| KIAA1363 affects retinyl ester turnover in cultured murine and human hepatic stellate cells. | KIAA1363 affects retinyl ester turnover in cultured murine and human hepatic stellate cells.
Wagner C, Hois V, Eggeling A, Pusch LM, Pajed L, Starlinger P, Claudel T, Trauner M, Zimmermann R, Taschler U, Lass A., Free PMC Article | 04/30/2022 |
| NAD(P)-dependent steroid dehydrogenase-like protein and neutral cholesterol ester hydrolase 1 serve as novel markers for early detection of gastric cancer identified using quantitative proteomics. | NAD(P)-dependent steroid dehydrogenase-like protein and neutral cholesterol ester hydrolase 1 serve as novel markers for early detection of gastric cancer identified using quantitative proteomics.
Xiao Y, Xie J, Liu L, Huang W, Han Q, Qin J, Liu S, Jiang Z., Free PMC Article | 10/30/2021 |
| Retinoic acid receptor-related orphan receptor alpha reduces lipid droplets by upregulating neutral cholesterol ester hydrolase 1 in macrophages. | Retinoic acid receptor-related orphan receptor α reduces lipid droplets by upregulating neutral cholesterol ester hydrolase 1 in macrophages.
Matsuoka H, Tokunaga R, Katayama M, Hosoda Y, Miya K, Sumi K, Ohishi A, Kamishikiryo J, Shima A, Michihara A., Free PMC Article | 11/28/2020 |
| Authors discovered that the presence of cholesterol, LDLR-mediated cholesterol endocytosis, and cholesterol efflux are all essential to NCEH-1-mediated neuroprotection. In protecting from alpha-synuclein neurotoxicity, NCEH-1 also stimulates cholesterol-derived neurosteroid formation and lowers cellular reactive oxygen species in mitochondria. | NCEH-1 modulates cholesterol metabolism and protects against α-synuclein toxicity in a C. elegans model of Parkinson's disease.
Zhang S, Glukhova SA, Caldwell KA, Caldwell GA., Free PMC Article | 01/27/2018 |
| Psoriasis inflammation induced microRNA targets NCEH1 in underlying subcutaneous adipose tissue. | Psoriasis Skin Inflammation-Induced microRNA-26b Targets NCEH1 in Underlying Subcutaneous Adipose Tissue.
Cheung L, Fisher RM, Kuzmina N, Li D, Li X, Werngren O, Blomqvist L, Ståhle M, Landén NX. | 07/16/2016 |
| Together, the results define the kinetics of inhibition of KIAA1363 by active metabolites of agrochemicals and indicate that KIAA1363 is highly sensitive to inhibition by these compounds. | Interaction of the serine hydrolase KIAA1363 with organophosphorus agents: Evaluation of potency and kinetics.
Ross MK, Pluta K, Bittles V, Borazjani A, Allen Crow J., Free PMC Article | 06/4/2016 |
| Pioglitazone increases ABCA1 expression in an LXR-dependent manner and NCEH1 expression in an LXRalpha-independent manner. | Pioglitazone reduces lipid droplets in cholesterolosis of the gallbladder by increasing ABCA1 and NCEH1 expression.
Wang JM, Wang D, Tan YY, Zhao G, Ji ZL. | 08/22/2015 |
| Inhibition of AADACL1 activity with a variety of agents blocked platelet aggregation in response to multiple agonists; blocked activation of the small GTPase RAP1 and protein kinase C (PKC). | Chemoproteomic discovery of AADACL1 as a regulator of human platelet activation.
Holly SP, Chang JW, Li W, Niessen S, Phillips RM, Piatt R, Black JL, Smith MC, Boulaftali Y, Weyrich AS, Bergmeier W, Cravatt BF, Parise LV., Free PMC Article | 03/29/2014 |
| NCEH1 is expressed in human atheromatous lesions, where it plays a critical role in the hydrolysis of cholesterol ester in human macrophage foam cells, thereby contributing to the initial part of reverse cholesterol transport in human atherosclerosis. | The critical role of neutral cholesterol ester hydrolase 1 in cholesterol removal from human macrophages.
Igarashi M, Osuga J, Uozaki H, Sekiya M, Nagashima S, Takahashi M, Takase S, Takanashi M, Li Y, Ohta K, Kumagai M, Nishi M, Hosokawa M, Fledelius C, Jacobsen P, Yagyu H, Fukayama M, Nagai R, Kadowaki T, Ohashi K, Ishibashi S. | 01/1/2011 |
| Ritonavir (at 100 mg once daily and 100 mg twice daily significantly down-regulated neutral cholesterol ester hydrolase 1 in 20 healthy individuals. | Investigation of low-dose ritonavir on human peripheral blood mononuclear cells using gene expression whole genome microarrays.
Yilmaz S, Boffito M, Collot-Teixeira S, De Lorenzo F, Waters L, Fletcher C, Back D, Pozniak A, Gazzard B, McGregor JL. | 10/23/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | See all PubMed (2) articlesAssociation of genetic variants with hemorrhagic stroke in Japanese individuals.
Yoshida T, Kato K, Yokoi K, Oguri M, Watanabe S, Metoki N, Yoshida H, Satoh K, Aoyagi Y, Nozawa Y, Yamada Y. Assessment of a polymorphism of SDK1 with hypertension in Japanese Individuals.
Oguri M, Kato K, Yokoi K, Yoshida T, Watanabe S, Metoki N, Yoshida H, Satoh K, Aoyagi Y, Nozawa Y, Yamada Y. | 12/2/2009 |
| NCEH is responsible for a major part of nCEH activity in macrophages and may be a potential therapeutic target for the prevention of atherosclerosis. | Identification of neutral cholesterol ester hydrolase, a key enzyme removing cholesterol from macrophages.
Okazaki H, Igarashi M, Nishi M, Sekiya M, Tajima M, Takase S, Takanashi M, Ohta K, Tamura Y, Okazaki S, Yahagi N, Ohashi K, Amemiya-Kudo M, Nakagawa Y, Nagai R, Kadowaki T, Osuga J, Ishibashi S., Free PMC Article | 01/21/2010 |
| The KIAA1363, an uncharacterized enzyme highly elevated in aggressive cancer cells, serves as a central node in an ether lipid signaling network that bridges platelet-activating factor and lysophosphatidic acid. | An enzyme that regulates ether lipid signaling pathways in cancer annotated by multidimensional profiling.
Chiang KP, Niessen S, Saghatelian A, Cravatt BF. | 01/21/2010 |
| KIAA1363, an uncharacterized enzyme highly elevated in aggressive cancer cells, serves as a central node in an ether lipid signaling network that bridges platelet-activating factor and lysophosphatidic acid. | Enzyme annotation with chemical tools.
Herman AG, Stockwell BR. | 01/21/2010 |