| Genome-Wide CRISPR Screen Identifies Semaphorin 6A and 6B as Receptors for Paeniclostridium sordellii Toxin TcsL. | Genome-Wide CRISPR Screen Identifies Semaphorin 6A and 6B as Receptors for Paeniclostridium sordellii Toxin TcsL.
Tian S, Liu Y, Wu H, Liu H, Zeng J, Choi MY, Chen H, Gerhard R, Dong M., Free PMC Article | 01/23/2021 |
| Semaphorin 6A Attenuates the Migration Capability of Lung Cancer Cells via the NRF2/HMOX1 Axis. | Semaphorin 6A Attenuates the Migration Capability of Lung Cancer Cells via the NRF2/HMOX1 Axis.
Chen LH, Liao CY, Lai LC, Tsai MH, Chuang EY., Free PMC Article | 10/31/2020 |
| RNA-guided epigenetic editing of Sema6a gene promoters via a dCas9-SunTag system with C11orf46 binding normalized SEMA6A expression and rescued transcallosal dysconnectivity via repressive chromatin remodeling by the SETDB1 repressor complex. | In vivo epigenetic editing of Sema6a promoter reverses transcallosal dysconnectivity caused by C11orf46/Arl14ep risk gene.
Peter CJ, Saito A, Hasegawa Y, Tanaka Y, Nagpal M, Perez G, Alway E, Espeso-Gil S, Fayyad T, Ratner C, Dincer A, Gupta A, Devi L, Pappas JG, Lalonde FM, Butman JA, Han JC, Akbarian S, Kamiya A., Free PMC Article | 12/28/2019 |
| The A alleles of SEMA6A and POMP genes are likely the risk factors of disease development in Georgians | NEW GENETIC MARKERS ASSOCIATED WITH SUSCEPTIBILITY TO EXFOLIATION SYNDROME AMONG GEORGIAN POPULATION.
Kobakhidze N, Tabagari S, Chichua G. | 11/23/2019 |
| describes the experiments and methods enabling the characterization of Semaphorin 6A as a critical regulator of endothelial cell survival and vessel function | Characterization of Semaphorin 6A-Mediated Effects on Angiogenesis Through Regulation of VEGF Signaling.
Ohnuki H, Tosato G., Free PMC Article | 02/17/2018 |
| miR-203 induces the apoptosis of YD-38 human oral cancer cells by directly targeting SEMA6A. | Suppression of Oral Carcinoma Oncogenic Activity by microRNA-203 via Down-regulation of SEMA6A.
Lim HS, Kim CS, Kim JS, Yu SK, Go DS, Lee SA, Moon SM, Chun HS, Kim SG, Kim DK. | 10/21/2017 |
| our findings indicated that SEMA6A may be a potential prognostic biomarker in the treatment of Glioblastoma multiforme | SEMA6A is a prognostic biomarker in glioblastoma.
Zhao J, Tang H, Zhao H, Che W, Zhang L, Liang P. | 04/9/2016 |
| Data suggest that Sema6A and Mical1 may represent new potential therapeutic targets in BRAFV600E melanoma. | Sema6A and Mical1 control cell growth and survival of BRAFV600E human melanoma cells.
Loria R, Bon G, Perotti V, Gallo E, Bersani I, Baldassari P, Porru M, Leonetti C, Di Carlo S, Visca P, Brizzi MF, Anichini A, Mortarini R, Falcioni R., Free PMC Article | 12/5/2015 |
| We identified the SEMA6A and HLA-DP loci as significant contributors to risk for granulomatosis with polyangiitis. | Association of granulomatosis with polyangiitis (Wegener's) with HLA-DPB1*04 and SEMA6A gene variants: evidence from genome-wide analysis.
Xie G, Roshandel D, Sherva R, Monach PA, Lu EY, Kung T, Carrington K, Zhang SS, Pulit SL, Ripke S, Carette S, Dellaripa PF, Edberg JC, Hoffman GS, Khalidi N, Langford CA, Mahr AD, St Clair EW, Seo P, Specks U, Spiera RF, Stone JH, Ytterberg SR, Raychaudhuri S, de Bakker PI, Farrer LA, Amos CI, Merkel PA, Siminovitch KA., Free PMC Article | 11/23/2013 |
| Data show that miR-27a/b regulated the expression of the angiogenesis inhibitor semaphorin 6A (SEMA6A) in vitro and in vivo and targeted the 3'-untranslated region of SEMA6A. | MicroRNA-27a/b controls endothelial cell repulsion and angiogenesis by targeting semaphorin 6A.
Urbich C, Kaluza D, Frömel T, Knau A, Bennewitz K, Boon RA, Bonauer A, Doebele C, Boeckel JN, Hergenreider E, Zeiher AM, Kroll J, Fleming I, Dimmeler S. | 04/7/2012 |
| Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) | Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR., Free PMC Article | 06/30/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | The ERAP2 gene is associated with preeclampsia in Australian and Norwegian populations.
Johnson MP, Roten LT, Dyer TD, East CE, Forsmo S, Blangero J, Brennecke SP, Austgulen R, Moses EK., Free PMC Article | 08/12/2009 |
| findings suggest for SEMA6A a novel function in the cytoskeleton and a role in modulating tubulin isotype composition and microtubule dynamics | From plasma membrane to cytoskeleton: a novel function for semaphorin 6A.
Prislei S, Mozzetti S, Filippetti F, De Donato M, Raspaglio G, Cicchillitti L, Scambia G, Ferlini C. | 01/21/2010 |
| NANOG-, SOX2-, and POU5F1 (OCT3/OCT4)-binding sites within intron 1 of the SEMA6A gene | Comparative integromics on non-canonical WNT or planar cell polarity signaling molecules: transcriptional mechanism of PTK7 in colorectal cancer and that of SEMA6A in undifferentiated ES cells.
Katoh M, Katoh M. | 01/21/2010 |
| Strong expression of SEMA6A is associated with langerhans cells of histiocytosis or dermatopathic lymphadenitis | The class 6 semaphorin SEMA6A is induced by interferon-gamma and defines an activation status of langerhans cells observed in pathological situations.
Gautier G, de Saint-Vis B, Sénéchal B, Pin JJ, Bates EE, Caux C, Geissmann F, Garrone P., Free PMC Article | 01/21/2010 |