| Cdon suppresses vascular smooth muscle calcification via repression of the Wnt/Runx2 Axis. | Cdon suppresses vascular smooth muscle calcification via repression of the Wnt/Runx2 Axis.
Ahn BY, Jeong Y, Kim S, Zhang Y, Kim SW, Leem YE, Kang JS., Free PMC Article | 02/25/2023 |
| Cytoneme delivery of Sonic Hedgehog from ligand-producing cells requires Myosin 10 and a Dispatched-BOC/CDON co-receptor complex. | Cytoneme delivery of Sonic Hedgehog from ligand-producing cells requires Myosin 10 and a Dispatched-BOC/CDON co-receptor complex.
Hall ET, Dillard ME, Stewart DP, Zhang Y, Wagner B, Levine RM, Pruett-Miller SM, Sykes A, Temirov J, Cheney RE, Mori M, Robinson CG, Ogden SK., Free PMC Article | 01/29/2022 |
| Compound heterozygous splicing CDON variants result in isolated ocular coloboma. | Compound heterozygous splicing CDON variants result in isolated ocular coloboma.
Reis LM, Basel D, McCarrier J, Weinberg DV, Semina EV., Free PMC Article | 08/21/2021 |
| Cdon mutation and fetal alcohol converge on Nodal signaling in a mouse model of holoprosencephaly. | Cdon mutation and fetal alcohol converge on Nodal signaling in a mouse model of holoprosencephaly.
Hong M, Christ A, Christa A, Willnow TE, Krauss RS., Free PMC Article | 02/27/2021 |
| The hedgehog co-receptor BOC differentially regulates SHH signaling during craniofacial development. | The hedgehog co-receptor BOC differentially regulates SHH signaling during craniofacial development.
Echevarría-Andino ML, Allen BL., Free PMC Article | 02/2/2021 |
| Desert Hedgehog-Driven Endothelium Integrity Is Enhanced by Gas1 (Growth Arrest-Specific 1) but Negatively Regulated by Cdon (Cell Adhesion Molecule-Related/Downregulated by Oncogenes). | Desert Hedgehog-Driven Endothelium Integrity Is Enhanced by Gas1 (Growth Arrest-Specific 1) but Negatively Regulated by Cdon (Cell Adhesion Molecule-Related/Downregulated by Oncogenes).
Chapouly C, Hollier PL, Guimbal S, Cornuault L, Gadeau AP, Renault MA. | 12/19/2020 |
| The Trithorax protein Ash1L promotes myoblast fusion by activating Cdon expression | The Trithorax protein Ash1L promotes myoblast fusion by activating Cdon expression.
Castiglioni I, Caccia R, Garcia-Manteiga JM, Ferri G, Caretti G, Molineris I, Nishioka K, Gabellini D., Free PMC Article | 01/5/2019 |
| Cdon deficiency causes hyperactive Wnt signaling leading to aberrant intercellular coupling and cardiac fibrosis. | Cdon deficiency causes cardiac remodeling through hyperactivation of WNT/β-catenin signaling.
Jeong MH, Kim HJ, Pyun JH, Choi KS, Lee DI, Solhjoo S, O'Rourke B, Tomaselli GF, Jeong DS, Cho H, Kang JS., Free PMC Article | 04/14/2018 |
| These results support a model whereby mutations in Cdon and prenatal ethanol exposure increase Septo-optic dysplasia risk through spatiotemporal perturbations in Shh signaling activity. | Prenatal ethanol exposure in mice phenocopies Cdon mutation by impeding Shh function in the etiology of optic nerve hypoplasia.
Kahn BM, Corman TS, Lovelace K, Hong M, Krauss RS, Epstein DJ., Free PMC Article | 12/9/2017 |
| Mutation in the Cdon gene is associated with congenital nevus development. | A mutation in the Cdon gene potentiates congenital nevus development mediated by NRAS(Q61K).
Chitsazan A, Ferguson B, Ram R, Mukhopadhyay P, Handoko HY, Gabrielli B, Soyer PH, Morahan G, Walker GJ. | 11/18/2017 |
| Study assessed the role of the Shh receptor Cdon in the development of ventral tegmental area and substantia nigra pars compacta dopamine neurons. Results suggest that Cdon plays an important role in the encoding of diversity within the population of dopamine neurons of the midbrain, influencing both the development of the mesocortical dopamine pathway as well as behavioral outputs that involve this neural circuitry. | Mesocortical Dopamine Phenotypes in Mice Lacking the Sonic Hedgehog Receptor Cdon.
Verwey M, Grant A, Meti N, Adye-White L, Torres-Berrío A, Rioux V, Lévesque M, Charron F, Flores C., Free PMC Article | 11/4/2017 |
| Results suggest that a promyogenic cell adhesion molecule Cdo signaling is critical for Inward rectifier potassium channel Kir2.1 activities in the induction of myogenic differentiation. | Cdo Regulates Surface Expression of Kir2.1 K+ Channel in Myoblast Differentiation.
Leem YE, Jeong HJ, Kim HJ, Koh J, Kang K, Bae GU, Cho H, Kang JS., Free PMC Article | 08/5/2017 |
| PKN2 formed complexes with Cdo, APPL1 and AKT via its C-terminal region and this interaction appeared to be important for induction of AKT activity as well as myoblast differentiation. | PKN2 and Cdo interact to activate AKT and promote myoblast differentiation.
Lee SJ, Hwang J, Jeong HJ, Yoo M, Go GY, Lee JR, Leem YE, Park JW, Seo DW, Kim YK, Hahn MJ, Han JW, Kang JS, Bae GU., Free PMC Article | 08/5/2017 |
| that Cdon participates in oligodendrocyte differentiation and myelination, most likely in the initial stages of development | Cdon, a cell surface protein, mediates oligodendrocyte differentiation and myelination.
Wang LC, Almazan G. | 02/25/2017 |
| Suggest that Cdo is required for the full Shh signaling activation to induce efficient dopaminergic neuron neurogenesis. | The Shh coreceptor Cdo is required for differentiation of midbrain dopaminergic neurons.
Kwon YR, Jeong MH, Leem YE, Lee SJ, Kim HJ, Bae GU, Kang JS. | 05/30/2015 |
| Rescue of holoprosencephaly in fetal alcohol-exposed Cdon mutant mice by reduced gene dosage of Ptch1. | Rescue of holoprosencephaly in fetal alcohol-exposed Cdon mutant mice by reduced gene dosage of Ptch1.
Hong M, Krauss RS., Free PMC Article | 11/29/2014 |
| Cx43 physically interacts with Cdo to form dynamic complexes during myoblast differentiation | A molecular imaging analysis of Cx43 association with Cdo during skeletal myoblast differentiation.
Nosi D, Mercatelli R, Chellini F, Soria S, Pini A, Formigli L, Quercioli F. | 09/13/2014 |
| Stim1 protein levels were decreased in Cdo-deficient perinatal hindlimb muscles or primary myoblasts; this correlates with defective NFATc3 activation in Cdo(-/-) myoblasts upon differentiation. | Phosphorylation of Stim1 at serine 575 via netrin-2/Cdo-activated ERK1/2 is critical for the promyogenic function of Stim1.
Lee HJ, Bae GU, Leem YE, Choi HK, Kang TM, Cho H, Kim ST, Kang JS., Free PMC Article | 09/15/2012 |
| ASK1 and TAK1 function as MAP3 kinases in Cdo-mediated p38MAPK activation to promote myogenic differentiation. | TGF-β-activated kinase 1 (TAK1) and apoptosis signal-regulating kinase 1 (ASK1) interact with the promyogenic receptor Cdo to promote myogenic differentiation via activation of p38MAPK pathway.
Tran P, Ho SM, Kim BG, Vuong TA, Leem YE, Bae GU, Kang JS., Free PMC Article | 06/9/2012 |
| Gas1 cooperates with Cdo and promotes myogenic differentiation via activation of p38MAPK | Gas1 cooperates with Cdo and promotes myogenic differentiation via activation of p38MAPK.
Leem YE, Han JW, Lee HJ, Ha HL, Kwon YL, Ho SM, Kim BG, Tran P, Bae GU, Kang JS. | 01/14/2012 |
| CDON must associate with both ligand and other hedgehog-receptor components, particularly PTCH1, for signaling to occur and disruption of the latter interactions is a mechanism of holoprosencephaly. | Mutations in CDON, encoding a hedgehog receptor, result in holoprosencephaly and defective interactions with other hedgehog receptors.
Bae GU, Domené S, Roessler E, Schachter K, Kang JS, Muenke M, Krauss RS., Free PMC Article | 10/15/2011 |
| the Integrin/FAK signaling pathway regulates the expression of the promyogenic factors, Cdo, MyoD and Cdc42 which are required for myoblast differentiation | Promyogenic function of Integrin/FAK signaling is mediated by Cdo, Cdc42 and MyoD.
Han JW, Lee HJ, Bae GU, Kang JS. | 09/17/2011 |
| Cdo;Boc double mutants on a largely Cdo-resistant genetic background have lobar holoprosencephaly. | Boc modifies the holoprosencephaly spectrum of Cdo mutant mice.
Zhang W, Hong M, Bae GU, Kang JS, Krauss RS., Free PMC Article | 09/3/2011 |
| The promyogenic function of Cdo involves a coordinated activation of p38MAPK and Akt via association with scaffold proteins, JLP and Bnip-2 for p38MAPK and APPL1 for Akt. | Cdo interacts with APPL1 and activates Akt in myoblast differentiation.
Bae GU, Lee JR, Kim BG, Han JW, Leem YE, Lee HJ, Ho SM, Hahn MJ, Kang JS., Free PMC Article | 10/23/2010 |
| Hedgehog proteins interact with cell adhesion molecule, down-regulated by oncogenes (CDO) and brother of CDO (BOC) in a conserved manner | All mammalian Hedgehog proteins interact with cell adhesion molecule, down-regulated by oncogenes (CDO) and brother of CDO (BOC) in a conserved manner.
Kavran JM, Ward MD, Oladosu OO, Mulepati S, Leahy DJ., Free PMC Article | 09/27/2010 |