| BMP7 increases protein synthesis in SW1353 cells and determines rRNA levels in a NKX3-2-dependent manner. | BMP7 increases protein synthesis in SW1353 cells and determines rRNA levels in a NKX3-2-dependent manner.
Ripmeester EGJ, Welting TJM, van den Akker GGH, Surtel DAM, Steijns JSJ, Cremers A, van Rhijn LW, Caron MMJ., Free PMC Article | 03/5/2022 |
| A novel NKX3-2 mutation causes perinatal lethal spondylo-megaepiphyseal-metaphyseal dysplasia. | A novel NKX3-2 mutation associated with perinatal lethal phenotype of spondylo-megaepiphyseal-metaphyseal dysplasia in a neonate.
Simsek-Kiper PO, Kosukcu C, Akgun-Dogan O, Gocmen R, Utine GE, Soyer T, Korkmaz-Toygar A, Nishimura G, Alikasifoglu M, Boduroglu K. | 03/9/2019 |
| NKL homeobox gene NKX2-5 was activated by NKX3-2 in CCRF-CEM and by FOXG1 in PEER, representing mutually inhibitory activators of this translocated oncogene. | Aberrant activity of NKL homeobox gene NKX3-2 in a T-ALL subset.
Nagel S, Meyer C, Kaufmann M, Zaborski M, MacLeod RAF, Drexler HG., Free PMC Article | 08/4/2018 |
| post-translational modification of Nkx3.2 employing HDAC9-PIASy-RNF4 axis plays a crucial role in controlling chondrocyte viability and hypertrophic maturation during skeletal development in vertebrates. | A post-translational modification cascade employing HDAC9-PIASy-RNF4 axis regulates chondrocyte hypertrophy by modulating Nkx3.2 protein stability.
Choi HJ, Kwon S, Kim DW. | 12/2/2017 |
| Bapx1 indicates poor prognosis for gastric cancer patients by promoting tumor migration and invasion via TGF-beta-induced epithelial-mesenchymal transition. | Bapx1 mediates transforming growth factor-β- induced epithelial-mesenchymal transition and promotes a malignancy phenotype of gastric cancer cells.
Ouyang S, Zhu G, Ouyang L, Luo Y, Zhou R, Pan C, Bin J, Liao Y, Liao W. | 06/24/2017 |
| PI3K-mediated suppression of Nkx3.2 in chondrocytes plays a role in the control of cartilage hypertrophy during skeletal development in vertebrates. | Suppression of Nkx3.2 by phosphatidylinositol-3-kinase signaling regulates cartilage development by modulating chondrocyte hypertrophy.
Kim JA, Im S, Cantley LC, Kim DW., Free PMC Article | 09/24/2016 |
| Our findings indicate that BAPX-1/NKX-3.2 is a molecular switch that is involved in controlling the hypertrophic phenotype of the postdevelopmental (OA) articular chondrocyte. | BAPX-1/NKX-3.2 acts as a chondrocyte hypertrophy molecular switch in osteoarthritis.
Caron MM, Emans PJ, Surtel DA, van der Kraan PM, van Rhijn LW, Welting TJ. | 02/6/2016 |
| Ihh-induced Nkx3.2 degradation requires Wnt5a, which is capable of triggering Nkx3.2 degradation | Indian Hedgehog signalling triggers Nkx3.2 protein degradation during chondrocyte maturation.
Choi SW, Jeong DU, Kim JA, Lee B, Joeng KS, Long F, Kim DW., Free PMC Article | 06/9/2012 |
| Data show that IkappaB kinase beta (IKKbeta) can be activated in the nucleus by Nkx3.2 in the absence of exogenous IKK-activating signals, allowing constitutive nuclear degradation of IkappaB-alpha. | Exogenous signal-independent nuclear IkappaB kinase activation triggered by Nkx3.2 enables constitutive nuclear degradation of IkappaB-alpha in chondrocytes.
Yong Y, Choi SW, Choi HJ, Nam HW, Kim JA, Jeong DU, Kim DY, Kim YS, Kim DW., Free PMC Article | 10/8/2011 |
| NKX3-2 plays an important role in endochondral ossification of both the axial and appendicular skeleton in humans | Homozygous inactivating mutations in the NKX3-2 gene result in spondylo-megaepiphyseal-metaphyseal dysplasia.
Hellemans J, Simon M, Dheedene A, Alanay Y, Mihci E, Rifai L, Sefiani A, van Bever Y, Meradji M, Superti-Furga A, Mortier G., Free PMC Article | 01/21/2010 |
| Data show that Meox1 activates the Bapx1 promoter in a dose-dependent manner and that this activity is enhanced in the presence of Pax1 and/or Pax9. | Meox homeodomain proteins are required for Bapx1 expression in the sclerotome and activate its transcription by direct binding to its promoter.
Rodrigo I, Bovolenta P, Mankoo BS, Imai K., Free PMC Article | 01/21/2010 |