| lincRNA00907 promotes NASH progression by targeting miRNA-942-5p/TAOK1. | lincRNA00907 promotes NASH progression by targeting miRNA-942-5p/TAOK1.
Du G, Jiang Z, Xia T, Liu M, Liu Z, Zhou H, Zhang H, Zhai X, Jin B., Free PMC Article | 05/31/2024 |
| Silencing of STE20-type kinase TAOK1 confers protection against hepatocellular lipotoxicity through metabolic rewiring. | Silencing of STE20-type kinase TAOK1 confers protection against hepatocellular lipotoxicity through metabolic rewiring.
Xia Y, Andersson E, Anand SK, Cansby E, Caputo M, Kumari S, Porosk R, Kilk K, Nair S, Marschall HU, Blüher M, Mahlapuu M., Free PMC Article | 03/22/2023 |
| Exosomal circTAOK1 contributes to diabetic kidney disease progression through regulating SMAD3 expression by sponging miR-520h. | Exosomal circTAOK1 contributes to diabetic kidney disease progression through regulating SMAD3 expression by sponging miR-520h.
Li B, Sun G, Yu H, Meng J, Wei F. | 08/20/2022 |
| Inherited and de novo variants extend the etiology of TAOK1-associated neurodevelopmental disorder. | Inherited and de novo variants extend the etiology of TAOK1-associated neurodevelopmental disorder.
Hunter JM, Massingham LJ, Manickam K, Bartholomew D, Williamson RK, Schwab JL, Marhabaie M, Siemon A, de Los Reyes E, Reshmi SC, Cottrell CE, Wilson RK, Koboldt DC., Free PMC Article | 04/30/2022 |
| [The role and mechanism of lncRNA C9ORF139 targeting miR-24-3P/TAOK1 in regulating the proliferation of acute myeloid leukemia cells]. | [The role and mechanism of lncRNA C9ORF139 targeting miR-24-3P/TAOK1 in regulating the proliferation of acute myeloid leukemia cells].
Qin W, Cai XH, Han WM, Lu XZ, Chen MY, Jia ZX, Liu J, Xiao R, Qian SX. | 03/5/2022 |
| miR-381-abundant small extracellular vesicles derived from kartogenin-preconditioned mesenchymal stem cells promote chondrogenesis of MSCs by targeting TAOK1. | miR-381-abundant small extracellular vesicles derived from kartogenin-preconditioned mesenchymal stem cells promote chondrogenesis of MSCs by targeting TAOK1.
Jing H, Zhang X, Luo K, Luo Q, Yin M, Wang W, Zhu Z, Zheng J, He X. | 06/19/2021 |
| Variants in TAOK1 Cause Neurodevelopmental Disorders. | De Novo Variants in TAOK1 Cause Neurodevelopmental Disorders.
Dulovic-Mahlow M, Trinh J, Kandaswamy KK, Braathen GJ, Di Donato N, Rahikkala E, Beblo S, Werber M, Krajka V, Busk ØL, Baumann H, Al-Sannaa NA, Hinrichs F, Affan R, Navot N, Al Balwi MA, Oprea G, Holla ØL, Weiss MER, Jamra RA, Kahlert AK, Kishore S, Tveten K, Vos M, Rolfs A, Lohmann K., Free PMC Article | 03/14/2020 |
| These results demonstrate that TAOK1 is a negative regulator of IL-17 signaling and that it may have therapeutic utility as a target for the treatment of IL-17-associated inflammatory disorders. | TAOK1 negatively regulates IL-17-mediated signaling and inflammation.
Zhang Z, Tang Z, Ma X, Sun K, Fan L, Fang J, Pan J, Wang X, An H, Zhou J., Free PMC Article | 10/26/2019 |
| we characterize a compound that inhibits TAOK1 and TAOK2 activity with IC50 values of 11 to 15 nmol/L, is ATP-competitive, and targets these kinases selectively. TAOK inhibition or depletion in centrosome-amplified SKBR3 or BT549 breast cancer cell models increases the mitotic population, the percentages of mitotic cells displaying amplified centrosomes and multipolar spindles, induces cell death, and inhibits cell growt | Targeting TAO Kinases Using a New Inhibitor Compound Delays Mitosis and Induces Mitotic Cell Death in Centrosome Amplified Breast Cancer Cells.
Koo CY, Giacomini C, Reyes-Corral M, Olmos Y, Tavares IA, Marson CM, Linardopoulos S, Tutt AN, Morris JDH. | 07/28/2018 |
| this study reveals a protective role for miR-706 by blocking the oxidative stress-induced activation of PKCalpha/TAOK1. Our results further identify a major implication for miR-706 in preventing hepatic fibrogenesis and suggest that miR-706 may be a suitable molecular target for anti-fibrosis therapy. | miR-706 inhibits the oxidative stress-induced activation of PKCα/TAOK1 in liver fibrogenesis.
Yin R, Guo D, Zhang S, Zhang X., Free PMC Article | 07/7/2018 |
| This study reports a novel set of Dengue virus (DENV) NS1-interacting host cell proteins in the HepG2 cell line and proposes possible roles for human NEK2, TAO1, and COG1 in DENV infection. | Mass spectrometric analysis of host cell proteins interacting with dengue virus nonstructural protein 1 in dengue virus-infected HepG2 cells.
Dechtawewat T, Paemanee A, Roytrakul S, Songprakhon P, Limjindaporn T, Yenchitsomanus PT, Saitornuang S, Puttikhunt C, Kasinrerk W, Malasit P, Noisakran S. | 10/7/2017 |
| The TAO1 kinase is required for ensuring the normal congression of chromosomes. Depletion of TAO1 reduces the density of growing interphase and mitotic microtubules in human cells, showing TAO1's role in controlling microtubule dynamics. | TAO1 kinase maintains chromosomal stability by facilitating proper congression of chromosomes.
Shrestha RL, Tamura N, Fries A, Levin N, Clark J, Draviam VM., Free PMC Article | 03/21/2015 |
| tau is a good substrate for PSK1 and PSK2 phosphorylation with mass spectrometric analysis of phosphorylated tau revealing more than 40 tau residues as targets of these kinases. | Prostate-derived sterile 20-like kinases (PSKs/TAOKs) phosphorylate tau protein and are activated in tangle-bearing neurons in Alzheimer disease.
Tavares IA, Touma D, Lynham S, Troakes C, Schober M, Causevic M, Garg R, Noble W, Killick R, Bodi I, Hanger DP, Morris JD., Free PMC Article | 08/10/2013 |
| Human TAO1 can phosphorylate and activate human MST2 | The sterile 20-like kinase Tao-1 controls tissue growth by regulating the Salvador-Warts-Hippo pathway.
Poon CL, Lin JI, Zhang X, Harvey KF. | 02/4/2012 |
| Data do not support the notion that Tao1 is a component of the spindle checkpoint. | Re-evaluating the role of Tao1 in the spindle checkpoint.
Westhorpe FG, Diez MA, Gurden MD, Tighe A, Taylor SS. | 11/6/2010 |
| the apparent role of the Tao1 kinase in spindle checkpoing signaling might in reality reflect an off-target effect produced by particular Tao1-directed siRNA oligonucleotides on Mad2 | Re-examination of siRNA specificity questions role of PICH and Tao1 in the spindle checkpoint and identifies Mad2 as a sensitive target for small RNAs.
Hübner NC, Wang LH, Kaulich M, Descombes P, Poser I, Nigg EA., Free PMC Article | 06/28/2010 |
| Observational study and genome-wide association study of gene-disease association. (HuGE Navigator) | A genome-wide association study identifies three loci associated with mean platelet volume.
Meisinger C, Prokisch H, Gieger C, Soranzo N, Mehta D, Rosskopf D, Lichtner P, Klopp N, Stephens J, Watkins NA, Deloukas P, Greinacher A, Koenig W, Nauck M, Rimmbach C, Völzke H, Peters A, Illig T, Ouwehand WH, Meitinger T, Wichmann HE, Döring A., Free PMC Article | 01/11/2009 |
| Spred1-MARKK binding has no effect on the activity of MARKK; therefore, it does not change microtubule (MT) stability. | Spred1 and TESK1--two new interaction partners of the kinase MARKK/TAO1 that link the microtubule and actin cytoskeleton.
Johne C, Matenia D, Li XY, Timm T, Balusamy K, Mandelkow EM., Free PMC Article | 01/21/2010 |
| It is concluded that human TAO kinase 1 induces apoptosis in SH-SY5Y cells and the kinase domain is essential, but its catalytic activity seems to be dispensable in this case. | Human TAO kinase 1 induces apoptosis in SH-SY5Y cells.
Wu MF, Wang SG. | 01/21/2010 |
| TAO kinases are regulators of p38-mediated responses to DNA damage and are intermediates in the activation of p38 by ATM. | TAO kinases mediate activation of p38 in response to DNA damage.
Raman M, Earnest S, Zhang K, Zhao Y, Cobb MH., Free PMC Article | 01/21/2010 |
| Prostate-derived sterile 20-like kinase 2 (PSK2) regulates apoptotic morphology via C-Jun N-terminal kinase and Rho kinase-1 | Prostate-derived sterile 20-like kinase 2 (PSK2) regulates apoptotic morphology via C-Jun N-terminal kinase and Rho kinase-1.
Zihni C, Mitsopoulos C, Tavares IA, Ridley AJ, Morris JD. | 01/21/2010 |
| Dual functions of TAO1 in regulating microtubule dynamics and checkpoint signalling may help to coordinate the establishment and monitoring of correct congression of chromosomes, thereby protecting genomic stability in human cells. | A functional genomic screen identifies a role for TAO1 kinase in spindle-checkpoint signalling.
Draviam VM, Stegmeier F, Nalepa G, Sowa ME, Chen J, Liang A, Hannon GJ, Sorger PK, Harper JW, Elledge SJ. | 01/21/2010 |