| Long Noncoding RNAs PTPRG Antisense RNA 1 Targets Cyclin D1 to Facilitate Cell Proliferation in Lung Adenocarcinoma. | Long Noncoding RNAs PTPRG Antisense RNA 1 Targets Cyclin D1 to Facilitate Cell Proliferation in Lung Adenocarcinoma.
Xue Y, Diao M, Lyu J, Li K, He L, Chen J, Li X. | 10/25/2024 |
| The EGFR phosphatase RPTPgamma is a redox-regulated suppressor of promigratory signaling. | The EGFR phosphatase RPTPγ is a redox-regulated suppressor of promigratory signaling.
Joshi MS, Stanoev A, Huebinger J, Soetje B, Zorina V, Roßmannek L, Michel K, Müller SA, Bastiaens PI., Free PMC Article | 05/17/2023 |
| Loss of RPTPgamma primes breast tissue for acid extrusion, promotes malignant transformation and results in early tumour recurrence and shortened survival. | Loss of RPTPγ primes breast tissue for acid extrusion, promotes malignant transformation and results in early tumour recurrence and shortened survival.
Sloth RA, Axelsen TV, Espejo MS, Toft NJ, Voss NCS, Burton M, Thomassen M, Vahl P, Boedtkjer E., Free PMC Article | 10/8/2022 |
| Gene Expression Landscape of Chronic Myeloid Leukemia K562 Cells Overexpressing the Tumor Suppressor Gene PTPRG. | Gene Expression Landscape of Chronic Myeloid Leukemia K562 Cells Overexpressing the Tumor Suppressor Gene PTPRG.
Lombardi G, Latorre RV, Mosca A, Calvanese D, Tomasello L, Boni C, Ferracin M, Negrini M, Dewik NA, Yassin M, Ismail MA, Carpentieri B, Sorio C, Lecca P., Free PMC Article | 10/1/2022 |
| A Comprehensive Review of Receptor-Type Tyrosine-Protein Phosphatase Gamma (PTPRG) Role in Health and Non-Neoplastic Disease. | A Comprehensive Review of Receptor-Type Tyrosine-Protein Phosphatase Gamma (PTPRG) Role in Health and Non-Neoplastic Disease.
Boni C, Laudanna C, Sorio C., Free PMC Article | 04/2/2022 |
| Description of PTPRG genetic variants identified in a cohort of Chronic Myeloid Leukemia patients and their ability to influence response to Tyrosine kinase Inhibitors. | Description of PTPRG genetic variants identified in a cohort of Chronic Myeloid Leukemia patients and their ability to influence response to Tyrosine kinase Inhibitors.
Ismail MA, Nasrallah GK, Monne M, AlSayab A, Yassin MA, Varadharaj G, Younes S, Sorio C, Cook R, Modjtahedi H, Al-Dewik NI. | 02/12/2022 |
| Predictive value of tyrosine phosphatase receptor gamma for the response to treatment tyrosine kinase inhibitors in chronic myeloid leukemia patients. | Predictive value of tyrosine phosphatase receptor gamma for the response to treatment tyrosine kinase inhibitors in chronic myeloid leukemia patients.
Ismail MA, Vezzalini M, Morsi H, Abujaber A, Al Sayab A, Siveen K, Yassin MA, Monne M, Samara M, Cook R, Sorio C, Modjtahedi H, Al-Dewik NI., Free PMC Article | 11/22/2021 |
| Activation of Protein Tyrosine Phosphatase Receptor Type gamma Suppresses Mechanisms of Adhesion and Survival in Chronic Lymphocytic Leukemia Cells. | Activation of Protein Tyrosine Phosphatase Receptor Type γ Suppresses Mechanisms of Adhesion and Survival in Chronic Lymphocytic Leukemia Cells.
Montresor A, Toffali L, Fumagalli L, Constantin G, Rigo A, Ferrarini I, Vinante F, Laudanna C. | 10/30/2021 |
| Aberrant DNA methylation of PTPRG as one possible mechanism of its under-expression in CML patients in the State of Qatar. | Aberrant DNA methylation of PTPRG as one possible mechanism of its under-expression in CML patients in the State of Qatar.
Ismail MA, Samara M, Al Sayab A, Alsharshani M, Yassin MA, Varadharaj G, Vezzalini M, Tomasello L, Monne M, Morsi H, Qoronfleh MW, Zayed H, Cook R, Sorio C, Modjtahedi H, Al-Dewik NI., Free PMC Article | 06/5/2021 |
| PTPRG is an ischemia risk locus essential for HCO3(-)-dependent regulation of endothelial function and tissue perfusion. | PTPRG is an ischemia risk locus essential for HCO(3)(-)-dependent regulation of endothelial function and tissue perfusion.
Hansen KB, Staehr C, Rohde PD, Homilius C, Kim S, Nyegaard M, Matchkov VV, Boedtkjer E., Free PMC Article | 02/27/2021 |
| Regulative Loop between beta-catenin and Protein Tyrosine Receptor Type gamma in Chronic Myeloid Leukemia. | Regulative Loop between β-catenin and Protein Tyrosine Receptor Type γ in Chronic Myeloid Leukemia.
Tomasello L, Vezzalini M, Boni C, Bonifacio M, Scaffidi L, Yassin M, Al-Dewik N, Takam Kamga P, Krampera M, Sorio C., Free PMC Article | 12/19/2020 |
| cMras was a sponge of miRNA-567 and released its direct target, PTPRG. cMras overexpression decreased miR-567 expression and subsequently increased PTPRG expression, while increased miRNA-567 expression blocked the effects induced by cMras. Moreover, PTPRG was downregulated in lung adenocarcinoma and patients with low PTPRG expression exhibited significantly poor prognosis. | Circular RNA cMras inhibits lung adenocarcinoma progression via modulating miR-567/PTPRG regulatory pathway.
Yu C, Tian F, Liu J, Su M, Wu M, Zhu X, Qian W., Free PMC Article | 06/22/2019 |
| OPCML and PTPRG, coordinate to repress AXL-dependent oncogenic signalling. | The tumour suppressor OPCML promotes AXL inactivation by the phosphatase PTPRG in ovarian cancer.
Antony J, Zanini E, Kelly Z, Tan TZ, Karali E, Alomary M, Jung Y, Nixon K, Cunnea P, Fotopoulou C, Paterson A, Roy-Nawathe S, Mills GB, Huang RY, Thiery JP, Gabra H, Recchi C., Free PMC Article | 05/18/2019 |
| PTPRG and FGFR1 interact and colocalize at the plasma membrane where PTPRG directly dephosphorylates activated FGFR1. | Protein Tyrosine Phosphatase Receptor Type G (PTPRG) Controls Fibroblast Growth Factor Receptor (FGFR) 1 Activity and Influences Sensitivity to FGFR Kinase Inhibitors.
Kostas M, Haugsten EM, Zhen Y, Sørensen V, Szybowska P, Fiorito E, Lorenz S, Jones N, de Souza GA, Wiedlocha A, Wesche J., Free PMC Article | 03/9/2019 |
| miR-19b inhibits PTPRG expression to promote tumorigenesis in human breast cancer | MiR-19b suppresses PTPRG to promote breast tumorigenesis.
Liu M, Yang R, Urrehman U, Ye C, Yan X, Cui S, Hong Y, Gu Y, Liu Y, Zhao C, Yan L, Zhang CY, Liang H, Chen X., Free PMC Article | 05/26/2018 |
| Co-localization experiments performed with both anti-PTPRG antibodies identified the presence of isoforms and confirmed protein downregulation at diagnosis in the Philadelphia-positive myeloid lineage (including CD34+/CD38bright/dim cells). | A new monoclonal antibody detects downregulation of protein tyrosine phosphatase receptor type γ in chronic myeloid leukemia patients.
Vezzalini M, Mafficini A, Tomasello L, Lorenzetto E, Moratti E, Fiorini Z, Holyoake TL, Pellicano F, Krampera M, Tecchio C, Yassin M, Al-Dewik N, Ismail MA, Al Sayab A, Monne M, Sorio C., Free PMC Article | 01/13/2018 |
| family-based GWAS of imputed SNPs revealed novel genomic variants in (or near) PTPRG, OSBPL6, and PDCL3 that influence risk for Alzheimer's Disease. rs7609954 in the gene PTPRG, rs1347297 in the gene OSBPL6, and rs1513625 near PDCL3. In addition, rs72953347 in OSBPL6 and two SNPs in the gene CDKAL1 showed marginally significant association with LOAD (rs10456232, P-value=4.76 x 10-7; rs62400067, P-value=3.54 x 10-7). | Family-based association analyses of imputed genotypes reveal genome-wide significant association of Alzheimer's disease with OSBPL6, PTPRG, and PDCL3.
Herold C, Hooli BV, Mullin K, Liu T, Roehr JT, Mattheisen M, Parrado AR, Bertram L, Lange C, Tanzi RE., Free PMC Article | 09/23/2017 |
| Results demonstrate that PTPRG plasmatic form (sPTPRG) represent a novel candidate protein biomarker in plasma whose increased expression is associated to hepatocyte damage. | Identification of protein tyrosine phosphatase receptor gamma extracellular domain (sPTPRG) as a natural soluble protein in plasma.
Moratti E, Vezzalini M, Tomasello L, Giavarina D, Sorio C., Free PMC Article | 01/23/2016 |
| Our results showed that there was no significant association between any of five reported SNPs of TCF4 and PTPRG genes and the occurrence of Fuchs' endothelial dystrophy; only rs7640737 in PTPRG showed an increased risk for corneal dystrophy. | Association of transcription factor 4 (TCF4) and protein tyrosine phosphatase, receptor type G (PTPRG) with corneal dystrophies in southern Chinese.
Wang KJ, Jhanji V, Chen J, Law RW, Leung AT, Zhang M, Wang N, Pang CP, Yam GH. | 08/15/2015 |
| SNPs in PTPRG were not associated with FCD in Caucasians. | Association of common variants in TCF4 and PTPRG with Fuchs' corneal dystrophy: a systematic review and meta-analysis.
Lau LC, Ma L, Young AL, Rong SS, Jhanji V, Brelen ME, Pang CP, Chen LJ., Free PMC Article | 06/20/2015 |
| PTPRG is a JAK2 phosphatase that negatively regulates leukocyte integrin beta2 activation. | Protein tyrosine phosphatase receptor type γ is a JAK phosphatase and negatively regulates leukocyte integrin activation.
Mirenda M, Toffali L, Montresor A, Scardoni G, Sorio C, Laudanna C. | 04/25/2015 |
| Mutations in PDGFRB cause infantile myofibromatosis while a mutation in PTPRG may act as an aggravating factor. | Modulation of expressivity in PDGFRB-related infantile myofibromatosis: a role for PTPRG?
Linhares ND, Freire MC, Cardenas RG, Bahia M, Puzenat E, Aubin F, Pena SD. | 04/11/2015 |
| Germline polymorphisms in PTPRG gene is associated with lung adenocarcinoma. | Germline polymorphisms and survival of lung adenocarcinoma patients: a genome-wide study in two European patient series.
Galvan A, Colombo F, Frullanti E, Dassano A, Noci S, Wang Y, Eisen T, Matakidou A, Tomasello L, Vezzalini M, Sorio C, Dugo M, Ambrogi F, Iacobucci I, Martinelli G, Incarbone M, Alloisio M, Nosotti M, Tosi D, Santambrogio L, Pelosi G, Pastorino U, Houlston RS, Dragani TA. | 02/28/2015 |
| PTPRG expression induces dephosphorylation of ERK, a downstream RAS target that may be critical for mutant RAS-induced cell growth. | PTPRG inhibition by DNA methylation and cooperation with RAS gene activation in childhood acute lymphoblastic leukemia.
Xiao J, Lee ST, Xiao Y, Ma X, Houseman EA, Hsu LI, Roy R, Wrensch M, de Smith AJ, Chokkalingam A, Buffler P, Wiencke JK, Wiemels JL., Free PMC Article | 08/16/2014 |
| found that the RPTP-gamma, RPTP-gamma(V948I, S970T) and RPTP-gamma(C858S, S970T) proteins could be stored at 193 K in their respective crystallization buffers without affecting crystallization or crystal quality | Cloning, purification, crystallization and preliminary X-ray analysis of the catalytic domain of human receptor-like protein tyrosine phosphatase γ in three different crystal forms.
Kish K, McDonnell PA, Goldfarb V, Gao M, Metzler WJ, Langley DR, Bryson JW, Kiefer SE, Carpenter B, Kostich WA, Westphal RS, Sheriff S., Free PMC Article | 10/22/2011 |