| Structural characterization of transcription-coupled repair protein UVSSA and its interaction with TFIIH protein. | Structural characterization of transcription-coupled repair protein UVSSA and its interaction with TFIIH protein.
Mistry H, Kumari S, Aswal VK, Gupta GD. | 10/24/2023 |
| Transcription coupled DNA repair protein UVSSA binds to DNA and RNA: Mapping of nucleic acid interaction sites on human UVSSA. | Transcription coupled DNA repair protein UVSSA binds to DNA and RNA: Mapping of nucleic acid interaction sites on human UVSSA.
Mistry H, Gupta GD. | 02/4/2023 |
| The UVSSA protein is part of a genome integrity homeostasis network with links to transcription-coupled DNA repair and ATM signaling. | The UVSSA protein is part of a genome integrity homeostasis network with links to transcription-coupled DNA repair and ATM signaling.
Kordon MM, Arron S, Cleaver JE, Bezrookove V, Karentz D, Lu B, Perr E, Chang D, Pederson T., Free PMC Article | 03/26/2022 |
| The UVSSA complex alleviates MYC-driven transcription stress. | The UVSSA complex alleviates MYC-driven transcription stress.
Sato M, Liebau RC, Liu Z, Liu L, Rabadan R, Gautier J., Free PMC Article | 09/4/2021 |
| USP7-mediated deubiquitination differentially regulates CSB but not UVSSA upon UV radiation-induced DNA damage. | USP7-mediated deubiquitination differentially regulates CSB but not UVSSA upon UV radiation-induced DNA damage.
Zhu Q, Ding N, Wei S, Li P, Wani G, He J, Wani AA., Free PMC Article | 02/2/2021 |
| TCR is initiated by RNAPIIo-bound CSB, which recruits CSA through a newly identified CSA-interaction motif (CIM); once recruited, CSA facilitates the association of UVSSA with stalled RNAPIIo; in addition, UVSSA is the key factor that recruits the TFIIH complex in a manner that is stimulated by CSB and CSA | The cooperative action of CSB, CSA, and UVSSA target TFIIH to DNA damage-stalled RNA polymerase II.
van der Weegen Y, Golan-Berman H, Mevissen TET, Apelt K, González-Prieto R, Goedhart J, Heilbrun EE, Vertegaal ACO, van den Heuvel D, Walter JC, Adar S, Luijsterburg MS., Free PMC Article | 08/13/2020 |
| Study reports nine UV-sensitive syndrome cases from two Pakistani families with a novel homozygous nonsense mutation, (c.1040 G > A [p.(Trp347*)]) in exon 6 of the UVSSA gene. | UV-sensitive syndrome: Whole exome sequencing identified a nonsense mutation in the gene UVSSA in two consanguineous pedigrees from Pakistan.
Ijaz A, Wolf S, Mandukhail SR, Basit S, Betz RC, Wali A. | 12/14/2019 |
| FACT subunit Spt16 controls UVSSA recruitment to lesion-stalled RNA Pol II and stimulates transcription-coupled nucleotide excision repair. | FACT subunit Spt16 controls UVSSA recruitment to lesion-stalled RNA Pol II and stimulates TC-NER.
Wienholz F, Zhou D, Turkyilmaz Y, Schwertman P, Tresini M, Pines A, van Toorn M, Bezstarosti K, Demmers JAA, Marteijn JA., Free PMC Article | 11/30/2019 |
| UVSSA is mono-ubiquitinated in vitro. Lys(414) is the target of ubiquitination. Lys(414) was also modified by poly-ubiquitin chains in vivo. The substitution of Lys(414) by Arg of UVSSA inhibited its degradation and thereby suppressed the deficiency in transcription-coupled nucleotide excision repair. | Inhibition of UVSSA ubiquitination suppresses transcription-coupled nucleotide excision repair deficiency caused by dissociation from USP7.
Higa M, Tanaka K, Saijo M. | 01/12/2019 |
| Data suggest that a common TFIIH subunit p62 recruitment mechanism is shared by UV-stimulated scaffold protein A (UVSSA) in transcription-coupled repair (TCR) and xeroderma pigmentosum, complementation group C protein (XPC) in global genome repair (GGR). | Common TFIIH recruitment mechanism in global genome and transcription-coupled repair subpathways.
Okuda M, Nakazawa Y, Guo C, Ogi T, Nishimura Y., Free PMC Article | 01/20/2018 |
| stabilization of UVSSA by interaction with USP7 is essential for Transcription-coupled Nucleotide Excision Repair | Stabilization of Ultraviolet (UV)-stimulated Scaffold Protein A by Interaction with Ubiquitin-specific Peptidase 7 Is Essential for Transcription-coupled Nucleotide Excision Repair.
Higa M, Zhang X, Tanaka K, Saijo M., Free PMC Article | 12/17/2016 |
| UVSSA together with USP7 is implicated in regulating transcription-coupled DNA repair.[review] | UVSSA and USP7, a new couple in transcription-coupled DNA repair.
Schwertman P, Vermeulen W, Marteijn JA., Free PMC Article | 02/1/2014 |
| Human UVSSA protein is required for the ubiquitination of RNA polymerase and DNA repair after light-induced DNA damage [review]. | [Molecular cloning and characterisation of UVSSA, the responsible gene for UV-sensitive syndrome].
Ogi T, Nakazawa Y, Sasaki K, Guo C, Yoshiura K, Utani A, Nagayama Y. | 08/10/2013 |
| KIAA1530 is an important player in TCR but also lead to a better understanding of the molecular mechanism underlying UV(s)S syndrome. | KIAA1530 protein is recruited by Cockayne syndrome complementation group protein A (CSA) to participate in transcription-coupled repair (TCR).
Fei J, Chen J., Free PMC Article | 01/5/2013 |
| Mutations in UVSSA cause UV-sensitive syndrome and destabilize ERCC6 in transcription-coupled DNA repair. | Mutations in UVSSA cause UV-sensitive syndrome and destabilize ERCC6 in transcription-coupled DNA repair.
Zhang X, Horibata K, Saijo M, Ishigami C, Ukai A, Kanno S, Tahara H, Neilan EG, Honma M, Nohmi T, Yasui A, Tanaka K. | 07/7/2012 |
| Mutations in UVSSA cause UV-sensitive syndrome and recruits USP7 to regulate transcription-coupled repair. | UV-sensitive syndrome protein UVSSA recruits USP7 to regulate transcription-coupled repair.
Schwertman P, Lagarou A, Dekkers DH, Raams A, van der Hoek AC, Laffeber C, Hoeijmakers JH, Demmers JA, Fousteri M, Vermeulen W, Marteijn JA. | 07/7/2012 |
| Mutations in the UVSSA gene is associated with UV-sensitive syndrome. | Mutations in UVSSA cause UV-sensitive syndrome and impair RNA polymerase IIo processing in transcription-coupled nucleotide-excision repair.
Nakazawa Y, Sasaki K, Mitsutake N, Matsuse M, Shimada M, Nardo T, Takahashi Y, Ohyama K, Ito K, Mishima H, Nomura M, Kinoshita A, Ono S, Takenaka K, Masuyama R, Kudo T, Slor H, Utani A, Tateishi S, Yamashita S, Stefanini M, Lehmann AR, Yoshiura K, Ogi T. | 07/7/2012 |