| Single-cell transcriptomics identifies prothymosin alpha restriction of HIV-1 in vivo. | Single-cell transcriptomics identifies prothymosin α restriction of HIV-1 in vivo.
Geretz A, Ehrenberg PK, Clifford RJ, Laliberté A, Prelli Bozzo C, Eiser D, Kundu G, Yum LK, Apps R, Creegan M, Gunady M, Shangguan S, Sanders-Buell E, Sacdalan C, Phanuphak N, Tovanabutra S, Russell RM, Bibollet-Ruche F, Robb ML, Michael NL, Ake JA, Vasan S, Hsu DC, Hahn BH, Kirchhoff F, Thomas R. | 08/4/2023 |
| Prothymosin Alpha: A Novel Contributor to Estradiol Receptor Alpha-Mediated CD8(+) T-Cell Pathogenic Responses and Recognition of Type 1 Collagen in Rheumatic Heart Valve Disease. | Prothymosin Alpha: A Novel Contributor to Estradiol Receptor Alpha-Mediated CD8(+) T-Cell Pathogenic Responses and Recognition of Type 1 Collagen in Rheumatic Heart Valve Disease.
Passos LSA, Jha PK, Becker-Greene D, Blaser MC, Romero D, Lupieri A, Sukhova GK, Libby P, Singh SA, Dutra WO, Aikawa M, Levine RA, Nunes MCP, Aikawa E., Free PMC Article | 03/5/2022 |
| lncRNA cytoskeleton regulator reduces nonsmall cell lung cancer radiosensitivity by downregulating miRNA206 and activating prothymosin alpha. | lncRNA cytoskeleton regulator reduces non‑small cell lung cancer radiosensitivity by downregulating miRNA‑206 and activating prothymosin α.
Jiang G, Yu H, Li Z, Zhang F., Free PMC Article | 01/29/2022 |
| Prothymosin alpha promotes colorectal carcinoma chemoresistance through inducing lipid droplet accumulation. | Prothymosin α promotes colorectal carcinoma chemoresistance through inducing lipid droplet accumulation.
Jin L, Zhu LY, Pan YL, Fu HQ, Zhang J. | 01/29/2022 |
| Prothymosin alpha activates type I collagen to develop a fibrotic placenta in gestational diabetes. | Prothymosin α activates type I collagen to develop a fibrotic placenta in gestational diabetes.
Wu HT, Kang L, Su YC, Ou HY, Chan FY, Chen YC, Su BH, Wang YS, Wu CL, Shiau AL, Wu P. | 03/28/2021 |
| Dynamics of the intrinsically disordered protein NUPR1 in isolation and in its fuzzy complexes with DNA and prothymosin alpha. | Dynamics of the intrinsically disordered protein NUPR1 in isolation and in its fuzzy complexes with DNA and prothymosin α.
Neira JL, Palomino-Schätzlein M, Ricci C, Ortore MG, Rizzuti B, Iovanna JL. | 01/18/2020 |
| Measure the binding affinity for the prothymosin-alpha (ProTalpha)-H1.0 complex using isothermal titration calorimetry and report a KD value of (4.6 +/- 0.5) x 10(-7) M. In addition, we show that ProTalpha facilitates the formation of the H1.0-nucleosome complex in vitro. | Binding Affinity and Function of the Extremely Disordered Protein Complex Containing Human Linker Histone H1.0 and Its Chaperone ProTα.
Feng H, Zhou BR, Bai Y., Free PMC Article | 08/3/2019 |
| Our data support that nuclear PTMA protein serves as a tumor suppressor in bladder cancer through upregulating PTEN and orchestrating TRIM21 for the regulation of Nrf2 signaling. | Prothymosin-α enhances phosphatase and tensin homolog expression and binds with tripartite motif-containing protein 21 to regulate Kelch-like ECH-associated protein 1/nuclear factor erythroid 2-related factor 2 signaling in human bladder cancer.
Tsai YS, Jou YC, Tsai HT, Shiau AL, Wu CL, Tzai TS., Free PMC Article | 04/20/2019 |
| According to the cellular function of the characterized targets of ProTalpha, and the evolution in the composition of the diverse ProTalpha-complexes when proliferation activity was reduced or apoptosis induced, leads to hypothesized that ProTalpha interactions might be related to the proliferation activity and control of the cell survival. | Prothymosin α interacts with SET, ANP32A and ANP32B and other cytoplasmic and mitochondrial proteins in proliferating cells.
Barbeito P, Sarandeses CS, Díaz-Jullien C, Muras J, Covelo G, Moreira D, Freire-Cobo C, Freire M. | 12/2/2017 |
| Prothymosin-alpha variants elicit anti-HIV-1 response via TLR4 dependent and independent pathways. | Prothymosin-α Variants Elicit Anti-HIV-1 Response via TLR4 Dependent and Independent Pathways.
Gusella GL, Teixeira A, Aberg J, Uversky VN, Mosoian A., Free PMC Article | 07/15/2017 |
| PTMA is a potential novel therapeutic target for type 2 diabetes | Prothymosin-α Overexpression Contributes to the Development of Insulin Resistance.
Su YC, Ou HY, Wu HT, Wu P, Chen YC, Su BH, Shiau AL, Chang CJ, Wu CL. | 02/20/2016 |
| disease-free survival and overall survival rates were significantly lower among colorectal cancer patients with PTMA- and TP53-positive tumors | Increased expression of prothymosin-α, independently or combined with TP53, correlates with poor prognosis in colorectal cancer.
Zhang M, Cui F, Lu S, Lu H, Jiang T, Chen J, Zhang X, Jin Y, Peng Z, Tang H., Free PMC Article | 06/20/2015 |
| Data suggest that KEAP1 (kelch-like ECH-associated protein 1) mutations (as those observed in lung cancer patients) affect conformation/folding/stability of KEAP1 and binding affinity for ligands PTMA and NRF2 (nuclear factor erythroid 2-like 2). | Molecular effects of cancer-associated somatic mutations on the structural and target recognition properties of Keap1.
Khan H, Killoran RC, Brickenden A, Fan J, Yang D, Choy WY. | 05/30/2015 |
| Data suggest that plasma thymosin-alpha1 (TA1) and prothymosin-alpha (PTMA) level may be a biomarker for differentiating between renal cell carcinoma (RCC) and urothelial carcinoma. | Plasma thymosin-α1 level as a potential biomarker in urothelial and renal cell carcinoma.
Jou YC, Tsai YS, Hsieh HY, Chen SY, Tsai HT, Chen KJ, Wang ST, Shiau AL, Wu CL, Tzai TS. | 08/9/2014 |
| prothymosin-alpha expression is a determinant of disease progression in superficial bladder cancer | Loss of nuclear prothymosin-α expression is associated with disease progression in human superficial bladder cancer.
Tsai YS, Jou YC, Tung CL, Lin CT, Shen CH, Chen SY, Tsai HT, Lai CL, Wu CL, Tzai TS. | 08/9/2014 |
| PTalpha offers cardioprotection against ischemic injury by an Akt-dependent mechanism. | Prothymosin alpha protects cardiomyocytes against ischemia-induced apoptosis via preservation of Akt activation.
Cannavo A, Rengo G, Liccardo D, Pironti G, Scimia MC, Scudiero L, De Lucia C, Ferrone M, Leosco D, Zambrano N, Koch WJ, Trimarco B, Esposito G. | 03/29/2014 |
| phosphorylation of ProTalpha is required for its antiapoptotic activity, but it does not affect its nuclear import | The influence of phosphorylation of prothymosin α on its nuclear import and antiapoptotic activity.
Moreira D, Díaz-Jullien C, Sarandeses CS, Covelo G, Barbeito P, Freire M. | 01/4/2014 |
| These results demonstrate the clinical relevance of prothymosin alpha in regulating acetylation events during the pathogenesis of emphysema. | Prothymosin α overexpression contributes to the development of pulmonary emphysema.
Su BH, Tseng YL, Shieh GS, Chen YC, Shiang YC, Wu P, Li KJ, Yen TH, Shiau AL, Wu CL., Free PMC Article | 01/4/2014 |
| Western blot analysis of protein extracts from sperm head fractions confirms that the peptide is specifically associated with the inner acrosomal membrane fraction. | First evidence of prothymosin α localization in the acrosome of mammalian male gametes.
Ferrara D, Pariante P, Di Matteo L, Serino I, Oko R, Minucci S. | 06/29/2013 |
| ProTalpha is crucial for the interaction with the Kelch domain, while the flanking residues play relatively minor roles in the affinity of binding. | Fuzzy complex formation between the intrinsically disordered prothymosin α and the Kelch domain of Keap1 involved in the oxidative stress response.
Khan H, Cino EA, Brickenden A, Fan J, Yang D, Choy WY. | 05/4/2013 |
| The decrease of ProTalpha mRNA during differentiation was not accompanied by changes in the methylation status | Preliminary methylation analysis of prothymosin α genomic sequences.
Álvarez-Fernández L, Gómez-Márquez J. | 11/17/2012 |
| The prothymosin alpha is one of miR-1 target genes which involve in miR-1 inducing apoptosis | MicroRNA-1 induces apoptosis by targeting prothymosin alpha in nasopharyngeal carcinoma cells.
Wu CD, Kuo YS, Wu HC, Lin CT, Wu CD, Kuo YS, Wu HC, Lin CT., Free PMC Articles: PMC3238347, PMC3238347 | 08/18/2012 |
| Findings suggest that the binding of prothymosin alpha (ProTalpha) and Neh2 to Keap1 occurs synergistically via preformed structural elements. | Microsecond molecular dynamics simulations of intrinsically disordered proteins involved in the oxidative stress response.
Cino EA, Wong-ekkabut J, Karttunen M, Choy WY., Free PMC Article | 04/7/2012 |
| The PTMA is one of miR-1 target genes which involve in miR-1 inducing apoptosis. | MicroRNA-1 induces apoptosis by targeting prothymosin alpha in nasopharyngeal carcinoma cells.
Wu CD, Kuo YS, Wu HC, Lin CT, Wu CD, Kuo YS, Wu HC, Lin CT., Free PMC Articles: PMC3238347, PMC3238347 | 03/19/2012 |
| when added to cultured cells expressing mHtt, the purified recombinant ProTalpha protein not only entered the cells but it also significantly suppressed the mHtt-caused cytotoxicity. | Prothymosin-α interacts with mutant huntingtin and suppresses its cytotoxicity in cell culture.
Dong G, Callegari EA, Gloeckner CJ, Ueffing M, Wang H., Free PMC Article | 03/3/2012 |