| Assessing the role of SH3RF1 and SH3RF2 polymorphisms in susceptibility to tuberculosis: A case-control study in the Han Chinese population. | Assessing the role of SH3RF1 and SH3RF2 polymorphisms in susceptibility to tuberculosis: A case-control study in the Han Chinese population.
Chen H, Zhou J, Jiao L, Song J, Zhong H, Zhao Z, Meng Z, Lu X, Chen X, Zhang W, Ying B. | 06/26/2021 |
| These results show that POSH plays a critical role in the progression of epileptic seizures via N-methyl-D-aspartate receptor trafficking | POSH participates in epileptogenesis by increasing the surface expression of the NMDA receptor: a promising therapeutic target for epilepsy.
Wang X, Tian X, Yang Y, Lu X, Li Y, Ma Y, Zhang Y, Zheng F, Lu S, Xu D, Xu X, Wang W, Wang X. | 11/18/2017 |
| Data show that the two N-terminal SH3 domains of SH3 domain containing ring finger 1 (SH3RF1) protein interact with FAT1 protein. | Protein interaction screening identifies SH3RF1 as a new regulator of FAT1 protein levels.
de Bock CE, Hughes MR, Snyder K, Alley S, Sadeqzadeh E, Dun MD, McNagny KM, Molloy TJ, Hondermarck H, Thorne RF. | 06/3/2017 |
| We found a genome-wide significant association for rs2282987 in CDK6 and a consistent association for rs2706748 in SH3RF1 . | Imputation-based association analyses identify new lung cancer susceptibility variants in CDK6 and SH3RF1 and their interactions with smoking in Chinese populations.
Deng Q, Guo H, Dai J, Yang L, Wu C, Wang Q, Hu Z, Yang M, Liu L, Yu D, Hu D, Hong X, Qiu F, Yang H, Wang T, Tan W, Chu M, Feng J, Teng K, Gong J, Sun C, Hu X, Zhang K, Lu J, Lin D, Shen H, Wu T. | 12/21/2013 |
| The data presented here define POSH and Siah2 as important mediators of death receptor mediated apoptosis and suggest targeting the interaction of these two E3 ligases is a promising novel cancer therapeutic strategy. | Possible role of death receptor-mediated apoptosis by the E3 ubiquitin ligases Siah2 and POSH.
Christian PA, Fiandalo MV, Schwarze SR., Free PMC Article | 09/24/2011 |
| POSH promotes cell survival in Drosophila and in human rheumatoid arthritis synovial fibroblasts | POSH promotes cell survival in Drosophila and in human RASF cells.
Tsuda M, Kawaida R, Kobayashi K, Shinagawa A, Sawada T, Yamada R, Yamamoto K, Aigaki T. | 01/1/2011 |
| Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) | Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR., Free PMC Article | 06/30/2010 |
| POSH inhibits ROMK channels by enhancing dynamin-dependent and clathrin-independent endocytosis and by stimulating ubiquitination of ROMK channels. | POSH stimulates the ubiquitination and the clathrin-independent endocytosis of ROMK1 channels.
Lin DH, Yue P, Pan CY, Sun P, Zhang X, Han Z, Roos M, Caplan M, Giebisch G, Wang WH., Free PMC Article | 01/21/2010 |
| Results identified ALIX as an ubiquitination substrate of POSH and indicate that POSH and ALIX cooperate to facilitate efficient virus release. | Exploring the functional interaction between POSH and ALIX and the relevance to HIV-1 release.
Votteler J, Iavnilovitch E, Fingrut O, Shemesh V, Taglicht D, Erez O, Sörgel S, Walther T, Bannert N, Schubert U, Reiss Y., Free PMC Article | 01/21/2010 |
| POSH disassociates from the JNK complex after phosphorylation of MLK3 by Akt2, which leads to down-regulation of the JNK signaling pathway | Akt2 negatively regulates assembly of the POSH-MLK-JNK signaling complex.
Figueroa C, Tarras S, Taylor J, Vojtek AB. | 01/21/2010 |
| A previously undescribed step in HIV biogenesis that suggests a direct function for hPOSH-mediated ubiquitination in protein sorting at the trans-Golgi network. | The trans-Golgi network-associated human ubiquitin-protein ligase POSH is essential for HIV type 1 production.
Alroy I, Tuvia S, Greener T, Gordon D, Barr HM, Taglicht D, Mandil-Levin R, Ben-Avraham D, Konforty D, Nir A, Levius O, Bicoviski V, Dori M, Cohen S, Yaar L, Erez O, Propheta-Meiran O, Koskas M, Caspi-Bachar E, Alchanati I, Sela-Brown A, Moskowitz H, Tessmer U, Schubert U, Reiss Y., Free PMC Article | 01/21/2010 |
| This publication pertains to studies in mice. | A new rac target POSH is an SH3-containing scaffold protein involved in the JNK and NF-kappaB signalling pathways.
Tapon N, Nagata K, Lamarche N, Hall A., Free PMC Article | 09/9/2004 |