| Protein tyrosine phosphatase receptor type O serves as a key regulator of insulin resistance-induced alpha-synuclein aggregation in Parkinson's disease. | Protein tyrosine phosphatase receptor type O serves as a key regulator of insulin resistance-induced α-synuclein aggregation in Parkinson's disease.
Tan S, Chi H, Wang P, Zhao R, Zhang Q, Gao Z, Xue H, Tang Q, Li G., Free PMC Article | 11/7/2024 |
| Protein tyrosine phosphatase PTPRO represses lung adenocarcinoma progression by inducing mitochondria-dependent apoptosis and restraining tumor metastasis. | Protein tyrosine phosphatase PTPRO represses lung adenocarcinoma progression by inducing mitochondria-dependent apoptosis and restraining tumor metastasis.
Dai Y, Shi S, Liu H, Zhou H, Ding W, Liu C, Jin L, Xie W, Kong H, Zhang Q., Free PMC Article | 01/26/2024 |
| PTPRO-related CD8(+) T-cell signatures predict prognosis and immunotherapy response in patients with breast cancer. | PTPRO-related CD8(+) T-cell signatures predict prognosis and immunotherapy response in patients with breast cancer.
Dong H, Xie C, Yao Z, Zhao R, Lin Y, Luo Y, Chen S, Qin Y, Chen Y, Zhang H., Free PMC Article | 09/3/2022 |
| PTPRO activates TLR4/NF-kappaB signaling to intensify lipopolysaccharide-induced pneumonia cell injury. | PTPRO activates TLR4/NF-κB signaling to intensify lipopolysaccharide-induced pneumonia cell injury.
Chen Y, Sun B. | 05/14/2022 |
| MiR-6869-5p Induces M2 Polarization by Regulating PTPRO in Gestational Diabetes Mellitus. | MiR-6869-5p Induces M2 Polarization by Regulating PTPRO in Gestational Diabetes Mellitus.
Wang P, Ma Z, Wang Z, Wang X, Zhao G, Wang Z., Free PMC Article | 04/9/2022 |
| Protein tyrosine phosphatase receptor type O (PTPRO) knockdown enhances the proliferative, invasive and angiogenic activities of trophoblast cells by suppressing ER resident protein 44 (ERp44) expression in preeclampsia. | Protein tyrosine phosphatase receptor type O (PTPRO) knockdown enhances the proliferative, invasive and angiogenic activities of trophoblast cells by suppressing ER resident protein 44 (ERp44) expression in preeclampsia.
Yang Y, Qiu X, Wang F., Free PMC Article | 02/19/2022 |
| PTPRO exaggerates inflammation in ulcerative colitis through TLR4/NF-kappaB pathway. | PTPRO exaggerates inflammation in ulcerative colitis through TLR4/NF-κB pathway.
Zhao J, Yan S, Zhu X, Bai W, Li J, Liang C. | 05/15/2021 |
| IL-6 promotes PD-L1 expression in monocytes and macrophages by decreasing protein tyrosine phosphatase receptor type O expression in human hepatocellular carcinoma. | IL-6 promotes PD-L1 expression in monocytes and macrophages by decreasing protein tyrosine phosphatase receptor type O expression in human hepatocellular carcinoma.
Zhang W, Liu Y, Yan Z, Yang H, Sun W, Yao Y, Chen Y, Jiang R., Free PMC Article | 03/20/2021 |
| LncRNA HULC promotes lung squamous cell carcinoma by regulating PTPRO via NF-kappaB. | LncRNA HULC promotes lung squamous cell carcinoma by regulating PTPRO via NF-κB.
Xu Y, Li J, Wang P, Zhang Z, Wang X. | 09/19/2020 |
| PTPRO was significantly upregulated and negatively associated with miR-548c-5p in placental mononuclear cells in patients with preeclampsia. | MiRNA-548c-5p downregulates inflammatory response in preeclampsia via targeting PTPRO.
Wang Z, Wang P, Wang Z, Qin Z, Xiu X, Xu D, Zhang X, Wang Y. | 05/23/2020 |
| the present study demonstrated that PTPRO inhibits tumor growth in vitro and in vivo, indicating the tumor suppressive function of PTPRO in LSCC. This study highlights PTPRO as an epigenetically silenced gene, and a candidate tumor-suppressor of LSCC. | Epigenetically silenced PTPRO functions as a prognostic marker and tumor suppressor in human lung squamous cell carcinoma.
Ming F, Sun Q., Free PMC Article | 03/31/2018 |
| Single nucleotide polymorphism in PTPRO gene is associated with Acute Renal Graft Rejection. | Genome-Wide Association Study of Acute Renal Graft Rejection.
Ghisdal L, Baron C, Lebranchu Y, Viklický O, Konarikova A, Naesens M, Kuypers D, Dinic M, Alamartine E, Touchard G, Antoine T, Essig M, Rerolle JP, Merville P, Taupin JL, Le Meur Y, Grall-Jezequel A, Glowacki F, Noël C, Legendre C, Anglicheau D, Broeders N, Coppieters W, Docampo E, Georges M, Ajarchouh Z, Massart A, Racapé J, Abramowicz D, Abramowicz M., Free PMC Article | 12/16/2017 |
| Results provide evidence that PTPRO inhibits ERBB2-driven breast cancer through dephosphorylation leading to dual effects of ERBB2 signaling suppression and endosomal internalization of ERBB2. | PTPRO represses ERBB2-driven breast oncogenesis by dephosphorylation and endosomal internalization of ERBB2.
Dong H, Ma L, Gan J, Lin W, Chen C, Yao Z, Du L, Zheng L, Ke C, Huang X, Song H, Kumar R, Yeung SC, Zhang H., Free PMC Article | 09/9/2017 |
| PTPRO is a novel candidate gene in emphysema with severe airflow obstruction. | Extreme Trait Whole-Genome Sequencing Identifies PTPRO as a Novel Candidate Gene in Emphysema with Severe Airflow Obstruction.
Radder JE, Zhang Y, Gregory AD, Yu S, Kelly NJ, Leader JK, Kaminski N, Sciurba FC, Shapiro SD., Free PMC Article | 08/5/2017 |
| PTPRO truncated serves as an important tumor suppressor in hepatocellular carcinoma microenvironment. | PTPROt maintains T cell immunity in the microenvironment of hepatocellular carcinoma.
Hou J, Deng L, Zhuo H, Lin Z, Chen Y, Jiang R, Chen D, Zhang X, Huang X, Sun B. | 02/20/2016 |
| These observations confirm that PTPRO plays a critical role in liver fibrogenesis by affecting PDGF signaling in HSC activation and might be developed into a feasible therapeutic approach for the treatment of chronic fibrotic liver diseases. | PTPRO-associated hepatic stellate cell activation plays a critical role in liver fibrosis.
Zhang X, Tan Z, Wang Y, Tang J, Jiang R, Hou J, Zhuo H, Wang X, Ji J, Qin X, Sun B. | 11/28/2015 |
| The optimal pH value of PTP-oc is approximately 7.0. | Expression, purification, and characterization of human osteoclastic protein-tyrosine phosphatase catalytic domain in Escherichia coli.
Jiang H, Sui Y, Cui Y, Lin P, Li W, Xing S, Wang D, Hu M, Fu X. | 09/5/2015 |
| Loss of PTPRO expression is associated with chronic lymphocytic leukemia. | PTPROt-mediated regulation of p53/Foxm1 suppresses leukemic phenotype in a CLL mouse model.
Motiwala T, Kutay H, Zanesi N, Frissora FW, Mo X, Muthusamy N, Jacob ST., Free PMC Article | 08/29/2015 |
| Results highlight the PTPRO contribution in negative regulation of SRC/EGFR signaling in colon cancer. | The tyrosine phosphatase PTPRO sensitizes colon cancer cells to anti-EGFR therapy through activation of SRC-mediated EGFR signaling.
Asbagh LA, Vazquez I, Vecchione L, Budinska E, De Vriendt V, Baietti MF, Steklov M, Jacobs B, Hoe N, Singh S, Imjeti NS, Zimmermann P, Sablina A, Tejpar S., Free PMC Article | 08/8/2015 |
| PTPRO was drastically decreased in fulminant hepatitis, and this was associated with enhanced beta-catenin accumulation but reduced IFN-gamma secretion. | Survival and inflammation promotion effect of PTPRO in fulminant hepatitis is associated with NF-κB activation.
Jiang R, Chen D, Hou J, Tan Z, Wang Y, Huang X, Wang X, Sun B. | 02/28/2015 |
| Our study suggests an interesting PTPRO/TLR4/NF-kappaB signaling feedback loop in Hhepatocellular carcinomcarcinogenesis and progression | Interaction of PTPRO and TLR4 signaling in hepatocellular carcinoma.
Xu D, Wang X, Yan S, Yin Y, Hou J, Wang X, Sun B. | 01/10/2015 |
| PTPRO level was decreased in the early phase but reversed in the late phase of hepatic ischemia reperfusion injury. | PTPRO plays a dual role in hepatic ischemia reperfusion injury through feedback activation of NF-κB.
Hou J, Xia Y, Jiang R, Chen D, Xu J, Deng L, Huang X, Wang X, Sun B. | 09/27/2014 |
| PTPRO methylation is associated with poor survival only in HER2-positive patients. | PTPRO promoter methylation is predictive of poorer outcome for HER2-positive breast cancer: indication for personalized therapy.
Huang YT, Li FF, Ke C, Li Z, Li ZT, Zou XF, Zheng XX, Chen YP, Zhang H., Free PMC Article | 07/12/2014 |
| methylation and downregulation of PTPRO in a subset of primary human HCC and establish VCP as a novel functionally important substrate of this tyrosine phosphatase that could be a potential molecular target for HCC therapy. | Methylation of the PTPRO gene in human hepatocellular carcinoma and identification of VCP as its substrate.
Hsu SH, Motiwala T, Roy S, Claus R, Mustafa M, Plass C, Freitas MA, Ghoshal K, Jacob ST., Free PMC Article | 11/2/2013 |
| ErbB2 is a direct substrate of PTPRO and decreased expression of PTPRO predicts poor prognosis for ErbB2-positive breast cancer patients. | Expression profiling during mammary epithelial cell three-dimensional morphogenesis identifies PTPRO as a novel regulator of morphogenesis and ErbB2-mediated transformation.
Yu M, Lin G, Arshadi N, Kalatskaya I, Xue B, Haider S, Nguyen F, Boutros PC, Elson A, Muthuswamy LB, Tonks NK, Muthuswamy SK., Free PMC Article | 12/8/2012 |