| STIM2 is involved in the regulation of apoptosis and the cell cycle in normal and malignant monocytic cells. | STIM2 is involved in the regulation of apoptosis and the cell cycle in normal and malignant monocytic cells.
Djordjevic S, Itzykson R, Hague F, Lebon D, Legrand J, Ouled-Haddou H, Jedraszak G, Harbonnier J, Collet L, Paubelle E, Marolleau JP, Garçon L, Boyer T., Free PMC Article | 06/18/2024 |
| STIM2 promotes the invasion and metastasis of breast cancer cells through the NFAT1/TGF-beta1 pathway. | STIM2 promotes the invasion and metastasis of breast cancer cells through the NFAT1/TGF-β1 pathway.
Cheng H, Chen L, Fang Z, Wan Q, Du Z, Ma N, Guo G, Lu W. | 07/16/2022 |
| Functional communication between IP3R and STIM2 at subthreshold stimuli is a critical checkpoint for initiation of SOCE. | Functional communication between IP(3)R and STIM2 at subthreshold stimuli is a critical checkpoint for initiation of SOCE.
Ahmad M, Ong HL, Saadi H, Son GY, Shokatian Z, Terry LE, Trebak M, Yule DI, Ambudkar I., Free PMC Article | 02/26/2022 |
| Oxidative Stress-Induced STIM2 Cysteine Modifications Suppress Store-Operated Calcium Entry. | Oxidative Stress-Induced STIM2 Cysteine Modifications Suppress Store-Operated Calcium Entry.
Gibhardt CS, Cappello S, Bhardwaj R, Schober R, Kirsch SA, Bonilla Del Rio Z, Gahbauer S, Bochicchio A, Sumanska M, Ickes C, Stejerean-Todoran I, Mitkovski M, Alansary D, Zhang X, Revazian A, Fahrner M, Lunz V, Frischauf I, Luo T, Ezerina D, Messens J, Belousov VV, Hoth M, Böckmann RA, Hediger MA, Schindl R, Bogeski I. | 10/23/2021 |
| Calmodulin Binding Proteins and Alzheimer's Disease: Biomarkers, Regulatory Enzymes and Receptors That Are Regulated by Calmodulin. | Calmodulin Binding Proteins and Alzheimer's Disease: Biomarkers, Regulatory Enzymes and Receptors That Are Regulated by Calmodulin.
O'Day DH., Free PMC Article | 02/27/2021 |
| Functional role of TRPC6 and STIM2 in cytosolic and endoplasmic reticulum Ca2+ content in resting estrogen receptor-positive breast cancer cells. | Functional role of TRPC6 and STIM2 in cytosolic and endoplasmic reticulum Ca2+ content in resting estrogen receptor-positive breast cancer cells.
Sanchez-Collado J, Lopez JJ, Gonzalez-Gutierrez L, Cantonero C, Jardin I, Salido GM, Rosado JA. | 02/27/2021 |
| Synergistic stabilization by nitrosoglutathione-induced thiol modifications in the stromal interaction molecule-2 luminal domain suppresses basal and store operated calcium entry. | Synergistic stabilization by nitrosoglutathione-induced thiol modifications in the stromal interaction molecule-2 luminal domain suppresses basal and store operated calcium entry.
Novello MJ, Zhu J, Zhang M, Feng Q, Stathopulos PB., Free PMC Article | 12/5/2020 |
| Transgenic Mice Overexpressing Human STIM2 and ORAI1 in Neurons Exhibit Changes in Behavior and Calcium Homeostasis but Show No Signs of Neurodegeneration. | Transgenic Mice Overexpressing Human STIM2 and ORAI1 in Neurons Exhibit Changes in Behavior and Calcium Homeostasis but Show No Signs of Neurodegeneration.
Majewski L, Maciąg F, Boguszewski PM, Kuznicki J., Free PMC Article | 11/21/2020 |
| STIM2 targets Orai1/STIM1 to the AKAP79 signaling complex and confers coupling of Ca(2+) entry with NFAT1 activation. | STIM2 targets Orai1/STIM1 to the AKAP79 signaling complex and confers coupling of Ca(2+) entry with NFAT1 activation.
Son GY, Subedi KP, Ong HL, Noyer L, Saadi H, Zheng C, Bhardwaj R, Feske S, Ambudkar IS., Free PMC Article | 09/26/2020 |
| L-type Ca(2+) channel blockers promote vascular remodeling through activation of STIM proteins. | L-type Ca(2+) channel blockers promote vascular remodeling through activation of STIM proteins.
Johnson MT, Gudlur A, Zhang X, Xin P, Emrich SM, Yoast RE, Courjaret R, Nwokonko RM, Li W, Hempel N, Machaca K, Gill DL, Hogan PG, Trebak M., Free PMC Article | 09/19/2020 |
| Treatment of CASR-transfected cells with Jag-1 further enhances CaSR-mediated increase in [Ca(2+)]cyt. Moreover, CaSR-mediated increase in [Ca(2+)]cyt was significantly augmented in cells co-transfected with CASR and STIM2. CaSR activation results in STIM2 clustering in CASR/STIM2-cotransfected cells. | Notch enhances Ca(2+) entry by activating calcium-sensing receptors and inhibiting voltage-gated K(+) channels.
Song S, Babicheva A, Zhao T, Ayon RJ, Rodriguez M, Rahimi S, Balistrieri F, Harrington A, Shyy JY, Thistlethwaite PA, Makino A, Yuan JX., Free PMC Article | 08/12/2020 |
| STIM1 is essential for IL-4 release after stimulation of FcepsilonRI, STIM2 mediates a delayed IL-3/IL-33-induced IL-4 release independent of STIM1. | Stepping out of the shadow: STIM2 promotes IL-3-induced cytokine release.
Alansary D, Niemeyer BA. | 07/4/2020 |
| Both STIM1 and STIM2 are necessary for cancer cell proliferation, but STIM1 is the dominant endoplasmic reticulum Ca2+ sensor involved in cancer cell migration. | The distinct role of STIM1 and STIM2 in the regulation of store-operated Ca(2+) entry and cellular function.
Chen YF, Chen LH, Shen MR. | 04/18/2020 |
| Stromal interaction molecule2 (STIM2) overexpression promotes human breast cancer metastasis. STIM2 overexpression activated the nuclear factor of activates T cells 1 (NFAT1) and transforming growth factor-beta signaling. Knockdown of STIM2 inhibits the motility of breast cancer cells by inhibiting epithelial-mesenchymal transition via specific suppression of NFAT1 and inhibits mammary tumor metastasis in mice. | Calcium-sensing stromal interaction molecule 2 upregulates nuclear factor of activated T cells 1 and transforming growth factor-β signaling to promote breast cancer metastasis.
Miao Y, Shen Q, Zhang S, Huang H, Meng X, Zheng X, Yao Z, He Z, Lu S, Cai C, Zou F., Free PMC Article | 02/29/2020 |
| STIM and FcgammaRII play an essential role in the regulation of diabetic kidney disease-induced podocyte epithelial-mesenchymal transition | STIM promotes the epithelial-mesenchymal transition of podocytes through regulation of FcγRII activity in diabetic nephropathy.
Jin J, Ye M, Hu K, Gong J, He Q. | 01/4/2020 |
| Cross-talk between N-terminal and C-terminal domains in stromal interaction molecule 2 (STIM2) determines enhanced STIM2 sensitivity. | Cross-talk between N-terminal and C-terminal domains in stromal interaction molecule 2 (STIM2) determines enhanced STIM2 sensitivity.
Emrich SM, Yoast RE, Xin P, Zhang X, Pathak T, Nwokonko R, Gueguinou MF, Subedi KP, Zhou Y, Ambudkar IS, Hempel N, Machaca K, Gill DL, Trebak M., Free PMC Article | 10/19/2019 |
| STIM2 is constitutively localized within ER-PM junctions in ER-Ca(2+) store replete cells. STIM2 traps STIM1 and triggers remodeling of STIM1 C terminus, causing STIM1/Orai1 coupling and enhancement of Orai1 function in cells with relatively high ER-[Ca(2+)]. | STIM2 Induces Activated Conformation of STIM1 to Control Orai1 Function in ER-PM Junctions.
Subedi KP, Ong HL, Son GY, Liu X, Ambudkar IS. | 09/21/2019 |
| We identified the key structural determinants, especially the corresponding G residue in STIM1, which define the distinct activation dynamics of STIM2. The chimeric E470G mutation could switch STIM2 from a slow and weak Orai channel activator into a fast and potent one like STIM1 and vice versa. | Identification of molecular determinants that govern distinct STIM2 activation dynamics.
Zheng S, Ma G, He L, Zhang T, Li J, Yuan X, Nguyen NT, Huang Y, Zhang X, Gao P, Nwokonko R, Gill DL, Dong H, Zhou Y, Wang Y., Free PMC Article | 06/22/2019 |
| Expression of full-length STIM1 with STIM2 in a 5:1 ratio causes suppression of sustained agonist-induced Ca(2+) oscillations and protects cells from Ca(2+) overload. | Cross-linking of Orai1 channels by STIM proteins.
Zhou Y, Nwokonko RM, Cai X, Loktionova NA, Abdulqadir R, Xin P, Niemeyer BA, Wang Y, Trebak M, Gill DL., Free PMC Article | 11/3/2018 |
| Stim2 deletion reduced SOCE by more than 90% in NIH 3T3 cells and abolishes STIM1 translocation to plasma membrane-associated ER membrane junctions. | Interplay between ER Ca(2+) Binding Proteins, STIM1 and STIM2, Is Required for Store-Operated Ca(2+) Entry.
Nelson HA, Leech CA, Kopp RF, Roe MW., Free PMC Article | 09/22/2018 |
| With STIM2 being essential for life, but apparently not for development, newly available data demonstrate a complex and still intriguing behaviour that this review summarizes, updating current knowledge of STIM2 function [review] | Role of STIM2 in cell function and physiopathology.
Berna-Erro A, Jardin I, Salido GM, Rosado JA., Free PMC Article | 03/3/2018 |
| The STIM2 protein play important roles in TGF-beta-induced EMT and these effects are related to both store-operated calcium entry and non-store-operated calcium entry. | STIM1 and STIM2 differently regulate endogenous Ca(2+) entry and promote TGF-β-induced EMT in breast cancer cells.
Zhang S, Miao Y, Zheng X, Gong Y, Zhang J, Zou F, Cai C. | 09/23/2017 |
| What is less clear is how the spatial and temporal spread of intracellular Ca(2+) is shaped and regulated by differential expression of the individual SOCE genes and their splice variants, their heteromeric combinations and pre- and posttranslational modifications. This review focuses on principle mechanisms regulating expression, splicing, and targeting of Ca(2+) release-activated Ca(2+) (CRAC) channels. | Changing calcium: CRAC channel (STIM and Orai) expression, splicing, and posttranslational modifiers.
Niemeyer BA. | 05/27/2017 |
| While STIM1 is a full Orai1-agonist, leucine-replacement of this crucial residue in STIM2 endows it with partial agonist properties, which may be critical for limiting Orai1 activation stemming from its enhanced sensitivity to store-depletion | Distinct Orai-coupling domains in STIM1 and STIM2 define the Orai-activating site.
Wang X, Wang Y, Zhou Y, Hendron E, Mancarella S, Andrake MD, Rothberg BS, Soboloff J, Gill DL., Free PMC Article | 03/12/2016 |
| These results imply that the splice variant STIM2.1 is an additional player tuning Orai1 activation in vivo. | A STIM2 splice variant negatively regulates store-operated calcium entry.
Miederer AM, Alansary D, Schwär G, Lee PH, Jung M, Helms V, Niemeyer BA., Free PMC Article | 03/5/2016 |