| METTL1/FOXM1 promotes lung adenocarcinoma progression and gefitinib resistance by inhibiting PTPN13 expression. | METTL1/FOXM1 promotes lung adenocarcinoma progression and gefitinib resistance by inhibiting PTPN13 expression.
Peng W, Fu J, Zhou L, Duan H., Free PMC Article | 07/9/2024 |
| PTPN13 rs989902 and CHEK2 rs738722 are associated with esophageal cancer. | PTPN13 rs989902 and CHEK2 rs738722 are associated with esophageal cancer.
Tu R, Zhong D, Li P, Li Y, Chen Z, Hu F, Yuan G, Chen Z, Yu S, Song J., Free PMC Article | 12/14/2023 |
| Protein tyrosine phosphatase PTPL1 suppresses lung cancer through Src/ERK/YAP1 signaling. | Protein tyrosine phosphatase PTPL1 suppresses lung cancer through Src/ERK/YAP1 signaling.
Wang J, Li S, Zhang X, Zhu N, Yiminniyaze R, Dong L, Li C, Gulinuer W, Xia J, Li J, Zhou D, Liu X, Zhang Y, Zhang Y, Li S., Free PMC Article | 11/5/2022 |
| Germline PTPN13 mutations in patients with bone marrow failure and acute lymphoblastic leukemia. | Germline PTPN13 mutations in patients with bone marrow failure and acute lymphoblastic leukemia.
Moshiri H, Cabrera Riofrío DA, Lim YJ, Lauhasurayotin S, Manisterski M, Elhasid R, Bonilla FA, Dhanraj S, Armstrong RN, Li H, Scherer SW, Hernández-Hernández A, Dror Y. | 10/22/2022 |
| PTPL1 suppresses lung cancer cell migration via inhibiting TGF-beta1-induced activation of p38 MAPK and Smad 2/3 pathways and EMT. | PTPL1 suppresses lung cancer cell migration via inhibiting TGF-β1-induced activation of p38 MAPK and Smad 2/3 pathways and EMT.
Zhu N, Zhang XJ, Zou H, Zhang YY, Xia JW, Zhang P, Zhang YZ, Li J, Dong L, Wumaier G, Li SQ., Free PMC Article | 11/6/2021 |
| Anti-oncogene PTPN13 inactivation by hepatitis B virus X protein counteracts IGF2BP1 to promote hepatocellular carcinoma progression. | Anti-oncogene PTPN13 inactivation by hepatitis B virus X protein counteracts IGF2BP1 to promote hepatocellular carcinoma progression.
Yan Y, Huang P, Mao K, He C, Xu Q, Zhang M, Liu H, Zhou Z, Zhou Q, Zhou Q, Ou B, Liu Q, Lin J, Chen R, Wang J, Zhang J, Xiao Z., Free PMC Article | 04/17/2021 |
| PTPN13 induces cell junction stabilization and inhibits mammary tumor invasiveness. | PTPN13 induces cell junction stabilization and inhibits mammary tumor invasiveness.
Hamyeh M, Bernex F, Larive RM, Naldi A, Urbach S, Simony-Lafontaine J, Puech C, Bakhache W, Solassol J, Coopman PJ, Hendriks WJAJ, Freiss G., Free PMC Article | 04/13/2021 |
| PTPN13 acts as a tumor suppressor in clear cell renal cell carcinoma by inactivating Akt signaling. | PTPN13 acts as a tumor suppressor in clear cell renal cell carcinoma by inactivating Akt signaling.
Long Q, Sun J, Lv J, Liang Y, Li H, Li X. | 03/13/2021 |
| This work demonstrates a novel function for PTEN during cell polarization in controlling apical membrane size and identifies PTPL1 as a critical apical membrane anchor for PTEN in this process. | The Phosphatase PTPL1 Is Required for PTEN-Mediated Regulation of Apical Membrane Size.
Bruurs LJM, van der Net MC, Zwakenberg S, Rosendahl Huber AKM, Post A, Zwartkruis FJ, Bos JL., Free PMC Article | 06/23/2019 |
| MicroRNA-30e-5p promotes cell growth by targeting PTPN13 and indicates poor survival and recurrence in lung adenocarcinoma. | MicroRNA-30e-5p promotes cell growth by targeting PTPN13 and indicates poor survival and recurrence in lung adenocarcinoma.
Zhuang L, Shou T, Li K, Gao CL, Duan LC, Fang LZ, Zhang QY, Chen ZN, Zhang C, Yang ST, Li GF., Free PMC Article | 06/16/2018 |
| The single nucleotide polymorphism genotype of PTPN13 exon 39 was determined in DNA extracted from blood samples from 174 sporadic colorectal cancer patients and 176 healthy individuals. The risk of colorectal cancer was 2.087 times greater for patients with the GG genotype than for those with the TT genotype. PTPN13 rs989902 is significantly associated with the risk of colorectal cancer in the Polish population. | The PTPN13 Y2081D (T>G) (rs989902) polymorphism is associated with an increased risk of sporadic colorectal cancer.
Laczmanska I, Karpinski P, Gil J, Laczmanski L, Makowska I, Bebenek M, Ramsey D, Sasiadek MM. | 04/21/2018 |
| suggest that CAFs, irrespective of identity, have low influence on the degree of tumor infiltration by inflammatory- and/or immune-cells. However, CAFFAP may exert immuno-adjuvant roles in NSCLC, and targeting CAFs should be cautiously considered | Tissue analyses reveal a potential immune-adjuvant function of FAP-1 positive fibroblasts in non-small cell lung cancer.
Kilvaer TK, Rakaee M, Hellevik T, Østman A, Strell C, Bremnes RM, Busund LT, Dønnem T, Martinez-Zubiaurre I., Free PMC Article | 03/24/2018 |
| we found that miR-26a confers epidermal growth factor receptor-targeted tyrosine kinase inhibitors resistance of non-small cell lung cancer cells by targeting and silencing PTPN13 | miR-26a desensitizes non-small cell lung cancer cells to tyrosine kinase inhibitors by targeting PTPN13.
Xu S, Wang T, Yang Z, Li Y, Li W, Wang T, Wang S, Jia L, Zhang S, Li S., Free PMC Article | 01/13/2018 |
| Fap1 inhibition increased Fas sensitivity and decreased beta-catenin activity in human CD34+ CML cells | The role of Fas-associated phosphatase 1 in leukemia stem cell persistence during tyrosine kinase inhibitor treatment of chronic myeloid leukemia.
Huang W, Luan CH, Hjort EE, Bei L, Mishra R, Sakamoto KM, Platanias LC, Eklund EA., Free PMC Article | 07/29/2017 |
| the crystal structure of the PTP-Bas PDZ1 domain at 1.6 A resolution, is reported. | High-resolution crystal structure of the PDZ1 domain of human protein tyrosine phosphatase PTP-Bas.
Lee SO, Lee MK, Ku B, Bae KH, Lee SC, Lim HM, Kim SJ, Chi SW. | 05/27/2017 |
| PTPN13 overexpression significantly inhibited the progression of HCC cells. | Tumour-suppressive role of PTPN13 in hepatocellular carcinoma and its clinical significance.
Zhan H, Jiang J, Luo C, Sun Q, Ke A, Sun C, Hu J, Hu Z, Hu B, Zhu K, Fan J, Zhou J, Huang X. | 02/18/2017 |
| Mutation in PTPN13 gene is associated with gastric cancer peritoneal carcinomatosis. | Genetic alterations and their clinical implications in gastric cancer peritoneal carcinomatosis revealed by whole-exome sequencing of malignant ascites.
Lim B, Kim C, Kim JH, Kwon WS, Lee WS, Kim JM, Park JY, Kim HS, Park KH, Kim TS, Park JL, Chung HC, Rha SY, Kim SY., Free PMC Article | 12/24/2016 |
| This work studied heat diffusion in the well-known PDZ-2 protein, and confirmed that this protein has two cognate allosteric pathways and that heat flows preferentially through these. | Allosteric communication pathways and thermal rectification in PDZ-2 protein: a computational study.
Miño-Galaz GA. | 02/13/2016 |
| Necl-4 serves as a novel regulator for contact inhibition of cell movement and proliferation cooperatively with the VEGF receptor and PTPN13 | The Cell Adhesion Molecule Necl-4/CADM4 Serves as a Novel Regulator for Contact Inhibition of Cell Movement and Proliferation.
Yamana S, Tokiyama A, Mizutani K, Hirata K, Takai Y, Rikitake Y., Free PMC Article | 02/6/2016 |
| A PDZ-mediated interaction of PTPN13 and PTEN is described with possible relevance for tumor suppression. | PTEN-PDZ domain interactions: binding of PTEN to PDZ domains of PTPN13.
Sotelo NS, Schepens JT, Valiente M, Hendriks WJ, Pulido R. | 01/16/2016 |
| The effect of the viscogens sucrose, and glycerol on the kinetic response of a photoperturbed PTPN13 is investigated. | Effect of viscogens on the kinetic response of a photoperturbed allosteric protein.
Waldauer SA, Stucki-Buchli B, Frey L, Hamm P. | 08/8/2015 |
| A comprehensive molecular dynamics simulation study of the PDZ2 domain of human tyrosine phosphatase 1E in the ligand-bound and -free state, as well as the photoswitchable protein in the cis and trans states of the photoswitch | Long-range conformational transition of a photoswitchable allosteric protein: molecular dynamics simulation study.
Buchenberg S, Knecht V, Walser R, Hamm P, Stock G. | 07/25/2015 |
| Thus, our results suggest a previously unknown Stat3-PTPN13 molecular network controlling squamous cell lung carcinoma development | Stat3 inhibits PTPN13 expression in squamous cell lung carcinoma through recruitment of HDAC5.
Han XJ, Xue L, Gong L, Zhu SJ, Yao L, Wang SM, Lan M, Zhang W, Li YH., Free PMC Article | 06/14/2014 |
| Association of rs7014346 in POU5F1P1, rs989902 in PTPN13, and rs7003146 in TCF7L2 with variations in the risk of breast cancer in a Chinese Han population. | Colorectal cancer susceptibility variants alter risk of breast cancer in a Chinese Han population.
Wei W, Jiang M, Luo L, Li Z, Wang P, Dong WQ. | 05/17/2014 |
| HCV induced increased expression of miR200c can down modulate the expression of FAP1, a critical regulator of Src and MAP kinase pathway that play an important role in the production of fibrogenic growth factors and development of fibrosis. | Hepatitis C virus induced miR200c down modulates FAP-1, a negative regulator of Src signaling and promotes hepatic fibrosis.
Ramachandran S, Ilias Basha H, Sarma NJ, Lin Y, Crippin JS, Chapman WC, Mohanakumar T., Free PMC Article | 03/8/2014 |