| The UAF1-USP1 Deubiquitinase Complex Stabilizes cGAS and Facilitates Antiviral Responses. | The UAF1-USP1 Deubiquitinase Complex Stabilizes cGAS and Facilitates Antiviral Responses.
Yu Z, Tong L, Ma C, Song H, Wang J, Chai L, Wang C, Wang M, Wang C, Yan R, Fu Y, Jia M, Zhao W, Zhao C. | 01/9/2024 |
| USP1-WDR48 deubiquitinase complex enhances TGF-beta induced epithelial-mesenchymal transition of TNBC cells via stabilizing TAK1. | USP1-WDR48 deubiquitinase complex enhances TGF-β induced epithelial-mesenchymal transition of TNBC cells via stabilizing TAK1.
Han D, Wang L, Chen B, Zhao W, Liang Y, Li Y, Zhang H, Liu Y, Wang X, Chen T, Li C, Song X, Luo D, Li Z, Yang Q., Free PMC Article | 12/4/2021 |
| ATAD5 suppresses centrosome over-duplication by regulating UAF1 and ID1. | ATAD5 suppresses centrosome over-duplication by regulating UAF1 and ID1.
Kim SJ, Wie M, Park SH, Kim TM, Park JH, Kim S, Myung K, Lee KY., Free PMC Article | 09/4/2021 |
| Structural basis of FANCD2 deubiquitination by USP1-UAF1. | Structural basis of FANCD2 deubiquitination by USP1-UAF1.
Rennie ML, Arkinson C, Chaugule VK, Toth R, Walden H. | 06/26/2021 |
| The DNA-binding activity of USP1-associated factor 1 is required for efficient RAD51-mediated homologous DNA pairing and homology-directed DNA repair. | The DNA-binding activity of USP1-associated factor 1 is required for efficient RAD51-mediated homologous DNA pairing and homology-directed DNA repair.
Liang F, Miller AS, Tang C, Maranon D, Williamson EA, Hromas R, Wiese C, Zhao W, Sung P, Kupfer GM., Free PMC Article | 01/2/2021 |
| In this report, the authors provide evidence that the previously described interaction between the viral E1 helicase and the cellular UAF1-USP1 deubiquitinating enzyme complex is required for the completion of the bidirectional theta replication of the human papilloma virus type 11 genome and the subsequent initiation of the unidirectional replication. | Interaction of the Human Papillomavirus E1 Helicase with UAF1-USP1 Promotes Unidirectional Theta Replication of Viral Genomes.
Orav M, Gagnon D, Archambault J., Free PMC Article | 05/25/2019 |
| There is evidence that USP1/WDR48 complex promotes cancer stem cell conservation and regulation of DNA damage repair. [REVIEW] | The Role of the Complex USP1/WDR48 in Differentiation and Proliferation Processes in Cancer Stem Cells.
Goncalves JM, Cordeiro MMR, Rivero ERC. | 04/14/2018 |
| Our results highlight the interfaces essential for regulation of USP12 activity and show a conserved second binding of UAF1 which could be important for regulatory functions independent of USP12 activity. | A conserved two-step binding for the UAF1 regulator to the USP12 deubiquitinating enzyme.
Dharadhar S, Clerici M, van Dijk WJ, Fish A, Sixma TK., Free PMC Article | 12/23/2017 |
| These results outline a novel mechanism for the control of TBK1 activity and suggest USP1-UAF1 complex as a potential target for the prevention of viral diseases. | USP1-UAF1 deubiquitinase complex stabilizes TBK1 and enhances antiviral responses.
Yu Z, Song H, Jia M, Zhang J, Wang W, Li Q, Zhang L, Zhao W., Free PMC Article | 12/23/2017 |
| UAF1 and WDR20 interact with USP12 at two distinct sites far from its catalytic center, allosterically activating the enzyme. | Allosteric Activation of Ubiquitin-Specific Proteases by β-Propeller Proteins UAF1 and WDR20.
Li H, Lim KS, Kim H, Hinds TR, Jo U, Mao H, Weller CE, Sun J, Chatterjee C, D'Andrea AD, Zheng N., Free PMC Article | 08/26/2017 |
| USP1-UAF1 complex promotes homologous recombination repair via multiple mechanisms: through FANCD2 deubiquitination, as well as by interacting with RAD51AP1. | The USP1-UAF1 complex interacts with RAD51AP1 to promote homologous recombination repair.
Cukras S, Lee E, Palumbo E, Benavidez P, Moldovan GL, Kee Y., Free PMC Article | 06/24/2017 |
| analysis of the function and regulation of the USP1-UAF1 complex | Mutations in the 'Fingers' subdomain of the deubiquitinase USP1 modulate its function and activity.
Olazabal-Herrero A, García-Santisteban I, Rodríguez JA. | 07/30/2016 |
| Coimmunoprecipitation experiments indicated that human papillomavirus type 31 E1 assembles into a ternary complex with UAF1 and any one of these three USPs: USP1, USP12 and USP46. | E1-mediated recruitment of a UAF1-USP deubiquitinase complex facilitates human papillomavirus DNA replication.
Lehoux M, Gagnon D, Archambault J., Free PMC Article | 10/4/2014 |
| our results reveal WDR48 and USP12 as novel PHLPP1 regulators and potential suppressors of tumor cell survival. | WD repeat protein WDR48 in complex with deubiquitinase USP12 suppresses Akt-dependent cell survival signaling by stabilizing PH domain leucine-rich repeat protein phosphatase 1 (PHLPP1).
Gangula NR, Maddika S., Free PMC Article | 02/22/2014 |
| Our findings revealed an intriguing mechanism of regulating USP1 activity that combines phosphorylation of a key serine residue in USP1 and the specific interaction of USP1 with a WD40-repeat protein UAF1 | Serine phosphorylation is critical for the activation of ubiquitin-specific protease 1 and its interaction with WD40-repeat protein UAF1.
Villamil MA, Liang Q, Chen J, Choi YS, Hou S, Lee KH, Zhuang Z., Free PMC Article | 02/23/2013 |
| USP1 and UAF1 form a complex in the cytoplasm that subsequently translocates to the nucleus through import mediated by USP1 nuclear localization signals. | Two nuclear localization signals in USP1 mediate nuclear import of the USP1/UAF1 complex.
Garcia-Santisteban I, Zorroza K, Rodriguez JA., Free PMC Article | 11/17/2012 |
| p80 is recruited to the viral origin in an E1- and E2-dependent manner. | Inhibition of human papillomavirus DNA replication by an E1-derived p80/UAF1-binding peptide.
Lehoux M, Fradet-Turcotte A, Lussier-Price M, Omichinski JG, Archambault J., Free PMC Article | 06/16/2012 |
| WDR20 serves as a stimulatory subunit for preserving and regulating the activity of the subset of the UAF1 x USP12 complexes | WDR20 regulates activity of the USP12 x UAF1 deubiquitinating enzyme complex.
Kee Y, Yang K, Cohn MA, Haas W, Gygi SP, D'Andrea AD., Free PMC Article | 05/10/2010 |
| two novel multisubunit deubiquitinating enzyme complexes containing USP12 and USP46, respectively. Both complexes contain the UAF1 protein as a bona fide subunit. Interestingly, UAF1 | UAF1 is a subunit of multiple deubiquitinating enzyme complexes.
Cohn MA, Kee Y, Haas W, Gygi SP, D'Andrea AD., Free PMC Article | 01/21/2010 |
| These findings suggest that the interaction of human papillomavirus 11 and 31 E1 proteins with p80 is required for efficient maintenance of the viral episome in undifferentiated keratinocytes. | Human papillomavirus E1 helicase interacts with the WD repeat protein p80 to promote maintenance of the viral genome in keratinocytes.
Côté-Martin A, Moody C, Fradet-Turcotte A, D'Abramo CM, Lehoux M, Joubert S, Poirier GG, Coulombe B, Laimins LA, Archambault J., Free PMC Article | 01/21/2010 |