| The risk variant rs11836367 contributes to breast cancer onset and metastasis by attenuating Wnt signaling via regulating NTN4 expression. | The risk variant rs11836367 contributes to breast cancer onset and metastasis by attenuating Wnt signaling via regulating NTN4 expression.
Yang H, Ting X, Geng YH, Xie Y, Nierenberg JL, Huo YF, Zhou YT, Huang Y, Yu YQ, Yu XY, Li XF, Ziv E, Zhang H, Fang WG, Shen Y, Tian XX., Free PMC Article | 06/18/2022 |
| Anti-Inflammatory Role of Netrin-4 in Diabetic Retinopathy. | Anti-Inflammatory Role of Netrin-4 in Diabetic Retinopathy.
Crespo-Garcia S, Reichhart N, Kociok N, Skosyrski S, Joussen AM., Free PMC Article | 05/29/2021 |
| netrin-4 disrupts laminin networks and basement membranes through high-affinity binding to the laminin gamma-1 chain. | Structural decoding of netrin-4 reveals a regulatory function towards mature basement membranes.
Reuten R, Patel TR, McDougall M, Rama N, Nikodemus D, Gibert B, Delcros JG, Prein C, Meier M, Metzger S, Zhou Z, Kaltenberg J, McKee KK, Bald T, Tüting T, Zigrino P, Djonov V, Bloch W, Clausen-Schaumann H, Poschl E, Yurchenco PD, Ehrbar M, Mehlen P, Stetefeld J, Koch M., Free PMC Article | 09/8/2018 |
| we found that Ntn4 promotes differentiation and migration of osteoblasts. | Netrin-4 Promotes Differentiation and Migration of Osteoblasts.
Enoki Y, Sato T, Kokabu S, Hayashi N, Iwata T, Yamato M, Usui M, Matsumoto M, Tomoda T, Ariyoshi W, Nishihara T, Yoda T., Free PMC Article | 05/5/2018 |
| Netrin-4 acted as an antiangiogenic factor in the cornea, with which the healthy cornea is enriched via its expression by corneal epithelial cells. | Netrin-4 Mediates Corneal Hemangiogenesis but Not Lymphangiogenesis in the Mouse-Model of Suture-Induced Neovascularization.
Maier AB, Klein S, Kociok N, Riechardt AI, Gundlach E, Reichhart N, Strauß O, Joussen AM. | 07/1/2017 |
| Our results indicate a role for netrin-4 as an angiogenesis modulating factor in O2-dependent vascular homeostasis while being less important during normal retinal developmental angiogenesis or during inflammatory neovascularization. | Lack of netrin-4 modulates pathologic neovascularization in the eye.
Kociok N, Crespo-Garcia S, Liang Y, Klein SV, Nürnberg C, Reichhart N, Skosyrski S, Moritz E, Maier AK, Brunken WJ, Strauß O, Koch M, Joussen AM., Free PMC Article | 12/17/2016 |
| These results indicate that netrin-4 shed new light on its potential roles in treatmenting for angiogenic diseases that affect the ocular surface, as well as other tissues | Therapeutic effects of topical netrin-4 inhibits corneal neovascularization in alkali-burn rats.
Han Y, Shao Y, Liu T, Qu YL, Li W, Liu Z., Free PMC Article | 03/26/2016 |
| Vascular endothelial cells interact with bone in suppressing bone through netrin-4. | Netrin-4 derived from murine vascular endothelial cells inhibits osteoclast differentiation in vitro and prevents bone loss in vivo.
Enoki Y, Sato T, Tanaka S, Iwata T, Usui M, Takeda S, Kokabu S, Matsumoto M, Okubo M, Nakashima K, Yamato M, Okano T, Fukuda T, Chida D, Imai Y, Yasuda H, Nishihara T, Akita M, Oda H, Okazaki Y, Suda T, Yoda T. | 08/16/2014 |
| Loss of Netrin-4 is associated with metastatic colorectal tumor progression. | Netrin-4 overexpression suppresses primary and metastatic colorectal tumor progression.
Eveno C, Contreres JO, Hainaud P, Nemeth J, Dupuy E, Pocard M. | 01/11/2014 |
| The alpha6beta1 integrin is a netrin-4 receptor in endothelial cells. | Netrin-4 activates endothelial integrin {alpha}6{beta}1.
Larrieu-Lahargue F, Welm AL, Thomas KR, Li DY., Free PMC Article | 11/12/2011 |
| NT-4 overexpression decreases tumor growth and carcinomatosis, probably via an antiangiogenic effect | Netrin-4 delays colorectal cancer carcinomatosis by inhibiting tumor angiogenesis.
Eveno C, Broqueres-You D, Feron JG, Rampanou A, Tijeras-Raballand A, Ropert S, Leconte L, Levy BI, Pocard M., Free PMC Article | 07/16/2011 |
| In vivo, Netrin-4 induces growth of lymphatic and blood vessels in the skin of transgenic mice. | Netrin-4 induces lymphangiogenesis in vivo.
Larrieu-Lahargue F, Welm AL, Thomas KR, Li DY., Free PMC Article | 08/9/2010 |
| netrin-4 is produced by selected GFAP-positive astrocytes positioned close to newborn neurons migrating in the anterior part of the rostral migratory stream and within the olfactory bulb | Discovery of a functional protein complex of netrin-4, laminin gamma1 chain, and integrin alpha6beta1 in mouse neural stem cells.
Staquicini FI, Dias-Neto E, Li J, Snyder EY, Sidman RL, Pasqualini R, Arap W., Free PMC Article | 01/21/2010 |
| Netrin-4 may improve poststroke functional recovery by enhancing blood vessel proliferation | Netrin-4 enhances angiogenesis and neurologic outcome after cerebral ischemia.
Hoang S, Liauw J, Choi M, Choi M, Guzman RG, Steinberg GK. | 01/21/2010 |
| Netrin-4 significantly reduced pathological angiogenesis in Matrigel and laser-induced choroidal neovascularization models. Netrin-4, neogenin, and Unc5B receptor expression was up-regulated in choroidal neovessel EC after laser injury | Netrin-4 inhibits angiogenesis via binding to neogenin and recruitment of Unc5B.
Lejmi E, Leconte L, Pédron-Mazoyer S, Ropert S, Raoul W, Lavalette S, Bouras I, Feron JG, Maitre-Boube M, Assayag F, Feumi C, Alemany M, Jie TX, Merkulova T, Poupon MF, Ruchoux MM, Tobelem G, Sennlaub F, Plouët J., Free PMC Article | 01/21/2010 |
| netrin-4 is a component of basement membranes and is integrated into the laminin polymer via interactions with the laminin gamma1 andgamma3 short arms. | Binding of netrin-4 to laminin short arms regulates basement membrane assembly.
Schneiders FI, Maertens B, Böse K, Li Y, Brunken WJ, Paulsson M, Smyth N, Koch M. | 01/21/2010 |