| POLD4 Promotes Glioma Cell Proliferation and Suppressive Immune Microenvironment: A Pan-Cancer Analysis Integrated with Experimental Validation. | POLD4 Promotes Glioma Cell Proliferation and Suppressive Immune Microenvironment: A Pan-Cancer Analysis Integrated with Experimental Validation.
Jiang C, Fan F, Xu W, Jiang X., Free PMC Article | 10/5/2023 |
| Expression Profile, Molecular Association, and Clinical Significance of POLD4 in Glioblastoma. | Expression Profile, Molecular Association, and Clinical Significance of POLD4 in Glioblastoma.
Alam MT, Ali MS, Goel H, Singh J, Chatterjee B, Bose S, Hadda V, Chopra A. | 09/6/2023 |
| Circular RNA circ_0026359 Enhances Cisplatin Resistance in Gastric Cancer via Targeting miR-1200/POLD4 Pathway. | Circular RNA circ_0026359 Enhances Cisplatin Resistance in Gastric Cancer via Targeting miR-1200/POLD4 Pathway.
Zhang Z, Yu X, Zhou B, Zhang J, Chang J., Free PMC Article | 05/8/2021 |
| The role in cellular processes (DNA replication, DNA repair, homologous recombination) and cell cycle regulation of 2 forms of human DNA polymerase delta: delta3 and delta4 was reviewed. (REVIEW) | Two forms of human DNA polymerase δ: Who does what and why?
Lee MYWT, Zhang S, Wang X, Chao HH, Zhao H, Darzynkiewicz Z, Zhang Z, Lee EYC. | 03/28/2020 |
| Human Poldelta is a pentameric complex with a dimeric p12 subunit. RKR-mediated dimerization plays a vital role in p12 binding to PCNA and Poldelta5 architecture, and the phenomenon appears to be conserved throughout evolution. | Human DNA polymerase delta is a pentameric holoenzyme with a dimeric p12 subunit.
Khandagale P, Peroumal D, Manohar K, Acharya N., Free PMC Article | 02/29/2020 |
| the p12/Pol delta is a target as a nuclear substrate of mu-calpain in a calcium-triggered apoptosis and appears to be a potential marker in the study of the chemotherapy of cancer therapies. | Proteolysis of the human DNA polymerase delta smallest subunit p12 by μ-calpain in calcium-triggered apoptotic HeLa cells.
Fan X, Zhang Q, You C, Qian Y, Gao J, Liu P, Chen H, Song H, Chen Y, Chen K, Zhou Y., Free PMC Article | 06/20/2015 |
| A parallel study of Pol delta4 and Pol delta3 in Okazaki fragment processing provides evidence for a role of Pol delta3 in DNA replication | The tail that wags the dog: p12, the smallest subunit of DNA polymerase δ, is degraded by ubiquitin ligases in response to DNA damage and during cell cycle progression.
Lee MY, Zhang S, Lin SH, Wang X, Darzynkiewicz Z, Zhang Z, Lee EY., Free PMC Article | 09/6/2014 |
| Findings provide evidence for the novel concept that Pol delta3 has a role in lagging strand synthesis, and that both forms of Pol delta3 and 4 may participate in DNA replication in higher eukaryotic cells. | Dynamics of enzymatic interactions during short flap human Okazaki fragment processing by two forms of human DNA polymerase δ.
Lin SH, Wang X, Zhang S, Zhang Z, Lee EY, Lee MY., Free PMC Article | 06/21/2014 |
| ubiquitination of p12 through CRL4(Cdt2) and subsequent degradation form one mechanism by which a cell responds to DNA damage to inhibit fork progression. | Degradation of p12 subunit by CRL4Cdt2 E3 ligase inhibits fork progression after DNA damage.
Terai K, Shibata E, Abbas T, Dutta A., Free PMC Article | 01/4/2014 |
| Data indicate that CRL4(Cdt2) regulates the degradation of the p12 subunit of Pol delta4. | A novel function of CRL4(Cdt2): regulation of the subunit structure of DNA polymerase δ in response to DNA damage and during the S phase.
Zhang S, Zhao H, Darzynkiewicz Z, Zhou P, Zhang Z, Lee EY, Lee MY., Free PMC Article | 12/14/2013 |
| The identification of RNF8 allows new insights into the integration of the control of p12 degradation by different DNA damage signaling pathways. | Identification of RNF8 as a ubiquitin ligase involved in targeting the p12 subunit of DNA polymerase δ for degradation in response to DNA damage.
Zhang S, Zhou Y, Sarkeshik A, Yates JR 3rd, Thomson TM, Zhang Z, Lee EY, Lee MY., Free PMC Article | 03/30/2013 |
| Low POLD4 is associated with lung cancer. | Regulation of DNA polymerase POLD4 influences genomic instability in lung cancer.
Huang QM, Tomida S, Masuda Y, Arima C, Cao K, Kasahara TA, Osada H, Yatabe Y, Akashi T, Kamiya K, Takahashi T, Suzuki M. | 01/1/2011 |
| these results indicate that POLD4 is required for the in vitro pol delta activity, and that it functions in cell proliferation and maintenance of genomic stability of human cells. | Roles of POLD4, smallest subunit of DNA polymerase delta, in nuclear structures and genomic stability of human cells.
Huang QM, Akashi T, Masuda Y, Kamiya K, Takahashi T, Suzuki M. | 03/22/2010 |
| The DNA polymerase delta enzyme, as well as the isolated p12 subunit, stimulates the DNA helicase activity of Bloom's syndrome helicase. | The Bloom's syndrome helicase (BLM) interacts physically and functionally with p12, the smallest subunit of human DNA polymerase delta.
Selak N, Bachrati CZ, Shevelev I, Dietschy T, van Loon B, Jacob A, Hübscher U, Hoheisel JD, Hickson ID, Stagljar I., Free PMC Article | 01/21/2010 |
| pol delta interacts with PCNA via at least two of its subunits, and p12 could play a role in stabilizing the overall pol delta-PCNA complex as well as pol delta itself | Functional roles of p12, the fourth subunit of human DNA polymerase delta.
Li H, Xie B, Zhou Y, Rahmeh A, Trusa S, Zhang S, Gao Y, Lee EY, Lee MY. | 01/21/2010 |