| Molecular insights into differentiated ligand recognition of the human parathyroid hormone receptor 2. | Molecular insights into differentiated ligand recognition of the human parathyroid hormone receptor 2.
Wang X, Cheng X, Zhao L, Wang Y, Ye C, Zou X, Dai A, Cong Z, Chen J, Zhou Q, Xia T, Jiang H, Xu HE, Yang D, Wang MW., Free PMC Article | 12/18/2021 |
| expressed in the epidermis in Darier disease | The parathyroid hormone family member TIP39 interacts with sarco/endoplasmic reticulum Ca(2+) - ATPase activity by influencing calcium homoeostasis.
Sato E, Williams MR, Sanford JA, Sen GL, Nakama T, Imafuku S, Gallo RL., Free PMC Article | 07/14/2018 |
| PTH2R and its ligand TIP39 regulate intracellular calcium and influence keratinocyte differentiation | The Parathyroid Hormone Second Receptor PTH2R and its Ligand Tuberoinfundibular Peptide of 39 Residues TIP39 Regulate Intracellular Calcium and Influence Keratinocyte Differentiation.
Sato E, Muto J, Zhang LJ, Adase CA, Sanford JA, Takahashi T, Nakatsuji T, Usdin TB, Gallo RL., Free PMC Article | 07/22/2017 |
| Authors report PTH2R as a gene that is disrupted in NSC. The disruption of the PTH2R gene may cause uncontrolled proliferation and differentiation of chondrocytes. | Breakpoint mapping by whole genome sequencing identifies PTH2R gene disruption in a patient with midline craniosynostosis and a de novo balanced chromosomal rearrangement.
Kim J, Won HH, Kim Y, Choi JR, Yu N, Lee KA., Free PMC Article | 01/28/2017 |
| Variation in the PTH2R gene (Chr2q34, rs897083) may contribute to the age-associated degenerative manifestations that develop at the lumbar spine | Variation in the PTH2R gene is associated with age-related degenerative changes in the lumbar spine.
Åkesson K, Tenne M, Gerdhem P, Luthman H, McGuigan FE. | 10/24/2015 |
| Data suggest role for PTH2R signaling in postnatal growth plate development and subsequent bone mass acquisition; overexpression of human PTH2R in chondrocytes of transgenic mice has key consequences on postnatal development of endochondral skeleton. | Defective postnatal endochondral bone development by chondrocyte-specific targeted expression of parathyroid hormone type 2 receptor.
Panda DK, Goltzman D, Karaplis AC., Free PMC Article | 03/2/2013 |
| PTH-receptors regulate norepinephrine release in human heart and kidney | PTH-receptors regulate norepinephrine release in human heart and kidney.
Potthoff SA, Janus A, Hoch H, Frahnert M, Tossios P, Reber D, Giessing M, Klein HM, Schwertfeger E, Quack I, Rump LC, Vonend O. | 12/31/2011 |
| The results demonstrate that TIP39 and the PTH2R are expressed in the brain of primates in locations that suggest involvement in regulation of fear, anxiety, reproductive behaviors, release of pituitary hormones, and nociception. | Parathyroid hormone 2 receptor and its endogenous ligand tuberoinfundibular peptide of 39 residues are concentrated in endocrine, viscerosensory and auditory brain regions in macaque and human.
Bagó AG, Dimitrov E, Saunders R, Seress L, Palkovits M, Usdin TB, Dobolyi A., Free PMC Article | 01/21/2010 |
| Different receptor subtype properties were used to demonstrate that residue 41 in PTH-1R, when either the native Leu or substituted by Ile or Met, can accommodate either Phe or Trp at position 23 of the ligand. | Ligand-receptor interactions at the parathyroid hormone receptors: subtype binding selectivity is mediated via an interaction between residue 23 on the ligand and residue 41 on the receptor.
Mann R, Wigglesworth MJ, Donnelly D. | 01/21/2010 |
| The distribution of PTH2R-immunoreactive fibers in viscerosensory brain regions is similar to that reported in mouse and rat suggesting a similar role of the PTH2R in human as in rodents. | Evidence for the expression of parathyroid hormone 2 receptor in the human brainstem.
Bagó AG, Palkovits M, Usdin TB, Seress L, Dobolyi A., Free PMC Article | 01/21/2010 |
| 6 SNPs in the PTH gene and 3 SNPs each in the PTHLH, PTHR1 and PTHR2 genes were investigated in relation to bone mineral density | Genetic variation in the PTH pathway and bone phenotypes in elderly women: evaluation of PTH, PTHLH, PTHR1 and PTHR2 genes.
Tenne M, McGuigan F, Jansson L, Gerdhem P, Obrant KJ, Luthman H, Akesson K, Tenne M, McGuigan F, Jansson L, Gerdhem P, Obrant KJ, Luthman H, Akesson K. | 01/21/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | Genetic variation in the PTH pathway and bone phenotypes in elderly women: evaluation of PTH, PTHLH, PTHR1 and PTHR2 genes.
Tenne M, McGuigan F, Jansson L, Gerdhem P, Obrant KJ, Luthman H, Akesson K, Tenne M, McGuigan F, Jansson L, Gerdhem P, Obrant KJ, Luthman H, Akesson K. | 04/3/2008 |
| specific interactions within the ligand-receptor bimolecular complex mediate distinct postactivation responses of class II G protein- coupled receptors and provide novel insights into the physiological regulation of PTH2R activity | Agonist-specific regulation of parathyroid hormone (PTH) receptor type 2 activity: structural and functional analysis of PTH- and tuberoinfundibular peptide (TIP) 39-stimulated desensitization and internalization.
Bisello A, Manen D, Pierroz DD, Usdin TB, Rizzoli R, Ferrari SL. | 01/21/2010 |