFkappaB signaling pathway through direct interaction with Dishevelled-1. | Neuroglobin Regulates Wnt/β-Catenin and NFκB Signaling Pathway through Dvl1.
Xun Y, Li Z, Tang Y, Yang M, Long S, Shu P, Li J, Xiao Y, Tang F, Wei C, Liu N, Xiang S., Free PMC Article | 10/27/2018 |
| This study demonstrated that serum NGB levels were significantly associated with 6-month unfavorable outcomes, indicating that Ngb can play a role in predicting 6-month unfavorable outcomes. | Neuroglobin as a Novel Biomarker for Predicting Poor Outcomes in Aneurysmal Subarachnoid Hemorrhage.
Cai H, Zheng S, Cai B, Yao P, Ding C, Chen F, Kang D. | 10/13/2018 |
| Results show that the expression of NGB in glioma is grade related and is negatively regulated at the transcriptional level by PPARgamma suggesting an important role of NGB in glioma progression. | Tumor grade related expression of neuroglobin is negatively regulated by PPARγ and confers antioxidant activity in glioma progression.
Hu J, Cao X, Pang D, Luo Q, Zou Y, Feng B, Li L, Chen Z, Huang C., Free PMC Article | 04/7/2018 |
| The authors demonstrate that Glu53, Glu60, and Glu118 of human Ngb are crucial for both the neuroprotective activity and interaction with Gi. Moreover, they show that Lys46, Lys70, Arg208, Lys209, and Lys210 residues of Gi are important for binding to human Ngb. | Identification of residues crucial for the interaction between human neuroglobin and the α-subunit of heterotrimeric Gi protein.
Takahashi N, Wakasugi K., Free PMC Article | 01/20/2018 |
| Ngb-H64Q-CCC binds CO about 500 times more strongly than hemoglobin, which could be useful in detecting and eliminating carbon monoxide poisoning | Five-coordinate H64Q neuroglobin as a ligand-trap antidote for carbon monoxide poisoning.
Azarov I, Wang L, Rose JJ, Xu Q, Huang XN, Belanger A, Wang Y, Guo L, Liu C, Ucer KB, McTiernan CF, O'Donnell CP, Shiva S, Tejero J, Kim-Shapiro DB, Gladwin MT., Free PMC Article | 12/30/2017 |