| Phagocytosis mediated by the human granulocyte receptor CEACAM3 is limited by the receptor-type protein tyrosine phosphatase PTPRJ. | Phagocytosis mediated by the human granulocyte receptor CEACAM3 is limited by the receptor-type protein tyrosine phosphatase PTPRJ.
Goob G, Adrian J, Cossu C, Hauck CR., Free PMC Article | 10/22/2022 |
| The effects of CD148 Q276P/R326Q polymorphisms in A431D epidermoid cancer cell proliferation and epidermal growth factor receptor signaling. | The effects of CD148 Q276P/R326Q polymorphisms in A431D epidermoid cancer cell proliferation and epidermal growth factor receptor signaling.
He L, Takahashi K, Pasic L, Narui C, Ellinger P, Grundmann M, Takahashi T., Free PMC Article | 09/24/2022 |
| PTPRJ is downregulated in cervical squamous cell carcinoma. | PTPRJ is downregulated in cervical squamous cell carcinoma.
Roychowdhury A, Basu M, Pal D, Dutta P, Samadder S, Mondal R, Roy AK, Roychoudhury S, Panda CK. | 07/9/2022 |
| The relative expression levels of CD148 and CD180 on clonal B cells and CD148/CD180 median fluorescence intensity ratios are useful in the characterization of mature B cell lymphoid neoplasms infiltrating blood and bone marrow - Results from a single centre pilot study. | The relative expression levels of CD148 and CD180 on clonal B cells and CD148/CD180 median fluorescence intensity ratios are useful in the characterization of mature B cell lymphoid neoplasms infiltrating blood and bone marrow - Results from a single centre pilot study.
Gautam A, Sreedharanunni S, Sachdeva MUS, Rana S, Kashyap D, Bose P, Bal A, Prakash G, Malhotra P, Das R, Varma N. | 12/4/2021 |
| CD148 Deficiency in Fibroblasts Promotes the Development of Pulmonary Fibrosis. | CD148 Deficiency in Fibroblasts Promotes the Development of Pulmonary Fibrosis.
Tsoyi K, Liang X, De Rossi G, Ryter SW, Xiong K, Chu SG, Liu X, Ith B, Celada LJ, Romero F, Robertson MJ, Esposito AJ, Poli S, El-Chemaly S, Perrella MA, Shi Y, Whiteford J, Rosas IO., Free PMC Article | 09/25/2021 |
| Loss of PTPRJ/DEP-1 enhances NF2/Merlin-dependent meningioma development. | Loss of PTPRJ/DEP-1 enhances NF2/Merlin-dependent meningioma development.
Waldt N, Scharnetzki D, Kesseler C, Kirches E, Stroscher N, Böhmer FD, Mawrin C. | 03/20/2021 |
| Loss-of-function mutations in PTPRJ gene is associated with a new form of inherited thrombocytopenia. | Loss-of-function mutations in PTPRJ cause a new form of inherited thrombocytopenia.
Marconi C, Di Buduo CA, LeVine K, Barozzi S, Faleschini M, Bozzi V, Palombo F, McKinstry S, Lassandro G, Giordano P, Noris P, Balduini CL, Savoia A, Balduini A, Pippucci T, Seri M, Katsanis N, Pecci A. | 11/9/2019 |
| results support a scenario by which T cell-derived microvesicles act as intercellular carriers of functional miR-4443, which might exert heterotypic regulation of PTPRJ gene expression in mast cells | MicroRNA-4443 regulates mast cell activation by T cell-derived microvesicles.
Shefler I, Salamon P, Levi-Schaffer F, Mor A, Hershko AY, Mekori YA. | 08/3/2019 |
| Arg326Gln polymorphism is associated with colorectal cancer. | Meta-analysis of association between Arg326Gln (rs1503185) and Gln276Pro (rs1566734) polymorphisms of PTPRJ gene and cancer risk.
Laczmanska I, Sasiadek MM., Free PMC Article | 03/16/2019 |
| PTPRJ variant of uncertain significance in candidate gene was identified in Familial Mitral Valve Prolapse. | Genetic Complexity of Mitral Valve Prolapse Revealed by Clinical and Genetic Evaluation of a Large Family.
Haskell GT, Jensen BC, Skrzynia C, Pulikkotil T, Tilley CR, Lu Y, Marchuk DS, Ann Samsa L, Wilhelmsen KC, Lange E, Patterson C, Evans JP, Berg JS., Free PMC Article | 09/1/2018 |
| Short variant of the receptor protein phosphatase PTPRJ generated by an alternative splicing promotes angiogenesis in HUVEC cells and tumor angiogenesis. | A novel splice variant of the protein tyrosine phosphatase PTPRJ that encodes for a soluble protein involved in angiogenesis.
Bilotta A, Dattilo V, D'Agostino S, Belviso S, Scalise S, Bilotta M, Gaudio E, Paduano F, Perrotti N, Florio T, Fusco A, Iuliano R, Trapasso F., Free PMC Article | 02/24/2018 |
| study reveals the crucial role of miR-155/PTPRJ/AKT axis in proliferation and migration of colorectal cancer cells and suggests a therapeutic potential of PTPRJ. | Tumor Suppressor PTPRJ Is a Target of miR-155 in Colorectal Cancer.
Zhang XF, Tu R, Li K, Ye P, Cui X. | 12/23/2017 |
| Authors demonstrate that mtp53 prevents the COP1/DET1 complex from ubiquitinating ETS2 and thereby marking it for destruction. Authors show that mtp53 destabilizes DET1 and also disrupts the DET1/ETS2 complex thereby preventing ETS2 degradation. | Mutant p53 protects ETS2 from non-canonical COP1/DET1 dependent degradation.
Carrero ZI, Kollareddy M, Chauhan KM, Ramakrishnan G, Martinez LA., Free PMC Article | 12/23/2017 |
| These data support that PTPN22 1858C/T, PTPRJ 2965C/G and 1176 A/C polymorphisms and ACP1 A, B and C alleles are not associated with a higher risk of immune thrombocytopenia P in adults. | No impact of PTPN22, PTPRJ and ACP1 genes polymorphisms on the risk of immune thrombocytopenia in French adult patients.
Lioger B, Rollin J, Vayne C, Perret-Gallix K, Pouplard C, Godeau B, Michel M, Gruel Y. | 04/15/2017 |
| Loss of PTPRJ expression may predict an aggressive clinical course in ESCC patients. | Loss of Protein Tyrosine Phosphatase Receptor J Expression Predicts an Aggressive Clinical Course in Patients with Esophageal Squamous Cell Carcinoma.
Qiao D, Li M, Pu J, Wang W, Zhu W, Liu H. | 03/18/2017 |
| The strongest association with frailty was observed in the Protein Tyrosine Phosphatase, Receptor type, J (PTPRJ) (rs1566729, P = 0.001372, beta = 0.09397) gene. | Proinflammatory genotype is associated with the frailty phenotype in the English Longitudinal Study of Ageing.
Mekli K, Nazroo JY, Marshall AD, Kumari M, Pendleton N., Free PMC Article | 12/17/2016 |
| the combination of CD200 and CD148 may have a potential differential diagnostic value in leukemic B-CLPDs, especially between CLL and MCL. | Expression patterns of CD200 and CD148 in leukemic B-cell chronic lymphoproliferative disorders and their potential value in differential diagnosis.
Fan L, Miao Y, Wu YJ, Wang Y, Guo R, Wang L, Shen AL, Chen YY, Xu W, Li JY. | 09/24/2016 |
| These results demonstrated Ptprj as a physiological enzyme that attenuates insulin signalling in vivo, and indicate that an inhibitor of Ptprj may be an insulin-sensitizing agent. | The R3 receptor-like protein tyrosine phosphatase subfamily inhibits insulin signalling by dephosphorylating the insulin receptor at specific sites.
Shintani T, Higashi S, Takeuchi Y, Gaudio E, Trapasso F, Fusco A, Noda M. | 06/28/2016 |
| CD148 tyrosine phosphatase promotes e-cadherin cell adhesion. | CD148 tyrosine phosphatase promotes cadherin cell adhesion.
Takahashi K, Matafonov A, Sumarriva K, Ito H, Lauhan C, Zemel D, Tsuboi N, Chen J, Reynolds A, Takahashi T., Free PMC Article | 04/2/2016 |
| The studies suggest induction of MMP-9 expression promoted by DEP-1 deficiency. | Deficiency of the protein-tyrosine phosphatase DEP-1/PTPRJ promotes matrix metalloproteinase-9 expression in meningioma cells.
Petermann A, Stampnik Y, Cui Y, Morrison H, Pachow D, Kliese N, Mawrin C, Böhmer FD. | 02/6/2016 |
| Moderate expression of DEP-1 was associated with the increased relapse. | The protein tyrosine phosphatase DEP-1/PTPRJ promotes breast cancer cell invasion and metastasis.
Spring K, Fournier P, Lapointe L, Chabot C, Roussy J, Pommey S, Stagg J, Royal I. | 02/6/2016 |
| C33A cells lacking PTPRJ had increased cell viability, growth, migration, G1-S transition, and 5-FU resistance. PTPRJ negatively regulated the JAK1/STAT3 pathway by decreasing phosphorylation levels of JAK1 and STAT3 and expression of downstream factors. | Blockage of PTPRJ promotes cell growth and resistance to 5-FU through activation of JAK1/STAT3 in the cervical carcinoma cell line C33A.
Yan CM, Zhao YL, Cai HY, Miao GY, Ma W. | 01/30/2016 |
| The expression profiles of DEP1 and B2MG correlate with increased cell senescence and survival in breast cancer. | Characterization of novel markers of senescence and their prognostic potential in cancer.
Althubiti M, Lezina L, Carrera S, Jukes-Jones R, Giblett SM, Antonov A, Barlev N, Saldanha GS, Pritchard CA, Cain K, Macip S., Free PMC Article | 07/4/2015 |
| Phosphorylation of T1318 is part of a regulatory mechanism that channels the activity of DEP-1 towards Src to allow its optimal activation and the promotion of endothelial cell permeability. | Phosphorylation of DEP-1/PTPRJ on threonine 1318 regulates Src activation and endothelial cell permeability induced by vascular endothelial growth factor.
Spring K, Lapointe L, Caron C, Langlois S, Royal I. | 11/29/2014 |
| Data indicate that CD148 is upregulated in macrophages and T cells in rheumatoid arthritis (RA) samples, and its activity is enhanced by treatment with tumour necrosis factor alpha (TNFalpha), and reduced by synovial fluid or oxidising conditions. | Differential expression of CD148 on leukocyte subsets in inflammatory arthritis.
Dave RK, Naylor AJ, Young SP, Bayley R, Hardie DL, Haworth O, Rider DA, Cook AD, Buckley CD, Kellie S., Free PMC Article | 08/9/2014 |