| KLF15 maintains contractile phenotype of vascular smooth muscle cells and prevents thoracic aortic dissection by interacting with MRTFB. | KLF15 maintains contractile phenotype of vascular smooth muscle cells and prevents thoracic aortic dissection by interacting with MRTFB.
Fang G, Tian Y, Huang S, Zhang X, Liu Y, Li Y, Du J, Gao S., Free PMC Article | 06/5/2024 |
| De novo variants in MRTFB have gain-of-function activity in Drosophila and are associated with a novel neurodevelopmental phenotype with dysmorphic features. | De novo variants in MRTFB have gain-of-function activity in Drosophila and are associated with a novel neurodevelopmental phenotype with dysmorphic features.
Andrews JC, Mok JW, Kanca O, Jangam S, Tifft C, Macnamara EF, Russell BE, Wang LK, Undiagnosed Diseases Network, Nelson SF, Bellen HJ, Yamamoto S, Malicdan MCV, Wangler MF., Free PMC Article | 06/9/2023 |
| Role of CRP2-MRTF interaction in functions of myofibroblasts. | Role of CRP2-MRTF interaction in functions of myofibroblasts.
Hayashi K, Horoiwa S, Mori K, Miyata H, Labios RJ, Morita T, Kobayashi Y, Yamashiro C, Higashijima F, Yoshimoto T, Kimura K, Nakagawa Y., Free PMC Article | 05/17/2023 |
| Oxidative Stress Enhances the TGF-beta2-RhoA-MRTF-A/B Axis in Cells Entering Endothelial-Mesenchymal Transition. | Oxidative Stress Enhances the TGF-β2-RhoA-MRTF-A/B Axis in Cells Entering Endothelial-Mesenchymal Transition.
Sobierajska K, Wawro ME, Niewiarowska J., Free PMC Article | 03/12/2022 |
| The New Model of Snail Expression Regulation: The Role of MRTFs in Fast and Slow Endothelial-Mesenchymal Transition. | The New Model of Snail Expression Regulation: The Role of MRTFs in Fast and Slow Endothelial-Mesenchymal Transition.
Sobierajska K, Ciszewski WM, Macierzynska-Piotrowska E, Klopocka W, Przygodzka P, Karakula M, Pestka K, Wawro ME, Niewiarowska J., Free PMC Article | 02/20/2021 |
| Lower MRTFB expression levels are associated with shorter survival of patients with GI tract cancer. MRTFB targets SPDL1 and MCAM to inhibit CRC cell motility and tumor growth. Depletion of MRTFB in human CRC Cells increases cell motility and accelerates tumor growth in xenograft assays. | MRTFB suppresses colorectal cancer development through regulating SPDL1 and MCAM.
Kodama T, Marian TA, Lee H, Kodama M, Li J, Parmacek MS, Jenkins NA, Copeland NG, Wei Z., Free PMC Article | 04/25/2020 |
| Ectomesenchymal chondromyxoid tumors are characterized by an RREB1-MKL2 fusion gene. | Ectomesenchymal Chondromyxoid Tumor: A Neoplasm Characterized by Recurrent RREB1-MKL2 Fusions.
Dickson BC, Antonescu CR, Argyris PP, Bilodeau EA, Bullock MJ, Freedman PD, Gnepp DR, Jordan RC, Koutlas IG, Lee CH, Leong I, Merzianu M, Purgina BM, Thompson LDR, Wehrli B, Wright JM, Swanson D, Zhang L, Bishop JA., Free PMC Article | 09/7/2019 |
| These studies implicate the actin cytoskeleton and ELK3, FLI1, and MKL2 in the transcriptional control of EDNRB and increase our understanding of the plasticity of this receptor | Expression of endothelin type B receptors (EDNRB) on smooth muscle cells is controlled by MKL2, ternary complex factors, and actin dynamics.
Krawczyk KK, Skovsted GF, Perisic L, Dreier R, Berg JO, Hedin U, Rippe C, Swärd K. | 07/13/2019 |
| Our new data identifies and important contribution of MKL1/2 to explaining the strikingly different response of VSMCs and ECs to cAMP elevation. Elucidation of these pathways promises to identify targets for specific inhibition of VSMC migration and proliferation. | Divergent Regulation of Actin Dynamics and Megakaryoblastic Leukemia-1 and -2 (Mkl1/2) by cAMP in Endothelial and Smooth Muscle Cells.
Smith MC, Hudson CA, Kimura TE, White SJ, Sala-Newby GB, Newby AC, Bond M., Free PMC Article | 06/15/2019 |
| Taken together, these findings suggest that MKL1 and MKL2 are present at synapses and involved in dendritic spine maturation. | Synaptic localisation of SRF coactivators, MKL1 and MKL2, and their role in dendritic spine morphology.
Kaneda M, Sakagami H, Hida Y, Ohtsuka T, Satou N, Ishibashi Y, Fukuchi M, Krysiak A, Ishikawa M, Ihara D, Kalita K, Tabuchi A., Free PMC Article | 11/24/2018 |
| Study showed that MRTF-A and MRTF-B were upregulated in pancreatic cancer tissues supporting the hypothesis that both of them are oncogenes in pancreatic cancer. | The MRTF-A/B function as oncogenes in pancreatic cancer.
Song Z, Liu Z, Sun J, Sun FL, Li CZ, Sun JZ, Xu LY. | 10/22/2016 |
| While disruption of the MKL2:SRF axis has been associated with severe microcephaly and disordered brain development in multiple model systems, the role of this transcription factor complex has not been previously demonstrated in human brain development. | Genetic variation in MKL2 and decreased downstream PCTAIRE1 expression in extreme, fatal primary human microcephaly.
Ramos EI, Bien-Willner GA, Li J, Hughes AE, Giacalone J, Chasnoff S, Kulkarni S, Parmacek M, Cole FS, Druley TE., Free PMC Article | 11/22/2014 |
| There were multiple independent HIV integrations in several genes, including MKL2 and BACH2; many of these integrations were in clonally expanded cells. | HIV latency. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells.
Maldarelli F, Wu X, Su L, Simonetti FR, Shao W, Hill S, Spindler J, Ferris AL, Mellors JW, Kearney MF, Coffin JM, Hughes SH., Free PMC Article | 08/9/2014 |
| MKL1/2 depletion resulted in Ras activation, elevated p16 expression and hypophosphorylation of the retinoblastoma (Rb) protein in DLC1-deficient hepatocellular carcinoma cells. | Depletion of the transcriptional coactivators megakaryoblastic leukaemia 1 and 2 abolishes hepatocellular carcinoma xenograft growth by inducing oncogene-induced senescence.
Hampl V, Martin C, Aigner A, Hoebel S, Singer S, Frank N, Sarikas A, Ebert O, Prywes R, Gudermann T, Muehlich S., Free PMC Article | 03/15/2014 |
| Based on a recurrent translocation t(11;16)(q13;p13), the C11orf95-MKL2 fusion gene has been found in eight further cases of chondroid lipomas. | Presence of C11orf95-MKL2 fusion is a consistent finding in chondroid lipomas: a study of eight cases.
Flucke U, Tops BB, de Saint Aubain Somerhausen N, Bras J, Creytens DH, Küsters B, Groenen PJ, Verdijk MA, Suurmeijer AJ, Mentzel T. | 12/28/2013 |
| study provides evidence that MKL1/2 mediates cancerous transformation in DLC1-deficient hepatocellular and mammary carcinoma cells | The transcriptional coactivators megakaryoblastic leukemia 1/2 mediate the effects of loss of the tumor suppressor deleted in liver cancer 1.
Muehlich S, Hampl V, Khalid S, Singer S, Frank N, Breuhahn K, Gudermann T, Prywes R. | 11/17/2012 |
| C11orf95-MKL2 is the resulting fusion oncogene of t(11;16)(q13;p13) in chondroid lipoma. | C11orf95-MKL2 is the resulting fusion oncogene of t(11;16)(q13;p13) in chondroid lipoma.
Huang D, Sumegi J, Dal Cin P, Reith JD, Yasuda T, Nelson M, Muirhead D, Bridge JA., Free PMC Article | 10/30/2010 |
| Observational study and meta-analysis of gene-disease association. (HuGE Navigator) | Linkage and candidate gene studies of autism spectrum disorders in European populations.
Holt R, Barnby G, Maestrini E, Bacchelli E, Brocklebank D, Sousa I, Mulder EJ, Kantojärvi K, Järvelä I, Klauck SM, Poustka F, Bailey AJ, Monaco AP, EU Autism MOLGEN Consortium., Free PMC Article | 06/30/2010 |
| RNA interference was used to investigate the contribution of the MRTF-SRF pathway to cytoskeletal dynamics in MDA-MB-231 breast carcinoma and B16F2 melanoma cells, in which basal MRTF-SRF activity is Rho-dependent. | Myocardin-related transcription factors and SRF are required for cytoskeletal dynamics and experimental metastasis.
Medjkane S, Perez-Sanchez C, Gaggioli C, Sahai E, Treisman R., Free PMC Article | 01/21/2010 |
| BMP signaling modulates VSMC phenotype via cross-talk with the RhoA/MRTFs pathway, and may contribute to the development of the pathological characteristics observed in patients with PAH and other obliterative vascular diseases. | Control of phenotypic plasticity of smooth muscle cells by bone morphogenetic protein signaling through the myocardin-related transcription factors.
Lagna G, Ku MM, Nguyen PH, Neuman NA, Davis BN, Hata A., Free PMC Article | 01/21/2010 |
| Myocardin-related transcription factors are critical mediators of transforming growth factor beta (TGF-beta) 1-induced epithelial-mesenchymal transition.[ | Dual roles of myocardin-related transcription factors in epithelial mesenchymal transition via slug induction and actin remodeling.
Morita T, Mayanagi T, Sobue K., Free PMC Article | 01/21/2010 |
| dominant negative MKL2 blocked differentiation-induced expression of SRF target genes skeletal alpha-actin and alpha-myosin heavy chain and blocked differentiation of the myoblasts to myotubes in vitro. | Megakaryoblastic leukemia-1/2, a transcriptional co-activator of serum response factor, is required for skeletal myogenic differentiation.
Selvaraj A, Prywes R. | 01/21/2010 |