| A Missense Variant in HACE1 Is Associated with Intellectual Disability, Epilepsy, Spasticity, and Psychomotor Impairment in a Pakistani Kindred. | A Missense Variant in HACE1 Is Associated with Intellectual Disability, Epilepsy, Spasticity, and Psychomotor Impairment in a Pakistani Kindred.
Usmani MA, Ghaffar A, Shahzad M, Akram J, Majeed AI, Malik K, Fatima K, Khan AA, Ahmed ZM, Riazuddin S, Riazuddin S., Free PMC Article | 08/28/2024 |
| Emerging role and mechanism of HACE1 in the pathogenesis of neurodegenerative diseases: A promising target. | Emerging role and mechanism of HACE1 in the pathogenesis of neurodegenerative diseases: A promising target.
Zang C, Liu H, Ning J, Chen Q, Jiang Y, Shang M, Yang Y, Ma J, Dong Y, Wang J, Li F, Bao X, Zhang D. | 03/6/2024 |
| HACE1 expression in heart failure patients might promote mitochondrial oxidative stress and ferroptosis by targeting NRF2. | HACE1 expression in heart failure patients might promote mitochondrial oxidative stress and ferroptosis by targeting NRF2.
Yin P, Wu Y, Long X, Zhu S, Chen S, Lu F, Lin K, Xu J., Free PMC Article | 12/28/2023 |
| Structural Basis for the Enzymatic Activity of the HACE1 HECT-Type E3 Ligase Through N-Terminal Helix Dimerization. | Structural Basis for the Enzymatic Activity of the HACE1 HECT-Type E3 Ligase Through N-Terminal Helix Dimerization.
Singh S, Machida S, Tulsian NK, Choong YK, Ng J, Shankar S, Liu Y, Chandiramani KV, Shi J, Sivaraman J., Free PMC Article | 09/29/2023 |
| HACE1-mediated NRF2 activation causes enhanced malignant phenotypes and decreased radiosensitivity of glioma cells. | HACE1-mediated NRF2 activation causes enhanced malignant phenotypes and decreased radiosensitivity of glioma cells.
Da C, Pu J, Liu Z, Wei J, Qu Y, Wu Y, Shi B, Yang J, He N, Hou P., Free PMC Article | 03/26/2022 |
| HACE1 negatively regulates neuroinflammation through ubiquitylating and degrading Rac1 in Parkinson's disease models. | HACE1 negatively regulates neuroinflammation through ubiquitylating and degrading Rac1 in Parkinson's disease models.
Zang CX, Wang L, Yang HY, Shang JM, Liu H, Zhang ZH, Ju C, Yuan FY, Li FY, Bao XQ, Zhang D., Free PMC Article | 03/19/2022 |
| HACE1 blocks HIF1alpha accumulation under hypoxia in a RAC1 dependent manner. | HACE1 blocks HIF1α accumulation under hypoxia in a RAC1 dependent manner.
Turgu B, Zhang F, El-Naggar A, Negri GL, Kogler M, Tortola L, Johnson F, Ng T, Li A, Yapp D, Lockwood W, Martinez D, Maris JM, Daugaard M, Penninger JM, Hughes CS, Sorensen PH., Free PMC Article | 10/16/2021 |
| Correlations of HACE1 expression with pathological stages, CT features and prognosis of hepatocellular carcinoma patients. | Correlations of HACE1 expression with pathological stages, CT features and prognosis of hepatocellular carcinoma patients.
Zhang Z, Teng M, Xu Z, Wang D. | 09/11/2021 |
| meQTL and ncRNA functional analyses of 102 GWAS-SNPs associated with depression implicate HACE1 and SHANK2 genes. | meQTL and ncRNA functional analyses of 102 GWAS-SNPs associated with depression implicate HACE1 and SHANK2 genes.
Ciuculete DM, Voisin S, Kular L, Jonsson J, Rask-Andersen M, Mwinyi J, Schiöth HB., Free PMC Article | 08/21/2021 |
| Ubiquitin-independent proteasomal degradation of Spindlin-1 by the E3 ligase HACE1 contributes to cell-cell adhesion. | Ubiquitin-independent proteasomal degradation of Spindlin-1 by the E3 ligase HACE1 contributes to cell-cell adhesion.
Palicharla VR, Gupta D, Bhattacharya D, Maddika S. | 07/31/2021 |
| Loss of the Tumor Suppressor HACE1 Contributes to Cancer Progression. | Loss of the Tumor Suppressor HACE1 Contributes to Cancer Progression.
Li JC, Chang X, Chen Y, Li XZ, Zhang XL, Yang SM, Hu CJ, Zhang H. | 08/22/2020 |
| HACE1-YAP1 axis had an important part in the Colorectal cancer development and progression. | Loss of HACE1 promotes colorectal cancer cell migration via upregulation of YAP1.
Zhou Z, Zhang HS, Zhang ZG, Sun HL, Liu HY, Gou XM, Yu XY, Huang YH. | 04/18/2020 |
| Ectopic expression of HACE1 markedly inhibited anchorage-independent growth and cell motility of HACE1 osteosarcoma cell lines, HACE1 overexpression blocked osteosarcoma xenograft growth and dramatically reduced pulmonary metastases. These findings point to a potential tumor suppressor function for HACE1 in osteosarcoma. | HACE1 is a potential tumor suppressor in osteosarcoma.
El-Naggar AM, Clarkson PW, Negri GL, Turgu B, Zhang F, Anglesio MS, Sorensen PH., Free PMC Article | 02/29/2020 |
| The present study demonstrates that KSHV infection induces the E3 ligase HACE1 protein to regulate KSHV-induced oxidative stress by promoting the activation of Nrf2 and nuclear translocation. | HACE1, an E3 Ubiquitin Protein Ligase, Mitigates Kaposi's Sarcoma-Associated Herpesvirus Infection-Induced Oxidative Stress by Promoting Nrf2 Activity.
Kumar B, Roy A, Asha K, Sharma-Walia N, Ansari MA, Chandran B., Free PMC Article | 02/1/2020 |
| our studies unveiled a suppressive role of HACE1 in tumor growth and migration of gastric cancer, and it might help to provide novel insights into the blockage of tumorigenesis and malignant process of early stage of gastric cancer. | Overexpression of HACE1 in gastric cancer inhibits tumor aggressiveness by impeding cell proliferation and migration.
Chen YL, Li DP, Jiang HY, Yang Y, Xu LL, Zhang SC, Gao H., Free PMC Article | 11/2/2019 |
| FIH interacts with the ankyrin repeat domain of HACE1.HACE1 is hydroxylated at asparagine 191 by FIH.FIH-dependent hydroxylation of HACE1 inhibits HACE1 ability to ubiquitinate Rac1.HACE1 expression inversely correlates with breast cancer progression. | Oxygen sensor FIH inhibits HACE1-dependent ubiquitination of Rac1 to enhance metastatic potential in breast cancer cells.
Kim I, Shin SH, Lee JE, Park JW. | 10/26/2019 |
| HACE1 promoted the K27 ubiquitination of fibronectin and regulated its secretion. Secreted fibronectin regulated ITGAV and ITGB1 expression, as well as melanoma cell adhesion and migration. | Uncovering and deciphering the pro-invasive role of HACE1 in melanoma cells.
El-Hachem N, Habel N, Naiken T, Bzioueche H, Cheli Y, Beranger GE, Jaune E, Rouaud F, Nottet N, Reinier F, Gaudel C, Colosetti P, Bertolotto C, Ballotti R., Free PMC Article | 09/7/2019 |
| A functional interplay between HACE1 and Rac1 in cancer, is reported. | Identification of cancer-associated missense mutations in hace1 that impair cell growth control and Rac1 ubiquitylation.
Andrio E, Lotte R, Hamaoui D, Cherfils J, Doye A, Daugaard M, Sorensen PH, Bost F, Ruimy R, Mettouchi A, Lemichez E., Free PMC Article | 12/22/2018 |
| Results identified HACE1 Ser-385 as a pivotal amino acid residue that is phosphorylated in response to CNF1 or VEGF treatments and that expression of activated Rac1 is sufficient to induce HACE1 phosphorylation and controlling its oligomerization state. | Group-I PAKs-mediated phosphorylation of HACE1 at serine 385 regulates its oligomerization state and Rac1 ubiquitination.
Acosta MI, Urbach S, Doye A, Ng YW, Boudeau J, Mettouchi A, Debant A, Manser E, Visvikis O, Lemichez E., Free PMC Article | 12/22/2018 |
| Results indicated that HACE1 rs9404576 polymorphism may be associated with Wilms' tumor susceptibility in the Chinese population. | Association Between HACE1 Gene Polymorphisms and Wilms' Tumor Risk in a Chinese Population.
Jia W, Deng Z, Zhu J, Fu W, Zhu S, Zhang LY, Hu J, Wang F, Xia H, Liu GC, He J. | 12/23/2017 |
| 3-deazaneplanocin A treatment increased HACE1 gene expression which was further increased by the addition of trichostatine A (TSA), a promising therapeutic compound for the treatment of human B-Lymphoma | Heterogeneous epigenetic regulation of HACE1 in Burkitt- Lymphoma-derived cells.
Bouzelfen A, Kora H, Alcantara M, Bertrand P, Latouche JB, Jardin F. | 11/4/2017 |
| Mechanistic studies showed that HACE1 exerts its inhibitory role on virus-induced signaling by disrupting the MAVS-TRAF3 complex. | HACE1 Negatively Regulates Virus-Triggered Type I IFN Signaling by Impeding the Formation of the MAVS-TRAF3 Complex.
Mao HT, Wang Y, Cai J, Meng JL, Zhou Y, Pan Y, Qian XP, Zhang Y, Zhang J., Free PMC Article | 09/23/2017 |
| HACE1 can act as a haploinsufficient tumor suppressor gene in most B-cell lymphomas and can be downregulated by deacetylation of its promoter region chromatin | HACE1 is a putative tumor suppressor gene in B-cell lymphomagenesis and is down-regulated by both deletion and epigenetic alterations.
Bouzelfen A, Alcantara M, Kora H, Picquenot JM, Bertrand P, Cornic M, Mareschal S, Bohers E, Maingonnat C, Ruminy P, Adriouch S, Boyer O, Dubois S, Bastard C, Tilly H, Latouche JB, Jardin F. | 07/22/2017 |
| Hepatocellular carcinoma patients with low HACE1 expression levels exhibited poorer overall survival and HACE1 was found to be an independent prognostic factor for survival. | Tumor-suppressive role of HACE1 in hepatocellular carcinoma and its clinical significance.
Gao ZF, Wu YN, Bai ZT, Zhang L, Zhou Q, Li X. | 03/18/2017 |
| HACE1 as a specific E3 ligase that polyubiquitinates YB-1 through non-canonical K27 linked ubiquitin chains. | HACE1 mediated K27 ubiquitin linkage leads to YB-1 protein secretion.
Palicharla VR, Maddika S. | 09/24/2016 |