| The Parathyroid Hormone-Related Protein/Parathyroid Hormone 1 Receptor Axis in Adipose Tissue. | The Parathyroid Hormone-Related Protein/Parathyroid Hormone 1 Receptor Axis in Adipose Tissue.
Izquierdo-Lahuerta A., Free PMC Article | 08/9/2024 |
| Identification of a novel heterozygous PTH1R variant in a Chinese family with incomplete penetrance. | Identification of a novel heterozygous PTH1R variant in a Chinese family with incomplete penetrance.
Wang J, Zhao C, Zhang X, Yang L, Hu Y., Free PMC Article | 02/7/2024 |
| Parathyroid hormone receptor-1 signaling aggravates hepatic fibrosis through upregulating cAMP response element-binding protein-like 2. | Parathyroid hormone receptor-1 signaling aggravates hepatic fibrosis through upregulating cAMP response element-binding protein-like 2.
Hong T, Xiong X, Chen Y, Wang Q, Fu X, Meng Q, Lu Y, Li X. | 11/16/2023 |
| Identification of a novel PTH1R variant in a family with primary failure of eruption. | Identification of a novel PTH1R variant in a family with primary failure of eruption.
Zha Y, Li S, Yu YL, Huang Z, Zhang HY, Kong W., Free PMC Article | 07/25/2023 |
| Class B1 GPCR activation by an intracellular agonist. | Class B1 GPCR activation by an intracellular agonist.
Kobayashi K, Kawakami K, Kusakizako T, Tomita A, Nishimura M, Sawada K, Okamoto HH, Hiratsuka S, Nakamura G, Kuwabara R, Noda H, Muramatsu H, Shimizu M, Taguchi T, Inoue A, Murata T, Nureki O., Free PMC Article | 07/5/2023 |
| Rare Variant of PTH1R Mutation in an Indian Family. | Rare Variant of PTH1R Mutation in an Indian Family.
Parameswaran AS, Singh K, Vyas V, Tada NK. | 05/3/2023 |
| A Novel Heterozygous Missense Variant in Parathyroid Hormone 1 is Related to the Occurrence of Developmental Dysplasia of the Hip. | A Novel Heterozygous Missense Variant in Parathyroid Hormone 1 is Related to the Occurrence of Developmental Dysplasia of the Hip.
Yang D, Zhou Z, Wang S, Ying H, Wang S, Ma Q, Wu J, Jiao Q, Fan L, Chen M, Wang Y, Zhao L. | 04/12/2023 |
| Molecular Mechanism of Ca[2+] in the Allosteric Regulation of Human Parathyroid Hormone Receptor-1. | Molecular Mechanism of Ca(2+) in the Allosteric Regulation of Human Parathyroid Hormone Receptor-1.
Li M, Li M, Guo J. | 11/26/2022 |
| Osteoporosis and its Association with Vitamin D Receptor, Oestrogen alpha Receptor, Parathyroid Receptor and Collagen Type I alpha Receptor Gene Polymorphisms with Bone Mineral Density: A Pilot Study from South Indian Postmenopausal Women of Tamil Nadu. | Osteoporosis and its Association with Vitamin D Receptor, Oestrogen α Receptor, Parathyroid Receptor and Collagen Type I alpha Receptor Gene Polymorphisms with Bone Mineral Density: A Pilot Study from South Indian Postmenopausal Women of Tamil Nadu.
Fernandez C, Tennyson J, Priscilla AS. | 11/5/2022 |
| Salt inducible kinases and PTH1R action. | Salt inducible kinases and PTH1R action.
Yoon SH, Tang CC, Wein MN. | 08/20/2022 |
| Parathyroid hormone-related peptide and parathyroid hormone-related peptide receptor type 1 in locally advanced laryngeal cancer as prognostic indicators of relapse and survival. | Parathyroid hormone-related peptide and parathyroid hormone-related peptide receptor type 1 in locally advanced laryngeal cancer as prognostic indicators of relapse and survival.
Almadori G, Coli A, De Corso E, Mele DA, Settimi S, Di Cintio G, Brigato F, Scannone D, Lauriola L, Ranelletti FO., Free PMC Article | 07/2/2022 |
| Actions of Parathyroid Hormone Ligand Analogues in Humanized PTH1R Knockin Mice. | Actions of Parathyroid Hormone Ligand Analogues in Humanized PTH1R Knockin Mice.
Daley EJ, Yoon SH, Reyes M, Bruce M, Brooks DJ, Bouxsein M, Potts JT, Kronenberg HM, Wein MN, Lanske B, Jüppner H, Gardella TJ., Free PMC Article | 06/18/2022 |
| PTHR1 Genetic Polymorphisms Are Associated with Osteoporosis among Postmenopausal Arab Women. | PTHR1 Genetic Polymorphisms Are Associated with Osteoporosis among Postmenopausal Arab Women.
Abdi S, Almiman AA, Ansari MGA, Alnaami AM, Mohammed AK, Aljohani NJ, Alenad A, Alghamdi A, Alokail MS, Al-Daghri NM., Free PMC Article | 01/22/2022 |
| Enzalutamide-induced and PTH1R-mediated TGFBR2 degradation in osteoblasts confers resistance in prostate cancer bone metastases. | Enzalutamide-induced and PTH1R-mediated TGFBR2 degradation in osteoblasts confers resistance in prostate cancer bone metastases.
Su S, Cao J, Meng X, Liu R, Vander Ark A, Woodford E, Zhang R, Stiver I, Zhang X, Madaj ZB, Bowman MJ, Wu Y, Xu HE, Chen B, Yu H, Li X., Free PMC Article | 01/8/2022 |
| Validating clinical characteristic of primary failure of eruption (PFE) associated with PTH1R variants. | Validating clinical characteristic of primary failure of eruption (PFE) associated with PTH1R variants.
Grippaudo C, D'Apolito I, Cafiero C, Re A, Chiurazzi P, Frazier-Bowers SA., Free PMC Article | 12/18/2021 |
| Functional Analysis of PTH1R Variants Found in Primary Failure of Eruption. | Functional Analysis of PTH1R Variants Found in Primary Failure of Eruption.
Izumida E, Suzawa T, Miyamoto Y, Yamada A, Otsu M, Saito T, Yamaguchi T, Nishimura K, Ohtaka M, Nakanishi M, Yoshimura K, Sasa K, Takimoto R, Uyama R, Shirota T, Maki K, Kamijo R. | 11/21/2020 |
| The oncogenic role of PTHLH appeared to be a consequence of its intracrine function, as downregulation of its receptor, PTH1R, increased anchorage-independent growth and induced a more undifferentiated, invasive phenotype. | Parathyroid hormone-like hormone plays a dual role in neuroblastoma depending on PTH1R expression.
García M, Rodríguez-Hernández CJ, Mateo-Lozano S, Pérez-Jaume S, Gonçalves-Alves E, Lavarino C, Mora J, de Torres C., Free PMC Article | 05/2/2020 |
| Type I collagen deposition was increased, whereas PTHR1 expression and type II collagen deposition were decreased by PTH supplementation. Expression of the (pre)hypertrophic markers MMP13, RUNX2, IHH and type X collagen were not affected by PTH | PTH decreases in vitro human cartilage regeneration without affecting hypertrophic differentiation.
Rutgers M, Bach F, Vonk L, van Rijen M, Akrum V, van Boxtel A, Dhert W, Creemers L., Free PMC Article | 12/21/2019 |
| PTHR1 may play important roles in progression of Osteosarcoma by activating miR-124-3p-AR-Tgfb1i1, miR-27a-3p-PPARG-Abca1, and miR-103/590-3p-AXIN2 axes. | PTHR1 May Be Involved in Progression of Osteosarcoma by Regulating miR-124-3p-AR-Tgfb1i1, miR-27a-3p-PPARG-Abca1, and miR-103/590-3p-AXIN2 Axes.
Li S, Wu X, Pei Y, Wang W, Zheng K, Qiu E, Zhang X. | 12/7/2019 |
| PTHR1 expression in U2OS cells was reduced by 0.18-, and 0.41-fold at 80, and 100 muM, respectively. | Quercetin suppresses the proliferation and metastasis of metastatic osteosarcoma cells by inhibiting parathyroid hormone receptor 1.
Li S, Pei Y, Wang W, Liu F, Zheng K, Zhang X. | 08/31/2019 |
| High PTH1R expression is associated with crohn's disease. | Parathyroid Hormone-Like Hormone Induces Epithelial-to-Mesenchymal Transition of Intestinal Epithelial Cells by Activating the Runt-Related Transcription Factor 2.
He S, Xue M, Liu C, Xie F, Bai L. | 07/6/2019 |
| this study reports the cryo-electron microscopy structure of human PTH1R bound to a long-acting PTH analog and the stimulatory G protein. | Structure and dynamics of the active human parathyroid hormone receptor-1.
Zhao LH, Ma S, Sutkeviciute I, Shen DD, Zhou XE, de Waal PW, Li CY, Kang Y, Clark LJ, Jean-Alphonse FG, White AD, Yang D, Dai A, Cai X, Chen J, Li C, Jiang Y, Watanabe T, Gardella TJ, Melcher K, Wang MW, Vilardaga JP, Xu HE, Zhang Y., Free PMC Article | 05/11/2019 |
| We further find that Ca(2+) allostery in the PTHR is strongly affected by the point mutation recently identified in the PTH (PTH(R25C)) as a new cause of hypocalcemia in humans. | Ca(2+) allostery in PTH-receptor signaling.
White AD, Fang F, Jean-Alphonse FG, Clark LJ, An HJ, Liu H, Zhao Y, Reynolds SL, Lee S, Xiao K, Sutkeviciute I, Vilardaga JP., Free PMC Article | 05/4/2019 |
| The results of this research confirm that mutations of the PTH1R gene are responsible for eruption failure with a varied clinical presentation consistent with previous descriptions of primary failure of eruption (PFE). These phenotypes can be found early at the level of the deciduous and then in the permanent dentition. | Primary failure of eruption: Clinical and genetic findings in the mixed dentition.
Grippaudo C, Cafiero C, D'Apolito I, Ricci B, Frazier-Bowers SA., Free PMC Article | 04/6/2019 |
| The results support that Parathyroid hormone (PTH)(1-34) not only activates PTH1R but also uniquely senses Ca(2+). | Parathyroid Hormone Senses Extracellular Calcium To Modulate Endocrine Signaling upon Binding to the Family B GPCR Parathyroid Hormone 1 Receptor.
Culhane KJ, Belina ME, Sims JN, Cai Y, Liu Y, Wang PSP, Yan ECY., Free PMC Article | 03/16/2019 |